RU2015118758A - The method of obtaining nanocapsules of rosuvastatin in sodium alginate - Google Patents
The method of obtaining nanocapsules of rosuvastatin in sodium alginate Download PDFInfo
- Publication number
- RU2015118758A RU2015118758A RU2015118758A RU2015118758A RU2015118758A RU 2015118758 A RU2015118758 A RU 2015118758A RU 2015118758 A RU2015118758 A RU 2015118758A RU 2015118758 A RU2015118758 A RU 2015118758A RU 2015118758 A RU2015118758 A RU 2015118758A
- Authority
- RU
- Russia
- Prior art keywords
- rosuvastatin
- sodium alginate
- nanocapsules
- suspension
- obtaining nanocapsules
- Prior art date
Links
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title claims abstract 5
- 229960000672 rosuvastatin Drugs 0.000 title claims abstract 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims abstract 3
- 239000002088 nanocapsule Substances 0.000 title claims abstract 3
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract 3
- 239000000661 sodium alginate Substances 0.000 title claims abstract 3
- 229940005550 sodium alginate Drugs 0.000 title claims abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000000725 suspension Substances 0.000 claims abstract 4
- 239000001793 Citric acid esters of mono and diglycerides of fatty acids Substances 0.000 claims abstract 2
- 239000003208 petroleum Substances 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract 2
- 238000003756 stirring Methods 0.000 claims abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Preparation (AREA)
- Formation And Processing Of Food Products (AREA)
Abstract
Способ получения нанокапсул розувастатина, характеризующийся тем, что розувастатин медленно добавляют в суспензию альгината натрия в гексане, в присутствии 0,005 г препарата Е472с при перемешивании 1000 об/мин, при массовом соотношении оболочка:ядро 3:1 или 1:5, затем приливают петролейный эфир в качестве осадителя, полученную суспензию отфильтровывают и сушат при комнатной температуре.A method of producing rosuvastatin nanocapsules, characterized in that rosuvastatin is slowly added to a suspension of sodium alginate in hexane, in the presence of 0.005 g of the preparation E472c with stirring 1000 rpm, with a shell: core mass ratio of 3: 1 or 1: 5, then petroleum ether is added as a precipitant, the resulting suspension is filtered off and dried at room temperature.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015118758/15A RU2605846C2 (en) | 2015-05-19 | 2015-05-19 | Method of producing nanocapsules of rosuvastatin in sodium alginate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015118758/15A RU2605846C2 (en) | 2015-05-19 | 2015-05-19 | Method of producing nanocapsules of rosuvastatin in sodium alginate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015118758A true RU2015118758A (en) | 2016-12-10 |
| RU2605846C2 RU2605846C2 (en) | 2016-12-27 |
Family
ID=57759824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118758/15A RU2605846C2 (en) | 2015-05-19 | 2015-05-19 | Method of producing nanocapsules of rosuvastatin in sodium alginate |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2605846C2 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2134967C1 (en) * | 1997-05-30 | 1999-08-27 | Шестаков Константин Алексеевич | Method of preparing microcapsulated preparations containing pyrethroid insecticides |
-
2015
- 2015-05-19 RU RU2015118758/15A patent/RU2605846C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2605846C2 (en) | 2016-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20170520 |