RU2019115447A - Водосодержащая гидрогелевая композиция, содержащая частицы элементарного серебра - Google Patents
Водосодержащая гидрогелевая композиция, содержащая частицы элементарного серебра Download PDFInfo
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- RU2019115447A RU2019115447A RU2019115447A RU2019115447A RU2019115447A RU 2019115447 A RU2019115447 A RU 2019115447A RU 2019115447 A RU2019115447 A RU 2019115447A RU 2019115447 A RU2019115447 A RU 2019115447A RU 2019115447 A RU2019115447 A RU 2019115447A
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- hydrogel composition
- water
- composition according
- wound dressing
- total weight
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- 239000000017 hydrogel Substances 0.000 title claims 23
- 239000000203 mixture Substances 0.000 title claims 23
- 239000002245 particle Substances 0.000 title claims 8
- 229910052709 silver Inorganic materials 0.000 title claims 7
- 239000004332 silver Substances 0.000 title claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- 206010052428 Wound Diseases 0.000 claims 7
- 208000027418 Wounds and injury Diseases 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 6
- 229920005830 Polyurethane Foam Polymers 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- 239000011496 polyurethane foam Substances 0.000 claims 3
- 230000002745 absorbent Effects 0.000 claims 2
- 239000002250 absorbent Substances 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 150000005846 sugar alcohols Polymers 0.000 claims 2
- 238000004627 transmission electron microscopy Methods 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920002396 Polyurea Polymers 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 238000002050 diffraction method Methods 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical group CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/30—Low-molecular-weight compounds
- C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
- C08G18/3225—Polyamines
-
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
- C08L79/02—Polyamines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2210/00—Compositions for preparing hydrogels
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
- C08K2003/0806—Silver
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/002—Physical properties
- C08K2201/003—Additives being defined by their diameter
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/002—Physical properties
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/05—Alcohols; Metal alcoholates
- C08K5/053—Polyhydroxylic alcohols
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Claims (21)
1. Водосодержащая гидрогелевая композиция, содержащая частицы элементарного серебра со средним диаметром частиц 5-20 нм, определенным с помощью просвечивающей электронной микроскопии (ТЕМ), и распределением частиц по размерам D90 ≤ 25 нм, определенным с помощью лазерной дифрактометрии, в которой содержание серебра в расчете на общую массу гидрогелевой композиции составляет от 15 до 500 ppm.
2. Водосодержащая гидрогелевая композиция по п. 1, отличающаяся тем, что средний диаметр частиц составляет 9-18 нм.
3. Водосодержащая гидрогелевая композиция по любому из пп. 1 или 2, отличающаяся тем, что содержание серебра в расчете на общую массу гидрогелевой композиции составляет от 25 до 250 ppm.
4. Водосодержащая гидрогелевая композиция по любому предшествующему пункту, отличающаяся тем, что гидрогелевая композиция содержит гидрофильный пенополиуретан.
5. Водосодержащая гидрогелевая композиция по любому предшествующему пункту, отличающаяся тем, что гидрогелевая композиция содержит сополимер полиуретан-полимочевина.
6. Водосодержащая гидрогелевая композиция по любому предшествующему пункту, отличающаяся тем, что гидрогелевая композиция дополнительно содержит неионное поверхностно-активное вещество.
7. Водосодержащая гидрогелевая композиция по п. 6, отличающаяся тем, что поверхностно-активное вещество выбрано из Tween 20, полиэтиленгликоля, сорбита и поливинилпирролидона или их смесей.
8. Водосодержащая гидрогелевая композиция по любому предшествующему пункту, дополнительно содержащая 5-30% масс., многоатомного спирта, выбранного из пропиленгликоля и/или глицерина, в расчете на общую массу гидрогелевой композиции.
9. Водосодержащая гидрогелевая композиция по любому предшествующему пункту, состоящая из 6-20% масс., форполимера с концевыми изофорондиизоцианатными группами, 4-15% масс., диамина на основе полиэтиленоксида, 15-20% масс., пропиленгликоля и/или глицерина, 40-70% масс., воды и 25-250 ppm элементарного серебра со средним диаметром частиц 9-18 нм, при этом все массовые значения указаны в расчете на общую массу гидрогелевой композиции.
