RU2015141324A - Композиции для ухода за полостью рта, содержащие частицы полиорганосилсесквиоксана - Google Patents
Композиции для ухода за полостью рта, содержащие частицы полиорганосилсесквиоксана Download PDFInfo
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- RU2015141324A RU2015141324A RU2015141324A RU2015141324A RU2015141324A RU 2015141324 A RU2015141324 A RU 2015141324A RU 2015141324 A RU2015141324 A RU 2015141324A RU 2015141324 A RU2015141324 A RU 2015141324A RU 2015141324 A RU2015141324 A RU 2015141324A
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- 239000000203 mixture Substances 0.000 title claims 37
- 239000002245 particle Substances 0.000 title claims 13
- 210000000214 mouth Anatomy 0.000 claims 11
- 239000000499 gel Substances 0.000 claims 6
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 4
- -1 fluoride ions Chemical class 0.000 claims 4
- 150000002978 peroxides Chemical class 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000002562 thickening agent Substances 0.000 claims 4
- 239000007800 oxidant agent Substances 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 206010006326 Breath odour Diseases 0.000 claims 2
- 208000006558 Dental Calculus Diseases 0.000 claims 2
- 208000032139 Halitosis Diseases 0.000 claims 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 230000003628 erosive effect Effects 0.000 claims 2
- 150000002191 fatty alcohols Chemical class 0.000 claims 2
- 208000007565 gingivitis Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920000728 polyester Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004343 Calcium peroxide Substances 0.000 claims 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims 1
- 235000019402 calcium peroxide Nutrition 0.000 claims 1
- 229940043256 calcium pyrophosphate Drugs 0.000 claims 1
- 229940078916 carbamide peroxide Drugs 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000002826 coolant Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 claims 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 229910001425 magnesium ion Inorganic materials 0.000 claims 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920005646 polycarboxylate Polymers 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229910001414 potassium ion Inorganic materials 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000012798 spherical particle Substances 0.000 claims 1
- 229910001427 strontium ion Inorganic materials 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/654—The particulate/core comprising macromolecular material
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Surgery (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cosmetics (AREA)
- Silicon Polymers (AREA)
Claims (24)
1. Композиция для ухода за полостью рта, характеризующаяся хорошей очисткой и стабильностью, при этом указанная композиция содержит:
a. по меньшей мере, 0,1%, по массе композиции, абразива, содержащего одну или более частиц полиметилсилсесквиоксана;
b. по меньшей мере, 0,01%, по массе композиции, активного вещества для ухода за полостью рта, при этом активное вещество содержит, по меньшей мере, один окислитель; и
c. от 0,001% до приблизительно 99%, по массе композиции, носителя, приемлемого для полости рта;
при этом частицы полиметилсилсесквиоксана являются по существу не растворимыми в композиции.
2. Композиция по п. 1, отличающаяся тем, что частицы полиметилсилсесквиоксана имеют средневзвешенный на объем средний размер частиц от приблизительно 1 до приблизительно 20 мкм.
3. Композиция по п. 1, отличающаяся тем, что окислитель представляет собой источник пероксида.
4. Композиция по п. 3, отличающаяся тем, что источник пероксида выбран из группы, состоящей из перекиси водорода, пероксида кальция, пероксида карбамида, перкарбонатов и их смесей.
5. Композиция по п. 1, отличающаяся тем, что носитель, приемлемый для полости рта, содержит загуститель, при этом загуститель выбран из группы, состоящей из поперечно-сшитого поливинилпирролидона, полиакрилатов, алкилированных полиакрилатов, алкилированных поперечно-сшитых полиакрилатов, полимерных алкилированных полиэфиров, карбомеров, алкилированных карбомеров, гелевых сеток на основе жирного спирта, гелевых сеток на основе жирного спирта и поверхностно-активного вещества, неионных полимерных загустителей и их смесей.
6. Композиция по п. 1, отличающаяся тем, что значение рН композиции составляет от приблизительно 3,5 до приблизительно 7,5.
7. Композиция по п. 1, отличающаяся тем, что композиция содержит от приблизительно 0,1% до приблизительно 30%, по массе композиции, частиц полиметилсилсесквиоксана.
