RU2014141023A - The method of obtaining nanocapsules of umifenovir (Arbidol) in sodium alginate - Google Patents
The method of obtaining nanocapsules of umifenovir (Arbidol) in sodium alginate Download PDFInfo
- Publication number
- RU2014141023A RU2014141023A RU2014141023A RU2014141023A RU2014141023A RU 2014141023 A RU2014141023 A RU 2014141023A RU 2014141023 A RU2014141023 A RU 2014141023A RU 2014141023 A RU2014141023 A RU 2014141023A RU 2014141023 A RU2014141023 A RU 2014141023A
- Authority
- RU
- Russia
- Prior art keywords
- umifenovir
- sodium alginate
- arbidol
- nanocapsules
- obtaining nanocapsules
- Prior art date
Links
- KCFYEAOKVJSACF-UHFFFAOYSA-N umifenovir Chemical compound CN1C2=CC(Br)=C(O)C(CN(C)C)=C2C(C(=O)OCC)=C1CSC1=CC=CC=C1 KCFYEAOKVJSACF-UHFFFAOYSA-N 0.000 title claims abstract 8
- 229960004626 umifenovir Drugs 0.000 title claims abstract 8
- 239000002088 nanocapsule Substances 0.000 title claims abstract 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims abstract 5
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract 5
- 229940005550 sodium alginate Drugs 0.000 title claims abstract 5
- 239000000661 sodium alginate Substances 0.000 title claims abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003208 petroleum Substances 0.000 claims abstract 2
- 238000001556 precipitation Methods 0.000 claims abstract 2
- 239000002904 solvent Substances 0.000 claims abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/32—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof from compositions containing microballoons, e.g. syntactic foams
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Способ получения нанокапсул умифеновира (Арбидола) в альгинате натрия, характеризующийся тем, что в качестве оболочки нанокапсул используется альгинат натрия, а в качестве ядра - умифеновир при получении нанокапсул методом осаждения нерастворителем с применением петролейного эфира в качестве осадителя.A method of producing nanocapsules of umifenovir (Arbidol) in sodium alginate, characterized in that sodium alginate is used as the shell of the nanocapsules, and umifenovir is used as the core when nanocapsules are prepared by the non-solvent precipitation method using petroleum ether as a precipitant.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014141023A RU2619331C2 (en) | 2014-10-10 | 2014-10-10 | Method of producing nanocapsules of umifenovir (arbidol) in sodium alginate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014141023A RU2619331C2 (en) | 2014-10-10 | 2014-10-10 | Method of producing nanocapsules of umifenovir (arbidol) in sodium alginate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014141023A true RU2014141023A (en) | 2016-04-27 |
| RU2619331C2 RU2619331C2 (en) | 2017-05-15 |
Family
ID=55759372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014141023A RU2619331C2 (en) | 2014-10-10 | 2014-10-10 | Method of producing nanocapsules of umifenovir (arbidol) in sodium alginate |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2619331C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022055449A1 (en) | 2020-09-14 | 2022-03-17 | Istanbul Universitesi Rektorlugu | Use of active substances with antiviral, anti malarial, and/or mucolytic properties in the treatment of viral lung diseases including covid-19 by soft mist inhaler or vibration mesh technology nebulizer through inhalation route |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2677248C1 (en) * | 2018-02-15 | 2019-01-16 | Александр Александрович Кролевец | Method of obtaining nanocapsules of eucalyptus dry extract |
| RU2677242C1 (en) * | 2018-03-02 | 2019-01-16 | Александр Александрович Кролевец | Method of producing nanocapsules of diacamph in sodium alginate |
| RU2678971C1 (en) * | 2018-03-19 | 2019-02-05 | Александр Александрович Кролевец | Method of producing nanocapsules of diakamfh in guaram gum |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2134967C1 (en) * | 1997-05-30 | 1999-08-27 | Шестаков Константин Алексеевич | Method of preparing microcapsulated preparations containing pyrethroid insecticides |
| CN102597203A (en) * | 2009-11-06 | 2012-07-18 | 宝洁公司 | High efficiency particle comprising benefit agent |
| EP2555742B2 (en) * | 2010-04-06 | 2018-12-05 | The Procter and Gamble Company | Encapsulates |
| EP2399667B1 (en) * | 2010-06-25 | 2017-03-08 | Cognis IP Management GmbH | Process for producing microcapsules |
-
2014
- 2014-10-10 RU RU2014141023A patent/RU2619331C2/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022055449A1 (en) | 2020-09-14 | 2022-03-17 | Istanbul Universitesi Rektorlugu | Use of active substances with antiviral, anti malarial, and/or mucolytic properties in the treatment of viral lung diseases including covid-19 by soft mist inhaler or vibration mesh technology nebulizer through inhalation route |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2619331C2 (en) | 2017-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171011 |