RU2021121383A - ANTIBODIES TO PMEL17 AND THEIR BASED CONJUGATES - Google Patents

Claims (351)

1. An antibody or antigen-binding fragment thereof that binds PMEL17, containing: a heavy chain variable region that contains a heavy chain CDR1 (complementarity determining region 1) of SEQ ID NO: 1, 4, 5, or 7, a heavy chain CDR2 (complementarity determining region 2) of SEQ ID NO: 2, 6, or 8, and CDR3 (complementarity determining region 3) heavy chain under SEQ ID NO:3 or 9; and a light chain variable region that contains a light chain CDR1 (complementarity determining region 1) of SEQ ID NO:14, 17 or 20, a light chain CDR2 (complementarity determining region 2) of SEQ ID NO:15 or 18, and a CDR3 (complementarity determining region region 3) light chain under SEQ ID NO:16 or 19; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO:33, 36, 37, or 39, a heavy chain CDR2 of SEQ ID NO:34, 38, or 40; heavy chain CDR3 under SEQ ID NO:35 or 41; light chain CDR1 under SEQ ID NO:46, 49 or 52; Light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:48 or 51; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 5, 7, 57, or 60, a heavy chain CDR2 of SEQ ID NO: 58, 61, or 62; heavy chain CDR3 under SEQ ID NO:59 or 63; light chain CDR1 under SEQ ID NO:68, 71 or 74; light chain CDR2 of SEQ ID NO:69 or 72 and light chain CDR3 of SEQ ID NO:70 or 73; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 79, 82, 83, or 85, a heavy chain CDR2 of SEQ ID NO: 80, 84, or 86; heavy chain CDR3 under SEQ ID NO:81 or 87; light chain CDR1 under SEQ ID NO:92, 95 or 98; light chain CDR2 of SEQ ID NO:93 or 96 and light chain CDR3 of SEQ ID NO:94 or 97; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:105 or 111; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:117 or 118; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 123, 126, 127, or 129, a heavy chain CDR2 of SEQ ID NO: 124, 128, or 130; heavy chain CDR3 of SEQ ID NO:125 or 131; light chain CDR1 under SEQ ID NO:136, 139 or 142; light chain CDR2 of SEQ ID NO:137 or 140 and light chain CDR3 of SEQ ID NO:138 or 141; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 123, 126, 127, or 129, a heavy chain CDR2 of SEQ ID NO: 124, 128, or 130; heavy chain CDR3 of SEQ ID NO:147 or 148; light chain CDR1 under SEQ ID NO:153, 156 or 158; light chain CDR2 of SEQ ID NO:50 or 154 and light chain CDR3 of SEQ ID NO:155 or 157; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:163 or 164; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:169 or 170; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 175, 178, 179, or 181, a heavy chain CDR2 of SEQ ID NO: 176, 180, or 182; heavy chain CDR3 of SEQ ID NO:177 or 183; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:188 or 189; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:194 or 195; light chain CDR1 under SEQ ID NO: 49, 52 or 116; light chain CDR2 of SEQ ID NO: 47 or 50 and light chain CDR3 of SEQ ID NO: 200 or 201; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO:206, 209, 210, or 212, a heavy chain CDR2 of SEQ ID NO:207, 211, or 213; heavy chain CDR3 under SEQ ID NO:208 or 214; light chain CDR1 under SEQ ID NO:153, 156 or 158; light chain CDR2 of SEQ ID NO:50 or 154 and light chain CDR3 of SEQ ID NO:219 or 220; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 206, 209, 210, or 212, a heavy chain CDR2 of SEQ ID NO: 207, 211, or 213; heavy chain CDR3 under SEQ ID NO: 225 or 226; light chain CDR1 under SEQ ID NO:136, 139 or 142; light chain CDR2 of SEQ ID NO:137 or 140 and light chain CDR3 of SEQ ID NO:231 or 232; a heavy chain variable region that contains a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, 209, 210, or 212, HCDR2 of SEQ ID NO: 207, 211, or 213, and HCDR3 of SEQ ID NO: 237 or 238; and a light chain variable region that contains LCDR1 of SEQ ID NO:243, 245, or 247, LCDR2 of SEQ ID NO:47 or 50, and LCDR3 of SEQ ID NO:244 or 246; a heavy chain variable region that contains a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, 209, 210, or 212, HCDR2 of SEQ ID NO: 207, 211, or 213, and HCDR3 of SEQ ID NO: 252 or 253; and a light chain variable region that contains LCDR1 of SEQ ID NO:153, 156, or 158, LCDR2 of SEQ ID NO:50 or 154, and LCDR3 of SEQ ID NO:258 or 259; Heavy chain CDR1 of SEQ ID NO:1, heavy chain CDR2 of SEQ ID NO:2, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:14, light chain CDR2 of SEQ ID NO:15, and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO: 4, heavy chain CDR2 of SEQ ID NO:2, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:14, light chain CDR2 of SEQ ID NO:15, and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO:5, heavy chain CDR2 of SEQ ID NO:6, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:17, light chain CDR2 of SEQ ID NO:18 and Light chain CDR3 under SEQ ID NO: 19; Heavy chain CDR1 of SEQ ID NO:7, heavy chain CDR2 of SEQ ID NO:8, heavy chain CDR3 of SEQ ID NO:9, light chain CDR1 of SEQ ID NO:20, light chain CDR2 of SEQ ID NO:18 and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO:33, heavy chain CDR2 of SEQ ID NO:34, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:46, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:36, heavy chain CDR2 of SEQ ID NO:34, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:46, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:37, heavy chain CDR2 of SEQ ID NO:38, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:51; Heavy chain CDR1 of SEQ ID NO: 39, heavy chain CDR2 of SEQ ID NO:40, heavy chain CDR3 of SEQ ID NO:41, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:57, heavy chain CDR2 of SEQ ID NO:58, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:68, light chain CDR2 of SEQ ID NO:69 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:60, heavy chain CDR2 of SEQ ID NO:58, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:68, light chain CDR2 of SEQ ID NO:69 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:5, heavy chain CDR2 of SEQ ID NO:61, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:71, light chain CDR2 