RU2146941C1 - Agent for tobacco smoking treatment - Google Patents

Abstract

FIELD: medicine, phytotherapy. SUBSTANCE: invention relates to drugs based on phytopreparations and used for treatment of smokers. Agent has aloe liquid extract for injection and the special additions, for example, anesthetics and nicotinic acid. Agent is used by injection route into patient submucosa posterior oral pharynx wall by pair and symmetrical injections at interval for 2-3 days. Agent ensures to recovery tobacco smoking for 6-7 days. EFFECT: enhanced effectiveness, rapid treatment. 4 cl, 3 ex

Description

 The invention relates to medicine, and in particular to herbal medicines intended for the treatment of tobacco smoking.

 Various plant-based medicines are known for the treatment of tobacco smoking. So, in aversion therapy, a 5% decoction of the rhizome of the coil, a 2% aqueous solution of tannin for rinsing the mouth are used (Karon B.I. Modern views on the fight against smoking. // Military Medical Journal. - 1988.-N8. -C.66-68), compositions containing alkoloids: cytisine obtained from broom and thermopsis, and lobelin obtained from lobelia. The last two compositions are used, respectively, in the well-known tablets "Tabex" and "Lobesil" (Metelitsa V.N. Pharmacological agents in the fight against smoking. // Bulletin of the All-Union Cardiology Scientific Center of the Academy of Medical Sciences of the USSR.-1987.-T.Kh.-N1.- S.109-112).

 The disadvantages of these funds are: low efficiency, long duration of treatment, the possibility of unpleasant side effects.

 Closest to the proposed invention is the tool "Antinic", which is two compositions of collections of medicinal plants (US Pat. RF N 2066196, A 61 K 35/78, 1995). It is used in the form of tea obtained from broth, and as a food supplement to the first and second courses. Take the drug twice a day (morning and evening). Means "Antinik" does not give adverse reactions in the form of allergic manifestations, nausea and vomiting and can be recommended without restrictions to a wide range of patients.

 The disadvantages of the “Antinik” remedy are the complexity of the composition, which requires about 20 medicinal plants, and the long duration of the course of treatment (3-5 months), as a result of which many patients interrupt treatment without achieving a result.

 The objective of the invention is the creation of a simple effective tool based on herbal medicine for the treatment of smoking with a duration of 3-6 days.

 The problem is solved by the described means for the treatment of smoking, including a herbal product, which according to the invention contains an extract of liquid aloe for injection (Extractum Aloes fluidum pro injectionibus) as a herbal preparation and target additives.

 As targeted additives, the product may contain anesthetics and nicotinic acid.

 The specific composition of the targeted additives is determined by the special conditions of use of the product, depending on the characteristics of the patient's body.

So, one of the preferred options for the drug, intended for patients with an increased threshold of pain sensitivity and intolerance to anesthetics, contains nicotinic acid as the target additive in the following ratio of ingredients (vol.%):
liquid aloe extract for injection - 33-83
nicotinic acid - the rest
Nicotinic acid supplementation accelerates the healing effect due to better absorption and distribution of aloe extract.

For patients with a reduced threshold of pain sensitivity, another preferred variant of the drug is intended, in which nicotinic acid and anesthetic are contained as the target additive in the following ratio of ingredients (vol.%):
liquid aloe extract for injection - 40-46
anesthetic - 40-46
nicotinic acid - the rest
For patients with initial arterial hypotension, the preferred version of the drug is intended in which only the anesthetic is contained as the target additive in the following ratio of ingredients (vol.%):
liquid aloe extract for injection - 33-67
anesthetic - rest
The tool is prepared immediately before injection according to known methods. If there is a pharmaceutical interaction of the ingredients, they are administered sequentially or the original dosage form is used - ready-made (filled) two-chamber disposable syringes of a known design, used, for example, by Merkle GmbH (Germany).

 The tool is used by injection. Injections are carried out in pairs and symmetrically into the submucosa of the posterior oropharyngeal wall of the patient at least twice with an interval of 2-3 days.

 The dose for one procedure is 0.5-1.0 ml, depending on the weight of the patient, his gender and smoking experience. The lower limit of the dose is selected from the condition for achieving a therapeutic effect, and the upper one from the condition of noninvasive injections.

 Examples of drug use are described in the following case histories.

 Example 1. Patient K., 31 years old, weight 57 kg, smoking experience 6 years, smokes 8-10 cigarettes per day. From the anamnesis: an allergic reaction to anesthetics. By testing revealed an increased threshold of pain sensitivity. On March 14, 1995, a pairwise symmetric injection into the submucosa of the posterior wall of the oropharynx was performed for the drug: Extractum Aloes fluidi 0.5 + Acidi Nicotinici 1% 0.1. The craving for smoking immediately decreased, and the next day the patient did not smoke. On the second day after the injection, I tried to smoke a cigarette, but after the second puff I felt disgust and did not smoke anymore. On March 17, 1995, to consolidate the therapeutic effect, a second session was conducted, after which the patient felt an aversion to tobacco smoke with second-hand smoke. To date, does not smoke. There are no complications.

 Example 2. Patient F., 48 years old, weight 91 kg, smoking experience 30 years, smokes 20-30 cigarettes per day. On October 20, 1997, the first treatment session with the use of the drug was conducted: Extractum Aloes fluidi 0.4 + Sol. Novocaini 0.4 + Acidi Nicotinici 1% 0.2. After the injection, the craving for smoking decreased, and the number of cigarettes smoked fell to 2-3 pieces per day (after eating). On October 24, 1997, a second treatment session was carried out using the same dose of this agent. From this moment, the patient does not smoke, the craving for smoking has completely disappeared. There are no complications.

 Example 3. Patient Yu., 26 years old, weight 85 kg, smoking experience 14 years, smokes 20 cigarettes per day. Testing revealed arterial hypotension. On January 22, 1998, the first treatment session was conducted using Extractum Aloes fluidi 0.6 + Sol.Novocaini 0.4. Craving for smoking after the injection did not decrease, however, the number of smoked cigarettes decreased to 8-10 per day. On January 26, 1998, the patient underwent a second treatment session with the same drug in the same dosage, after which the patient felt an aversion to tobacco smoke even with second-hand smoke. The next day I made an attempt to smoke, but, feeling dizzy and profuse salivation, stopped trying. On the second day after the second session, a mild desire to smoke appeared, as reported by the attending physician. On January 29, 1998, the patient underwent a third treatment session using the same dose of the drug. Since then he has not smoked. There are no complications.

 The tool provides the effectiveness and rapid treatment of smoking. The duration of the course is 3-6 days, depending on the length of smoking and gender of the patient. The tool is simple in composition and can be easily manufactured.

Claims (2)

 1. An agent for the treatment of smoking, including a phytopreparation, characterized in that it contains an extract of aloe liquid for injection (Aloes fluidum pro injectionibus) as a phytopreparation and targeted additives. 2. The tool according to claim 1, characterized in that as the target additive it contains nicotinic acid in the following ratio of ingredients, vol.%:
Aloe liquid liquid for injection - 33 - 83
Niacin - Else
3. The tool according to p. 1, characterized in that as the target additive contains anesthetic and nicotinic acid in the following ratio of ingredients, vol.%:
Liquid Aloe Extract For Injection - 40 - 46
Anesthetic - 40 - 46
Niacin - Else
4. The tool according to claim 1, characterized in that as the target additive it contains an anesthetic in the following ratio of ingredients, vol.%:
Liquid Aloe Vera Injection - 33 - 67
Anesthetic - Rest