[go: up one dir, main page]

RU2016131840A - Hemostatic antibacterial composition, method for its preparation, medical device based on composition - Google Patents

Hemostatic antibacterial composition, method for its preparation, medical device based on composition Download PDF

Info

Publication number
RU2016131840A
RU2016131840A RU2016131840A RU2016131840A RU2016131840A RU 2016131840 A RU2016131840 A RU 2016131840A RU 2016131840 A RU2016131840 A RU 2016131840A RU 2016131840 A RU2016131840 A RU 2016131840A RU 2016131840 A RU2016131840 A RU 2016131840A
Authority
RU
Russia
Prior art keywords
medical device
composition
antibacterial composition
vancomycin
hemostatic antibacterial
Prior art date
Application number
RU2016131840A
Other languages
Russian (ru)
Other versions
RU2665950C2 (en
Inventor
Елена Ильинична Черняк
Александра Романовна Таркова
Наталья Ивановна Ткачёва
Владимир Иванович Родионов
Елена Викторовна Карпова
Сергей Владимирович Морозов
Игорь Алексеевич Григорьев
Александр Михайлович Чернявский
Original Assignee
Федеральное государственное бюджетное учреждение "Сибирский федеральный биомедицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "СФБМИЦ им. ак. Е.Н. Мешалкина" Минздрава России)
Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное государственное бюджетное учреждение "Сибирский федеральный биомедицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "СФБМИЦ им. ак. Е.Н. Мешалкина" Минздрава России), Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) filed Critical Федеральное государственное бюджетное учреждение "Сибирский федеральный биомедицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "СФБМИЦ им. ак. Е.Н. Мешалкина" Минздрава России)
Priority to RU2016131840A priority Critical patent/RU2665950C2/en
Publication of RU2016131840A publication Critical patent/RU2016131840A/en
Application granted granted Critical
Publication of RU2665950C2 publication Critical patent/RU2665950C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (18)

1. Гемостатическая антибактериальная композиция, содержащая окисленную целлюлозу, связанную с ванкомицином посредством нековалентных межмолекулярных водородных связей.1. Hemostatic antibacterial composition containing oxidized cellulose bound to vancomycin via non-covalent intermolecular hydrogen bonds. 2. Гемостатическая антибактериальная композиция по п. 1, содержание ванкомицина в композиции составляет от 20 до 40 мас.%.2. Hemostatic antibacterial composition according to claim 1, the content of vancomycin in the composition is from 20 to 40 wt.%. 3. Гемостатическая антибактериальная композиция по п. 1 представляет собой порошок.3. The hemostatic antibacterial composition according to claim 1 is a powder. 4. Применение композиции по п. 1 для остановки диффузных кровотечений из паренхиматозных органов, сосудистых анастомозов.4. The use of a composition according to claim 1 for stopping diffuse bleeding from parenchymal organs, vascular anastomoses. 5. Способ получения гемостатической антибактериальной композиции, заключающийся в том, что механическую смесь окисленной порошковой целлюлозы с ванкомицином добавляют в воду при перемешивании, затем перемешивают, полученную суспензию центрифугируют, затем осадок и центрифугат разделяют и высушивают при температуре 50-70°C в течение 6-8 ч, после высушенные центрифугат и осадок смешивают в измельчителе.5. A method of obtaining a hemostatic antibacterial composition, which consists in adding a mechanical mixture of oxidized powder cellulose with vancomycin with stirring, then stirring, the resulting suspension is centrifuged, then the precipitate and centrifugate are separated and dried at a temperature of 50-70 ° C for 6 -8 h, after the dried centrifuge and sediment are mixed in a grinder. 6. Способ по п. 5, заключающийся в том, что механическую смесь готовят на измельчителе роторного типа.6. The method according to p. 5, which consists in the fact that the mechanical mixture is prepared on a rotary-type grinder. 7. Способ по п. 5, заключающийся в том, что механическую смесь перемешивают в воде в течение 16-20 ч при температуре 20-25°C.7. The method according to p. 5, which consists in the fact that the mechanical mixture is stirred in water for 16-20 hours at a temperature of 20-25 ° C. 8. Способ по п. 5, заключающийся в том, что полученную суспензию центрифугируют в течение 15-20 мин при скорости 5500-6000 об/мин.8. The method according to p. 5, namely, that the resulting suspension is centrifuged for 15-20 minutes at a speed of 5500-6000 rpm 9. Способ по п. 5, заключающийся в том, что центрифугат высушивают при перемешивании на магнитной мешалке с поддувом воздуха.9. The method according to p. 5, which consists in the fact that the centrifuge is dried with stirring on a magnetic stirrer with air blowing. 10. Медицинское изделие, включающее гемостатическую антибактериальную композицию, содержащую окисленную целлюлозу, связанную с ванкомицином, и стерильный растворитель.10. A medical device comprising a hemostatic antibacterial composition comprising oxidized cellulose bound to vancomycin and a sterile solvent. 11. Медицинское изделие по п. 10, в котором стерильным растворителем является физиологический раствор.11. The medical device according to claim 10, wherein the sterile solvent is physiological saline. 12. Медицинское изделие по п. 10, в котором стерильным растворителем является дистиллированная вода.12. The medical device according to claim 10, wherein the sterile solvent is distilled water. 13. Медицинское изделие по п. 10, где содержание ванкомицина в композиции составляет от 20 до 40 мас.%.13. The medical device according to p. 10, where the content of vancomycin in the composition is from 20 to 40 wt.%. 14. Медицинское изделие по п. 10, в котором гемостатическая антибактериальная композиция представляет собой порошок.14. The medical device according to claim 10, in which the hemostatic antibacterial composition is a powder. 15. Медицинское изделие по п. 10, содержащее от 33,3 до 55,5 мас.% гемостатической антибактериальной композиции.15. The medical device according to claim 10, containing from 33.3 to 55.5 wt.% Hemostatic antibacterial composition. 16. Медицинское изделие по п. 10, содержащее от 44,4 до 66,6 мас.% стерильного растворителя.16. The medical device according to claim 10, containing from 44.4 to 66.6 wt.% A sterile solvent. 17. Медицинское изделие по п. 10 представляет собой пасту.17. The medical device according to claim 10 is a paste. 18. Применение медицинского изделия по п. 10 для остановки кровотечений из губчатых, плоских, смешанных костей.18. The use of a medical device according to claim 10 for stopping bleeding from spongy, flat, mixed bones.
RU2016131840A 2016-08-02 2016-08-02 Hemostatic antibacterial agent, method for its preparation, medical product based on hemostatic antibacterial agent RU2665950C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016131840A RU2665950C2 (en) 2016-08-02 2016-08-02 Hemostatic antibacterial agent, method for its preparation, medical product based on hemostatic antibacterial agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016131840A RU2665950C2 (en) 2016-08-02 2016-08-02 Hemostatic antibacterial agent, method for its preparation, medical product based on hemostatic antibacterial agent