of SEQ ID NO:72 and Light chain CDR3 of SEQ ID NO:73; Heavy chain CDR1 of SEQ ID NO:7, heavy chain CDR2 of SEQ ID NO:62, heavy chain CDR3 of SEQ ID NO:63, light chain CDR1 of SEQ ID NO:74, light chain CDR2 of SEQ ID NO:72 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:79, heavy chain CDR2 of SEQ ID NO:80, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:92, light chain CDR2 of SEQ ID NO:93 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:82, heavy chain CDR2 of SEQ ID NO:80, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:92, light chain CDR2 of SEQ ID NO:93 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:83, heavy chain CDR2 of SEQ ID NO:84, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:95, light chain CDR2 of SEQ ID NO:96 and Light chain CDR3 under SEQ ID NO: 97; Heavy chain CDR1 of SEQ ID NO: 85, heavy chain CDR2 of SEQ ID NO:86, heavy chain CDR3 of SEQ ID NO:87, light chain CDR1 of SEQ ID NO:98, light chain CDR2 of SEQ ID NO:96 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:103, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:116; Light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:106, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:107, heavy chain CDR2 of SEQ ID NO:108, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:118; Heavy chain CDR1 of SEQ ID NO:109, heavy chain CDR2 of SEQ ID NO:110, heavy chain CDR3 of SEQ ID NO:111, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:123, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:126, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:127, heavy chain CDR2 of SEQ ID NO:128, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:139, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 under SEQ ID NO: 141; Heavy chain CDR1 of SEQ ID NO: 129, heavy chain CDR2 of SEQ ID NO:130, heavy chain CDR3 of SEQ ID NO:131, light chain CDR1 of SEQ ID NO:142, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:123, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:126, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:127, heavy chain CDR2 of SEQ ID NO:128, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:156, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:157; Heavy chain CDR1 of SEQ ID NO: 129, heavy chain CDR2 of SEQ ID NO:130, heavy chain CDR3 of SEQ ID NO:148, light chain CDR1 of SEQ ID NO:158, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:103, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:106, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:107, heavy chain CDR2 of SEQ ID NO:108, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 under SEQ ID NO:170; Heavy chain CDR1 of SEQ ID NO: 109, heavy chain CDR2 of SEQ ID NO:110, heavy chain CDR3 of SEQ ID NO:164, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:175, heavy chain CDR2 of SEQ ID NO:176, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO:178, heavy chain CDR2 of SEQ ID NO:176, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO:179, heavy chain CDR2 of SEQ ID NO:180, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:189; Heavy chain CDR1 of SEQ ID NO: 181, heavy chain CDR2 of SEQ ID NO:182, heavy chain CDR3 of SEQ ID NO:183, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO: 103, heavy chain CDR2 of SEQ ID NO: 104, heavy chain CDR3 of SEQ ID NO: 194, light chain CDR1 of SEQ ID NO: 116, light chain CDR2 of SEQ ID NO: 47 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO: 106, heavy chain CDR2 of SEQ ID NO: 104, heavy chain CDR3 of SEQ ID NO: 194, light chain CDR1 of SEQ ID NO: 116, light chain CDR2 of SEQ ID NO: 47 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO: 107, heavy chain CDR2 of SEQ ID NO: 108, heavy chain CDR3 of SEQ ID NO:194, light chain CDR1 of SEQ ID NO: 49, light chain CDR2 of SEQ ID NO: 50 and Light chain CDR3 under SEQ ID NO: 201; Heavy chain CDR1 of SEQ ID NO: 109, heavy chain CDR2 of SEQ ID NO: 110, heavy chain CDR3 of SEQ ID NO: 195, light chain CDR1 of SEQ ID NO: 52, light chain CDR2 of SEQ ID NO: 50 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO:206, heavy chain CDR2 of SEQ ID NO:207, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO:209, heavy chain CDR2 of SEQ ID NO:207, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO:210, heavy chain CDR2 of SEQ ID NO:211, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:156, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 under SEQ ID NO:220; Heavy chain CDR1 of SEQ ID NO: 212, heavy chain CDR2 of SEQ ID NO:213, heavy chain CDR3 of SEQ ID NO:214, light chain CDR1 of SEQ ID NO:158, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO: 206, heavy chain CDR2 of SEQ ID NO: 207, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137, and Light chain CDR3 of SEQ ID NO:231; Heavy chain CDR1 of SEQ ID NO: 209, heavy chain CDR2 of SEQ ID NO: 207, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137, and Light chain CDR3 of SEQ ID NO:231; Heavy chain CDR1 of SEQ ID NO: 210, heavy chain CDR2 of SEQ ID NO: 211, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:139, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 under SEQ ID NO: 232; Heavy chain CDR1 of SEQ ID NO: 212, heavy chain CDR2 of SEQ ID NO: 213, heavy chain CDR3 of SEQ ID NO: 226, light chain CDR1 of SEQ ID NO:142; light chain CDR2 of SEQ ID NO: 140 and light chain CDR3 of SEQ ID NO: 231; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:243, LCDR2 of SEQ ID NO:47 and LCDR3 under SEQ ID NO:244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 209, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:243, LCDR2 of SEQ ID NO:47 and LCDR3 under SEQ ID NO:244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 210, HCDR2 of SEQ ID NO: 211 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:245, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:246; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 212, HCDR2 of SEQ ID NO: 213 and HCDR3 of SEQ ID NO:238, and a light chain variable region that contains LCDR1 of SEQ ID NO:247, LCDR2 of SEQ ID NO: 50 and LCDR3 under SEQ ID NO: 244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:153, LCDR2 of SEQ ID NO: 154 and LCDR3 under SEQ ID NO: 258; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 209, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:153, LCDR2 of SEQ ID NO:154 and LCDR3 under SEQ ID NO:258; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 210, HCDR2 of SEQ ID NO: 211 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:156, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:259; or a heavy chain variable region that contains HCDR1 of SEQ ID NO: 212, HCDR2 of SEQ ID NO: 213 and HCDR3 of SEQ ID NO: 253, and a light chain variable region that contains LCDR1 of SEQ ID NO:158, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:258. 