10. Многослойная повязка на рану, содержащая по меньшей мере один слой подложки, непроницаемый для воды и непроницаемый для водяного пара, абсорбирующий слой и слой, содержащий водосодержащую гидрогелевую композицию по любому из пп. 1-9.
11. Многослойная повязка на рану по п. 10, отличающаяся тем, что абсорбирующий слой содержит гидрофильный пенополиуретан и гидрогель.
12. Многослойная повязка на рану по п. 11, отличающаяся тем, что поверхность гидрофильного пенополиуретана по меньшей мере частично пропитана гидрогелем.
13. Многослойная повязка на рану по любому из пп. 10-12, отличающаяся тем, что повязку на рану используют в фазе воспаления и/или фазе грануляции заживления раны.
14. Многослойная повязка на рану по любому из пп. 10-12 для применения для лечения ожогов и/или хронических ран.
15. Способ получения гидрогелевой композиции, включающий приведение во взаимодействие смеси, содержащей:
(a) полиамин,
(b) необязательно неионное поверхностно-активное вещество,
(c) дополнительно необязательно многоатомный спирт, выбранный из пропиленгликоля и/или глицерина,
(d) частицы элементарного серебра со средним диаметром частиц 5-20 нм, определенным с помощью просвечивающей электронной микроскопии (ТЕМ), и
(e) воду,
с алифатическим диизоцианатным полимером для получения водосодержащей гидрогелевой композиции, в которой содержание серебра в расчете на общую массу гидрогелевой композиции составляет от 15 до 500 ppm.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEDE102016125579.3 | 2016-12-23 | ||
| DE102016125579.3A DE102016125579A1 (de) | 2016-12-23 | 2016-12-23 | Wasserhaltige Hydrogelzusammensetzung, umfassend elementare Silberpartikel |
| PCT/EP2017/084410 WO2018115453A1 (de) | 2016-12-23 | 2017-12-22 | Wasserhaltige hydrogelzusammensetzung, umfassend elementare silberpartikel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019115447A true RU2019115447A (ru) | 2021-01-25 |
| RU2019115447A3 RU2019115447A3 (ru) | 2021-01-25 |
| RU2752081C2 RU2752081C2 (ru) | 2021-07-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019115447A RU2752081C2 (ru) | 2016-12-23 | 2017-12-22 | Водосодержащая гидрогелевая композиция, содержащая частицы элементарного серебра |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200095421A1 (ru) |
| EP (1) | EP3558401B1 (ru) |
| CN (1) | CN110072563A (ru) |
| DE (1) | DE102016125579A1 (ru) |
| RU (1) | RU2752081C2 (ru) |
| WO (1) | WO2018115453A1 (ru) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| JP6151186B2 (ja) | 2010-12-08 | 2017-06-21 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 創傷滲出液システム付属装置 |
| EP4162968A1 (en) | 2010-12-08 | 2023-04-12 | ConvaTec Technologies Inc. | System for removing exudates from a wound site |
| CN103347561B (zh) | 2010-12-08 | 2016-09-07 | 康沃特克科技公司 | 用于评估伤口分泌液的集成系统 |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| CN105008611A (zh) | 2012-12-20 | 2015-10-28 | 康沃特克科技公司 | 化学改性的纤维素纤维的处理 |
| GB2543544A (en) | 2015-10-21 | 2017-04-26 | Brightwake Ltd | Wound dressing |
| CN109310528B (zh) | 2016-03-30 | 2021-07-20 | 康沃特克科技公司 | 检测伤口中的微生物感染 |
| CA3019436A1 (en) | 2016-03-30 | 2017-10-05 | Qualizyme Diagnostics Gmbh & Co Kg | Detecting microbial infection in wounds |
| GB201608099D0 (en) | 2016-05-09 | 2016-06-22 | Convatec Technologies Inc | Negative pressure wound dressing |
| TW201805034A (zh) | 2016-07-08 | 2018-02-16 | 美商康瓦鐵克科技股份有限公司 | 彈性的負壓系統 |
| PL3481360T3 (pl) | 2016-07-08 | 2022-05-02 | Convatec Technologies Inc. | Wykrywanie przepływu płynu |
