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RU2013127155A - Новые замещенные бициклические ароматические соединения в качестве ингибиторов s-нитрозоглутатион-редуктазы - Google Patents

Новые замещенные бициклические ароматические соединения в качестве ингибиторов s-нитрозоглутатион-редуктазы Download PDF

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RU2013127155A
RU2013127155A RU2013127155/04A RU2013127155A RU2013127155A RU 2013127155 A RU2013127155 A RU 2013127155A RU 2013127155/04 A RU2013127155/04 A RU 2013127155/04A RU 2013127155 A RU2013127155 A RU 2013127155A RU 2013127155 A RU2013127155 A RU 2013127155A
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Russia
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group
compound according
hydroxynaphthalen
compound
benzoic acid
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RU2013127155/04A
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English (en)
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Сичэн СУНЬ
Цзянь ЦЮ
Адам СТАУТ
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Н30 Фармасьютикалс, Инк.
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Publication of RU2013127155A publication Critical patent/RU2013127155A/ru

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Abstract

1. Соединение Формулы 1:Формула 1где Rвыбран из группы, состоящей из Н, F и Cl;Rи Rнезависимо выбраны из группы, состоящей из Н, F, Cl, Br, Me, ОСНи циано;Rвыбран из группы, состоящей из Н, F, Cl, Br, Me и ОСН;Х выбран из группы, состоящей из,,,,,,,,,,, и;А выбран из группы, состоящей из,,,,,,, и;Rвыбран из группы, состоящей из F, Cl, Br, СН, CF, ОСН, циано, N(СН)и морфолино;n выбран из группы, состоящей из 0, 1 и 2;Rвыбран из группы, состоящей из Н, F, Cl, Br, СН, CF, ОСН, циано, N(СН)и морфолино;при условии, что если Х является, а A является СООН, то по меньшей мере один из R, R, R, Rи Rне является водородом, или n должен быть >0, и R, будучи в мета-положении к нафталину, не может быть СН.2. Соединение по п.1, отличающееся тем, чтоХ выбран из группы, состоящей из,,, и.3. Соединение по п.1, отличающееся тем, что Х является.4. Соединение по п.3, отличающееся тем, что Rявляется водородом.5. Соединение по п.3, отличающееся тем, что Rявляется водородом.6. Соединение по п.1, отличающееся тем, что соединением является соединение Формулы 2Формула 27. Соединение по п.6, отличающееся тем, чтоRвыбран из группы, состоящей из Н и F;Rвыбран из группы, состоящей из Н, F, Cl, Br и циано;Rвыбран из группы, состоящей из Н, F и Cl;Rявляется Н; иRвыбран из группы, состоящей из Н, F, Cl и циано.8. Соединение по п.6, отличающееся тем, что Rвыбран из группы, состоящей из F и Cl.9. Соединение по п.6, отличающееся тем, что Rвыбран из группы, состоящей из F, Cl, Br, Me, ОСНи циано.10. Соединение по п.6, отличающееся тем, что Rвыбран из группы, состоящей из F, Cl, Br, Me, ОСНи циано.11. Соединение по п.6, отличающееся тем, что Rвыбран из группы, состоящей из F, Cl, Br, Me и ОСН;12. Соединение по п.6, отличающееся тем, что Rвыбран из группы, состоящей из F, Cl, Br, СН, CF, ОСН, циано, N(СН)и морфолин�

Claims (32)

1. Соединение Формулы 1:
Figure 00000001
Формула 1
где R1 выбран из группы, состоящей из Н, F и Cl;
R2a и R2b независимо выбраны из группы, состоящей из Н, F, Cl, Br, Me, ОСН3 и циано;
R2c выбран из группы, состоящей из Н, F, Cl, Br, Me и ОСН3;
Х выбран из группы, состоящей из
Figure 00000002
,
Figure 00000003
,
Figure 00000004
,
Figure 00000005
,
Figure 00000006
Figure 00000007
,
Figure 00000008
,
Figure 00000009
,
Figure 00000010
,
Figure 00000011
Figure 00000012
,
Figure 00000013
,
Figure 00000014
, и
Figure 00000015
;
А выбран из группы, состоящей из
Figure 00000016
,
Figure 00000017
,
Figure 00000018
,
Figure 00000019
,
Figure 00000020
,
Figure 00000021
,
Figure 00000022
, и
Figure 00000023
;
R3 выбран из группы, состоящей из F, Cl, Br, СН3, CF3, ОСН3, циано, N(СН3)2 и морфолино;
n выбран из группы, состоящей из 0, 1 и 2;
R4 выбран из группы, состоящей из Н, F, Cl, Br, СН3, CF3, ОСН3, циано, N(СН3)2 и морфолино;
при условии, что если Х является
Figure 00000002
, а A является СООН, то по меньшей мере один из R1, R2a, R2b, R2c и R4 не является водородом, или n должен быть >0, и R3, будучи в мета-положении к нафталину, не может быть СН3.