2. An antibody or antigen-binding fragment thereof that binds PMEL17, containing: a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:21; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:25; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:29; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:42 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:53; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:64 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:75; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:88 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:99; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:112 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:119; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:132 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:143; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:149 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:159; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:165 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:171; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:184 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:190; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:196 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:202; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:215 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:221; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:227 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:233; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:239 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:248; or a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:254; and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:260. 3. An antibody or antigen-binding fragment thereof that binds PMEL17, containing: a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:23; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:27; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:31; a heavy chain containing the amino acid sequence of SEQ ID NO:44 and a light chain containing the amino acid sequence of SEQ ID NO:55; a heavy chain containing the amino acid sequence of SEQ ID NO:66 and a light chain containing the amino acid sequence of SEQ ID NO:77; a heavy chain containing the amino acid sequence of SEQ ID NO:90 and a light chain containing the amino acid sequence of SEQ ID NO:101; a heavy chain containing the amino acid sequence of SEQ ID NO:114 and a light chain containing the amino acid sequence of SEQ ID NO:121; a heavy chain containing the amino acid sequence of SEQ ID NO:134 and a light chain containing the amino acid sequence of SEQ ID NO:145; a heavy chain containing the amino acid sequence of SEQ ID NO:151 and a light chain containing the amino acid sequence of SEQ ID NO:161; a heavy chain containing the amino acid sequence of SEQ ID NO:167 and a light chain containing the amino acid sequence of SEQ ID NO:173; a heavy chain containing the amino acid sequence of SEQ ID NO:186 and a light chain containing the amino acid sequence of SEQ ID NO:192; a heavy chain containing the amino acid sequence of SEQ ID NO:198 and a light chain containing the amino acid sequence of SEQ ID NO:204; a heavy chain containing the amino acid sequence of SEQ ID NO:217 and a light chain containing the amino acid sequence of SEQ ID NO:223; a heavy chain containing the amino acid sequence of SEQ ID NO:229 and a light chain containing the amino acid sequence of SEQ ID NO:235; a heavy chain containing the amino acid sequence of SEQ ID NO:241 and a light chain containing the amino acid sequence of SEQ ID NO:250; or a heavy chain containing the amino acid sequence of SEQ ID NO:256; and a light chain containing the amino acid sequence of SEQ ID NO:262. 4. An antibody according to any one of paragraphs. 1-3, where the antibody or antigen-binding fragment contains one or more cysteine substitutions. 5. An antibody according to claim 4, wherein the antibody or antigen-binding fragment thereof contains one or more cysteine substitutions selected from E152C, S375C, or both E152C and S375C, in the heavy chain of the antibody or antigen-binding fragment, where the position numbering corresponds to the EU system. 6. An antibody according to any one of paragraphs. 1-5, wherein said antibody is a monoclonal antibody. 7. An antibody-drug conjugate comprising formula (C): Ab-(L _A -(D) _n ) _y (C), where D is a GNAQ inhibitor, GNA11 inhibitor or GNAQ and GNA11 inhibitor; Ab is an antibody or antigen-binding fragment thereof that binds to the human PMEL17 protein; L _A is a linker; n is 1, 2, 3 or 4 and y is 1, 2, 3, or 4. 8. The antibody-drug conjugate of claim 7, wherein said n is 1. 9. Conjugate antibodies and drugs according to any one of paragraphs. 7 or 8, where y is from about 1 to about 4. 10. Conjugate antibodies and drugs according to any one of paragraphs. 7-9, wherein said linker is a cleavable linker or a non-cleavable linker. 11. The antibody drug conjugate of claim 10, wherein the linker comprises a ValCit peptide linker. 12. Conjugate antibodies and drugs according to any one of paragraphs. 7-11, wherein said drug fragment is an inhibitor of GNAQ and GNA11. 13. An antibody-drug conjugate according to any one of paragraphs. 7-11 where D is .

