RU2122859C1 - Phytoconcentrate with curative-prophylactic effect used in gastroenterology - Google Patents

Abstract

FIELD: medicine, gastroenterology. SUBSTANCE: phytoconcentrate has a biologically active addition - quercitin or dihydroquercitin, or rutin, or ascorutin. Also, it has medicinal plants, meat or chicken or vegetable concentrate with addition of special additions. Phytoconcentrate can be used at clinic and ambulatory conditions in different age groups and showed good clinical results. EFFECT: enhanced effectiveness of phytoconcentrate. 5 cl, 3 ex

Description

 The invention relates to medicine, namely to the creation of phytotherapeutic agents for the prevention and treatment of gastrointestinal diseases.

 In the treatment of gastrointestinal drugs, both chemical preparations and drugs of natural origin are used, which doctors have increasingly turned to recently, due to the fact that they exclude side effects. (M. D. Mashkovsky, "Medicines", M. Meditsina, 1995).

 It is also known the use of dietophytoses for the treatment of various diseases of the gastrointestinal tract. These concentrates contain medicinal plants and dried vegetables (see 1996 Diefito products of Yugoslavia).

 The objective of the present invention is the expansion of pharmacological agents of a new direction in the form of phytoconcentrate, which can be used in therapy both independently and in combination with other drugs.

The proposed phytoconcentrate contains a biologically active additive - quercetin, or dihydroquercetin, or rutin, or ascorutin; as medicinal plants - grass of the common spirit, St. John's wort grass, roots of the common marshmallow, grass of the yarrow, stinging nettle leaves and fillers - meat, or vegetable, or chicken concentrate in the following ratio of components, g per serving:
Quercetin, - 0.018 - 0.022
or dihydroquercetin, - 0.009 - 0.011
or Rutin, - 0,045 - 0,055
or Ascorutin - 0.10 - 0.30
Oregano grass - 0.15 - 0.30
St. John's wort grass - 0.15 - 0.30
Althaea officinalis herb - 0.15 - 0.30
Yarrow grass - 0.15 - 0.30
Stinging nettle leaves - 0.15 - 0.30
Concentrate of meat, or chicken, or vegetable - 4.0 - 6.25
In this case, either St. John's wort is perforated, or spotted, or tetrahedral.

 In addition, phytoconcentrates are used in the form of a broth containing 250 ml of water per serving, and may additionally include beets, or oatmeal, or spinach to taste, or mixtures thereof in various combinations.

 The phytoconcentrate in the treatment and prophylactic course is 25 - 30 days, 1-2 servings per day, with a repetition of the course after 3-4 weeks.

Characteristics of the components used:
Dihydroquercetin (DHQ), also called "Taxifolin", belongs to the group of bioflavonoids. The plant source of the proposed DHA is shredded larch wood.

 DKV (3,3 ', 4', 5,7 - pentahydroxyflavonone) - a crystalline or amorphous powder, readily soluble in ethanol and hot water.

 DHQ is a well-known antioxidant. It inhibits the processes of lipid peroxidation of food products, which results in an extension of the shelf life and improvement of their quality by reducing the content of harmful oxidation products. In terms of antioxidant action, DHQ is comparable to a - tocopherol and is superior to β - carotene, but mainly DHA is highly stable.

 DHQ is of great interest as a substance with a wide spectrum of pharmacological activity. Its capillary-protective and antioxidant properties are combined with anti-inflammatory, gastro-and hepatoprotective, hypolipidemic (anti-atherosclerotic) and diuretic effects.

 DHQ does not exhibit allergenic and toxic properties.

 The quality of DKV is determined by the technical specifications of TU 9354-04868244-96.

 Quercetin - 3, 4,7, 3'4-pentaoxiflavone.

 Rutin - quercetin 3-rutinoside. For medical use, it is extracted from the green mass of buckwheat and from the buds of Japanese sodury flowers.

 Ascorutin contains 0.05 g of rutin and ascorbic acid.

 Quarcetin, rutin and ascorutin are used for the prevention and treatment of hypo- and vitamin deficiency R and in diseases accompanied by impaired vascular permeability, hemorrhagic diathesis, retinal hemorrhages, radiation sickness, rheumatism, etc.

 Oregano increases appetite, improves digestion, especially with secretory insufficiency of the gastrointestinal tract, cholecystitis, biliary dyskinesia. It has antimicrobial and analgesic effects. Facilitates flatulence.

 St. John's wort has an antispasmodic, choleretic, astringent, antibacterial, anti-inflammatory effect. Restores normal intestinal motility. St. John's wort flavonoids increase the digestive tract's ability to digest food.

 Marshmallow - polysaccharides, starch, pectins, carotene and other biologically active substances of the marshmallow roots have an enveloping, protective, anti-inflammatory effect. Mucus, swelling, protects the mucous membranes from irritation, facilitating the regeneration of stomach and duodenal ulcer tissue damaged by peptic ulcer.

 Yarrow, flavonoids, essential oils, tannins and other substances contained in it. BAS have antispasmodic, choleretic, hemostatic, bactericidal, anti-inflammatory, wound healing effects, increase gastric secretion, and reduce flatulence.