2. Соединение по п.1, отличающееся тем, что
Х выбран из группы, состоящей из
Figure 00000002
,
Figure 00000004
,
Figure 00000003
, и
Figure 00000005
.
3. Соединение по п.1, отличающееся тем, что Х является
Figure 00000002
.
4. Соединение по п.3, отличающееся тем, что R2c является водородом.
5. Соединение по п.3, отличающееся тем, что R2b является водородом.
6. Соединение по п.1, отличающееся тем, что соединением является соединение Формулы 2
Figure 00000024
Формула 2
7. Соединение по п.6, отличающееся тем, что
R1 выбран из группы, состоящей из Н и F;
R2a выбран из группы, состоящей из Н, F, Cl, Br и циано;
R2b выбран из группы, состоящей из Н, F и Cl;
R2c является Н; и
R4 выбран из группы, состоящей из Н, F, Cl и циано.
8. Соединение по п.6, отличающееся тем, что R1 выбран из группы, состоящей из F и Cl.
9. Соединение по п.6, отличающееся тем, что R2a выбран из группы, состоящей из F, Cl, Br, Me, ОСН3 и циано.
10. Соединение по п.6, отличающееся тем, что R2b выбран из группы, состоящей из F, Cl, Br, Me, ОСН3 и циано.
11. Соединение по п.6, отличающееся тем, что R2c выбран из группы, состоящей из F, Cl, Br, Me и ОСН3;
12. Соединение по п.6, отличающееся тем, что R4 выбран из группы, состоящей из F, Cl, Br, СН3, CF3, ОСН3, циано, N(СН3)2 и морфолино.
13. Соединение по п.1, отличающееся тем, что соединением является соединение Формулы 3
Figure 00000025
Формула 3
14. Соединение по п.13, отличающееся тем, что Х является
Figure 00000002
15. Соединение по п.14, отличающееся тем, что А является СООН.
16. Соединение по п.13, отличающееся тем, что соединением является соединение Формулы 4
Figure 00000026
Формула 4
17. Соединение по п.16, отличающееся тем, что R2c является Н.
18. Соединение по п.16, отличающееся тем, что R2b является Н.
19. Соединение по п.16, отличающееся тем, что
R1 выбран из группы, состоящей из Н и F;
R2b выбран из группы, состоящей из Н, F и Cl;
R2c является Н; и
R4 выбран из группы, состоящей из Н, F, Cl и циано.
20. Соединение по п.1, отличающееся тем, что соединением является соединение Формулы 5
Figure 00000027
Формула 5
21. Соединение по п.20, отличающееся тем, что Х является
Figure 00000002
.
22. Соединение по п.21, отличающееся тем, что А является СООН.
23. Соединение по п.20, отличающееся тем, что соединением является соединение Формулы 6
Figure 00000028
Формула 6
24. Соединение по п.23, отличающееся тем, что R2c является Н.
25. Соединение по п.23, отличающееся тем, что K2b является Н.
26. Соединение по п.23, отличающееся тем, что
R2a выбран из группы, состоящей из Н, F, Cl, Br и циано;
R2a выбран из группы, состоящей из Н, F и Cl;
R2c является H; и
R4 выбран из группы, состоящей из Н, F, Cl и циано.
