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RU2016100626A - METHOD FOR PREDICTING THE SEVERITY OF THE COURSE AND THE OUTCOME OF THE DISEASE IN PATIENTS WITH SURGICAL SEPSIS - Google Patents

METHOD FOR PREDICTING THE SEVERITY OF THE COURSE AND THE OUTCOME OF THE DISEASE IN PATIENTS WITH SURGICAL SEPSIS Download PDF

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Publication number
RU2016100626A
RU2016100626A RU2016100626A RU2016100626A RU2016100626A RU 2016100626 A RU2016100626 A RU 2016100626A RU 2016100626 A RU2016100626 A RU 2016100626A RU 2016100626 A RU2016100626 A RU 2016100626A RU 2016100626 A RU2016100626 A RU 2016100626A
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Russia
Prior art keywords
ic3ar
disease
monocytes
c3ar
expression
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RU2016100626A
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Russian (ru)
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RU2674252C2 (en
Inventor
Анатолий Владимирович Лазанович
Елена Владимировна Маркелова
Игорь Владимирович Кудрявцев
Original Assignee
Государственное бюджетное образовательное учреждение высшего профессионального образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГОУ ВПО ТГМУ Минздрава России)
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Priority to RU2016100626A priority Critical patent/RU2674252C2/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (9)

Способ прогнозирования тяжести течения и исхода заболевания у пациентов с хирургическим сепсисом путем исследования крови, отличающийся тем, что у пациентов, в первые 48 часов, после установления диагноза сепсиса, берут 4 мл крови из периферической вены в пробирку с добавлением К3ЭДТА, не более 2-х часов после забора крови, проводят количественную оценку уровня экспрессии C3aR на моноцитах по средней интенсивности флюоресценции на проточном цитометре, в каждой пробе анализируют не менее 104 клеток, далее, в процессе лечения берут повторно кровь, определяют уровень экспрессии C3aR на моноцитах и рассчитывают прогностический индекс IC3aR по формуле:A method for predicting the severity and outcome of a disease in patients with surgical sepsis by blood testing, characterized in that in the first 48 hours after the diagnosis of sepsis, 4 ml of blood is taken from the peripheral vein into a tube with the addition of K 3 EDTA, not more than 2 hours after blood sampling, a quantitative assessment of the level of C3aR expression on monocytes is carried out according to the average fluorescence intensity on a flow cytometer, at least 10 4 cells are analyzed in each sample, then, in the course of treatment, they repeatedly take blood b, determine the level of expression of C3aR on monocytes and calculate the prognostic index IC3aR according to the formula: IC3aR1=N2/N1,IC3aR 1 = N 2 / N 1 , IC3aR2=N3/N1,IC3aR 2 = N 3 / N 1 , IC3aR3=N4/N1,IC3aR 3 = N 4 / N 1 , IC3aR4=N5/N1,IC3aR 4 = N 5 / N 1 , где IC3aR1 - прогностический индекс (с точностью до одного знака после запятой),where IC3aR 1 is the prognostic index (accurate to one decimal place), IC3aR2-5 - прогностический индекс в динамике заболевания,IC3aR 2-5 - prognostic index in the dynamics of the disease, N1 - исходное значение на начальном этапе заболевания (в первые 48 часов) показатель экспрессии на C3aR моноцитах (MFI),N 1 - the initial value at the initial stage of the disease (in the first 48 hours), the indicator of expression on C3aR monocytes (MFI), N2-5 - значение экспрессии на C3aR моноцитах (MFI) при последующих исследованиях в динамике, и при величине IC3aR более 1,0 прогнозируют неблагоприятный прогноз исхода сепсиса.N 2-5 - the value of expression on C3aR monocytes (MFI) in subsequent studies in dynamics, and with an IC3aR value of more than 1.0, an unfavorable prognosis of the outcome of sepsis is predicted.
RU2016100626A 2016-01-11 2016-01-11 Method for predicting disease severity and outcome in patients with surgical sepsis RU2674252C2 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2684904C1 (en) * 2018-03-05 2019-04-16 Федеральное государственное бюджетное учреждение науки Оренбургский федеральный исследовательский центр Уральского отделения Российской академии наук Method for assessing severity of sepsis

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2720824C1 (en) * 2019-05-16 2020-05-13 Юрий Леонидович Кецко Method for assessing nearest disease prognosis and protein-energy deficiency correction in patients with inflammatory syndrome of bacterial genesis
RU2713930C1 (en) * 2019-10-16 2020-02-11 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний" (НИИ КПССЗ) Method for prediction of sepsis following cardiosurgical operations performed in conditions of artificial blood circulation

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Publication number Priority date Publication date Assignee Title
RU2331882C1 (en) * 2006-11-30 2008-08-20 Наталья Валериановна Безручко Method of endogenous intoxication severity evaluation in urgent abdominal pathology in early post-operative period
RU2374646C1 (en) * 2008-05-20 2009-11-27 Федеральное Государственное Учреждение Ростовский НИИ акушерства и педиатрии Федерального агентства по высокотехнологичной медицинской помощи Early diagnostic technique for development of neonatal sepsis in newborns suffering from respiratory disorder syndrome and hypoxic damage of cns

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2684904C1 (en) * 2018-03-05 2019-04-16 Федеральное государственное бюджетное учреждение науки Оренбургский федеральный исследовательский центр Уральского отделения Российской академии наук Method for assessing severity of sepsis

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Effective date: 20200702