RU2013137675A - COMPOSITE MATRIX BASED ON SILK FIBROIN, GELATIN AND HYDROXYAPATITIS FOR BONE TISSUE REGENERATION - Google Patents
COMPOSITE MATRIX BASED ON SILK FIBROIN, GELATIN AND HYDROXYAPATITIS FOR BONE TISSUE REGENERATION Download PDFInfo
- Publication number
- RU2013137675A RU2013137675A RU2013137675/15A RU2013137675A RU2013137675A RU 2013137675 A RU2013137675 A RU 2013137675A RU 2013137675/15 A RU2013137675/15 A RU 2013137675/15A RU 2013137675 A RU2013137675 A RU 2013137675A RU 2013137675 A RU2013137675 A RU 2013137675A
- Authority
- RU
- Russia
- Prior art keywords
- composite matrix
- gelatin
- matrix according
- bone tissue
- fibroin
- Prior art date
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- 239000011159 matrix material Substances 0.000 title claims abstract 15
- 239000002131 composite material Substances 0.000 title claims abstract 13
- 210000000988 bone and bone Anatomy 0.000 title claims abstract 9
- 108010022355 Fibroins Proteins 0.000 title claims abstract 7
- 108010010803 Gelatin Proteins 0.000 title claims abstract 7
- 229920000159 gelatin Polymers 0.000 title claims abstract 7
- 239000008273 gelatin Substances 0.000 title claims abstract 7
- 235000019322 gelatine Nutrition 0.000 title claims abstract 7
- 235000011852 gelatine desserts Nutrition 0.000 title claims abstract 7
- 230000017423 tissue regeneration Effects 0.000 title claims abstract 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract 6
- 238000000034 method Methods 0.000 claims abstract 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000001035 drying Methods 0.000 claims abstract 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims abstract 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000011780 sodium chloride Substances 0.000 claims abstract 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000007872 degassing Methods 0.000 claims abstract 2
- 235000019253 formic acid Nutrition 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000011148 porous material Substances 0.000 claims abstract 2
- 230000001172 regenerating effect Effects 0.000 claims abstract 2
- 239000006228 supernatant Substances 0.000 claims abstract 2
- 238000005406 washing Methods 0.000 claims abstract 2
- 239000012153 distilled water Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000012154 double-distilled water Substances 0.000 abstract 1
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- Materials For Medical Uses (AREA)
Abstract
1. Способ получения композитного матрикса, включающий стадии: смешивания гидроксиапатита с NaCl, растворения желатина и фиброина в 10%-ном растворе лития хлористого в 90%-ной муравьиной кислоте в течение 30 минут при температуре 60-70°C, центрифугирования раствора, содержащего фиброин и желатин, послойного нанесения супернатанта в форму, смешивая его со смесью гидроксиапатита с NaCl, высушивания образцов при температуре 75-80°C, дальнейшего высушивания при комнатной температуре, обработки полученных матриксов в течение 120 минут 96%-ным этанолом, промывания бидистиллированной водой, дегазации.2. Композитный матрикс, полученный способом по п.1.3. Композитный матрикс по п.2, содержащий 60% фиброина, 10% желатина и 30% гидроксиапатита.4. Композитный матрикс по п.2, в котором размер пор составляет 150-300 мкм.5. Композитный матрикс по п.2, применяемый для регенерации костной ткани.6. Способ регенерации костной ткани, заключающийся во введении эффективного количества матрикса по любому из пп.2-5 в область повреждения костной ткани нуждающегося субъекта.7. Применение композитного матрикса по любому из пп.2-5 для регенерации костной ткани.1. A method of producing a composite matrix, comprising the steps of: mixing hydroxyapatite with NaCl, dissolving gelatin and fibroin in a 10% solution of lithium chloride in 90% formic acid for 30 minutes at a temperature of 60-70 ° C, centrifuging a solution containing fibroin and gelatin, layer-by-layer application of the supernatant into the form, mixing it with a mixture of hydroxyapatite with NaCl, drying the samples at a temperature of 75-80 ° C, further drying at room temperature, processing the obtained matrixes for 120 minutes with 96% ethanol, washing double distilled water, degassing. 2. The composite matrix obtained by the method according to claim 1.3. The composite matrix according to claim 2, containing 60% fibroin, 10% gelatin and 30% hydroxyapatite. The composite matrix according to claim 2, wherein the pore size is 150-300 microns. The composite matrix according to claim 2, used for bone tissue regeneration. A method for regenerating bone tissue, comprising administering an effective amount of a matrix according to any one of claims 2-5 to the area of bone damage of a needy subject. The use of the composite matrix according to any one of claims 2-5 for bone tissue regeneration.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013137675/15A RU2563992C2 (en) | 2013-08-12 | 2013-08-12 | Composite matrices based on silk fibroin, gelatine and hydroxyapatite for bone tissue regeneration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013137675/15A RU2563992C2 (en) | 2013-08-12 | 2013-08-12 | Composite matrices based on silk fibroin, gelatine and hydroxyapatite for bone tissue regeneration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013137675A true RU2013137675A (en) | 2015-02-20 |
| RU2563992C2 RU2563992C2 (en) | 2015-09-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013137675/15A RU2563992C2 (en) | 2013-08-12 | 2013-08-12 | Composite matrices based on silk fibroin, gelatine and hydroxyapatite for bone tissue regeneration |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2563992C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2692578C1 (en) * | 2017-12-29 | 2019-06-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Implant for bone regeneration and method for production thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG161218A1 (en) * | 2005-01-06 | 2010-05-27 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| RU2478706C1 (en) * | 2011-12-23 | 2013-04-10 | Игорь Иванович Агапов | Method of producing suspensions of hydrogel microparticles with given dimensions based on recombinant cobweb protein and use thereof |
| RU2483756C1 (en) * | 2012-01-24 | 2013-06-10 | Игорь Иванович Агапов | METHOD FOR PREPARING BIODEGRADED COMPOSITE MATRIX OF REGENERATED SILK FIBROIN Bombyx mori AND ITS USE |
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2013
- 2013-08-12 RU RU2013137675/15A patent/RU2563992C2/en active
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| Publication number | Publication date |
|---|---|
| RU2563992C2 (en) | 2015-09-27 |
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