RU2015131149A - N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные - Google Patents
N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные Download PDFInfo
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- RU2015131149A RU2015131149A RU2015131149A RU2015131149A RU2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A
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- benzyl
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- -1 N- (SUBSTITUTED) -5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydro-pyrimidine-1 (2H) -carboxamide Chemical class 0.000 title claims 2
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 208000031888 Mycoses Diseases 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 239000002689 soil Substances 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241001360088 Zymoseptoria tritici Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000008654 plant damage Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (16)
1. Соединение Формулы I:
где R1 представляет собой -C(=O)N(R4)R5 или -C(=S)N(R4)R5;
R2 представляет собой C1-C6 алкил, C2-C6 алкенил, C3-C6 алкинил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C1-C6 аминоалкил, C2-C6 алкилкарбонил, арилкарбонил, C2-C6 алкоксикарбонил, C2-C6 алкиламинокарбонил, -S(O)2R5 фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатомов, где каждый цикл необязательно может быть замещен 1-3 R6;
R3 независимо представляет собой H, C1-C6 алкил, C2-C6 алкенил, C3-C6 алкинил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C2-C6 алкилкарбонил, арилкарбонил, C2-C6 алкоксикарбонил, C2-C6 алкиламинокарбонил, фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатома, где каждый цикл необязательно может быть замещен 1-3 R6;
R4 независимо может представлять собой H, C1-C6 алкил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C2-C6 алкилкарбонил, фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатома, где каждый из циклов необязательно может быть замещен 1-3 R6;
R5 представляет собой H, C1-C6 алкил, C1-C6 галогеналкил, C1-
C6 алкоксиалкил, C2-C6 алкилкарбонил, или бензил, где бензил необязательно может быть замещен с 1-3 R6; и
R6 независимо представляет собой галоген, C1-C6 алкил, C1-C6 галогеналкил, C1-C6 алкокси, C1-C6 галогеналкокси C1-C6 алкилтио, C1-C6 галогеналкилтио, амино, C1-C6 алкиламино, C2-C6 алкоксикарбонил, или C2-C6 алкилкарбонил, циано, гидроксил или нитро.
2. Соединение по п. 1, где R4 представляет собой тиено или фенил, и R5 представляет собой H, где фенил необязательно может быть замещен 1-3 R6.
3. Соединение по п. 2, где R4 представляет собой фенил, и каждый R6 независимо выбран из C1 алкила, галогена, C1 алкокси, C1 галогеналкила и цианогруппы.
4. Композиция для контроля грибкового заболевания, содержащая композицию для контроля, по меньшей мере, одного грибкового заболевания, причем указанная композиция включает фунгицидно эффективное количество соединения Формулы I по п. 1 и фитологически приемлемый материал носителя.
5. Композиция по п. 4 где грибковое заболевание представляет собой Septoria tritici.
6. Способ контроля и предотвращения поражения растения грибками, причем способ включает стадии:
нанесения фунгицидно эффективного количества, по меньшей мере, одного из соединений Формулы I по п. 1 на, по меньшей мере, одну поверхность, выбранную из группы поверхностей, выбранных из группы, состоящей из: части растения, области, соседней с растением, почвы, контактирующей с растением, почвы, соседней с растением, любой поверхности, соседней с растением, любой поверхности, контактирующей с растением, семян и оборудования, использующегося в сельском хозяйстве.
7. Способ по п. 6, где фунгицидно эффективное количество соединения Формулы I наносят на поверхность в количестве, которое находится в интервале примерно от 0,01 г/м2 примерно до 0,45 г/м2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746837P | 2012-12-28 | 2012-12-28 | |
| US61/746,837 | 2012-12-28 | ||
| PCT/US2013/077533 WO2014105841A1 (en) | 2012-12-28 | 2013-12-23 | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxamides derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015131149A true RU2015131149A (ru) | 2017-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015131149A RU2015131149A (ru) | 2012-12-28 | 2013-12-23 | N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9321734B2 (ru) |
| EP (1) | EP2945634A4 (ru) |
| JP (1) | JP6258969B2 (ru) |
| KR (1) | KR20150100869A (ru) |