27. Соединение по п.1, отличающееся тем, что соединение выбрано из группы, состоящей из
3-хлор-4-(6-гидроксинафталин-2-ил)бензойной кислоты;
3-фтор-4-(6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидроксинафталин-2-ил)-3-метоксибензойной кислоты;
3-(диметиламино)-4-(6-гидроксинафталин-2-ил)бензойной кислоты;
3-циано-4-(6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидроксинафталин-2-ил)-3-морфолинобензойной кислоты;
4-(1-бром-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидрокси-1-метилнафталин-2-ил)бензойной кислоты;
4-(1-циано-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидрокси-3-метоксинафталин-2-ил)бензойной кислоты;
4-(1-хлор-6-гидроксинафталин-2-ил)бензойной кислоты;
6-(4-(1Н-тетразол-5-ил)фенил)нафталин-2-ола;
5-(6-гидроксинафталин-2-ил)пиколиновой кислоты;
6-(6-гидроксинафталин-2-ил)никотиновой кислоты;
5-(6-гидроксинафталин-2-ил)пиразин-2-карбоновой кислоты;
2-(6-гидроксинафталин-2-ил)пиримидин-5-карбоновой кислоты;
6-(6-гидроксинафталин-2-ил)пиридазин-3-карбоновой кислоты;
5-(6-гидроксинафталин-2-ил)пиримидин-2-карбоновой кислоты;
6-(1H-бензо[d][1,2,3]триазол-6-ил)нафталин-2-ола;
4-(6-гидроксинафталин-2-ил)-3-(трифторметил)бензойной кислоты;
3-хлор-4-(3-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(3-хлор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(3-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидрокси-1-метоксинафталин-2-ил)бензойной кислоты;
4-(1-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(6-гидрокси-3-метилнафталин-2-ил)бензойной кислоты;
4-(1-циано-5-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(1-циано-6-гидроксинафталин-2-ил)-3-фторбензойной кислоты;
3-хлор-4-(5-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
4-(5-фтор-6-гидроксинафталин-2-ил)бензойной кислоты;
3-фтор-4-(5-фтор-6-гидроксинафталин-2-ил)бензойной кислоты; и
4-(5-фтор-6-гидроксинафталин-2-ил)-3-метилбензойной кислоты.
28. Применение соединения Формулы 1 по п.1 или его фармацевтически приемлемой соли в качестве ингибитора GSNOR.
29. Применение соединения по п.27 или его фармацевтически приемлемой соли в качестве ингибитора GSNOR.
30. Фармацевтическая композиция, включающая терапевтически эффективное количество соединения по п.1 вместе с фармацевтически приемлемым носителем или формообразующим средством.
31. Способ лечения заболевания или состояния, который включает введение терапевтически эффективного количества соединения Формулы 1 по п.1 пациенту, нуждающемуся в этом.
32. Способ получения соединения Формулы 1 по п.1.
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2599144C2 (ru) 2010-10-08 2016-10-10 Нивалис Терапьютикс,Инк. Новые замещенные хинолиновые соединения как ингибиторы s-нитрозоглутатион-редуктазы
AU2011343518B2 (en) 2010-12-16 2016-11-10 Nivalis Therapeutics, Inc. Novel substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
WO2012170371A1 (en) * 2011-06-10 2012-12-13 N30 Pharmaceuticals, Llc Compounds as s-nitrosoglutathione reductase inhibitors
WO2016128905A1 (en) * 2015-02-10 2016-08-18 Glenmark Pharmaceuticals S.A. Thienopyrrole compounds as s-nitrosoglutathione reductase inhibitors
WO2017044766A1 (en) * 2015-09-10 2017-03-16 Nivalis Therapeutics, Inc. Solid forms of an s-nitrosoglutathione reductase inhibitor
WO2017151725A1 (en) * 2016-03-03 2017-09-08 Nivalis Therapeutics, Inc. Formulations of an s-nitrosoglutathione reductase inhibitor
EP3448842A1 (en) 2016-04-26 2019-03-06 AbbVie S.À.R.L. Modulators of cystic fibrosis transmembrane conductance regulator protein
CN109999029B (zh) * 2019-03-07 2020-03-31 南京医科大学 N6022在治疗糖尿病外周动脉疾病中的医药用途
EP4116308A4 (en) * 2020-03-04 2024-04-24 National University Corporation Tokai National Higher Education and Research System METHOD FOR PRODUCING NAPHTHYSILOLE, NAPHTHYSILOLE HAVING HETEROCYCLIC GROUP, AND GRAPHENE NANORIBBONS HAVING HETEROCYCLIC GROUP
CN112574193B (zh) * 2020-12-31 2022-05-17 南京医科大学 一类口服gsnor抑制剂及其药物用途
CN115417913B (zh) * 2022-08-26 2024-10-29 天津医科大学 靶向雌激素受体的谷胱甘肽响应protac降解剂的制备方法及应用
AU2023379802A1 (en) 2022-11-17 2025-06-26 Changchun Genescience Pharmaceutical Co., Ltd. Mc4r antagonist compound, pharmaceutical composition and pharmaceutical use thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431440A (en) 1981-02-20 1984-02-14 American Cyanamid Company Method to alter or control the development and/or the life cycle of various plant species
LU86022A1 (fr) 1985-07-25 1987-02-04 Cird Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique
FR2676052B1 (fr) 1991-05-02 1994-04-29 Cird Galderma Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique.
