RU2018127403A - Поливалентная вакцина против hyo и ее применение - Google Patents
Поливалентная вакцина против hyo и ее применение Download PDFInfo
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- RU2018127403A RU2018127403A RU2018127403A RU2018127403A RU2018127403A RU 2018127403 A RU2018127403 A RU 2018127403A RU 2018127403 A RU2018127403 A RU 2018127403A RU 2018127403 A RU2018127403 A RU 2018127403A RU 2018127403 A RU2018127403 A RU 2018127403A
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- Prior art keywords
- antigen
- prrsv
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- 229940031348 multivalent vaccine Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 229960005486 vaccine Drugs 0.000 claims 7
- 241001465754 Metazoa Species 0.000 claims 6
- 241001673669 Porcine circovirus 2 Species 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 230000001681 protective effect Effects 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000621943 Acholeplasma phage L2 Probable integrase/recombinase Proteins 0.000 claims 1
- 101000618348 Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) Uncharacterized protein Alvin_0065 Proteins 0.000 claims 1
- 101000781117 Autographa californica nuclear polyhedrosis virus Uncharacterized 12.4 kDa protein in CTL-LEF2 intergenic region Proteins 0.000 claims 1
- 101000708323 Azospirillum brasilense Uncharacterized 28.8 kDa protein in nifR3-like 5'region Proteins 0.000 claims 1
- 101000770311 Azotobacter chroococcum mcd 1 Uncharacterized 19.8 kDa protein in nifW 5'region Proteins 0.000 claims 1
- 101000748761 Bacillus subtilis (strain 168) Uncharacterized MFS-type transporter YcxA Proteins 0.000 claims 1
- 101000765620 Bacillus subtilis (strain 168) Uncharacterized protein YlxP Proteins 0.000 claims 1
- 101000916134 Bacillus subtilis (strain 168) Uncharacterized protein YqxJ Proteins 0.000 claims 1
- 101000754349 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) UPF0065 protein BP0148 Proteins 0.000 claims 1
- 101000827633 Caldicellulosiruptor sp. (strain Rt8B.4) Uncharacterized 23.9 kDa protein in xynA 3'region Proteins 0.000 claims 1
- 101000947628 Claviceps purpurea Uncharacterized 11.8 kDa protein Proteins 0.000 claims 1
- 101000686796 Clostridium perfringens Replication protein Proteins 0.000 claims 1
- 101000788129 Escherichia coli Uncharacterized protein in sul1 3'region Proteins 0.000 claims 1
- 101000788370 Escherichia phage P2 Uncharacterized 12.9 kDa protein in GpA 3'region Proteins 0.000 claims 1
- 101000787096 Geobacillus stearothermophilus Uncharacterized protein in gldA 3'region Proteins 0.000 claims 1
- 101000976889 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101000827627 Klebsiella pneumoniae Putative low molecular weight protein-tyrosine-phosphatase Proteins 0.000 claims 1
- 101001130841 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF5 Proteins 0.000 claims 1
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 claims 1
- 101000974028 Rhizobium leguminosarum bv. viciae (strain 3841) Putative cystathionine beta-lyase Proteins 0.000 claims 1
- 101000756519 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) Uncharacterized protein RCAP_rcc00048 Proteins 0.000 claims 1
- 101000948219 Rhodococcus erythropolis Uncharacterized 11.5 kDa protein in thcD 3'region Proteins 0.000 claims 1
- 101000936711 Streptococcus gordonii Accessory secretory protein Asp4 Proteins 0.000 claims 1
- 101000929863 Streptomyces cinnamonensis Monensin polyketide synthase putative ketoacyl reductase Proteins 0.000 claims 1
- 101000788468 Streptomyces coelicolor Uncharacterized protein in mprR 3'region Proteins 0.000 claims 1
- 101000845085 Streptomyces violaceoruber Granaticin polyketide synthase putative ketoacyl reductase 1 Proteins 0.000 claims 1
- 101000711771 Thiocystis violacea Uncharacterized 76.5 kDa protein in phbC 3'region Proteins 0.000 claims 1
- 101000711318 Vibrio alginolyticus Uncharacterized 11.6 kDa protein in scrR 3'region Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Вакцинная композиция для индукции иммуногенного или защитного ответа у животного против одного или нескольких патогенов свиньи, включающая (i) антиген Mycoplasma hyopneumoniae (M. Hyo), (ii) убитый антиген вируса репродуктивного и респираторного синдрома свиней (PRRSV) и (iii) модифицированный живой антиген PRRSV.