| US11266774B2 (en) | 2016-07-08 | 2022-03-08 | Convatec Technologies Inc. | Fluid collection apparatus |
| GB201711183D0 (en) | 2017-07-12 | 2017-08-23 | Smith & Nephew | Antimicrobial or wound care materials, devices and uses |
| GB201711179D0 (en) | 2017-07-12 | 2017-08-23 | Smith & Nephew | Wound care materials, devices and uses |
| GB201711181D0 (en) | 2017-07-12 | 2017-08-23 | Smith & Nephew | Polymer foam material, device and use |
| US12161792B2 (en) | 2017-11-16 | 2024-12-10 | Convatec Limited | Fluid collection apparatus |
| EP3893785A4 (en) * | 2018-12-10 | 2022-08-17 | C.P. Medical Corporation | COMPOSITIONS AND METHODS FOR TREATMENT OF WOUNDS |
| JP7511585B2 (ja) | 2019-06-03 | 2024-07-05 | コンバテック リミティド | 病原体を破壊して封じ込めるための方法およびデバイス |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
| DE102020134827A1 (de) * | 2020-12-23 | 2022-06-23 | Paul Hartmann Ag | Hydrogel zur Behandlung von Druckgeschwüren |
| DE102022117861A1 (de) * | 2022-07-18 | 2024-01-18 | Paul Hartmann Ag | Hydrogel zur Reduktion von Biofilmen |
| EP4578454A1 (en) | 2023-12-28 | 2025-07-02 | Lysatpharma GmbH | Compositions comprising platelet derived extracellular vesicles |
| CN119258264B (zh) * | 2024-10-09 | 2025-04-01 | 广东云曌医疗科技有限公司 | 一种含纳米海螵蛸的水凝胶伤口敷料 |
Family Cites Families (11)
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|---|---|---|---|---|
| EP1066825A1 (en) * | 1999-06-17 | 2001-01-10 | The Procter & Gamble Company | An anti-microbial body care product |
| DE19958697A1 (de) * | 1999-12-06 | 2001-06-07 | Basf Ag | Absorbierende Zubereitung |
| US20050035327A1 (en) * | 2003-08-14 | 2005-02-17 | Canada T. Andrew | Topical silver-based antimicrobial composition for wound care devices |
| CN101426530B (zh) * | 2004-05-12 | 2012-03-07 | 梅迪沃什有限公司 | 创伤愈合聚合物组合物及其使用方法 |
| DE102006050793A1 (de) * | 2006-10-27 | 2008-04-30 | Bayer Materialscience Ag | Neuartige Hydrogele auf Basis aliphatischer NCO-Prepolymere |
| EP2108387A1 (de) * | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Wässrige silberhaltige nichtionische Polyurethandispersionen |
| DE102008031183A1 (de) * | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage |
| DE102008031182A1 (de) | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | Wundauflage mit Hydrogelmatrix |
| EP2338528B1 (de) * | 2009-12-24 | 2013-05-29 | Paul Hartmann AG | Hydrogelmatrix mit erhöhter Absorptionskapazität für Flüssigkeiten |
| DE102010020050A1 (de) | 2010-05-11 | 2011-11-17 | Ivf Hartmann Ag | Wundauflage |
| PL2654429T3 (pl) * | 2010-12-21 | 2018-12-31 | Aap Implantate Ag | Sposób wytwarzania zawiesiny zawierającej nanocząstki srebra oraz zastosowanie mieszaniny zawierającej nanocząstki srebra jako środka powlekającego |
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2016
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- 2017-12-22 CN CN201780077443.2A patent/CN110072563A/zh active Pending
- 2017-12-22 WO PCT/EP2017/084410 patent/WO2018115453A1/de not_active Ceased
- 2017-12-22 US US16/472,149 patent/US20200095421A1/en not_active Abandoned
- 2017-12-22 RU RU2019115447A patent/RU2752081C2/ru active
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|---|---|
| WO2018115453A1 (de) | 2018-06-28 |
| RU2752081C2 (ru) | 2021-07-22 |
| EP3558401A1 (de) | 2019-10-30 |
| EP3558401B1 (de) | 2022-12-07 |
| RU2019115447A3 (ru) | 2021-01-25 |
| US20200095421A1 (en) | 2020-03-26 |
| DE102016125579A1 (de) | 2018-06-28 |
| CN110072563A (zh) | 2019-07-30 |
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