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
DE19522195A1 (de) 1994-06-20 1995-12-21 Hoechst Ag Trifluornaphthalin-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
DE19522167B4 (de) 1994-06-20 2007-05-10 Merck Patent Gmbh 1,2-Difluornaphthalin-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
DE4427199A1 (de) 1994-08-01 1996-02-08 Hoechst Ag 3,4-Difluorpyridine und ihre Verwendung in flüssigkristallinen Mischungen
DE19517060A1 (de) 1995-05-10 1996-11-14 Hoechst Ag 1-Fluorisochinolinderivate und ihre Verwendung in flüssigkristallinen Mischungen
DE19517038A1 (de) 1995-05-10 1996-11-14 Hoechst Ag 1,8-Difluorisochinolinderivate und ihre Verwendung in flüssigkristallinen Mischungen
EP0839173A1 (en) 1995-07-17 1998-05-06 Hoechst Research & Technology Deutschland GmbH & Co. KG Ferroelectric liquid crystal mixture
KR20000022040A (ko) 1996-06-20 2000-04-25 보오드 오브 리젠츠, 더 유니버시티 오브 텍사스 시스템 약학적 활성 제제를 제공하기 위한 화합물, 방법 및 그의 용도
US6057367A (en) 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
US6180632B1 (en) 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
EP1001945B1 (en) 1997-05-28 2011-03-02 Aventis Pharmaceuticals Inc. QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56lck TYROSINE KINASES
ES2317688T3 (es) 1998-01-29 2009-04-16 Amgen Inc. Moduladores ppar-gamma.
AU4058399A (en) * 1998-11-20 2000-06-13 Torii Pharmaceutical Co., Ltd. Naphthalene derivatives
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
WO2001083456A1 (en) * 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Condensed heteroaryl derivatives
JP2004510767A (ja) 2000-10-02 2004-04-08 モレキュラー・プロウブズ・インコーポレーテッド アルデヒド部分またはケトン部分を有する生物分子を標識するための試薬
US7049308B2 (en) 2000-10-26 2006-05-23 Duke University C-nitroso compounds and use thereof
US6359182B1 (en) 2000-10-26 2002-03-19 Duke University C-nitroso compounds and use thereof
US7179791B2 (en) 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
JP2002226464A (ja) 2001-01-30 2002-08-14 Sumitomo Pharmaceut Co Ltd トリアリール類縁体およびその利用
US7173128B2 (en) 2001-08-13 2007-02-06 Ciba Specialty Chemicals Corporation Ultraviolet light absorbers
AT500490A1 (de) 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
AU2003265493A1 (en) 2002-08-19 2004-03-03 Rensselaer Polytechnic Institute Liquid crystal polymers
WO2004035522A1 (ja) 2002-08-30 2004-04-29 Bf Research Institute, Inc. プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
JPWO2004054978A1 (ja) 2002-12-16 2006-04-20 株式会社 ビーエフ研究所 タウ蛋白蓄積性疾患の診断プローブとしてのキノリン誘導体
EP1603395A2 (en) 2003-03-10 2005-12-14 Basf Aktiengesellschaft Amino substituted benzo(hetero)cyclic derivatives
CL2004000985A1 (es) 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
CA2528155A1 (en) 2003-06-04 2005-01-06 Duke University Compositions and methods for modulating s-nitrosoglutathione reductase
AU2003304416A1 (en) 2003-08-13 2005-03-07 Bf Research Institute, Inc. Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change
EP1701943A1 (en) 2003-12-23 2006-09-20 Myogen, Inc. 5-ht2 receptors modulators, their pharmaceutical compositions and their use for the treatment of cardiovascular and muscle diseases
ITTO20040125A1 (it) 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
WO2005118580A2 (en) 2004-05-12 2005-12-15 The Government Of The United States Of America As Represented By The Secretary, Department Of Health Tricyclic compounds as inhibitors of the hypoxic signaling pathway
WO2006004722A2 (en) 2004-06-30 2006-01-12 Biomol Research Laboratories, Inc. Compositions and methods for selectively activating human sirtuins
WO2006023821A2 (en) 2004-08-20 2006-03-02 The Trustees Of Columbia University In The City Of New York Ligands for aldoketoreductases
WO2006034491A2 (en) 2004-09-23 2006-03-30 Bayer Pharmaceuticals Corporation Phenyl-substituted quinoline and quinazoline compounds for the treatment of diabetes