2. Композиция по п. 1, дополнительно включающая антиген свиного цирковируса 2 (PCV2).
3. Композиция по любому из пп. 1 или 2, где антиген M. hyo является инактивированной M. hyo.
4. Композиция по любому из пп. 2 или 3, где антиген PCV2 является инактивированным PCV2.
5. Композиция по любому из пп. 1-4, где антиген PRRSV содержит инактивированный PRRSV, включающий полинуклеотид, кодирующий белок ORF5, имеющий по меньшей мере 91% идентичность последовательности с последовательностью, указанной в SEQ ID NO: 2, 3, 4, 5, 6, 7, 8 или 9.
6. Композиция по любому из пп. 1-5, повышающая способность свиней прибавлять вес или снижающая падеж.
7. Композиция или вакцина по любому из пп. 1-6, дополнительно включающая один или несколько фармацевтически или ветеринарно приемлемых носителей, адъювантов, растворителей или наполнителей.
8. Способ вакцинации животного для индукции иммуногенного или защитного ответа у животного против одного или нескольких патогенов свиньи, включающий по меньшей мере одно применение вакцинной композиции по любому из пп. 1-7.
9. Способ по п. 8, включающий прайм-буст режим применения.
10. Способ по п. 9, включающий примирующее применение композиции или вакцины, включающей антиген M. hyo, антиген PCV2 и антиген PRRSV, и бустерное применение композиции или вакцины, включающей антиген PRRSV.
11. Способ по п. 10, где антиген PRRSV из примирующего применения является модифицированным живым PRRSV, и где антиген PRRSV из бустерного применения является инактивированным PRRSV.
12. Способ по любому из пп. 8-11, предназначенный для повышения способности свиней прибавлять в весе.
13. Способ по любому из пп. 8-11, предназначенный для снижения падежа.
14. Способ по любому из пп. 8-13, где животное является свиньей.
15. Набор для вакцинации животного для индукции иммуногенного или защитного ответа у животного против одного или нескольких патогенов свиньи, включающий один или несколько флаконов с вакциной, содержащих вакцинную композицию по любому из пп. 1-7.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272017P | 2015-12-28 | 2015-12-28 | |
| US62/272,017 | 2015-12-28 | ||
| PCT/US2016/066481 WO2017116698A1 (en) | 2015-12-28 | 2016-12-14 | M hyo multivalent vaccine and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021112503A Division RU2021112503A (ru) | 2015-12-28 | 2016-12-14 | Поливалентная вакцина против м. hyo и её применение |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018127403A3 RU2018127403A3 (ru) | 2020-01-30 |
| RU2018127403A true RU2018127403A (ru) | 2020-01-30 |
Family
ID=57681803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018127403A RU2018127403A (ru) | 2015-12-28 | 2016-12-14 | Поливалентная вакцина против hyo и ее применение |
| RU2021112503A RU2021112503A (ru) | 2015-12-28 | 2016-12-14 | Поливалентная вакцина против м. hyo и её применение |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021112503A RU2021112503A (ru) | 2015-12-28 | 2016-12-14 | Поливалентная вакцина против м. hyo и её применение |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20170182141A1 (ru) |
| EP (1) | EP3397279A1 (ru) |
| JP (1) | JP6839714B2 (ru) |
| KR (1) | KR102166196B1 (ru) |
| CN (1) | CN108601824A (ru) |
| AU (1) | AU2016380864B2 (ru) |
| CA (1) | CA3009656A1 (ru) |
| MA (1) | MA43517A (ru) |
| MX (1) | MX2018007950A (ru) |
| MY (1) | MY191905A (ru) |
| NZ (1) | NZ743977A (ru) |
| PH (1) | PH12018501368A1 (ru) |
| RU (2) | RU2018127403A (ru) |
| SG (1) | SG11201805379QA (ru) |
| WO (1) | WO2017116698A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753942A (zh) * | 2017-09-30 | 2018-03-06 | 天津瑞普生物技术股份有限公司 | 一种pcv2、prrsv、猪肺炎支原体三联灭活疫苗制备方法 |
