RU2017123388A - Пептиды и их применение в уходе за кожей - Google Patents
Пептиды и их применение в уходе за кожей Download PDFInfo
- Publication number
- RU2017123388A RU2017123388A RU2017123388A RU2017123388A RU2017123388A RU 2017123388 A RU2017123388 A RU 2017123388A RU 2017123388 A RU2017123388 A RU 2017123388A RU 2017123388 A RU2017123388 A RU 2017123388A RU 2017123388 A RU2017123388 A RU 2017123388A
- Authority
- RU
- Russia
- Prior art keywords
- specified
- peptide
- composition
- amino acids
- skin
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 4
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims 4
- 230000032683 aging Effects 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Claims (15)
1. Способ уменьшения появления дерматологических признаков старения, включающий в себя наружное нанесение на кожу композиции, содержащей, в пригодном для наружного применения средстве доставки, пептид, имеющий в своем составе от 3 до 12 аминокислот, соответствующих последовательности GDF11, или его соль, сложный эфир или пролекарство.
2. Способ согласно п. 1, где указанные дерматологические признаки старения включают появление мелких морщинок и морщин.
3. Способ согласно п. 1, где указанный пептид повышает выработку коллагена в коже.
4. Способ согласно п. 1, где указанный пептид повышает выработку гиалуроновой кислоты в коже.
5. Способ согласно п. 1, где указанную композицию наносят не менее одного раза в день в течение не менее одной недели.
6. Способ согласно п. 1, где указанный пептид имеет в своем составе от 3 до 8 аминокислот, соответствующих последовательности GDF11.
7. Способ согласно п. 1, где указанный пептид имеет в своем составе от 3 до 6 аминокислот, соответствующих последовательности GDF11.
8. Способ согласно п. 1, где указанный пептид имеет в своем составе MVV(SEQ ID NO: 7).
9. Способ согласно п. 1, где указанный пептид состоит в основном из MVV(SEQ ID NO: 7).
10. Способ согласно п. 1, где указанный пептид имеет в своем составе три или четыре последовательные аминокислоты из аминокислот 395-407 в GDF11.
11. Способ согласно п. 1, где указанный пептид дополнительно содержит углеводородную цепь на аминном конце.
12. Способ согласно п. 11, где указанная углеводородная цепь представляет собой C1-24 алифатический углеводород.
13. Способ согласно п. 1, где указанная композиция включает в себя пролекарство указанного пептида, где указанное пролекарство включает N-ацетильные производные указанного пептида.
14. Способ уменьшения появления дерматологических признаков старения, включающий в себя наружное нанесение на кожу композиции, содержащей, в пригодном для наружного применения средстве доставки, пептид, имеющий в своем составе от 3 до 12 аминокислот, соответствующих последовательности TGFβ, или его соль, сложный эфир или пролекарство.
15. Способ согласно п. 14, где указанные дерматологические признаки старения включают появление мелких морщинок и морщин.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095873P | 2014-12-23 | 2014-12-23 | |
| US62/095,873 | 2014-12-23 | ||
| PCT/US2015/048240 WO2016105607A1 (en) | 2014-12-23 | 2015-09-03 | Peptides and their use in the treatment of skin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017123388A true RU2017123388A (ru) | 2019-01-24 |
| RU2017123388A3 RU2017123388A3 (ru) | 2019-01-25 |
| RU2709778C2 RU2709778C2 (ru) | 2019-12-20 |
Family
ID=56128191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017123388A RU2709778C2 (ru) | 2014-12-23 | 2015-09-03 | Пептиды и их применение в уходе за кожей |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10034826B2 (ru) |
| EP (1) | EP3236992B1 (ru) |
| CN (1) | CN107106652A (ru) |
| BR (1) | BR112017013696B1 (ru) |
| CA (1) | CA2972015A1 (ru) |
| MX (1) | MX389490B (ru) |
| PH (1) | PH12017501070B1 (ru) |
| RU (1) | RU2709778C2 (ru) |
| WO (1) | WO2016105607A1 (ru) |
| ZA (1) | ZA201704726B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101810385B1 (ko) * | 2016-02-04 | 2017-12-20 | 주식회사 강스템바이오텍 | Gdf11을 포함하는 조성물 및 그의 용도 |