8. Композиция по п. 7, отличающаяся тем, что частицы полиметилсилсесквиоксана имеют средневзвешенный на объем средний размер частиц от приблизительно 3 до приблизительно 7 мкм.
9. Композиция по п. 1, отличающаяся тем, что частицы полиметилсилсесквиоксана представляют собой сферические частицы с гладкой поверхностью.
10. Композиция по п. 1, отличающаяся тем, что носитель, приемлемый для полости рта, выбран из буферных агентов, вторичных абразивных веществ, бикарбонатных солей щелочных металлов, загустителей, гелевых сеток, увлажнителей, воды, поверхностно-активных веществ, диоксида титана, ароматизирующих веществ, охлаждающих агентов, подсластителей, красителей, других приемлемых веществ и их смесей.
11. Композиция по п. 1, отличающаяся тем, что носитель, приемлемый для полости рта, содержит вторичный абразив, выбранный из пирофосфата кальция, осажденного кремнезема, аморфного кварца и их смесей.
12. Композиция по п. 1, отличающаяся тем, что абразив содержит от приблизительно 50% до приблизительно 100%, по массе всего абразива в композиции, частиц полиметилсилсесквиоксана.
13. Композиция по п. 1, отличающаяся тем, что активное вещество для ухода за полостью рта дополнительно содержит один или более из группы, состоящей из источника фторид-ионов, источника ионов цинка, источника ионов кальция, источника ионов фосфата, источника ионов калия, источника ионов стронция, источника ионов алюминия, источника ионов магния.
14. Композиция по п. 1, отличающаяся тем, что активное вещество для ухода за полостью рта дополнительно содержит хелатирующий агент, выбранный из группы, состоящей из полифосфатов, поликарбоксилатов, поливинилпирролидона, поливинилового спирта, полимерного полиэфира, полимерного алкилфосфата, сополимеров метилвинилового эфира и малеинового ангидрида, полифосфонатов и их смесей.
15. Композиция по п. 1, отличающаяся тем, что композиция представляет собой средство для чистки зубов и находится в форме, выбранной из паст, суспензий, гелей или их комбинаций.
16. Композиция по п. 1, отличающаяся тем, что носитель, приемлемый для полости рта, содержит гелевую сетку.
17. Композиция для ухода за полостью рта, содержащая абразив на основе частиц полиметилсилсесквиоксана, источник ионов олова (II), гелевую сетку и хелатирующий агент.
18. Композиция по п. 1, отличающаяся тем, что через приблизительно 30 дней при 40°C сохраняется, по меньшей мере, приблизительно 50% окислителя.
19. Способ уменьшения зубного налета, гингивита, чувствительности, неприятного запаха изо рта, эрозии, полостей, зубного камня и/или окрашивания, включающий стадию, на которой вводят в полость рта субъекта композицию, содержащую абразив на основе частиц полиорганосилсесквиоксана и пероксид.
20. Способ уменьшения зубного налета, гингивита, чувствительности, неприятного запаха изо рта, эрозии, полостей, зубного камня и/или окрашивания, включающий стадию, на которой вводят в полость рта субъекта сначала композицию, не содержащую пероксид, а затем композицию, содержащую абразив на основе частиц полиорганосилсесквиоксана и пероксид.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201361810400P | 2013-04-10 | 2013-04-10 | |
| US61/810,400 | 2013-04-10 | ||
| PCT/US2014/033631 WO2014169109A1 (en) | 2013-04-10 | 2014-04-10 | Oral care compositions containing polyorganosilsesquioxane particles |
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| RU2015141324A true RU2015141324A (ru) | 2017-05-15 |
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| US (3) | US9114095B2 (ru) |
| EP (1) | EP2983637A1 (ru) |
| JP (1) | JP2016515633A (ru) |
| CN (1) | CN105101945A (ru) |
| AU (1) | AU2014250971B2 (ru) |
| BR (1) | BR112015025484A2 (ru) |