| JP7510874B2 (ja) | 2017-12-22 | 2024-07-04 | ヒプラ シエンティフィック エセ．エレ．ウ． | マイコプラズマ及びブタサーコウイルスに対する皮内混合ワクチン |
| KR102228308B1 (ko) * | 2018-12-19 | 2021-03-16 | 주식회사 이노백 | 마이코플라즈마 폐렴 및 흉막폐렴 예방용 백신 조성물 |
| WO2021018806A1 (en) * | 2019-07-26 | 2021-02-04 | Ceva Sante Animale | Igg-depleted porcine serum and the uses thereof |
| KR102646305B1 (ko) * | 2021-03-04 | 2024-03-13 | 주식회사 이노백 | 돼지 마이코플라스마균 및 돼지 써코바이러스 감염 예방을 위한 다가 백신 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008011247A (es) * | 2006-03-03 | 2008-09-11 | Merial Ltd | Vacuna de micoplasma hyopneumoniae. |
| CA2646574C (en) * | 2006-04-10 | 2012-08-21 | Intervet International B.V. | Vaccine against mycoplasma and prrsv |
| US20090162398A1 (en) * | 2007-12-21 | 2009-06-25 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
| CA2712006A1 (en) * | 2008-01-23 | 2009-10-15 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions |
| AR078253A1 (es) * | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
| UA114504C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| ES2662022T3 (es) * | 2012-07-17 | 2018-04-05 | Merial, Inc. | Vacunas atenuadas de la gripe porcina y procedimientos de fabricación y uso de las mismas |
| CN104043118A (zh) * | 2013-03-11 | 2014-09-17 | 普莱柯生物工程股份有限公司 | 猪prrsv、猪肺炎支原体和pvc-2抗原在制备疫苗中的应用 |
| CN105073130A (zh) * | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
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2016
- 2016-12-14 MY MYPI2018001113A patent/MY191905A/en unknown
- 2016-12-14 EP EP16820125.9A patent/EP3397279A1/en active Pending
- 2016-12-14 CN CN201680080280.9A patent/CN108601824A/zh active Pending
- 2016-12-14 KR KR1020187021708A patent/KR102166196B1/ko not_active Expired - Fee Related
- 2016-12-14 RU RU2018127403A patent/RU2018127403A/ru unknown
- 2016-12-14 JP JP2018534139A patent/JP6839714B2/ja not_active Expired - Fee Related
- 2016-12-14 MA MA043517A patent/MA43517A/fr unknown
- 2016-12-14 US US15/378,165 patent/US20170182141A1/en not_active Abandoned
- 2016-12-14 CA CA3009656A patent/CA3009656A1/en not_active Abandoned
- 2016-12-14 WO PCT/US2016/066481 patent/WO2017116698A1/en not_active Ceased
- 2016-12-14 AU AU2016380864A patent/AU2016380864B2/en not_active Ceased
- 2016-12-14 NZ NZ743977A patent/NZ743977A/en not_active IP Right Cessation
- 2016-12-14 MX MX2018007950A patent/MX2018007950A/es unknown
- 2016-12-14 SG SG11201805379QA patent/SG11201805379QA/en unknown
- 2016-12-14 RU RU2021112503A patent/RU2021112503A/ru unknown
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2018
- 2018-06-25 PH PH12018501368A patent/PH12018501368A1/en unknown
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2023
- 2023-06-28 US US18/343,081 patent/US20240024448A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019501180A (ja) | 2019-01-17 |
| US20240024448A1 (en) | 2024-01-25 |
| JP6839714B2 (ja) | 2021-03-10 |
| RU2018127403A3 (ru) | 2020-01-30 |
| EP3397279A1 (en) | 2018-11-07 |
| MY191905A (en) | 2022-07-18 |
| KR20180096786A (ko) | 2018-08-29 |
| SG11201805379QA (en) | 2018-07-30 |
| AU2016380864B2 (en) | 2019-10-31 |
| MA43517A (fr) | 2018-11-07 |
| NZ743977A (en) | 2020-01-31 |
| US20170182141A1 (en) | 2017-06-29 |
| WO2017116698A1 (en) | 2017-07-06 |
| KR102166196B1 (ko) | 2020-10-15 |
| PH12018501368A1 (en) | 2019-02-18 |
| CA3009656A1 (en) | 2017-07-06 |
| MX2018007950A (es) | 2018-09-21 |
| AU2016380864A1 (en) | 2018-07-19 |
| RU2021112503A (ru) | 2021-05-05 |
| CN108601824A (zh) | 2018-09-28 |
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