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RU2018128137A - Способы лечения или предотвращения астмы посредством введения антагониста il-4r - Google Patents

Способы лечения или предотвращения астмы посредством введения антагониста il-4r Download PDF

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Publication number
RU2018128137A
RU2018128137A RU2018128137A RU2018128137A RU2018128137A RU 2018128137 A RU2018128137 A RU 2018128137A RU 2018128137 A RU2018128137 A RU 2018128137A RU 2018128137 A RU2018128137 A RU 2018128137A RU 2018128137 A RU2018128137 A RU 2018128137A
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Russia
Prior art keywords
antagonist
introducing
treating
methods
preventing asthma
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RU2018128137A
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English (en)
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RU2018128137A3 (ru
RU2801531C2 (ru
Inventor
Мариус АРДЕЛЕАНУ
Намита ГАНДХИ
Нейл ГРЭХЕМ
Стефан К. КИРКЕССЕЛИ
Судип КУНДУ
Аллен РЕЙДИН
Росс Э. РОКЛИН
Стивен ВАЙНШТЕЙН
Дженнифер ДЭВИДСОН ХЭМИЛТОН
Джеффри МИНГ
Original Assignee
Санофи Байотекнолоджи
Ридженерон Фармасьютикалз Инк.
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Application filed by Санофи Байотекнолоджи, Ридженерон Фармасьютикалз Инк. filed Critical Санофи Байотекнолоджи
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Publication of RU2018128137A3 publication Critical patent/RU2018128137A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Otolaryngology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)

Claims (1)

  1. Способ уменьшения частоты возникновения одного или более обострений астмы у субъекта, нуждающегося в этом, включающий введение субъекту терапевтически эффективного количества фармацевтической композиции, включающей антагонист рецептора интерлейкина 4 (IL-4R).
RU2018128137A 2012-08-21 2013-08-20 Способы лечения или предотвращения астмы посредством введения антагониста il-4r RU2801531C2 (ru)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201261691625P 2012-08-21 2012-08-21
US61/691,625 2012-08-21
US201361758097P 2013-01-29 2013-01-29
US61/758,097 2013-01-29
US201361761279P 2013-02-06 2013-02-06
US61/761,279 2013-02-06
US201361783796P 2013-03-14 2013-03-14
US61/783,796 2013-03-14
US201361805797P 2013-03-27 2013-03-27
US61/805,797 2013-03-27
FR1356994 2013-07-16
FR1356994 2013-07-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2015109716A Division RU2690675C2 (ru) 2012-08-21 2013-08-20 Способы лечения или предотвращения астмы посредством введения антагониста il-4r

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2023120407A Division RU2023120407A (ru) 2012-08-21 2023-08-03 Способы лечения или предотвращения астмы посредством введения антагониста il-4r

Publications (3)

Publication Number Publication Date
RU2018128137A true RU2018128137A (ru) 2018-10-08
RU2018128137A3 RU2018128137A3 (ru) 2022-02-10
RU2801531C2 RU2801531C2 (ru) 2023-08-10

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KR20230028592A (ko) 2023-02-28
EP3470432B1 (en) 2021-10-06
CN110624107A (zh) 2019-12-31
AU2013305945B2 (en) 2018-07-26
US20240199751A1 (en) 2024-06-20
KR102307248B1 (ko) 2021-10-01
NZ783258A (en) 2023-06-30
ES2701093T3 (es) 2019-02-20
TW201420116A (zh) 2014-06-01
PL3470432T3 (pl) 2022-02-07
ES2971088T3 (es) 2024-06-03
MX2015002292A (es) 2015-10-09
RU2018128137A3 (ru) 2022-02-10
DK2888281T3 (en) 2019-01-07
EP2888281A1 (en) 2015-07-01
HRP20181963T1 (hr) 2019-02-08
EP4011915B8 (en) 2023-11-15
BR112015003590A8 (pt) 2017-10-31
PL2888281T3 (pl) 2019-03-29
JP7609901B2 (ja) 2025-01-07
US9574004B2 (en) 2017-02-21
JP2015527364A (ja) 2015-09-17
AU2018253544B2 (en) 2020-09-17
HK1211605A1 (en) 2016-05-27
RS58091B1 (sr) 2019-02-28
US11845800B2 (en) 2023-12-19
TWI656880B (zh) 2019-04-21
ES2900342T3 (es) 2022-03-16
IL312711A (en) 2024-07-01
CN104755495A (zh) 2015-07-01
KR102386304B1 (ko) 2022-04-14
EP2888281B1 (en) 2018-09-19
KR20220049621A (ko) 2022-04-21
IL293398B1 (en) 2024-06-01
LT2888281T (lt) 2018-12-27
EP4324479A2 (en) 2024-02-21
RU2690675C2 (ru) 2019-06-05
RU2015109716A (ru) 2016-10-10
EP3470432A1 (en) 2019-04-17
IL237258B (en) 2019-12-31
EP4324479A3 (en) 2024-04-24
PT4011915T (pt) 2024-01-02
WO2014031610A8 (en) 2014-11-20
PL4011915T3 (pl) 2024-04-08
AU2018253544A1 (en) 2018-11-22
US20140056920A1 (en) 2014-02-27
KR20240101727A (ko) 2024-07-02
AU2020277207B2 (en) 2024-05-16
EP4011915A1 (en) 2022-06-15
NZ744109A (en) 2023-01-27
SG11201500889TA (en) 2015-03-30
KR20210118976A (ko) 2021-10-01
JP2023052457A (ja) 2023-04-11
SI2888281T1 (sl) 2019-03-29
CA2882416A1 (en) 2014-02-27
NZ727717A (en) 2021-09-24
IL237258A0 (en) 2015-04-30
JP6306588B2 (ja) 2018-04-04
KR102679182B1 (ko) 2024-06-28
US20180016343A1 (en) 2018-01-18
IN2015KN00414A (ru) 2015-07-17
PT3470432T (pt) 2021-12-14
AU2013305945A1 (en) 2015-03-12
KR20250099415A (ko) 2025-07-01
AU2024205683A1 (en) 2024-09-19
AU2020277207A1 (en) 2020-12-24
KR20150044909A (ko) 2015-04-27
UY34984A (es) 2014-03-31
BR112015003590A2 (ru) 2017-08-22
JP2025038127A (ja) 2025-03-18
HUE064945T2 (hu) 2024-04-28
KR102502640B1 (ko) 2023-02-23
JP2018109056A (ja) 2018-07-12
NZ631562A (en) 2017-03-31
IL293398A (en) 2022-07-01
MX371344B (es) 2020-01-27
AR092177A1 (es) 2015-03-25
WO2014031610A1 (en) 2014-02-27
IL293398B2 (en) 2024-10-01
SG10201701331SA (en) 2017-04-27
EP4011915B1 (en) 2023-10-11

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