| CN (1) | CN104884062B (ru) |
| AU (1) | AU2013370490B2 (ru) |
| BR (1) | BR102013033716B1 (ru) |
| CA (1) | CA2894510A1 (ru) |
| CL (1) | CL2015001863A1 (ru) |
| EC (1) | ECSP15032846A (ru) |
| GT (1) | GT201500195A (ru) |
| HK (1) | HK1215376A1 (ru) |
| IL (1) | IL239563B (ru) |
| MX (1) | MX2015008444A (ru) |
| RU (1) | RU2015131149A (ru) |
| UA (1) | UA117743C2 (ru) |
| WO (1) | WO2014105841A1 (ru) |
| ZA (1) | ZA201504197B (ru) |
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| HK1214518A1 (zh) * | 2012-12-28 | 2016-07-29 | Adama Makhteshim Ltd. | 1-(经取代之苯甲醯基)-5-氟-4-亚胺基-3-甲基-3，4-二氢嘧啶-2(1h)-酮衍生物 |
| US9321734B2 (en) * | 2012-12-28 | 2016-04-26 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide derivatives |
| PT2938191T (pt) | 2012-12-28 | 2018-05-09 | Dow Agrosciences Llc | Misturas fungicidas sinérgicas para controlo fúngico em cereais |
| US9622474B2 (en) * | 2012-12-28 | 2017-04-18 | Adama Makhteshim Ltd. | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxylate derivatives |
| AU2013370494B2 (en) | 2012-12-31 | 2017-08-17 | Adama Makhteshim Ltd. | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides |
| EA030056B1 (ru) | 2013-12-31 | 2018-06-29 | Адама Мактешим Лтд. | Синергетические фунгицидные смеси и синергетические фунгицидные композиции для борьбы с грибами |
| CN106068268A (zh) | 2013-12-31 | 2016-11-02 | 阿达玛马克西姆股份有限公司 | 5‑氟‑4‑亚氨基‑3‑（烷基/取代烷基）‑1‑（芳基磺酰基）‑3,4‑二氢嘧啶‑2（1h）‑酮及其制备方法 |
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| BR112017013767A2 (pt) | 2014-12-30 | 2018-03-13 | Dow Agrosciences Llc | uso de picolinamidas como fungicidas |
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| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| TW201842851A (zh) | 2017-05-02 | 2018-12-16 | 美商陶氏農業科學公司 | 用於穀類中的真菌防治之協同性混合物 |
| MA49639A (fr) | 2017-07-17 | 2020-05-27 | Adama Makhteshim Ltd | Polymorphes de 5-fluoro-4-imino-3-méthyl-1-tosyl-3,4-dihydropyrimidin-2-one |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
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2013
- 2013-12-23 US US14/655,566 patent/US9321734B2/en not_active Expired - Fee Related
- 2013-12-23 WO PCT/US2013/077533 patent/WO2014105841A1/en not_active Ceased
- 2013-12-23 CN CN201380068060.0A patent/CN104884062B/zh not_active Expired - Fee Related
- 2013-12-23 MX MX2015008444A patent/MX2015008444A/es unknown
- 2013-12-23 EP EP13868442.8A patent/EP2945634A4/en not_active Withdrawn
- 2013-12-23 KR KR1020157020065A patent/KR20150100869A/ko not_active Withdrawn
- 2013-12-23 CA CA2894510A patent/CA2894510A1/en not_active Abandoned
- 2013-12-23 HK HK16103305.6A patent/HK1215376A1/zh unknown
- 2013-12-23 RU RU2015131149A patent/RU2015131149A/ru not_active Application Discontinuation
- 2013-12-23 JP JP2015550741A patent/JP6258969B2/ja not_active Expired - Fee Related
- 2013-12-23 AU AU2013370490A patent/AU2013370490B2/en not_active Ceased
- 2013-12-23 UA UAA201507545A patent/UA117743C2/uk unknown
- 2013-12-27 BR BR102013033716-1A patent/BR102013033716B1/pt not_active IP Right Cessation
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2015
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- 2015-06-21 IL IL239563A patent/IL239563B/en active IP Right Grant
- 2015-06-26 CL CL2015001863A patent/CL2015001863A1/es unknown
- 2015-06-26 GT GT201500195A patent/GT201500195A/es unknown
- 2015-07-28 EC ECIEPI201532846A patent/ECSP15032846A/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| US9840475B2 (en) | 2017-12-12 |
| AU2013370490B2 (en) | 2018-05-10 |
| US20150353506A1 (en) | 2015-12-10 |
| CA2894510A1 (en) | 2014-07-03 |
| US9321734B2 (en) | 2016-04-26 |
| BR102013033716A2 (pt) | 2015-11-10 |
| HK1215376A1 (zh) | 2016-08-26 |
| IL239563A0 (en) | 2015-08-31 |
| CL2015001863A1 (es) | 2015-10-02 |
| ECSP15032846A (es) | 2016-01-29 |
| US20160198711A1 (en) | 2016-07-14 |
| KR20150100869A (ko) | 2015-09-02 |
| JP2016505605A (ja) | 2016-02-25 |
| EP2945634A1 (en) | 2015-11-25 |
| CN104884062A (zh) | 2015-09-02 |
| JP6258969B2 (ja) | 2018-01-10 |
| IL239563B (en) | 2018-02-28 |
| GT201500195A (es) | 2016-02-14 |
| BR102013033716B1 (pt) | 2019-05-14 |
| MX2015008444A (es) | 2015-09-23 |
| ZA201504197B (en) | 2017-04-26 |
| WO2014105841A1 (en) | 2014-07-03 |
| CN104884062B (zh) | 2018-11-06 |
| UA117743C2 (uk) | 2018-09-25 |
| EP2945634A4 (en) | 2016-05-25 |
| AU2013370490A1 (en) | 2015-07-02 |
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