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RU2016129894A - Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения - Google Patents

Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения Download PDF

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RU2016129894A
RU2016129894A RU2016129894A RU2016129894A RU2016129894A RU 2016129894 A RU2016129894 A RU 2016129894A RU 2016129894 A RU2016129894 A RU 2016129894A RU 2016129894 A RU2016129894 A RU 2016129894A RU 2016129894 A RU2016129894 A RU 2016129894A
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amino acid
antibody
acid sequence
helicar
conjugate according
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RU2016129894A
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RU2016129894A3 (ru
RU2694981C2 (ru
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Ульрих БРИНКМАНН
Гай ГЕОРГЕС
Айке ХОФФМАНН
Георг ТИФЕНТАЛЕР
Эккехард Мёсснер
Стефан ДЕНГЛЬ
Ахим ГЕРТНЕР
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Ф. Хоффманн-Ля Рош Аг
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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Claims (17)

1. Конъюгат, содержащий i) соединение, содержащее аминокислотную последовательность мотива хеликар, выбранное из группы, содержащей SEQ ID NO: 01, вариант SEQ ID NO: 01, где один аминокислотный остаток был заменен на цистеин, SEQ ID NO: 02 и SEQ ID NO: 03, и ii) антитело, которое специфично связывается с аминокислотной последовательностью мотива хеликар, где данный конъюгат содержит ковалентную связь между соединением, содержащим аминокислотную последовательность мотива хеликар, и аминокислотным остатком в CDR2 антитела против хеликара, при этом CDR2 определяется согласно Kabat.
2. Конъюгат по п. 1, характеризующийся тем, что CDR2 представляет собой CDR2 легкой цепи.
3. Конъюгат по п. 1, характеризующийся тем, что ковалентная связь представляет собой дисульфидную связь, и аминокислотный остаток в CDR2 представляет собой остаток цистеина.
4. Конъюгат по п. 1, характеризующийся тем, что соединение, содержащее аминокислотную последовательность мотива хеликар, представляет собой полипептид, содержащий аминокислотную последовательность мотива хеликар либо слитую с одним из его концов, либо находящуюся внутри последовательности полипептида.
5. Конъюгат по п. 1, характеризующийся тем, что остаток цистеина в CDR2 легкой цепи антитела находится в положении 55 или в положении 51 согласно нумерации вариабельного домена легкой цепи по Kabat.
6. Конъюгат по п. 1, характеризующийся тем, что антитело представляет собой биспецифичное антитело, содержащее первый функционал связывания в отношении антигена, не являющегося аминокислотной последовательностью мотива хеликар, и второй функционал связывания в отношении аминокислотной последовательности мотива хеликар.
7. Конъюгат по п. 1, характеризующийся тем, что дисульфидная связь образуется между остатками цистеина без добавления окислительно-восстановительно активного агента.
8. Антитело против аминокислотной последовательности мотива хеликар, которое имеет в легкой цепи остаток цистеина в CDR2, при этом CDR определяются согласно Kabat.
9. Антитело по п. 8, характеризующееся тем, что остаток цистеина в CDR2 легкой цепи антитела находится в положении 55 или в положении 51 согласно нумерации вариабельного домена легкой цепи по Kabat.
10. Антитело по любому из пп. 8-9, характеризующееся тем, что данное антитело содержит такие же гипервариабельные петли, как и в вариабельном домене SEQ ID NO: 04 для тяжелой цепи, и такие же, как и в любом из вариабельных доменов SEQ ID NO: 05 или SEQ ID NO: 06, или SEQ ID NO: 07 для вариабельного домена легкой цепи, и дополнительно содержит человеческий акцепторный каркас.
11. Конъюгат по п. 1, характеризующийся содержанием в качестве антитела, которое специфично связывается с аминокислотной последовательностью мотива хеликар, антитела по любому из пп. 8-10.
12. Фармацевтическая композиция, содержащая конъюгат по любому из пп. 1-7 и 11, и фармацевтически приемлемый носитель.
13. Конъюгат по любому из пп. 1-7 и 11 для применения в качестве лекарственного средства.
14. Конъюгат по п. 13, где лекарственное средство предназначено для лечения рака.
15. Применение конъюгата по любому из пп. 1-7 и 11, содержащего терапевтический полипептид, для увеличения стабильности терапевтического полипептида.
16. Применение конъюгата по любому из пп. 1-7 и 11, содержащего терапевтический полипептид, для увеличения периода полувыведения терапевтического полипептида in vivo.
17. Биспецифичное антитело против хеликара для целевой доставки соединения, содержащего аминокислотную последовательность мотива хеликар, в клетку-мишень, где данное биспецифичное антитело содержит первый сайт связывания, который специфично связывается с соединением, содержащим аминокислотную последовательность мотива хеликар, и второй функционал связывания, который специфично связывается с маркером клеточной поверхности клетки-мишени.
RU2016129894A 2014-01-03 2014-12-29 Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения RU2694981C2 (ru)

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EP14150087.6 2014-01-03
EP14150087 2014-01-03
PCT/EP2014/079352 WO2015101587A1 (en) 2014-01-03 2014-12-29 Covalently linked helicar-anti-helicar antibody conjugates and uses thereof

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CN (1) CN105873615B (ru)
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KR20160101721A (ko) 2016-08-25
US20170058050A1 (en) 2017-03-02
JP2017505296A (ja) 2017-02-16
RU2694981C2 (ru) 2019-07-18
EP3089758A1 (en) 2016-11-09
KR102278979B1 (ko) 2021-07-19
CN105873615A (zh) 2016-08-17
BR112016012666A2 (pt) 2017-09-26
WO2015101587A1 (en) 2015-07-09
US10407511B2 (en) 2019-09-10
CA2930154A1 (en) 2015-07-09
CN105873615B (zh) 2020-12-25

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