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RU2016149077A - Микроорганизм для продуцирования О-ацетилгомосерина и способ получения О-ацетилгомосерина с использованием этого микроорганизма - Google Patents

Микроорганизм для продуцирования О-ацетилгомосерина и способ получения О-ацетилгомосерина с использованием этого микроорганизма Download PDF

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RU2016149077A
RU2016149077A RU2016149077A RU2016149077A RU2016149077A RU 2016149077 A RU2016149077 A RU 2016149077A RU 2016149077 A RU2016149077 A RU 2016149077A RU 2016149077 A RU2016149077 A RU 2016149077A RU 2016149077 A RU2016149077 A RU 2016149077A
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microorganism
genus escherichia
producing
activity
acetyl homoserine
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RU2016149077A
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RU2016149077A3 (ru
RU2676137C2 (ru
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Джи Ён БЭ
Хён А КИМ
Ёнг Ук СИН
Со Ён КИМ
Сан Кём КИМ
Кванг Хо НА
Джу Хи СО
Сун Кван СОН
Хе Рён Ю
Джин Гын ЧОЙ
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Сиждей Чейлджеданг Корпорейшн
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Claims (9)

1. Микроорганизм рода Escherichia, продуцирующий О-ацетилгомосерин, где активность белка, содержащего аминокислотную последовательность SEQ ID NO: 1, повышена по сравнению с немодифицированным микроорганизмом.
2. Микроорганизм рода Escherichia по п. 1, представляющий собой Escherichia coli.
3. Микроорганизм рода Escherichia по п. 1, где активность цистатионинсинтазы дополнительно понижена или инактивирована.
4. Микроорганизм рода Escherichia по п. 1, где активность гомосеринкиназы дополнительно понижена или инактивирована.
5. Микроорганизм рода Escherichia по п. 1, где активность гомосеринацетилтрансферазы дополнительно повышена по сравнению с немодифицированным микроорганизмом.
6. Микроорганизм рода Escherichia по п. 1, где активность по меньшей мере одного фермента, выбранного из группы, состоящей из фосфоенолпируваткарбоксилазы, аспартатаминотрансферазы и аспартат-полуальдегид-дегидрогеназы, дополнительно повышена.
7. Микроорганизм рода Escherichia по п. 1, где активность аспартаткиназы повышена по сравнению с немодифицированным микроорганизмом.
8. Способ получения О-сукцинилгомосерина, включающий культивирование микроорганизма рода Escherichia, продуцирующего О-ацетилгомосерин, по любому из пп. 1-7 для получения культуральной среды.
9. Способ по п. 8, дополнительно включающий выделение О-ацетилгомосерина из культивированного микроорганизма или культуральной среды.
RU2016149077A 2014-06-05 2015-06-05 Микроорганизм для продуцирования О-ацетилгомосерина и способ получения О-ацетилгомосерина с использованием этого микроорганизма RU2676137C2 (ru)

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Application Number Priority Date Filing Date Title
KR10-2014-0068613 2014-06-05
KR1020140068613A KR101825777B1 (ko) 2014-06-05 2014-06-05 O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법
PCT/KR2015/005659 WO2015186990A1 (ko) 2014-06-05 2015-06-05 O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법

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RU2016149077A3 RU2016149077A3 (ru) 2018-07-10
RU2016149077A true RU2016149077A (ru) 2018-07-10
RU2676137C2 RU2676137C2 (ru) 2018-12-26

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RU2018132244A RU2710323C2 (ru) 2014-06-05 2015-06-05 Микроорганизм для продуцирования O-ацетилгомосерина и способ получения O-ацетилгомосерина с использованием этого микроорганизма

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US (1) US10501763B2 (ru)
EP (1) EP3153574B1 (ru)
JP (1) JP6375391B2 (ru)
KR (1) KR101825777B1 (ru)
CN (1) CN106574237B (ru)
AU (1) AU2015269041B2 (ru)
BR (1) BR112016028527B1 (ru)
MY (1) MY183321A (ru)
RU (2) RU2676137C2 (ru)
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KR101825777B1 (ko) * 2014-06-05 2018-02-07 씨제이제일제당 (주) O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법
KR101915433B1 (ko) * 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법
WO2020138178A1 (en) 2018-12-27 2020-07-02 Ajinomoto Co., Inc. Method for producing basic l-amino acids or salts thereof by fermentation of an enterobacteriaceae bacterium
CN110804634B (zh) * 2019-12-04 2022-02-25 深圳瑞德林生物技术有限公司 酶催化法制备2,4-二氨基丁酸的工艺
KR102182497B1 (ko) * 2019-12-20 2020-11-24 씨제이제일제당 주식회사 내막 단백질의 변이체 및 이를 이용한 목적 산물 생산 방법
CN112094872A (zh) * 2020-09-22 2020-12-18 浙江工业大学 一种产o-乙酰l-高丝氨酸菌株发酵方法
CN113388564B (zh) * 2021-06-04 2022-03-01 浙江工业大学 一种o-乙酰-l-高丝氨酸生产菌、构建方法及应用
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