Publications (2)

Publication Number Publication Date
RU2016131840A true RU2016131840A (en) 2018-02-05
RU2665950C2 RU2665950C2 (en) 2018-09-05

Family

ID=61174095

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016131840A RU2665950C2 (en) 2016-08-02 2016-08-02 Hemostatic antibacterial agent, method for its preparation, medical product based on hemostatic antibacterial agent

Country Status (1)

Country Link
RU (1) RU2665950C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2756316C1 (en) * 2020-06-15 2021-09-29 Федеральное государственное бюджетное учреждение науки Байкальский институт природопользования Сибирского отделения Российской академии наук (БИП СО РАН) Local hemostatic antibacterial agent, method for production thereof, and medical product based thereon

Also Published As

Publication number Publication date
RU2665950C2 (en) 2018-09-05

Similar Documents

Publication Publication Date Title
CN106620825B (en) A two-component rapid hemostatic gel and its application
Li et al. Emerging biopolymer‐based bioadhesives
CN108744023A (en) A kind of fibroin albumen medical bio adhesive and preparation method thereof
JP5660781B2 (en) β-1,3-glucan-derived polyaldehyde / polyamine hydrogel
Huang et al. Nature‐derived okra gel as strong hemostatic bioadhesive in human blood, liver, and heart trauma of rabbits and dogs
CN108744055B (en) Silk fibroin bone cement biological adhesive and preparation method thereof
He et al. Facile preparation of PVA hydrogels with adhesive, self-healing, antimicrobial, and on-demand removable capabilities for rapid hemostasis
CN106390185A (en) Preparation method of biological mimetic tissue adhesive
Guo et al. A biodegradable supramolecular adhesive with robust instant wet adhesion for urgent hemostasis and wound repair
CN114344556A (en) Polyphenol-silk fibroin-polyethylene glycol medical tissue adhesive, preparation method and application
Alinezhad et al. Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration
Luo et al. Development and evaluation of tilapia skin-derived gelatin, collagen, and acellular dermal matrix for potential use as hemostatic sponges
Chen et al. Effects of guar gum on adhesion properties of soybean protein isolate onto porcine bones
CN113412875A (en) Protein ultrasonic composite acid/alkali treatment combined with catechin to improve oxidation resistance
CN115636960B (en) Photo-crosslinking silk fibroin hemostatic adhesive and preparation method thereof
CN101564552B (en) Method for preparing high-strength collagen tissue repair material product
CN109999216A (en) A kind of trauma hemostasis sponge and its preparation method and application
CN104474576A (en) Chitosan hemostatic material formed by covalent crosslinking and preparation method thereof
CN1947800A (en) Hemostatic particles and preparation method thereof
RU2016131840A (en) Hemostatic antibacterial composition, method for its preparation, medical device based on composition
Gorab et al. Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
Wang et al. Nature‐Inspired Gelatin‐Based Adhesive Hydrogel: A Rapid and User‐Friendly Solution for Hemostatic Applications
RU2018102360A (en) POWDERED, SEMI-SYNTHETIC MATERIAL OBTAINED BY CHANGING THE COMPOSITION OF MARINE NATURAL BIOMATERIAL, METHOD OF ITS PRODUCTION AND APPLICATION
Tang et al. Tranexamic acid-loaded catechol-modified hyaluronic acid/carboxymethyl chitosan double cross-linked porous gel micropowders for rapid hemostasis and wound healing
CN108245700A (en) A kind of hydroxypropyl methyl cellulose chitosan film dressing and preparation method thereof

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant