RU2017131447A - Способы получения и использования ингибитора sglt2 - Google Patents
Способы получения и использования ингибитора sglt2 Download PDFInfo
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- RU2017131447A RU2017131447A RU2017131447A RU2017131447A RU2017131447A RU 2017131447 A RU2017131447 A RU 2017131447A RU 2017131447 A RU2017131447 A RU 2017131447A RU 2017131447 A RU2017131447 A RU 2017131447A RU 2017131447 A RU2017131447 A RU 2017131447A
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- Prior art keywords
- agent
- inhibitor
- compound
- administered
- obesity
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- 238000000034 method Methods 0.000 title claims 15
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
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- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims 1
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- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 claims 1
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Claims (18)
1. Способ лечения или замедления прогрессирования или начала диабета, диабетической ретинопатии, диабетической нейропатии, диабетической нефропатии, медленного заживления ран, инсулиновой резистентности, гипергликемии, гиперинсулинемии, повышенных уровней жирных кислот или глицерина в крови, гиперлипидемии, ожирения, гипертриглицеридемии, Синдрома X, осложнений диабета, атеросклероза или гипертензии, или повышения в крови уровней липопротеинов высокой плотности, включающий введение млекопитающим, нуждающимся в лечении, терапевтически эффективного количества соединения, имеющего структуру
или его фармацевтически приемлемой соли, стереоизомера или сложного эфира, представляющего собой пролекарство.
2. Способ по п. 1, в котором соединение имеет структуру
3. Способ лечения диабета 2-го типа, включающий введение млекопитающим, нуждающимся в лечении, терапевтически эффективного количества соединения, имеющего структуру 
или его фармацевтически приемлемой соли, стереоизомера или сложного эфира, представляющего собой пролекарство, отдельно или в комбинации с другим антидиабетическим средством, средством для лечения осложнений диабета, средством против ожирения, антигипертензивным средством, антитромбоцитарным средством, антиатеросклеротическим средством и/или гиполипидемическим средством.
4. Способ по п. 3, в котором соединение вводят отдельно.
5. Способ по п. 3, в котором соединение вводят в комбинации с другим антидиабетическим средством.
6. Способ по п. 5, в котором антидиабетическое средство представляет собой 1, 2, 3 или более из бигуанида, сульфонилмочевины, ингибитора глюкозидазы, PRAR γ агониста, PRAR α/γ двойного агониста, ингибитора аР2, ингибитора DP4, сенсибилизатора инсулина, глюкагоноподобного пептида-1 (GLP-1), инсулина, меглитинида, ингибитора РТР1В, ингибитора гликоген-фосфорилазы и/или ингибитора глюкозо-6-фосфатазы.
7. Способ по п. 5, в котором антидиабетическое средство представляет собой 1, 2, 3 или более из метформина, глибурида, глимепирида, глипирида, глипизида, хлорпропамида, гликлазида, акарбозы, миглитола, пиоглитазона, троглитазона, розиглитазона, инсулина, G1-262570, изаглитазона, JTT-501, NN-2344, L895645, YM-440, R-119702, AJ9677, репаглинида, натеглинида, KAD1129, AR-НO39242, GW-409544, KRP297, АС2993, LY315902 и/или NVP-DPP-728А.
8. Способ по п. 5, в котором соединение и антидиабетическое средство вводят в весовом соотношении, находящемся в пределах от приблизительно 0.01:1 до приблизительно 300:1.
9. Способ по п. 3, в котором соединение вводят в комбинации со средством для лечения ожирения.
10. Способ по п. 9, в котором средство для лечения ожирения представляет собой агонист бета-3-адренергических рецепторов, ингибитор липазы, ингибитор обратного захвата серотонина (и допамина), средство для воздействия на бета-рецепторы щитовидной железы, и/или аноректическое средство.
11. Способ по п. 9, в котором средство для лечения ожирения представляет собой орлистат, ATL-962, AJ9677, L750355, СР331648, сибутрамин, топирамат, аксокин, дексамфетамин, фентермин, фенилпропаноламин, и/или мазиндол.
12. Способ по п. 3, в котором соединение вводят в комбинации с гиполипидемическим средством.
13. Способ по п. 12, в котором гиполипидемическое средство представляет собой ингибитор МРТ, ингибитор ГМГ-КоА редуктазы, ингибитор сквален-синтетазы, производное фиброевой кислоты, регулятор активности рецепторов ЛПНП, ингибитор липоксигеназы или ингибитор АЛАТ.
14. Способ по п. 12, в котором гиполипидемическое средство представляет собой правастатин, ловастатин, симвастатин, аторвастатин, церивастатин, флувастатин, нисвастатин, визастатин, атавастатин, розувастатин, фенофибрат, гемфиброзил, клофибрат, авазимиб, TS-962, MD-700 и/или LY295427.
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| RU2013115635A RU2643764C9 (ru) | 2002-05-20 | 2013-04-08 | Способы получения и использования ингибитора sglt2 |
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| CN1020944C (zh) * | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| FR2809310B1 (fr) * | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
| DE60142632D1 (de) | 2000-11-30 | 2010-09-02 | Novodermix Internat Ltd | Heilung von wunden |
| MXPA03007349A (es) * | 2001-02-24 | 2003-12-04 | Boehringer Ingelheim Pharma | Derivados de xantina, su preparacion y su empleo como medicamentos. |
| US6936590B2 (en) * | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| JP4590159B2 (ja) * | 2001-04-04 | 2010-12-01 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | グルコース再吸収阻害剤およびｐｐａｒモジュレーターを含んで成る併用療法 |
| JP2004536047A (ja) * | 2001-04-11 | 2004-12-02 | ブリストル−マイヤーズ スクイブ カンパニー | 糖尿病処置用ｃ−アリールグルコシドのアミノ酸複合体および方法 |
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