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RU2015143437A - Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака - Google Patents

Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака Download PDF

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RU2015143437A
RU2015143437A RU2015143437A RU2015143437A RU2015143437A RU 2015143437 A RU2015143437 A RU 2015143437A RU 2015143437 A RU2015143437 A RU 2015143437A RU 2015143437 A RU2015143437 A RU 2015143437A RU 2015143437 A RU2015143437 A RU 2015143437A
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cancer
kdm5
agent
antagonist
treatment
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RU2015143437A
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Брайан К. Альбрехт
Шейн БУКЕР
Мари КЛАССОН
Виктор С. Гелинг
Жан-Кристоф Арманж
Эрика Л. ДЖЭКСОН
Цзюнь ЛЯН
Хейди ФИЛЛИПС
Питер СЭНДИ
Джеффри СЕТТЛМЭН
Жан-Филипп СТЕФАН
Шилпи АРОРА
Майкл Роберт КОСТА
Тед ЛАУ
Патрик ТРОДЖЕР
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Дженентек, Инк.
Констеллейшн Фармасьтикалз, Инк.
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Claims (32)

1. Способ лечения рака у индивидуума, включающий введение указанному индивидууму (a) антагониста KDM5 и (b) средства для терапии рака.
2. Способ по п.1, отличающийся тем, что соответствующие количества антагониста KDM5 и средства для терапии рака являются эффективными для увеличения периода чувствительности рака и/или замедления развития устойчивости клеток к средству для терапии рака.
3. Способ увеличения эффективности лечения рака, включающего средство для терапии рака, у индивидуума, причем указанный способ включает введение указанному индивидууму (a) эффективного количества антагониста KDM5.
4. Способ лечения рака у индивидуума, отличающийся тем, что лечение рака включает введение указанному индивидууму (a) эффективного количества антагониста KDM5 и (b) терапию рака, причем указанное лечение рака обладает увеличенной эффективностью по сравнению с лечением (например, согласно стандарту лечения), включающим введение эффективного количества средства для терапии рака без (при отсутствии) антагониста KDM5.
5. Способ замедления и/или предотвращения развития устойчивости рака к средству для терапии рака у индивидуума, включающий введение указанному индивидууму (a) эффективного количества антагониста KDM5.
6. Способ лечения индивидуума, страдающего раком, который характеризуется увеличенной вероятностью развития устойчивости к средству для терапии рака, включающий введение указанному индивидууму (a) эффективного количества антагониста KDM5 и (b) эффективного количества средства для терапии рака.
7. Способ увеличения чувствительности к средству для терапии рака у индивидуума, страдающего раком, включающий введение указанному индивидууму (a) эффективного количества антагониста KDM5.
8. Способ увеличения периода чувствительности к средству для терапии рака у индивидуума, страдающего раком, включающий введение указанному индивидууму (a) эффективного количества антагониста KDM5.
9. Способ увеличения длительности ответа на терапию рака у индивидуума, страдающего раком, включающий введение указанному индивидууму (a) эффективного количества антагониста KDM5.
10. Способ по любому из пп.3, 5, 7, 8 или 9, причем способ дополнительно включает (b) введение индивидууму эффективного количества средства для терапии рака.
11. Способ по любому из пп.1-10, в котором антагонист KDM5 представляет собой ингибитор, который является антителом, ингибитор, который является связывающей малой молекулой, ингибитор, который является связывающим полипептидом, и/или полинуклеотидный антагонист.
12. Способ по п.11, в котором антагонист KDM5 связывается с KDM5 и ингибирует деметилазную активность KDM5.
13. Способ по любому из пп.1-12, в котором KDM5 представляет собой один или более из KDM5A, KDM5B, KDM5C и KDM5D.
14. Способ по п.13, в котором KDM5 представляет собой один или более из KDM5A и/или KDM5B.
15. Способ по п.13, в котором KDM5 представляет собой KDM5A и KDM5B.
16. Способ по п.13, в котором KDM5 представляет собой KDM5B.
17. Способ по п.13, в котором KDM5 представляет собой KDM5A, KDM5B, KDM5C и KDM5D.
18. Способ по любому из пп.1-17, в котором средство для терапии рака представляет собой химиотерапию.
19. Способ по любому из пп.1-18, в котором средство для терапии рака представляет собой химиотерапию, и указанная химиотерапия включает таксан.
20. Способ по п.19, в котором таксан представляет собой паклитаксел или доцетаксел.
21. Способ по любому из пп.1-20, в котором средство для терапии рака представляет собой химиотерапию, и указанная химиотерапия включает средство на основе платины.
22. Способ по любому из пп.1-17, в котором средство для терапии рака представляет собой средство для направленной терапии.
23. Способ по любому из пп.1-17, в котором средство для терапии рака представляет собой средство для направленной терапии, и указанная направленная терапия включает антагонист EGFR.
24. Способ по п.23, в котором антагонист EGFR представляет собой N-(3-этинилфенил)-6,7-бис(2-метоксиэтокси)хиназолин-4-амин или фармацевтически приемлемую соль указанного вещества (например эрлотиниб).
25. Способ по п.22, в котором средство для терапии рака представляет собой средство для направленной терапии, и указанная направленная терапия представляет собой терапию ингибитором RAF.
26. Способ по п.25, в котором ингибитор RAF представляет собой ингибитор BRAF и/или CRAF.
27. Способ по п.25, в котором ингибитор RAF представляет собой вемурафениб.
28. Способ по любому из пп.1-17, в котором средство для терапии рака представляет собой средство для направленной терапии, и указанная направленная терапия представляет собой терапию ингибитором PI3K.
29. Способ по любому из пп.1-28, в котором антагонист KDM5 представляет собой низкомолекулярный антагонист KDM5.
30. Способ по любому из пп.1-29, в котором антагонист KDM5 и указанное средство для терапии рака вводят одновременно.
31. Способ по любому из пп.1-30, в котором антагонист KDM5 вводят до и/или одновременно со средством для терапии рака.
32. Способ по любому из пп.1-30, в котором рак представляет собой рак легкого (например немелкоклеточный рак легкого (НМКРЛ)), меланому, колоректальный рак, рак поджелудочной железы и/или рак молочной железы.
RU2015143437A 2013-03-15 2014-03-14 Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака RU2015143437A (ru)

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US201361801414P 2013-03-15 2013-03-15
US61/801,414 2013-03-15
US201361804083P 2013-03-21 2013-03-21
US61/804,083 2013-03-21
PCT/US2014/029432 WO2014144850A1 (en) 2013-03-15 2014-03-14 Methods of treating cancer and preventing cancer drug resistance

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US (1) US20160143910A1 (ru)
EP (1) EP2968537A1 (ru)
JP (1) JP2016520528A (ru)
KR (1) KR20150130451A (ru)
CN (1) CN105339001A (ru)
BR (1) BR112015023203A8 (ru)
CA (1) CA2905123A1 (ru)
HK (1) HK1214533A1 (ru)
MX (1) MX2015011899A (ru)
RU (1) RU2015143437A (ru)
WO (1) WO2014144850A1 (ru)

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BR112015023203A2 (pt) 2017-11-21
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CA2905123A1 (en) 2014-09-18
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