14. Conjugate antibodies and drugs according to any one of paragraphs. 7-11 where D is

. 15. Conjugate antibodies and drugs according to any one of paragraphs. 7-14 having the following structure:

. 16. Conjugate antibodies and drugs according to any one of paragraphs. 7-14 having the following structure:

. 17. An antibody drug conjugate having the following formula (C-2):

(C-2) where R ⁰ represents methyl or ethyl; R ¹ is methyl or isopropyl; R ² is methyl or ethyl; Ab is an antibody or antigen-binding fragment thereof that binds to the human PMEL17 protein; X ₁ is a bivalent linking group; X ₂ is a self-cleaving spacer; L ₁ is a bivalent peptide linker; L ₂ is a bond or linker, and y is 1, 2, 3, or 4. 18. Conjugate antibodies and drugs according to any one of paragraphs. 7-17, where Ab is an antibody or antigen-binding fragment thereof that binds PMEL17, containing: a heavy chain variable region that contains a heavy chain CDR1 (complementarity determining region 1) of SEQ ID NO: 1, 4, 5, or 7, a heavy chain CDR2 (complementarity determining region 2) of SEQ ID NO: 2, 6, or 8, and CDR3 (complementarity determining region 3) heavy chain under SEQ ID NO:3 or 9; and a light chain variable region that contains a light chain CDR1 (complementarity determining region 1) of SEQ ID NO:14, 17 or 20, a light chain CDR2 (complementarity determining region 2) of SEQ ID NO:15 or 18, and a CDR3 (complementarity determining region region 3) light chain under SEQ ID NO:16 or 19; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO:33, 36, 37, or 39, a heavy chain CDR2 of SEQ ID NO:34, 38, or 40; heavy chain CDR3 under SEQ ID NO:35 or 41; light chain CDR1 under SEQ ID NO:46, 49 or 52; Light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:48 or 51; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 5, 7, 57, or 60, a heavy chain CDR2 of SEQ ID NO: 58, 61, or 62; heavy chain CDR3 under SEQ ID NO:59 or 63; light chain CDR1 under SEQ ID NO:68, 71 or 74; light chain CDR2 of SEQ ID NO:69 or 72 and light chain CDR3 of SEQ ID NO:70 or 73; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 79, 82, 83, or 85, a heavy chain CDR2 of SEQ ID NO: 80, 84, or 86; heavy chain CDR3 under SEQ ID NO:81 or 87; light chain CDR1 under SEQ ID NO:92, 95 or 98; light chain CDR2 of SEQ ID NO:93 or 96 and light chain CDR3 of SEQ ID NO:94 or 97; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:105 or 111; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:117 or 118; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 123, 126, 127, or 129, a heavy chain CDR2 of SEQ ID NO: 124, 128, or 130; heavy chain CDR3 of SEQ ID NO:125 or 131; light chain CDR1 under SEQ ID NO:136, 139 or 142; light chain CDR2 of SEQ ID NO:137 or 140 and light chain CDR3 of SEQ ID NO:138 or 141; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 123, 126, 127, or 129, a heavy chain CDR2 of SEQ ID NO: 124, 128, or 130; heavy chain CDR3 of SEQ ID NO:147 or 148; light chain CDR1 under SEQ ID NO:153, 156 or 158; light chain CDR2 of SEQ ID NO:50 or 154 and light chain CDR3 of SEQ ID NO:155 or 157; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:163 or 164; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:169 or 170; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 175, 178, 179, or 181, a heavy chain CDR2 of SEQ ID NO: 176, 180, or 182; heavy chain CDR3 of SEQ ID NO:177 or 183; light chain CDR1 under SEQ ID NO:49, 52 or 116; light chain CDR2 of SEQ ID NO:47 or 50 and light chain CDR3 of SEQ ID NO:188 or 189; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 103, 106, 107, or 109, a heavy chain CDR2 of SEQ ID NO: 104, 108, or 110; heavy chain CDR3 of SEQ ID NO:194 or 195; light chain CDR1 under SEQ ID NO: 49, 52 or 116; light chain CDR2 of SEQ ID NO: 47 or 50 and light chain CDR3 of SEQ ID NO: 200 or 201; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO:206, 209, 210, or 212, a heavy chain CDR2 of SEQ ID NO:207, 211, or 213; heavy chain CDR3 under SEQ ID NO:208 or 214; light chain CDR1 under SEQ ID NO:153, 156 or 158; light chain CDR2 of SEQ ID NO:50 or 154 and light chain CDR3 of SEQ ID NO:219 or 220; a heavy chain variable region that contains a heavy chain CDR1 of SEQ ID NO: 206, 209, 210, or 212, a heavy chain CDR2 of SEQ ID NO: 207, 211, or 213; heavy chain CDR3 under SEQ ID NO: 225 or 226; light chain CDR1 under SEQ ID NO:136, 139 or 142; light chain CDR2 of SEQ ID NO:137 or 140 and light chain CDR3 of SEQ ID NO:231 or 232; a heavy chain variable region that contains a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, 209, 210, or 212, HCDR2 of SEQ ID NO: 207, 211, or 213, and HCDR3 of SEQ ID NO: 237 or 238; and a light chain variable region that contains LCDR1 of SEQ ID NO:243, 245, or 247, LCDR2 of SEQ ID NO:47 or 50, and LCDR3 of SEQ ID NO:244 or 246; a heavy chain variable region that contains a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, 209, 210, or 212, HCDR2 of SEQ ID NO: 207, 211, or 213, and HCDR3 of SEQ ID NO: 252 or 253; and a light chain variable region that contains LCDR1 of SEQ ID NO:153, 156, or 158, LCDR2 of SEQ ID NO:50 or 154, and LCDR3 of SEQ ID NO:258 or 259; Heavy chain CDR1 of SEQ ID NO:1, heavy chain CDR2 of SEQ ID NO:2, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:14, light chain CDR2 of SEQ ID NO:15, and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO: 4, heavy chain CDR2 of SEQ ID NO:2, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:14, light chain CDR2 of SEQ ID NO:15, and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO:5, heavy chain CDR2 of SEQ ID NO:6, heavy chain CDR3 of SEQ ID NO:3, light chain CDR1 of SEQ ID NO:17, light chain CDR2 of SEQ ID NO:18 and Light chain CDR3 under SEQ ID NO: 19; Heavy chain CDR1 of SEQ ID NO:7, heavy chain CDR2 of SEQ ID NO:8, heavy chain CDR3 of SEQ ID NO:9, light chain CDR1 of SEQ ID NO:20, light chain CDR2 of SEQ ID NO:18 and Light chain CDR3 under SEQ ID NO:16; Heavy chain CDR1 of SEQ ID NO:33, heavy chain CDR2 of SEQ ID NO:34, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:46, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:36, heavy chain CDR2 of SEQ ID NO:34, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:46, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:37, heavy chain CDR2 of SEQ ID NO:38, heavy chain CDR3 of SEQ ID NO:35, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:51; Heavy chain CDR1 of SEQ ID NO: 39, heavy chain CDR2 of SEQ ID NO:40, heavy chain CDR3 of SEQ ID NO:41, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:48; Heavy chain CDR1 of SEQ ID NO:57, heavy chain CDR2 of SEQ ID NO:58, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:68, light chain CDR2 of SEQ ID NO:69 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:60, heavy chain CDR2 of SEQ ID NO:58, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:68, light chain CDR2 of SEQ ID NO:69 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:5, heavy chain CDR2 of SEQ ID NO:61, heavy chain CDR3 of SEQ ID NO:59, light chain CDR1 of SEQ ID NO:71, light chain CDR2 of SEQ ID NO:72 and Light chain CDR3 of SEQ ID NO:73; Heavy chain CDR1 of SEQ ID NO:7, heavy chain CDR2 of SEQ ID NO:62, heavy chain CDR3 of SEQ ID NO:63, light chain CDR1 of SEQ ID NO:74, light chain CDR2 of SEQ ID NO:72 and Light chain CDR3 of SEQ ID NO:70; Heavy chain CDR1 of SEQ ID NO:79, heavy chain CDR2 of SEQ ID NO:80, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:92, light chain CDR2 of SEQ ID NO:93 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:82, heavy chain CDR2 of SEQ ID NO:80, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:92, light chain CDR2 of SEQ ID NO:93 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:83, heavy chain CDR2 of SEQ ID NO:84, heavy chain CDR3 of SEQ ID NO:81, light chain CDR1 of SEQ ID NO:95, light chain CDR2 of SEQ ID NO:96 and Light chain CDR3 under SEQ ID NO: 97; Heavy chain CDR1 of SEQ ID NO: 85, heavy chain CDR2 of SEQ ID NO:86, heavy chain CDR3 of SEQ ID NO:87, light chain CDR1 of SEQ ID NO:98, light chain CDR2 of SEQ ID NO:96 and Light chain CDR3 of SEQ ID NO:94; Heavy chain CDR1 of SEQ ID NO:103, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:116; Light chain CDR2 of SEQ ID NO:47 and light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:106, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:107, heavy chain CDR2 of SEQ ID NO:108, heavy chain CDR3 of SEQ ID NO:105, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:118; Heavy chain CDR1 of SEQ ID NO:109, heavy chain CDR2 of SEQ ID NO:110, heavy chain CDR3 of SEQ ID NO:111, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:117; Heavy chain CDR1 of SEQ ID NO:123, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:126, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:127, heavy chain CDR2 of SEQ ID NO:128, heavy chain CDR3 of SEQ ID NO:125, light chain CDR1 of SEQ ID NO:139, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 under SEQ ID NO: 141; Heavy chain CDR1 of SEQ ID NO: 129, heavy chain CDR2 of SEQ ID NO:130, heavy chain CDR3 of SEQ ID NO:131, light chain CDR1 of SEQ ID NO:142, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 of SEQ ID NO:138; Heavy chain CDR1 of SEQ ID NO:123, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 under SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:126, heavy chain CDR2 of SEQ ID NO:124, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:127, heavy chain CDR2 of SEQ ID NO:128, heavy chain CDR3 of SEQ ID NO:147, light chain CDR1 of SEQ ID NO:156, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:157; Heavy chain CDR1 of SEQ ID NO: 129, heavy chain CDR2 of SEQ ID NO:130, heavy chain CDR3 of SEQ ID NO:148, light chain CDR1 of SEQ ID NO:158, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 under SEQ ID NO:155; Heavy chain CDR1 of SEQ ID NO:103, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:106, heavy chain CDR2 of SEQ ID NO:104, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:107, heavy chain CDR2 of SEQ ID NO:108, heavy chain CDR3 of SEQ ID NO:163, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 under SEQ ID NO:170; Heavy chain CDR1 of SEQ ID NO: 109, heavy chain CDR2 of SEQ ID NO:110, heavy chain CDR3 of SEQ ID NO:164, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:169; Heavy chain CDR1 of SEQ ID NO:175, heavy chain CDR2 of SEQ ID NO:176, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO:178, heavy chain CDR2 of SEQ ID NO:176, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:116, light chain CDR2 of SEQ ID NO:47 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO:179, heavy chain CDR2 of SEQ ID NO:180, heavy chain CDR3 of SEQ ID NO:177, light chain CDR1 of SEQ ID NO:49, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:189; Heavy chain CDR1 of SEQ ID NO: 181, heavy chain CDR2 of SEQ ID NO:182, heavy chain CDR3 of SEQ ID NO:183, light chain CDR1 of SEQ ID NO:52, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:188; Heavy chain CDR1 of SEQ ID NO: 103, heavy chain CDR2 of SEQ ID NO: 104, heavy chain CDR3 of SEQ ID NO: 194, light chain CDR1 of SEQ ID NO: 116, light chain CDR2 of SEQ ID NO: 47 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO: 106, heavy chain CDR2 of SEQ ID NO: 104, heavy chain CDR3 of SEQ ID NO: 194, light chain CDR1 of SEQ ID NO: 116, light chain CDR2 of SEQ ID NO: 47 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO: 107, heavy chain CDR2 of SEQ ID NO: 108, heavy chain CDR3 of SEQ ID NO:194, light chain CDR1 of SEQ ID NO: 49, light chain CDR2 of SEQ ID NO: 50 and Light chain CDR3 under SEQ ID NO: 201; Heavy chain CDR1 of SEQ ID NO: 109, heavy chain CDR2 of SEQ ID NO: 110, heavy chain CDR3 of SEQ ID NO: 195, light chain CDR1 of SEQ ID NO: 52, light chain CDR2 of SEQ ID NO: 50 and Light chain CDR3 of SEQ ID NO:200; Heavy chain CDR1 of SEQ ID NO:206, heavy chain CDR2 of SEQ ID NO:207, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO:209, heavy chain CDR2 of SEQ ID NO:207, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:153, light chain CDR2 of SEQ ID NO:154 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO:210, heavy chain CDR2 of SEQ ID NO:211, heavy chain CDR3 of SEQ ID NO:208, light chain CDR1 of SEQ ID NO:156, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 under SEQ ID NO:220; Heavy chain CDR1 of SEQ ID NO: 212, heavy chain CDR2 of SEQ ID NO:213, heavy chain CDR3 of SEQ ID NO:214, light chain CDR1 of SEQ ID NO:158, light chain CDR2 of SEQ ID NO:50 and Light chain CDR3 of SEQ ID NO:219; Heavy chain CDR1 of SEQ ID NO: 206, heavy chain CDR2 of SEQ ID NO: 207, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137, and Light chain CDR3 of SEQ ID NO:231; Heavy chain CDR1 of SEQ ID NO: 209, heavy chain CDR2 of SEQ ID NO: 207, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:136, light