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RU2183213C2 - Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты - Google Patents

Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты Download PDF

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Publication number
RU2183213C2
RU2183213C2 RU96121584/04A RU96121584A RU2183213C2 RU 2183213 C2 RU2183213 C2 RU 2183213C2 RU 96121584/04 A RU96121584/04 A RU 96121584/04A RU 96121584 A RU96121584 A RU 96121584A RU 2183213 C2 RU2183213 C2 RU 2183213C2
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RU
Russia
Prior art keywords
ppm
triphosphates
nmr spectrum
compound
compounds
Prior art date
Application number
RU96121584/04A
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English (en)
Russian (ru)
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RU96121584A (ru
Inventor
Н.Б. Дяткина
А.А. Арзуманов
Е.А. Широкова
М.В. Ясько
Л.А. Александрова
Л.С. Викторова
Л.Е. Горюнова
Р.Ш. Бибилашвили
А.А. Краевский
Original Assignee
ЗАО "Производственно-коммерческая ассоциация АЗТ"
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Priority to RU96121584/04A priority Critical patent/RU2183213C2/ru
Priority to PCT/RU1997/000348 priority patent/WO1998020017A1/fr
Publication of RU96121584A publication Critical patent/RU96121584A/ru
Application granted granted Critical
Publication of RU2183213C2 publication Critical patent/RU2183213C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU96121584/04A 1996-11-05 1996-11-05 Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты RU2183213C2 (ru)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU96121584/04A RU2183213C2 (ru) 1996-11-05 1996-11-05 Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты
PCT/RU1997/000348 WO1998020017A1 (fr) 1996-11-05 1997-11-05 Nucleoside-5'-triphosphates modifies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU96121584/04A RU2183213C2 (ru) 1996-11-05 1996-11-05 Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты

Publications (2)

Publication Number Publication Date
RU96121584A RU96121584A (ru) 1999-02-10
RU2183213C2 true RU2183213C2 (ru) 2002-06-10

Family

ID=20187094

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96121584/04A RU2183213C2 (ru) 1996-11-05 1996-11-05 Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты

Country Status (2)

Country Link
RU (1) RU2183213C2 (fr)
WO (1) WO1998020017A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2225808C2 (ru) * 2002-05-15 2004-03-20 Федеральное государственное унитарное предприятие "Летно-исследовательский институт им. М.М. Громова" Устройство для обеспечения посадки летательного аппарата в ночное время, универсальное, двойного применения (упла-уд)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
EP1485395A4 (fr) * 2002-02-28 2011-04-13 Biota Scient Management Mimetiques nucleotidiques et leurs promedicaments
RU2293739C2 (ru) * 2002-07-26 2007-02-20 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" 5`-холинфосфат 3`-азидо-3`-дезокситимидина как антивирусный агент
BRPI0508428A (pt) 2004-03-04 2007-07-24 Leuven K U Res & Dev fosfonato nucleosìdeos utilizáveis como ingredientes ativos em composições farmacêuticas para o tratamento de infecções virais e intermediários para sua produção

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3543346A1 (de) * 1984-12-07 1986-06-12 Boryung Pharmaceutical Co., Ltd., Seoul Neue nucleosidderivate und verfahren zu ihrer herstellung
WO1990006320A1 (fr) * 1988-11-30 1990-06-14 Kaellander Clas Fredrik Runess Substrat pour la detection de l'activite de polymerase
US5043437A (en) * 1987-12-29 1991-08-27 Khorlin Alexandr A 5'phosphonates of 3'-azido-2',3'dideoxynucleosides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU455958A1 (ru) * 1973-03-23 1975-01-05 Предприятие П/Я А-1758 Способ тимидин-5 " -дифосфата
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0145739B1 (fr) * 1983-05-24 1989-02-08 Sri International Nouveaux agents antiviraux
CA2479846C (fr) * 1989-05-15 2007-07-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic Derives de phosphonomethoxymethylpurine/pyrimidine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3543346A1 (de) * 1984-12-07 1986-06-12 Boryung Pharmaceutical Co., Ltd., Seoul Neue nucleosidderivate und verfahren zu ihrer herstellung
US5043437A (en) * 1987-12-29 1991-08-27 Khorlin Alexandr A 5'phosphonates of 3'-azido-2',3'dideoxynucleosides
WO1990006320A1 (fr) * 1988-11-30 1990-06-14 Kaellander Clas Fredrik Runess Substrat pour la detection de l'activite de polymerase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2225808C2 (ru) * 2002-05-15 2004-03-20 Федеральное государственное унитарное предприятие "Летно-исследовательский институт им. М.М. Громова" Устройство для обеспечения посадки летательного аппарата в ночное время, универсальное, двойного применения (упла-уд)

Also Published As

Publication number Publication date
WO1998020017A1 (fr) 1998-05-14

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