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RU2018104870A - Пористая структура для костных имплантатов - Google Patents

Пористая структура для костных имплантатов Download PDF

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Publication number
RU2018104870A
RU2018104870A RU2018104870A RU2018104870A RU2018104870A RU 2018104870 A RU2018104870 A RU 2018104870A RU 2018104870 A RU2018104870 A RU 2018104870A RU 2018104870 A RU2018104870 A RU 2018104870A RU 2018104870 A RU2018104870 A RU 2018104870A
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RU
Russia
Prior art keywords
bone
tetrapods
layer
porous structure
bone implant
Prior art date
Application number
RU2018104870A
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English (en)
Other versions
RU2712032C2 (ru
RU2018104870A3 (ru
Inventor
Экхард БАУЭР
Original Assignee
ВАЛЬДЕМАР ЛИНК ГМБХ энд КО. КГ
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Application filed by ВАЛЬДЕМАР ЛИНК ГМБХ энд КО. КГ filed Critical ВАЛЬДЕМАР ЛИНК ГМБХ энд КО. КГ
Publication of RU2018104870A publication Critical patent/RU2018104870A/ru
Publication of RU2018104870A3 publication Critical patent/RU2018104870A3/ru
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • B22F5/10—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
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    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
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    • A—HUMAN NECESSITIES
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
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    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2999/00—Aspects linked to processes or compositions used in powder metallurgy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
    • B22F7/002—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
    • B22F7/002—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature
    • B22F7/004—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature comprising at least one non-porous part
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

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  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Prostheses (AREA)

Claims (36)