chain CDR2 of SEQ ID NO:137, and Light chain CDR3 of SEQ ID NO:231; Heavy chain CDR1 of SEQ ID NO: 210, heavy chain CDR2 of SEQ ID NO: 211, heavy chain CDR3 of SEQ ID NO:225, light chain CDR1 of SEQ ID NO:139, light chain CDR2 of SEQ ID NO:140 and Light chain CDR3 under SEQ ID NO: 232; Heavy chain CDR1 of SEQ ID NO: 212, heavy chain CDR2 of SEQ ID NO: 213, heavy chain CDR3 of SEQ ID NO: 226, light chain CDR1 of SEQ ID NO:142; light chain CDR2 of SEQ ID NO: 140 and light chain CDR3 of SEQ ID NO: 231; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:243, LCDR2 of SEQ ID NO:47 and LCDR3 under SEQ ID NO:244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 209, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:243, LCDR2 of SEQ ID NO:47 and LCDR3 under SEQ ID NO:244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 210, HCDR2 of SEQ ID NO: 211 and HCDR3 of SEQ ID NO:237, and a light chain variable region that contains LCDR1 of SEQ ID NO:245, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:246; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 212, HCDR2 of SEQ ID NO: 213 and HCDR3 of SEQ ID NO:238, and a light chain variable region that contains LCDR1 of SEQ ID NO:247, LCDR2 of SEQ ID NO: 50 and LCDR3 under SEQ ID NO: 244; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 206, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:153, LCDR2 of SEQ ID NO: 154 and LCDR3 under SEQ ID NO: 258; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 209, HCDR2 of SEQ ID NO: 207 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:153, LCDR2 of SEQ ID NO:154 and LCDR3 under SEQ ID NO:258; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 210, HCDR2 of SEQ ID NO: 211 and HCDR3 of SEQ ID NO:252, and a light chain variable region that contains LCDR1 of SEQ ID NO:156, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:259; a heavy chain variable region that contains HCDR1 of SEQ ID NO: 212, HCDR2 of SEQ ID NO: 213 and HCDR3 of SEQ ID NO: 253, and a light chain variable region that contains LCDR1 of SEQ ID NO:158, LCDR2 of SEQ ID NO:50 and LCDR3 under SEQ ID NO:258; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:21; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:25; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:29; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:42 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:53; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:64 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:75; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:88 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:99; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:112 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:119; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:132 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:143; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:149 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:159; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:165 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:171; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:184 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:190; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:196 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:202; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:215 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:221; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:227 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:233; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:239 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:248; or a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:254 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:260; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:23; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:27; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:31; a heavy chain containing the amino acid sequence of SEQ ID NO:44 and a light chain containing the amino acid sequence of SEQ ID NO:55; a heavy chain containing the amino acid sequence of SEQ ID NO:66 and a light chain containing the amino acid sequence of SEQ ID NO:77; a heavy chain containing the amino acid sequence of SEQ ID NO:90 and a light chain containing the amino acid sequence of SEQ ID NO:101; a heavy chain containing the amino acid sequence of SEQ ID NO:114 and a light chain containing the amino acid sequence of SEQ ID NO:121; a heavy chain containing the amino acid sequence of SEQ ID NO:134 and a light chain containing the amino acid sequence of SEQ ID NO:145; a heavy chain containing the amino acid sequence of SEQ ID NO:151 and a light chain containing the amino acid sequence of SEQ ID NO:161; a heavy chain containing the amino acid sequence of SEQ ID NO:167 and a light chain containing the amino acid sequence of SEQ ID NO:173; a heavy chain containing the amino acid sequence of SEQ ID NO:186 and a light chain containing the amino acid sequence of SEQ ID NO:192; a heavy chain containing the amino acid sequence of SEQ ID NO:198 and a light chain containing the amino acid sequence of SEQ ID NO:204; a heavy chain containing the amino acid sequence of SEQ ID NO:217 and a light chain containing the amino acid sequence of SEQ ID NO:223; a heavy chain containing the amino acid sequence of SEQ ID NO:229 and a light chain containing the amino acid sequence of SEQ ID NO:235; a heavy chain containing the amino acid sequence of SEQ ID NO:241 and a light chain containing the amino acid sequence of SEQ ID NO:250; or a heavy chain containing the amino acid sequence of SEQ ID NO:256; and a light chain containing the amino acid sequence of SEQ ID NO:262. 19. An antibody-drug conjugate containing the structure

