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RU2018143006A - METHOD FOR ORGAN-CONSERVING TREATMENT OF UROTHELIAL CANCER OF THE KIDNEY OF THE KIDNEY - Google Patents

METHOD FOR ORGAN-CONSERVING TREATMENT OF UROTHELIAL CANCER OF THE KIDNEY OF THE KIDNEY Download PDF

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Publication number
RU2018143006A
RU2018143006A RU2018143006A RU2018143006A RU2018143006A RU 2018143006 A RU2018143006 A RU 2018143006A RU 2018143006 A RU2018143006 A RU 2018143006A RU 2018143006 A RU2018143006 A RU 2018143006A RU 2018143006 A RU2018143006 A RU 2018143006A
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RU
Russia
Prior art keywords
kidney
dose
nephroscope
organ
urothelial cancer
Prior art date
Application number
RU2018143006A
Other languages
Russian (ru)
Other versions
RU2691549C2 (en
RU2018143006A3 (en
Inventor
Андрей Дмитриевич Каприн
Олег Иванович Аполихин
Борис Яковлевич Алексеев
Дмитрий Александрович Рощин
Дмитрий Станиславович Меринов
Елена Вячеславовна Филоненко
Дмитрий Владимирович Перепечин
Шамиль Шукурович Гурбанов
Александр Александрович Качмазов
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
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Application filed by Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) filed Critical Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России)
Priority to RU2018143006A priority Critical patent/RU2691549C2/en
Publication of RU2018143006A publication Critical patent/RU2018143006A/en
Publication of RU2018143006A3 publication Critical patent/RU2018143006A3/ru
Application granted granted Critical
Publication of RU2691549C2 publication Critical patent/RU2691549C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/307—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laser Surgery Devices (AREA)

Claims (1)

Способ органосохраняющего лечения уротелиального рака лоханки почки, включающий выполнение перкутанного удаление опухоли лоханки и проведения сеанса фотодинамической терапии, отличающийся тем, что до операции вводят фотосенсибилизатор - хлорин Е6 в дозе 1,0 мг/кг за 3 часа однократно в виде в/в капельной инфузии в течение 30 мин из расчета дозы препарата 1,0 мг/кг, далее выполняют фиброуретеропиелоскопию, производят оценку объема опухолевого поражения, формируют основной перкутанный доступ под нефроскоп 24 Ch, дополнительно устанавливают мининефроскоп 5,5 Ch, производят удаление опухолей с помощью монополярного резектоскопа и лазерной установки, проводят сеанс интраоперационной фотодинамической терапии, по рабочему ходу нефроскопа проводят оптическое волокно и выполняют облучение полости лоханки лазером со световым воздействием излучения с длиной волны 662±3 НМ в дозе 50-100 Дж/см2.A method of organ-preserving treatment of urothelial cancer of the renal pelvis, including performing percutaneous removal of the pelvis tumor and conducting a session of photodynamic therapy, characterized in that a photosensitizer, chlorin E6, is administered at a dose of 1.0 mg / kg for 3 hours once a day in the form of an intravenous drip infusion within 30 min, based on the dose of the drug, 1.0 mg / kg, then fibroureteropyeloscopy is performed, the tumor lesion volume is estimated, the main percutaneous access is formed under a 24 Ch nephroscope, additionally, min 5.5 Ch nephroscope, tumors are removed using a monopolar resectoscope and a laser unit, an intraoperative photodynamic therapy session is performed, an optical fiber is carried out along the nephroscope working path and a laser is irradiated with a light with a wavelength of 662 ± 3 nm at a dose of 50 at a dose of 50 -100 J / cm 2 .
RU2018143006A 2018-12-05 2018-12-05 Method of organ-preserving treatment of urothelial cancer of renal pelvis RU2691549C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2018143006A RU2691549C2 (en) 2018-12-05 2018-12-05 Method of organ-preserving treatment of urothelial cancer of renal pelvis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2018143006A RU2691549C2 (en) 2018-12-05 2018-12-05 Method of organ-preserving treatment of urothelial cancer of renal pelvis

Publications (3)

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RU2018143006A true RU2018143006A (en) 2019-01-15
RU2018143006A3 RU2018143006A3 (en) 2019-05-16
RU2691549C2 RU2691549C2 (en) 2019-06-14

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2718307C2 (en) * 2019-07-12 2020-04-01 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method for percutaneous endoscopic pelvic tumor removal by a single unit
RU2737704C2 (en) * 2020-05-15 2020-12-02 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Method of intraoperative photodynamic therapy in combined treatment of locally advanced soft tissue sarcomas
RU2739701C2 (en) * 2020-07-15 2020-12-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method of organ-preserving treatment of urothelial cancer of renal pelvis

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* Cited by examiner, † Cited by third party
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RU2115371C1 (en) * 1997-08-08 1998-07-20 Российская медицинская академия последипломного образования Министерства здравоохранения РФ Method of kidney cysts treatment
RU2163824C2 (en) * 1997-10-16 2001-03-10 Московский научно-исследовательский онкологический институт им. П.А. Герцена МЗ РФ Method for treating initial cancer of hollow organs with endoscopic photodynamic therapy
RU2161053C1 (en) * 1999-07-09 2000-12-27 Московский научно-исследовательский онкологический институт им. П.А. Герцена Method for applying photodynamic therapy in treating patients having malignant tumors
RU2286111C2 (en) * 2004-12-08 2006-10-27 Государственное образовательное учреждение высшего профессионального образования Алтайский государственный медицинский университет Минздрава России (ГОУ ВПО АГМУ МЗ РФ) Method for treating renal carbuncle
CN1329398C (en) * 2006-02-25 2007-08-01 贵州法澳医疗器械科技有限公司 Dihydroporphine E6 zinc compound photosensitizer and its preparation method and application

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Publication number Publication date
RU2691549C2 (en) 2019-06-14
RU2018143006A3 (en) 2019-05-16

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