1. Костный имплантат, содержащий тело, характеризующееся пористой структурой (3), и имеющий размер и форму, подобранные для подгонки к кости, предпочтительно в дефекте кости,
отличающийся тем, что пористая структура (3) состоит из регулярно расположенных элементарных ячеек (4), внутренние пространства которых образуют сообщающиеся поры, и
элементарные ячейки (4) образованы основными элементами, расположенными послойно, при этом основные элементы выполнены в форме тетраподов (5, 5'), причем тетраподы (5) в каждом слое расположены в параллельной ориентации и занимают в своем слое положения, повернутые по отношению к тетраподам (5') соседнего слоя.
2. Костный имплантат по п. 1, в котором в пределах слоя три соседних тетрапода (5) соединены друг с другом одним из своих лучей (52, 53, 54) в узловой точке (55), и узловые точки (55) определяют базовую плоскость (45) вышеупомянутого слоя, а четвертый луч (54) вышеупомянутых тетраподов (5) ориентирован по существу перпендикулярно базовой плоскости (45).
3. Костный имплантат по п. 2, в котором узловые точки (55) вышеупомянутого слоя расположены непосредственно под четвертым лучом (54') тетраподов (5') соседнего верхнего слоя таким образом, что вышеупомянутый четвертый луч (54') находится на некотором расстоянии от вышеупомянутой узловой точки (55), расположенной непосредственно под ним.
4. Костный имплантат по п. 2 или 3, в котором лучи (51, 52, 53, 54) тетраподов (5, 5') ориентированы по существу перпендикулярно или наклонно, но не параллельно базовой плоскости (45).
5. Костный имплантат по любому из пп. 2-4, в котором угол между лучами (52, 53, 54), соединяющимися в узловой точке, и базовой плоскостью (45) составляет более чем 20°, предпочтительно от 25° до 35°.
6. Костный имплантат по любому из пп. 2-5, в котором четвертый луч (51) имеет меньшую длину, чем другие лучи (52, 53, 54).
7. Костный имплантат по любому из предыдущих пунктов, в котором слои поочередно сдвинуты таким образом, что тетраподы (5) одного слоя повернуты по отношению к тетраподам (5') соседнего слоя, предпочтительно с чередующимся расположением слоев, имеющих повернутые и неповернутые тетраподы (5, 5').
8. Костный имплантат по любому из предыдущих пунктов, в котором тетраподы (5, 5') изготовлены на месте посредством нанесения и затвердевания материала, предпочтительно в последовательных слоях.
9. Костный имплантат по любому из предыдущих пунктов, в котором тетраподы (5, 5') получены способом электронно-лучевого плавления (ЭЛП) или селективного лазерного плавления (СЛП).
10. Костный имплантат по любому из предыдущих пунктов, в котором пористая структура предпочтительно состоит из биосовместимого материала, выбранного из группы, включающей в себя титановые сплавы, чистый титан, кобальтохромовый сплав, тантал, нержавеющую сталь и цирконий.
11. Костный имплантат по п. 10, в котором материал представляет собой чистый титан, предпочтительно титан марки 2, или титановый сплав, предпочтительно Ti6A14V.
12. Костный имплантат по любому из предыдущих пунктов, в котором пористая структура имеет полученное способом ФОПФ покрытие (30), предпочтительно выбранное из группы, включающей в себя ниобий, тантал, цирконий и их оксиды.
13. Костный имплантат по любому из предыдущих пунктов, в котором пористая структура имеет покрытие (30) на основе фосфата кальция.
14. Костный имплантат по п. 12 или 13, в котором толщина покрытия (30) составляет от 1 мкм до 10 мкм, предпочтительно менее чем 7 мкм.
15. Костный имплантат по любому из предыдущих пунктов, в котором предусмотрена структура в виде сплошного тела, к которой присоединена пористая структура, предпочтительно с образованием единой структуры.
16. Костный имплантат по любому из предыдущих пунктов, у которого форма и размер подобраны таким образом, чтобы он подходил для применения в качестве вертлужной или плечевой чашки, устройства для наращивания кости, предпочтительно вертлужного, плечевого, бедренного или большеберцового устройства (8) для наращивания кости, или кейджа (9), предпочтительно межпозвонкового кейджа.
17. Имплантат для эндопротезирования, включающий в себя тело, состоящее из сплошного материала, и контактирующую с костью часть, состоящую из пористой структуры (3), отличающийся тем, что
пористая структура (3) состоит из регулярно расположенных элементарных ячеек (4), внутренние пространства которых образуют сообщающиеся поры, и
элементарные ячейки (4) образованы основными элементами, расположенными послойно, при этом основные элементы выполнены в форме тетраподов (5, 5'), причем тетраподы (5) в каждом слое расположены в параллельной ориентации и занимают в своем слое положения, повернутые по отношению к тетраподам (5') соседнего слоя.
18. Имплантат для эндопротезирования по п. 17, в котором тело представляет собой компонент шарнирного соединения, предпочтительно чашку (6) с необязательным покрытием.
19. Имплантат для эндопротезирования по п. 17, в котором тело представляет собой элемент (70, 80) в виде перегородки, разделяющий пористую структуру на две отдельные секции (71, 72, 81, 82), причем элемент (70, 80) в виде перегородки предпочтительно выполнен с возможностью блокирования растекания цемента.
20. Имплантат для эндопротезирования по любому из пп. 17-19, в котором тело представляет собой армирующий элемент (75).
21. Имплантат для эндопротезирования по п. 17 или 20, в котором тело образует кейдж (9) для позвоночника и выполнено с возможностью окружения сердцевины (91), состоящей из пористой структуры.
22. Способ изготовления костного имплантата, который содержит тело, характеризующееся пористой структурой, и имеет размер и форму, подобранные для подгонки к кости, предпочтительно в дефекте кости, причем способ предусматривает изготовление костного имплантата с использованием технологии послойного нанесения для образования пористой структуры, что включает в себя
- образование чередующихся слоев основных элементов, выполненных в форме тетраподов;
- расположение тетраподов в каждом слое в по существу параллельной ориентации;
- поворот тетраподов в каждом следующем слое по отношению к тетраподам предшествующего слоя;
- образование регулярно расположенных элементарных ячеек, внутренние пространства которых образуют сообщающиеся поры, причем элементарные ячейки ограничены основными элементами, расположенными послойно.
23. Способ по п. 22, дополнительно предусматривающий следующие стадии:
- создание трехмерной модели костного имплантата;
- задание тела костного имплантата;
- задание контактирующей с костью поверхности костного имплантата, которая выполнена с возможностью дополнения соответствующей поверхности кости, при этом, по меньшей мере, контактирующая с костью поверхность изготовлена в качестве пористой структуры.
24. Способ по п. 22 или 23, дополнительно предусматривающий нанесение покрытия на пористую структуру в процессе физического осаждения из паровой фазы (ФОПФ), предпочтительно с использованием тантала для покрытия.
25. Способ по п. 22 или 23, дополнительно предусматривающий нанесение на пористую структуру покрытия, которое представляет собой покрытие на основе СаР (фосфата кальция).
RU2018104870A 2015-07-09 2016-06-24 Пористая структура для костных имплантатов RU2712032C2 (ru)

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FR2932674B1 (fr) 2008-06-20 2011-11-18 Tornier Sa Procede de modelisation d'une surface glenoidienne d'une omoplate, dispositif d'implantation d'un composant glenoidien d'une prothese d'epaule, et procede de fabrication d'un tel compose.
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