RU2022113551A - Benzamide Compounds - Google Patents

Claims (27)

1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, having the structure

where R ¹ represents -CH ₂ F, -CHF ₂ or -CF ₃ ; each R ² is independently selected from the group consisting of halo, substituted or unsubstituted C ₁ -C ₆ alkyl, substituted or unsubstituted C ₁ -C ₆ haloalkyl, and substituted or unsubstituted C ₃ -C ₆ cycloalkyl; or when m is 2 or 3, each R ² is independently selected from the group consisting of halo, substituted or unsubstituted C ₁ -C ₆ alkyl, substituted or unsubstituted C ₁ -C ₆ haloalkyl, and substituted or unsubstituted C ₃ -C ₆ cycloalkyl, or two R ² groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C ₃ -C ₆ cycloalkyl or a substituted or unsubstituted 3-6 membered heterocyclyl; R ³ is selected from the group consisting of XR ^3A ,

and

; R ^3A is a substituted or unsubstituted 5-10 membered heteroaryl; R ⁴ is selected from the group consisting of NO ₂ , S(O)R ⁶ , SO ₂ R ⁶ , halogen, cyano and unsubstituted C ₁ -C ₆ haloalkyl; R ⁵ is selected from the group consisting of -X ¹ -(Alk ¹ ) _n -R ⁷ and -X ² (CHR ⁸ )-(Alk ² ) _p -X ³ -R ⁹ ; Alk ¹ and Alk ² are independently selected from unsubstituted C ₁ -C ₄ alkylene and C ₁ -C ₄ alkylene substituted with 1, 2 or 3 substituents independently selected from fluorine, chlorine, unsubstituted C ₁ -C ₃ alkyl and unsubstituted C ₁ - C ₃ haloalkyl; R ⁶ is selected from the group consisting of substituted or unsubstituted C ₁ -C ₆ alkyl, substituted or unsubstituted C ₁ -C ₆ haloalkyl, and substituted or unsubstituted C ₃ -C ₆ cycloalkyl; R ⁷ is selected from substituted or unsubstituted C ₁ -C ₆ alkoxy, substituted or unsubstituted C ₃ -C ₁₀ cycloalkyl, substituted or unsubstituted 3-10 membered heterocyclyl, hydroxy, amino group, substituted or unsubstituted monosubstituted amino group, substituted or unsubstituted disubstituted amino group, substituted or unsubstituted N-carbamyl, substituted or unsubstituted C-amido, and substituted or unsubstituted N-amido; R ⁸ is selected from substituted or unsubstituted 3-10 membered heterocyclyl(C ₁ -C ₆ alkyl), substituted or unsubstituted di-C ₁ -C ₆ alkylamine(C ₁ -C ₆ alkyl), and substituted or unsubstituted mono-C ₁ - C ₆ alkylamine (C ₁ -C ₆ alkyl); R ⁹ is selected from substituted or unsubstituted 5-10 membered heteroaryl and substituted or unsubstituted C ₆ -C ₁₀ aryl; m is 0, 1, 2, or 3; n and p are independently selected from 0 and 1; X ¹ and X ² are -NH-; and X and X ³ are independently selected from the group consisting of -O-, -S- and -NH-. 2. A compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R ¹ is -CH ₂ F. 3. A compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R ¹ is -CHF ₂ . 4. A compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R ¹ is -CHF ₃ . 5. Connection according to any one of paragraphs. 1-4 or a pharmaceutically acceptable salt thereof, wherein m is 1. 6. Connection according to any one of paragraphs. 1-4 or a pharmaceutically acceptable salt thereof, wherein m is 2. 7. The connection according to any one of paragraphs. 1-4 or a pharmaceutically acceptable salt thereof, wherein m is 3. 8. Connection according to any one of paragraphs. 1-7 or a pharmaceutically acceptable salt thereof, wherein one R ² is unsubstituted C ₁ -C ₆ alkyl and any other R ² (if any) is independently selected from the group consisting of halogen, substituted or unsubstituted C ₁ -C ₆ alkyl, substituted or unsubstituted C ₁ -C ₆ haloalkyl, and substituted or unsubstituted C ₃ -C ₆ cycloalkyl. 9. Connection according to any one of paragraphs. 1-8 or a pharmaceutically acceptable salt thereof, wherein each R ² is independently unsubstituted C ₁ -C ₆ alkyl. 10. Connection according to any one of paragraphs. 1-4, 8 or 9 or a pharmaceutically acceptable salt thereof, wherein m is 2; and each R ² is unsubstituted methyl.