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RU2019101864A - Фармацевтическая композиция для лечения недержания мочи и способ ее применения - Google Patents

Фармацевтическая композиция для лечения недержания мочи и способ ее применения Download PDF

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RU2019101864A
RU2019101864A RU2019101864A RU2019101864A RU2019101864A RU 2019101864 A RU2019101864 A RU 2019101864A RU 2019101864 A RU2019101864 A RU 2019101864A RU 2019101864 A RU2019101864 A RU 2019101864A RU 2019101864 A RU2019101864 A RU 2019101864A
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pharmaceutical composition
acetaminophen
amount
specified
treatment
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RU2019101864A
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Дэвид А. ДИЛЛ
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УЭЛЛСЛИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Priority claimed from US13/560,665 external-priority patent/US8445011B2/en
Priority claimed from US13/800,761 external-priority patent/US20130196012A1/en
Priority claimed from US13/847,940 external-priority patent/US8703184B2/en
Application filed by УЭЛЛСЛИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical УЭЛЛСЛИ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Publication of RU2019101864A publication Critical patent/RU2019101864A/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24069Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (17)

1. Применение фармацевтической композиции для лечения ночного недержания мочи у ребенка, где указанная фармацевтическая композиция содержит множество активных ингредиентов, выбранных из группы состоящей из
ацетаминофена, и
ингибиторов фосфодиэстеразы 5 типа (ингибитор ФДЭ-5) и
где указанная фармацевтическая композиция составлена для немедленного высвобождения, замедленного высвобождения, отсроченного высвобождения или их комбинаций.
2. Применение по п.1, где указанная фармацевтическая композиция дополнительно покрыта кишечнорастворимой оболочкой.
3. Применение по п. 1, где указанная фармацевтическая композиция включает ацетаминофен в количестве 1-1000 мг.
4. Применение по п.1, где указанная фармацевтическая композиция включает ацетаминофен в количестве 10-300 мг.
5. Применение по п.1, где указанная фармацевтическая композиция включает ацетаминофен в количестве 300-1000 мг.
6. Фармацевтическая композиция для лечения ночного недержания мочи у ребенка, содержащая множество активных ингредиентов, выбранных из группы состоящей из
ацетаминофена, и
ингибиторов фосфодиэстеразы 5 типа (ингибитор ФДЭ-5), и
фармацевтически приемлемого носителя,
где указанная фармацевтическая композиция составлена для немедленного высвобождения, замедленного высвобождения, отсроченного высвобождения или их комбинаций.
7. Фармацевтическая композиция по п.6, где указанная фармацевтическая композиция дополнительно покрыта кишечнорастворимой оболочкой.
8. Фармацевтическая композиция по п. 6, где указанная фармацевтическая композиция включает ацетаминофен в количестве 1-1000 мг.
9. Фармацевтическая композиция по п.6, где указанная фармацевтическая композиция включает ацетаминофен в количестве 10-300 мг.
10. Фармацевтическая композиция по п.6, где указанная фармацевтическая композиция включает ацетаминофен в количестве 300-1000 мг.
RU2019101864A 2012-07-27 2013-06-28 Фармацевтическая композиция для лечения недержания мочи и способ ее применения RU2019101864A (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13/560,665 US8445011B2 (en) 2010-07-08 2012-07-27 Delayed-release formulation for reducing the frequency of urination and method of use thereof
US13/560,665 2012-07-27
US13/800,761 US20130196012A1 (en) 2010-11-30 2013-03-13 Extended-release formulation for reducing the frequency of urination and method of use thereof
US13/800,761 2013-03-13
US13/847,940 2013-03-20
US13/847,940 US8703184B2 (en) 2010-07-08 2013-03-20 Delayed-release formulation for reducing the frequency of urination and method of use thereof

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RU2015106762A Division RU2015106762A (ru) 2012-07-27 2013-06-28 Фармацевтическая композиция для лечения недержания мочи и способ ее применения

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RU2015106672A RU2015106672A (ru) 2012-07-27 2013-06-28 Фармацевтическая композиция для уменьшения частоты мочеиспускания и способ ее применения
RU2019101864A RU2019101864A (ru) 2012-07-27 2013-06-28 Фармацевтическая композиция для лечения недержания мочи и способ ее применения

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RU2015106672A RU2015106672A (ru) 2012-07-27 2013-06-28 Фармацевтическая композиция для уменьшения частоты мочеиспускания и способ ее применения

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US (3) US20160022615A1 (ru)
EP (3) EP2844241A4 (ru)
JP (4) JP2015522658A (ru)
KR (2) KR20150048741A (ru)
CN (4) CN107335057A (ru)
AU (3) AU2013293489B2 (ru)
BR (2) BR112014031306A2 (ru)
CA (2) CA2879640A1 (ru)
HK (4) HK1205932A1 (ru)
IL (3) IL236028A0 (ru)
MX (2) MX2015001188A (ru)
MY (1) MY171526A (ru)
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SG (2) SG11201500601QA (ru)
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EP2844241A1 (en) 2015-03-11
HK1246203A1 (zh) 2018-09-07
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IL236622A0 (en) 2015-02-26
JP2015522659A (ja) 2015-08-06
CN104470522A (zh) 2015-03-25
AU2018208765A1 (en) 2018-08-16
CN107661326A (zh) 2018-02-06
BR112014031306A2 (pt) 2017-06-27
ZA201500459B (en) 2016-09-28
AU2013293488A2 (en) 2015-02-26
SG11201500578VA (en) 2015-03-30
AU2013293488A1 (en) 2015-02-19
WO2014018223A1 (en) 2014-01-30
IL261232A (en) 2018-10-31
CA2875818A1 (en) 2014-01-30
SG11201500601QA (en) 2015-04-29
CA2879640A1 (en) 2014-01-03
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EP2877179A1 (en) 2015-06-03
US20160022615A1 (en) 2016-01-28
JP2018039831A (ja) 2018-03-15
CN107335057A (zh) 2017-11-10
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RU2015106762A (ru) 2016-09-20
RU2015106672A (ru) 2016-09-20
HK1205931A1 (en) 2015-12-31
HK1205932A1 (en) 2015-12-31
HK1250628A1 (zh) 2019-01-11
IL236028A0 (en) 2015-01-29
BR112015001627A2 (pt) 2017-07-04
MX2015001190A (es) 2015-05-07
KR20150048741A (ko) 2015-05-07
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MY171526A (en) 2019-10-16
ZA201408993B (en) 2016-09-28
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MX2015001188A (es) 2015-05-07
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US20170100351A1 (en) 2017-04-13
EP3527204A1 (en) 2019-08-21
US20180344674A1 (en) 2018-12-06
AU2013293489A1 (en) 2015-03-12

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