| US11766467B2 (en) | 2017-09-01 | 2023-09-26 | University Of Wyoming | Methods of treating wounds using cathepsin K inhibitors |
| US10758559B1 (en) | 2017-09-01 | 2020-09-01 | University Of Wyoming | Targeting cathepsin K to facilitate wound healing |
| JP2020533375A (ja) | 2017-09-15 | 2020-11-19 | カイン サイエンス シーオー., エルティーディー.KINE SCIENCES Co., Ltd. | 自己免疫疾患および骨疾患の治療剤としてのペプチドの用途 |
| CN108586575B (zh) * | 2018-04-11 | 2020-08-14 | 福建省中科生物股份有限公司 | 一种多肽及其皮肤修复功能的应用 |
| BR112021013164B1 (pt) | 2019-01-04 | 2023-10-17 | Avon Products, Inc | Composição tópica compreendendo derivados oxidados de fragmentos de gdf-11 e método não terapêutico para diminuir o aparecimento de sinais dermatológicos de envelhecimento |
| CN114007589A (zh) * | 2019-04-24 | 2022-02-01 | 富力卡姆股份公司 | 局部制剂 |
| US20230320967A1 (en) * | 2020-09-11 | 2023-10-12 | Chemyunion Ltda. | Composition, use of the composition, cosmetic method for modulating the production of sebum |
| KR20240133853A (ko) * | 2023-02-28 | 2024-09-05 | 루다큐어 주식회사 | 신규 펩타이드 및 이의 용도 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
| US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
| WO2001046220A2 (en) * | 1999-12-22 | 2001-06-28 | Polymun Scientific Immunbiologische Forschung Gmbh | Bioactive oligopeptides |
| KR20050033512A (ko) | 2001-10-05 | 2005-04-12 | 프로사이트 코포레이션 | 펩타이드 구리 착물 및 레티놀, 레티놀 유도체 또는이들의 혼합물을 함유하는 피부 보호 조성물 |
| WO2004011650A2 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| ATE505199T1 (de) * | 2002-11-08 | 2011-04-15 | Soc Extraction Principes Actif | Pharmazeutische, kosmetische oder therapeutische zusammensetzungen enthaltend peptide mit dem motiv arg-gly-ser |
| US7141544B2 (en) * | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
| ES2611984T3 (es) * | 2004-06-14 | 2017-05-11 | Basf Beauty Care Solutions France S.A.S. | Preparaciones cosméticas que contienen fragmentos de PTH |
| TWI415628B (zh) | 2006-02-28 | 2013-11-21 | Avon Prod Inc | 包含具有非天然胺基酸之胜肽之組合物及其使用方法 |
| HRP20120698T1 (hr) * | 2007-01-25 | 2013-09-30 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Uporaba dgf-5 za poboljšanje ili održavanje izgleda kože |
| US8987212B2 (en) | 2007-08-07 | 2015-03-24 | Muhammed Majeed | Oleanoyl peptide composition and method of treating skin aging |
| JP5647972B2 (ja) * | 2008-04-08 | 2015-01-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 環状ペプチドを含む組成物および使用方法 |
| EP2454368A4 (en) * | 2009-07-17 | 2013-01-09 | Aaron Thomas Tabor | COMPOSITIONS AND METHOD FOR THE GENETIC MODIFICATION OF COSMETIC FUNCTION CELLS FOR IMPROVING THE COSMETIC APPEARANCE PICTURE |
| WO2011063128A1 (en) * | 2009-11-18 | 2011-05-26 | Affinergy, Inc. | Implantable bone graft materials |
| JP2013515771A (ja) * | 2009-12-28 | 2013-05-09 | エヌ・ブイ・ペリコーン・リミテッド・ライアビリティ・カンパニー | 局所用アシルグルタチオン製剤 |
| CN101884602A (zh) * | 2010-03-03 | 2010-11-17 | 孙杰 | 一种皮肤美容修复抗衰除皱的化妆品制剂 |
| KR20130052441A (ko) * | 2011-11-11 | 2013-05-22 | (주) 코웰메디 | 재조합 인간 골형성 단백질과 트위스트 전사인자를 활성성분으로 함유하는 피부조직 재생용 조성물 및 키트 |
| HK1206601A1 (en) | 2012-04-02 | 2016-01-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| FR2998570B1 (fr) * | 2012-11-26 | 2016-12-02 | Sederma Sa | Peptides, compositions les comprenant et utilisations notamment cosmetiques propigmentantes |
| WO2014140890A2 (en) * | 2013-03-13 | 2014-09-18 | Neocutis Sa | Peptides for skin rejuvenation and methods of using the same |
| WO2014160496A1 (en) * | 2013-03-13 | 2014-10-02 | Stemetrix, Inc. | Skin compositions and uses |
| ITRM20130199A1 (it) | 2013-04-03 | 2014-10-04 | Irbm Science Park S P A | Peptidi per uso dermatologico e/o cosmetico |
| JP2016518357A (ja) * | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
| US9125843B2 (en) * | 2013-10-03 | 2015-09-08 | Elc Management Llc | Methods and compositions for improving the appearance of skin |
| WO2016105375A1 (en) * | 2014-12-23 | 2016-06-30 | Avon Products, Inc. | Peptides and their use in the treatment of skin |
| US20170281507A1 (en) * | 2014-12-23 | 2017-10-05 | Avon Products, Inc. | Peptides and Their Use in the Treatment of Skin |