 Nettle has a hemostatic, choleretic, anti-inflammatory effect, increases the regeneration of the mucous membrane of the stomach and intestines. Stimulates the main metabolism, normalizes lipid metabolism.

 Beetroot stimulates gastric secretion and intestinal stability.

 Oatmeal has an enveloping effect on gastric and duodenal ulcers and stimulates intestinal motility during atony.

 Spinach is useful for hypacid gastritis, enterocolitis, sluggish intestinal motility and flatulence.

A method of obtaining a phytoconcentrate of therapeutic and prophylactic action:
Grinding plant materials to a particle size of 1-2 mm should be carried out immediately before mixing it with meat, chicken or vegetable concentrate. This ensures maximum preservation of biologically active substances.

 Before being introduced into the broth, the crushed vegetable raw materials should be irradiated with a bactericidal lamp in order to reduce microbial contamination, since the process of preparation of phytoconcentrate does not require a long heat treatment. For this, the crushed raw materials are scattered with a thin layer (approximately 20 mm) and irradiated with an ultraviolet lamp with a wavelength of 360 nm for 2-3 hours with periodic stirring every 15-20 minutes.

 Cooked vegetable raw materials, DHQ and broth concentrate powder are mixed mechanically. For this purpose mixers are used.

 Next, the prepared mass is packaged in 1 portion with the inclusion of special additives for the broth to taste.

 As meat, vegetable and chicken concentrates they use possible options for products of domestic enterprises, as well as products of Knorr, Gallina Blanco and others.

The invention is illustrated by the following examples:
Example 1. The contents of one package, g:
DKV - 0.009
Oregano grass - 0.20
Hypericum perforatum - 0.15
The roots of Althea officinalis - 0.30
Yarrow grass - 0.20
Stinging nettle leaves - 0.25
Meat Concentrate - 6.25
And special additives to taste - beets and spinach. The contents are filled with 250 ml of hot (up to 90 ^o C) boiled water. Insist a few minutes, after wrapping the container with a napkin.

Example 2. The contents of one package, g:
Quercetin - 0.02
Oregano grass - 0.30
Hypericum spotted grass - 0.25
The roots of Althea officinalis - 0.15
Yarrow grass - 0.15
Stinging nettle leaves - 0.25
Vegetable Concentrate - 5.5
Add oatmeal to taste. Content pour 250 ml of boiled water (up to 90 ^o C). After brewing, insist for several minutes, closing and wrapping the container with a napkin.

Example 3. The contents of one package, g:
Routine - 0.05
Oregano grass - 0.30
St. John's wort herb tetrahedral - 0.15
The roots of Althea officinalis - 0.30
Yarrow grass - 0.25
Stinging nettle leaves - 0.30
Chicken Concentrate - 6.0 g
And special additives - spinach and oatmeal, taken to taste. The contents are brewed with 250 ml of boiled water (up to 90 ^o C). After brewing, insist for several minutes, closing and wrapping the container with a napkin.

 The treatment and prevention course is 25-30 days, repeated courses can be carried out in 3-4 weeks. Daily dose 1-2 servings. For the purpose of a variety of tastes, you can independently add products familiar to everyone (potatoes, vermicelli, etc.).

 Testing phytoconcentrate was carried out on the basis of the Medical Academy. Sechenov (Moscow) and at the Department of Children's Diseases (Irkutsk).

 This phytoconcentrate was prescribed in the form of a prophylactic, as well as in the form of an independent treatment or in combination with other drugs. In both cases, at different age groups, the phytoconcentrate showed good clinical results.

 It successfully combines a promising direction, combining nutrition, prevention and mild forms of human treatment in one system.

Claims (4)

1. Phytoconcentrate therapeutic and preventive action for diseases in the gastrointestinal tract, containing medicinal plants and excipients, characterized in that it additionally contains a biologically active additive - quercetin, or dihydroquercetin, or rutin, or ascorutin, and as medicinal plants - common oregano grass, St. John's wort grass, Althaea officinalis roots, yarrow grass, nettle leaves, and filler concentrate, meat, or chicken, or vegetable in the following ratio and components, per serving:
Quercetin - 0.018-0.022
or dihydroquercetin - 0.009-0.011
or rutin - 0.045-0.055
or Ascorutin - 0.10-0.30
Oregano grass - 0.15-0.30
St. John's wort grass - 0.15-0.30
The roots of Althea officinalis - 0.15-0.30
Yarrow grass - 0.15-0.30
Stinging nettle leaves - 0.15-0.30
Concentrate, meat, or chicken, or vegetable - 4.0-6.25
2. Phytoconcentrate according to claim 1, characterized in that it contains St. John's wort perforated, or spotted, or tetrahedral.  3. Phytoconcentrate according to claim 2, characterized in that it is used in the form of a broth containing 250 ml of water per 1 serving.  4. Phytoconcentrate according to claim 3, characterized in that the broth additionally includes beets or oatmeal, or spinach to taste, or mixtures thereof in various combinations.  5. Phytoconcentrate according to any one of claims 1 to 4, characterized in that the therapeutic and prophylactic course of taking it is 25-30 days, 1-2 servings per day, with a repeat of the course after 2-3 weeks.