| CA (1) | CA2908523A1 (ru) |
| MX (1) | MX2015014322A (ru) |
| RU (1) | RU2015141324A (ru) |
| WO (1) | WO2014169109A1 (ru) |
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| RU2639121C2 (ru) * | 2013-04-10 | 2017-12-19 | Дзе Проктер Энд Гэмбл Компани | Композиции для ухода за полостью рта, содержащие частицы полиорганосилсесквиоксана |
| WO2014169083A1 (en) * | 2013-04-10 | 2014-10-16 | The Procter & Gamble Company | Oral care compositions containing polyorganosilsesquioxane particles |
| US9186306B2 (en) | 2013-04-10 | 2015-11-17 | The Procter & Gamble Company | Oral compositions containing polymethylsilsesquioxane particles |
| MX2015014322A (es) | 2013-04-10 | 2015-12-08 | Procter & Gamble | Composiciones pare el cuidado bucal que contienen particulas de poliorganosilsesquioxano. |
| KR101709986B1 (ko) * | 2015-07-17 | 2017-03-09 | (주) 바이오에스텍 | 실리카 및 이산화티탄을 함유하는 치아 미백용 조성물 |
| WO2017019321A1 (en) * | 2015-07-28 | 2017-02-02 | The Procter & Gamble Company | Oral care compositions containing amps polymers, copolymers, or cross polymers |
| CN108348442A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有抗牙垢和抗菌有益效果的牙粉组合物 |
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| US11105973B2 (en) * | 2019-01-11 | 2021-08-31 | Schott Corporation | Optically enhanced high resolution image guides |
| SI25540A (sl) * | 2019-01-14 | 2019-05-31 | Tompa Majcen Dominika | Formulacije s spojinami aktivnega kisika in pripomočki za njihovo aplikacijo |
| KR102377031B1 (ko) * | 2019-04-17 | 2022-03-22 | 단국대학교 산학협력단 | 폴리 아크릴산 그래프트 다면체 올리고머 실세스퀴옥산을 이용한 pH 민감성 약물전달체 |
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| CN114630656B (zh) * | 2019-08-26 | 2025-03-21 | 埃斯普投资有限公司 | 黏膜黏附剂组合物及其使用方法 |
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| RU2639121C2 (ru) * | 2013-04-10 | 2017-12-19 | Дзе Проктер Энд Гэмбл Компани | Композиции для ухода за полостью рта, содержащие частицы полиорганосилсесквиоксана |
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-
2014
- 2014-04-10 MX MX2015014322A patent/MX2015014322A/es unknown
- 2014-04-10 BR BR112015025484A patent/BR112015025484A2/pt not_active IP Right Cessation
- 2014-04-10 EP EP14723262.3A patent/EP2983637A1/en not_active Withdrawn
- 2014-04-10 CA CA2908523A patent/CA2908523A1/en not_active Abandoned
- 2014-04-10 JP JP2016506692A patent/JP2016515633A/ja active Pending
- 2014-04-10 AU AU2014250971A patent/AU2014250971B2/en not_active Ceased
- 2014-04-10 RU RU2015141324A patent/RU2015141324A/ru not_active Application Discontinuation
- 2014-04-10 US US14/249,617 patent/US9114095B2/en not_active Expired - Fee Related
- 2014-04-10 WO PCT/US2014/033631 patent/WO2014169109A1/en not_active Ceased
- 2014-04-10 CN CN201480020439.9A patent/CN105101945A/zh active Pending
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2015
- 2015-06-26 US US14/751,167 patent/US9649273B2/en not_active Expired - Fee Related
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2017
- 2017-04-13 US US15/486,326 patent/US10206865B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015025484A2 (pt) | 2017-07-18 |
| CA2908523A1 (en) | 2014-10-16 |
| CN105101945A (zh) | 2015-11-25 |
| EP2983637A1 (en) | 2016-02-17 |
| JP2016515633A (ja) | 2016-05-30 |
| MX2015014322A (es) | 2015-12-08 |
| US20150290115A1 (en) | 2015-10-15 |
| US20140308320A1 (en) | 2014-10-16 |
| US20170216192A1 (en) | 2017-08-03 |
| US9114095B2 (en) | 2015-08-25 |
| US10206865B2 (en) | 2019-02-19 |
| AU2014250971A1 (en) | 2015-10-15 |
| US9649273B2 (en) | 2017-05-16 |
| WO2014169109A1 (en) | 2014-10-16 |
| AU2014250971B2 (en) | 2016-07-21 |
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