, where Ab is an antibody containing: a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:21; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:25; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:29; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:42 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:53; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:64 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:75; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:88 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:99; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:112 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:119; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:132 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:143; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:149 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:159; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:165 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:171; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:184 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:190; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:196 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:202; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:215 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:221; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:227 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:233; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:239 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:248; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:254 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:260; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:23; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:27; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:31; a heavy chain containing the amino acid sequence of SEQ ID NO:44 and a light chain containing the amino acid sequence of SEQ ID NO:55; a heavy chain containing the amino acid sequence of SEQ ID NO:66 and a light chain containing the amino acid sequence of SEQ ID NO:77; a heavy chain containing the amino acid sequence of SEQ ID NO:90 and a light chain containing the amino acid sequence of SEQ ID NO:101; a heavy chain containing the amino acid sequence of SEQ ID NO:114 and a light chain containing the amino acid sequence of SEQ ID NO:121; a heavy chain containing the amino acid sequence of SEQ ID NO:134 and a light chain containing the amino acid sequence of SEQ ID NO:145; a heavy chain containing the amino acid sequence of SEQ ID NO:151 and a light chain containing the amino acid sequence of SEQ ID NO:161; a heavy chain containing the amino acid sequence of SEQ ID NO:167 and a light chain containing the amino acid sequence of SEQ ID NO:173; a heavy chain containing the amino acid sequence of SEQ ID NO:186 and a light chain containing the amino acid sequence of SEQ ID NO:192; a heavy chain containing the amino acid sequence of SEQ ID NO:198 and a light chain containing the amino acid sequence of SEQ ID NO:204; a heavy chain containing the amino acid sequence of SEQ ID NO:217 and a light chain containing the amino acid sequence of SEQ ID NO:223; a heavy chain containing the amino acid sequence of SEQ ID NO:229 and a light chain containing the amino acid sequence of SEQ ID NO:235; a heavy chain containing the amino acid sequence of SEQ ID NO:241 and a light chain containing the amino acid sequence of SEQ ID NO:250; or a heavy chain containing the amino acid sequence of SEQ ID NO:256; and a light chain containing the amino acid sequence of SEQ ID NO:262. 20. An antibody-drug conjugate containing the structure

, where Ab is an antibody containing: a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:21; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:25; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:10 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:29; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:42 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:53; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:64 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:75; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:88 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:99; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:112 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:119; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:132 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:143; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:149 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:159; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:165 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:171; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:184 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:190; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:196 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:202; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:215 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:221; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:227 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:233; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:239 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:248; a heavy chain variable region (VH) containing the amino acid sequence of SEQ ID NO:254 and a light chain variable region (VL) containing the amino acid sequence of SEQ ID NO:260; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:23; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:27; a heavy chain containing the amino acid sequence of SEQ ID NO:12 and a light chain containing the amino acid sequence of SEQ ID NO:31; a heavy chain containing the amino acid sequence of SEQ ID NO:44 and a light chain containing the amino acid sequence of SEQ ID NO:55; a heavy chain containing the amino acid sequence of SEQ ID NO:66 and a light chain containing the amino acid sequence of SEQ ID NO:77; a heavy chain containing the amino acid sequence of SEQ ID NO:90 and a light chain containing the amino acid sequence of SEQ ID NO:101; a heavy chain containing the amino acid sequence of SEQ ID NO:114 and a light chain containing the amino acid sequence of SEQ ID NO:121; a heavy chain containing the amino acid sequence of SEQ ID NO:134 and a light chain containing the amino acid sequence of SEQ ID NO:145; a heavy chain containing the amino acid sequence of SEQ ID NO:151 and a light chain containing the amino acid sequence of SEQ ID NO:161; a heavy chain containing the amino acid sequence of SEQ ID NO:167 and a light chain containing the amino acid sequence of SEQ ID NO:173; a heavy chain containing the amino acid sequence of SEQ ID NO:186 and a light chain containing the amino acid sequence of SEQ ID NO:192; a heavy chain containing the amino acid sequence of SEQ ID NO:198 and a light chain containing the amino acid sequence of SEQ ID NO:204; a heavy chain containing the amino acid sequence of SEQ ID NO:217 and a light chain containing the amino acid sequence of SEQ ID NO:223; a heavy chain containing the amino acid sequence of SEQ ID NO:229 and a light chain containing the amino acid sequence of SEQ ID NO:235; a heavy chain containing the amino acid sequence of SEQ ID NO:241 and a light chain containing the amino acid sequence of SEQ ID NO:250; or a heavy chain containing the amino acid sequence of SEQ ID NO:256; and a light chain containing the amino acid sequence of SEQ ID NO:262. 