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RU2019108032A - Способы и системы для обнаружения биологических анализируемых веществ - Google Patents

Способы и системы для обнаружения биологических анализируемых веществ Download PDF

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RU2019108032A
RU2019108032A RU2019108032A RU2019108032A RU2019108032A RU 2019108032 A RU2019108032 A RU 2019108032A RU 2019108032 A RU2019108032 A RU 2019108032A RU 2019108032 A RU2019108032 A RU 2019108032A RU 2019108032 A RU2019108032 A RU 2019108032A
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sensor system
hydrogel
analyte
sensor
nanostructure
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RU2019108032A
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English (en)
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Фернандо ПАТОЛЬСКИ
Вадим КРИВИТСКИ
Марина ЗВЕРЖИНЕТСКИ
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Рамот Эт Тель-Авив Юниверсити Лтд.
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Publication of RU2019108032A publication Critical patent/RU2019108032A/ru

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Claims (30)

1. Сенсорная система для определения и/или отслеживания наличия и/или уровня анализируемого вещества в образце, причем система предусматривает наноструктуру и гидрогель, ковалентно соединенный с указанной наноструктурой, при этом указанный гидрогель ассоциирован с сенсорным компонентом, который избирательно взаимодействует с анализируемым веществом и выполнен так, что при контактировании с анализируемым веществом указанная наноструктура претерпевает обнаруживаемое изменение электрического свойства.
2. Сенсорная система по п. 1, где образец представляет собой биологический образец.
3. Сенсорная система по п. 1, где анализируемое вещество представляет собой метаболит.
4. Сенсорная система по п. 1, где анализируемое вещество представляет собой биомаркерный белок.
5. Сенсорная система по п. 1, где указанный гидрогель ковалентно соединен с указанной наноструктурой посредством связывающего фрагмента.
6. Сенсорная система по п. 1, где при контактировании с анализируемым веществом указанный гидрогель претерпевает деформацию, при этом указанная деформация приводит к указанному обнаруживаемому изменению указанного электрического свойства указанной наноструктуры.
7. Сенсорная система по п. 6, где указанная деформация предусматривает изменение объема указанного гидрогеля.
8. Сенсорная система по п. 6, где указанная деформация предусматривает изменение пространственного распределения молекул и/или заряда в гидрогеле.
9. Сенсорная система по п. 1, где указанное электрическое свойство предусматривает электронную плотность на поверхности указанной наноструктуры.
10. Сенсорная система по п. 1, где указанная наноструктура представляет собой нанопроволоку.
11. Сенсорная система по п. 1, предусматривающая множество указанных наноструктур.
12. Сенсорная система по п. 11, где указанный гидрогель ковалентно соединен по меньшей мере с двумя из указанных наноструктур.
13. Сенсорная система по п. 11, где по меньшей мере в одной части указанных наноструктур указанный гидрогель ассоциирован с первым сенсорным компонентом и по меньшей мере в другой части указанных наноструктур указанный гидрогель ассоциирован со вторым сенсорным компонентом, причем указанные первый и второй сенсорные компоненты отличаются друг от друга.
14. Сенсорная система по п. 13, дополнительно предусматривающая по меньшей мере одну наноструктуру, с которой ковалентно соединен гидрогель, при этом указанный гидрогель ассоциирован с несенсорным компонентом.
15. Сенсорная система по п. 1, где указанный гидрогель находится в форме наночастицы.
16. Сенсорная система по п. 1, где указанный гидрогель находится в форме пленки.
17. Система, предусматривающая сенсорную ячейку, содержащую сенсорную систему по любому из пп. 1-16, и по меньшей мере одну дополнительную ячейку, находящуюся в сообщении с сенсорной ячейкой.
18. Система по п. 17, где указанная по меньшей мере одна дополнительная ячейка находится в сообщении по текучей среде с сенсорной ячейкой.
19. Система по п. 17, где указанная по меньшей мере одна дополнительная ячейка выполнена с возможностью содержания по меньшей мере части указанного образца.
20. Система по п. 17, где указанная по меньшей мере одна дополнительная ячейка выполнена с возможностью содержания терапевтически активного средства.
21. Система по п. 20, где указанная дополнительная ячейка выполнена с возможностью контролируемого высвобождения указанного терапевтически активного средства.
22. Система по п. 21, где указанная дополнительная ячейка выполнена с возможностью контролируемого высвобождения указанного терапевтически активного средства в ответ на указанное обнаруживаемое изменение электрического свойства указанной наноструктуры.
23. Система по п. 17, где указанная по меньшей мере одна дополнительная ячейка содержит дополнительную сенсорную систему.
24. Сенсорная система по любому из пп. 1-16 или система по любому из пп. 17-23, выполненная с возможностью обнаружения и/или отслеживания указанного анализируемого вещества in vivo.
25. Сенсорная система или система по п. 24, находящаяся в форме кожного пластыря.
26. Сенсорная система по любому из пп. 1-16 или система по любому из пп. 17-23, выполненная с возможностью обнаружения и/или отслеживания указанного анализируемого вещества ex vivo.
27. Способ определения или отслеживания наличия и/или уровня по меньшей мере одного анализируемого вещества в образце, причем способ предусматривает приведение по меньшей мере части образца в контакт с сенсорной системой по любому из пп. 1-16 или системой по любому из пп. 17-23, при этом указанное обнаруживаемое изменение указанного электрического свойства указывает на наличие и/или уровень анализируемого вещества в образце.
28. Способ по п. 27, где указанный образец представляет собой биологический образец.
29. Способ по п. 27, предназначенный для диагностирования и/или наблюдения за течением заболевания, ассоциированного с указанным анализируемым веществом, у субъекта.
30. Способ по п. 29, где указанная система дополнительно предусматривает ячейку, выполненную с возможностью высвобождения терапевтически активного средства, причем способ предназначен для определения и/или отслеживания эффективности указанного терапевтического средства в отношении указанного заболевания у указанного субъекта и/или для лечения указанного заболевания.
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