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RU2014117666A - Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами атr - Google Patents

Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами атr Download PDF

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RU2014117666A
RU2014117666A RU2014117666/15A RU2014117666A RU2014117666A RU 2014117666 A RU2014117666 A RU 2014117666A RU 2014117666/15 A RU2014117666/15 A RU 2014117666/15A RU 2014117666 A RU2014117666 A RU 2014117666A RU 2014117666 A RU2014117666 A RU 2014117666A
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Джон Роберт ПОЛЛАРД
Филип Майкл РИПЕР
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Вертекс Фармасьютикалз Инкорпорейтед
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    • A61N5/00—Radiation therapy
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Abstract

1. Способ лечения рака поджелудочной железы у пациента посредством введения пациенту ингибитора ATR, выбранного изв сочетании с другим видом противоопухолевой терапии, выбранным из терапии гемцитабином, лучевой терапии или обеих терапий гемцитабином и лучевой терапии вместе.2. Способ повышения чувствительности клеток рака поджелудочной железы к противоопухолевой терапии, выбранной из терапии гемцитабином или лучевой терапии у пациента посредством введения пациенту ингибитора ATR, выбранного изв сочетании с противоопухолевой терапией.3. Способ по п. 1, в котором противоопухолевая терапия представляет собой терапию гемцитабином.4. Способ по п. 1, в котором противоопухолевая терапия представляет собой лучевую терапию.5. Способ повышения чувствительности гипоксических клеток рака поджелудочной железы к противоопухолевой терапии, выбранной из терапии гемцитабином или лучевой терапии у пациента посредством введения пациенту ингибитора ATR, выбранного изв сочетании с противоопухолевой терапией.6. Способ ингибирования фосфорилирования Chkl (Ser 345) в клетках рака поджелудочной железы, содержащий введение пациенту ингибитора ATR, выбранного изв сочетании с гемцитабином и/или облучением.7. Способ радиосенсибилизации гипоксических клеток рака поджелудочной железы посредством введения пациенту ингибитора ATR, выбранного изв сочетании с лучевой терапией.8. Способ повышения чувствительности гипоксических клеток рака поджелудочной железы посредством введения пациенту ингибитора ATR, выбранного изв сочетании с гемцитабином.9. Способ повышения чувствительности клеток рака поджелудочной железы к химиолучевой терапии поср�

Claims (22)

1. Способ лечения рака поджелудочной железы у пациента посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000001
в сочетании с другим видом противоопухолевой терапии, выбранным из терапии гемцитабином, лучевой терапии или обеих терапий гемцитабином и лучевой терапии вместе.
2. Способ повышения чувствительности клеток рака поджелудочной железы к противоопухолевой терапии, выбранной из терапии гемцитабином или лучевой терапии у пациента посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000002
в сочетании с противоопухолевой терапией.
3. Способ по п. 1, в котором противоопухолевая терапия представляет собой терапию гемцитабином.
4. Способ по п. 1, в котором противоопухолевая терапия представляет собой лучевую терапию.
5. Способ повышения чувствительности гипоксических клеток рака поджелудочной железы к противоопухолевой терапии, выбранной из терапии гемцитабином или лучевой терапии у пациента посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000003
в сочетании с противоопухолевой терапией.
6. Способ ингибирования фосфорилирования Chkl (Ser 345) в клетках рака поджелудочной железы, содержащий введение пациенту ингибитора ATR, выбранного из
Figure 00000004
в сочетании с гемцитабином и/или облучением.
7. Способ радиосенсибилизации гипоксических клеток рака поджелудочной железы посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000005
в сочетании с лучевой терапией.
8. Способ повышения чувствительности гипоксических клеток рака поджелудочной железы посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000006
в сочетании с гемцитабином.
9. Способ повышения чувствительности клеток рака поджелудочной железы к химиолучевой терапии посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000007
в сочетании с химиолучевой терапией.
10. Способ по п. 9, в котором химиотерапия представляет собой терапию гемцитабином.
11. Способ прерывания клеточного цикла, обусловленного повреждением, в сверочных точках посредством введения пациенту ингибитора ATR, выбранного из
Figure 00000008
в сочетании с лучевой терапией.
12. Способ ингибирования репарации поврежденной ДНК посредством гомологической рекомбинации в клетке рака поджелудочной железы посредством введения ингибитора ATR, выбранного из
Figure 00000009
в сочетании с лучевой терапией.
13. Способ по любому и пп. 1-12, в котором клетки рака поджелудочной железы получены из клеточной линии поджелудочной железы, выбранной из PSN-1, MiaPaCa-2 или Panc-1.
14. Способ по любому из пп. 1-12, в котором клетки рака поджелудочной железы находятся в организме онкологического пациента.
15. Способ по любому из пп. 1-12, в котором соединение вводится в организм пациента.
16. Способ по любому из пп. 1-12, в котором соединение вводится в клетки рака поджелудочной железы.
17. Способ лечения немелкоклеточного рака легкого у пациента, содержащий введение пациенту соединения с формулой 821 или 822:
Figure 00000010
в сочетании с одним или более из следующих дополнительных лекарственных агентов: цисплатин или карбоплатин, этопозид и ионизирующее излучение.
18. Способ по п. 17, содержащий введение пациенту соединения с формулой 821 или 822 в сочетании с противоопухолевой терапией, выбранной из группы, состоящей из цисплатина или карбоплатина, этопозида и ионизирующего излучения.
19. Способ по п. 18, в котором противоопухолевая терапия представляет собой терапию цисплатином или карбоплатином и этопозидом.
20. Способ по п. 18, в котором противоопухолевая терапия представляет собой терапию цисплатином или карбоплатином и этопозидом и ионизирующим излучением.
21. Способ по п. 18, в котором противоопухолевая терапия представляет собой ионизирующее излучение.
22. Способ в соответствии с одним из пп. 1-21, в котором ингибитор ATR представляет собой 822.
RU2014117666A 2011-09-30 2012-10-01 Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr RU2648507C2 (ru)

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