21. An antibody-drug conjugate according to any one of paragraphs. 18-20, where the antibody or antigen-binding fragment thereof contains one or more cysteine substitutions selected from E152C, S375C, or both E152C and S375C, in the heavy chain of the antibody or antigen-binding fragment, where the position numbering corresponds to the EU system. 22. Pharmaceutical composition containing the antibody or antigennegative fragment according to any one of paragraphs. 1-6 and a pharmaceutically acceptable carrier. 23. A pharmaceutical composition containing an antibody-drug conjugate according to any one of paragraphs. 7-21 and a pharmaceutically acceptable carrier. 24. A method of treating or preventing cancer in a patient in need thereof, comprising administering to said patient an antibody-drug conjugate according to any one of paragraphs. 7-21 or a pharmaceutical composition according to any one of paragraphs. 22 or 23, wherein the cancer expresses PMEL17, contains a GNAQ or GNA11 gene mutation, or the cancer expresses PMEL17 and contains a GNAQ, GNA11 mutation, or both. 25. The method of claim 24 wherein the antibody drug conjugate or pharmaceutical composition is administered to the patient in combination with one or more additional therapeutic compounds. 26. The method of claim 25, wherein the one or more additional therapeutic compounds are selected from a standard chemotherapeutic agent, an MDM2 inhibitor, an MRC2 inhibitor, a PKC inhibitor, a MAPK inhibitor, a costimulatory molecule, or an immune response checkpoint inhibitor. 27. The method of claim 26 wherein the co-stimulatory molecule is selected from OX40 agonist, CD2, CD27, CDS, ICAM-1, LFA-1 (CD11a/CD18), ICOS (CD278), 4-1BB (CD137), GITR, CD30 , CD40, BAFFR, HVEM, CD7, LIGHT, NKG2C, SLAMF7, NKp80, CD160, B7-H3, STING or CD83 ligand. 28. The method of claim 26 wherein the immune checkpoint inhibitor is selected from a PD-1, PD-L1, PD-L2, CTLA4, TIM3, LAG3, VISTA, BTLA, TIGIT, LAIR1, CD160, 2B4 and/or TGFR inhibitor -beta. 29. Conjugate antibodies and drugs according to any one of paragraphs. 7-21 or a pharmaceutical composition according to any one of paragraphs 22 or 23 for use as a drug. 30. Conjugate antibodies and drugs according to any one of paragraphs. 7-21 or a pharmaceutical composition according to any one of claims 22 or 23 for use in the treatment or prevention of a PMEL17 expressing cancer or a cancer that contains a GNAQ or GNA11 gene mutation in a patient in need thereof. 31. The use of an antibody or antigen-binding fragment according to any one of paragraphs. 1-6, an antibody-drug conjugate according to any one of paragraphs. 7-21 or a pharmaceutical composition according to any one of paragraphs. 22 or 23 for treating or preventing a PMEL17 expressing cancer or a cancer that contains a GNAQ or GNA11 gene mutation in a patient in need thereof. 32. The use of an antibody or antigen-binding fragment according to any one of paragraphs. 1-6, an antibody-drug conjugate according to any one of paragraphs. 7-21 or a pharmaceutical composition according to any one of paragraphs. 22 or 23 in the manufacture of a medicinal product. 33. The method according to any one of paragraphs. 24-28, the antibody-drug conjugate according to any one of paragraphs. 29-30 or the use according to any one of paragraphs. 31-32, where the cancer expresses PMEL17 or contains a GNAQ or GNA11 gene mutation. 34. The method, antibody-drug conjugate or use of claim 33, wherein the cancer is uveal melanoma, subcutaneous melanoma, hepatocellular carcinoma, or a metastatic form of these cancers. 35. A nucleic acid that encodes an antibody or antigen-binding fragment according to any one of paragraphs. 1-6. 36. Nucleic acid according to claim 35, where the nucleic acid contains the nucleotide sequence under SEQ ID NO: 13, 24, 28, 32, 45, 56, 67, 78, 91, 102, 115, 122, 135, 146, 152, 162, 168, 174, 187, 193, 199, 205, 218, 224, 230, 236, 242, 251, 257 or 263. 37. A vector containing a nucleic acid according to claim 35 or 36. 38. A host cell containing a vector according to claim 37 or a nucleic acid according to claim 35 or 36. 39. A method for producing an antibody or an antigen-binding fragment, comprising culturing a host cell according to claim 38 and extracting the antibody from the cell culture. 40. The method according to p. 39, where the extraction of antibodies from cell culture involves the following steps: a) removing cells and filtering the culture; b) carrying out purification of the culture by affinity chromatography; c) inactivating any viruses in the culture by adjusting the pH to 3.4-3.6, then re-adjusting the pH to 5.8-6.2 and filtering the culture; d) carrying out purification of the culture by cation exchange chromatography and carrying out recovery of the culture on the column; e) performing anion exchange chromatography on the culture; f) removal of viruses by nanofiltration; g) filtering the culture containing the antibody, and h) obtaining a purified antibody. 41. A method for producing a conjugate of an antibody to PMEL17 and a drug, comprising: (a) preforming a linker-drug moiety of the following formula (B): R ⁸ -L _B - (D) _n (B), where D is a GNAQ inhibitor, GNA11 inhibitor or GNAQ and GNA11 inhibitor; R ⁸ is a reactive group; L _B is a cleavable or non-cleavable linker and n is 1, 2, 3 or 4; (b) conjugating said fragment, which is a linker-drug, with an antibody extracted from the cell culture of claim 35 to obtain an antibody-drug conjugate; and (c) performing purification of the antibody-drug conjugate. 42. Diagnostic reagent containing the antibody or antigennegative fragment according to any one of paragraphs. 1-6. 43. The diagnostic reagent of claim 42, wherein the antibody or antigen-binding fragment thereof is labeled with a radioactive label, fluorophore, chromophore, imaging agent, or metal ion.