| US20170281508A1 (en) * | 2014-12-23 | 2017-10-05 | Avon Products, Inc. | Peptides and Their Use in the Treatment of Skin |
| US9597274B2 (en) * | 2015-06-17 | 2017-03-21 | Avon Products, Inc. | Peptides and their use in the treatment of skin |
-
2015
- 2015-09-03 CA CA2972015A patent/CA2972015A1/en not_active Abandoned
- 2015-09-03 BR BR112017013696-1A patent/BR112017013696B1/pt active IP Right Grant
- 2015-09-03 EP EP15868680.8A patent/EP3236992B1/en active Active
- 2015-09-03 WO PCT/US2015/048240 patent/WO2016105607A1/en not_active Ceased
- 2015-09-03 MX MX2017008454A patent/MX389490B/es unknown
- 2015-09-03 RU RU2017123388A patent/RU2709778C2/ru active
- 2015-09-03 PH PH1/2017/501070A patent/PH12017501070B1/en unknown
- 2015-09-03 US US14/844,095 patent/US10034826B2/en active Active
- 2015-09-03 CN CN201580070540.XA patent/CN107106652A/zh active Pending
-
2017
- 2017-07-13 ZA ZA2017/04726A patent/ZA201704726B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2709778C2 (ru) | 2019-12-20 |
| EP3236992A1 (en) | 2017-11-01 |
| MX389490B (es) | 2025-03-20 |
| EP3236992B1 (en) | 2025-10-29 |
| PH12017501070A1 (en) | 2017-12-11 |
| WO2016105607A1 (en) | 2016-06-30 |
| US10034826B2 (en) | 2018-07-31 |
| RU2017123388A3 (ru) | 2019-01-25 |
| CN107106652A (zh) | 2017-08-29 |
| EP3236992A4 (en) | 2018-09-05 |
| BR112017013696B1 (pt) | 2024-01-02 |
| BR112017013696A2 (pt) | 2018-02-06 |
| ZA201704726B (en) | 2019-01-30 |
| PH12017501070B1 (en) | 2022-04-29 |
| MX2017008454A (es) | 2017-10-31 |
| US20160175225A1 (en) | 2016-06-23 |
| CA2972015A1 (en) | 2016-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2017123388A (ru) | Пептиды и их применение в уходе за кожей | |
| ES2572260T3 (es) | Péptidos útiles en el tratamiento y/o cuidado de la piel y/o membranas mucosas y su uso en composiciones cosméticas o farmacéuticas | |
| EP3936141A3 (en) | Anti-senescence compounds and uses thereof | |
| BR112017012474A2 (pt) | composto peptídico, composição cosmética ou dermofarmacêutica, uso de pelo menos um composto peptídico, e, método para aumentar a atividade na síntese de macromoléculas do ecm da pele de um composto peptídico. | |
| WO2009087082A3 (de) | Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil | |
| WO2017009843A3 (en) | Compositions, articles of manufacture and methods for treating cancer | |
| EP3363458A3 (en) | A peptide | |
| EA201990071A1 (ru) | Композиция пептидной вакцины | |
| MX383664B (es) | Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares. | |
| NZ628625A (en) | Polypeptides binding to human complement c5 | |
| EA201691146A1 (ru) | Иммуногенное соединение | |
| EP4349359A3 (en) | Peptide exhibiting wrinkle-improving activity and uses thereof | |
| EP3360895A3 (en) | Preparation comprising factor viii and von willebrand factor peptides | |
| WO2015086686A3 (en) | Protease resistant peptides | |
| CY1125043T1 (el) | Ενωση τριπεπτιδιο, μεθοδος παρασκευης αυτης, και εφαρμογη αυτης | |
| BR112014028130A2 (pt) | Sal de cloridrato de um peptídeo, composição farmacêutica, uso de um sal de cloridrato, uso de uma composição farmacêutica, e, método para evitar ou tratar alergia a gatos | |
| EA201590601A1 (ru) | Применение pedf-производных полипептидов для лечения остеоартрита | |
| MX2018011121A (es) | Prevención de la adherencia de tejido biológico. | |
| MX2018011082A (es) | Péptido o aminoácido n-lipoico, derivados y sus usos. | |
| AR098615A1 (es) | Péptido para el tratamiento de hipoglicemia severa | |
| NZ595060A (en) | Treatment of cancer with immunostimulatory hiv tat derivative polypeptides | |
| CO2022010207A2 (es) | Uso de derivados del ácido hialurónico en la regeneración de tejidos óseos y cartilaginosos | |
| EA202190014A1 (ru) | Композиция, содержащая глицирризин, и ее косметическое средство и фармацевтические применения | |
| AR098616A1 (es) | Péptido para el tratamiento de hipoglicemia severa | |
| EA201592019A1 (ru) | Лиофилизат, содержащий циклический пептид формулы x-gqretpegaeakpwy-x |