CA2589629A1 (en) 2004-12-03 2006-06-29 Merck & Co., Inc. Quinoline tachykinin receptor antagonists
EP1683523A1 (en) 2005-01-25 2006-07-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. 2-Phenylquinoxalines as inhibitors for MPP1
JP5112297B2 (ja) 2005-05-20 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なキノリン誘導体
EP2778234B1 (en) 2005-05-31 2017-09-27 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
AU2006265835B2 (en) 2005-06-30 2012-05-03 Amgen Inc. Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer
EP1909788A2 (en) * 2005-07-29 2008-04-16 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
JP2009508952A (ja) * 2005-09-20 2009-03-05 メルク エンド カムパニー インコーポレーテッド ナイアシン受容体アゴニスト、このような化合物を含有する組成物、および治療方法
US20100016293A1 (en) 2006-07-03 2010-01-21 Rogier Adriaan Smits Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use
GB0618168D0 (en) 2006-09-15 2006-10-25 Babraham Inst Compounds
KR101299233B1 (ko) 2006-10-31 2013-08-22 삼성디스플레이 주식회사 유기 금속 착물 및 이를 이용한 유기 전계 발광 소자
AU2007328336B2 (en) 2006-12-01 2014-04-17 President And Fellows Of Harvard College Compounds and methods for enzyme-mediated tumor imaging and therapy
WO2009008906A2 (en) 2007-02-06 2009-01-15 The Trustees Of The University Of Pennsylvania Therapeutic compounds for blocking dna synthesis of pox viruses
DE102007015169A1 (de) 2007-03-27 2008-10-02 Universität des Saarlandes Campus Saarbrücken 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
BRPI0701664A2 (pt) 2007-05-28 2009-01-13 Fundacao Universidade Fed De Sco Carlos 4-quinolinonas e quinolinas, processo de preparaÇço, formulaÇÕes farmacÊuticas e uso das mesmas
WO2008157500A1 (en) 2007-06-17 2008-12-24 Kalypsys, Inc. Aminoquinazoline cannabinoid receptor modulators for treatment of disease
KR20100044810A (ko) 2007-07-02 2010-04-30 글락소스미스클라인 엘엘씨 파네소이드 ｘ 수용체 효능제
EP2014651A1 (en) 2007-07-12 2009-01-14 Exonhit Therapeutics SA Compounds and methods for modulating Rho GTPases
JP2011507811A (ja) 2007-12-13 2011-03-10 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 哺乳動物のｓ−ニトロソグルタチオンレダクターゼを阻害するための材料および方法
US20100144733A1 (en) 2008-04-28 2010-06-10 Institute For Oneworld Health Compounds, compositions and methods comprising heteroaromatic derivatives
WO2010018458A2 (en) 2008-08-12 2010-02-18 Crystalgenomics, Inc. Phenol derivatives and methods of use thereof
AU2009281747B2 (en) * 2008-08-15 2015-01-15 Nivalis Therapeutics, Inc. Novel pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
JP5524209B2 (ja) * 2008-08-15 2014-06-18 エヌサーティー・ファーマシューティカルズ・インコーポレーテッド Ｓ−ニトロソグルタチオンレダクターゼのピロール阻害剤
DK2318007T3 (da) 2008-08-15 2013-03-25 N30 Pharmaceuticals Inc Nye pyrrol-inhibitorer af s-nitrosoglutathion-reduktase som terapeutiske midler
BRPI0919773A2 (pt) 2008-10-15 2015-12-08 Kissei Pharmaceutical derivado de anel fundido e aplicação do mesmo na medicina
UA104601C2 (ru) 2008-10-23 2014-02-25 Вертекс Фармасьютікалз, Інкорпорейтед Модуляторы регулятора трансмембранной проводимости при муковисцидозе
WO2010080414A2 (en) 2008-12-19 2010-07-15 The University Of North Carolina At Chapel Hill Substituted fno (2-[furan-2-yl] naphthalen-1-ol) derivatives as anti-cancer agents
WO2010107476A1 (en) 2009-03-19 2010-09-23 Duke University Inhibiting gsnor
HRP20160450T1 (hr) 2010-02-12 2016-05-20 Nivalis Therapeutics, Inc. Novi inhibitori reduktaze s-nitrozoglutationa
WO2012009227A1 (en) 2010-07-16 2012-01-19 N30 Pharmaceuticals, Llc Novel dihydropyridin-2(1h)-one compounds as s-nitrosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists
RU2599144C2 (ru) * 2010-10-08 2016-10-10 Нивалис Терапьютикс,Инк. Новые замещенные хинолиновые соединения как ингибиторы s-нитрозоглутатион-редуктазы
AU2011343518B2 (en) 2010-12-16 2016-11-10 Nivalis Therapeutics, Inc. Novel substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
WO2012170371A1 (en) 2011-06-10 2012-12-13 N30 Pharmaceuticals, Llc Compounds as s-nitrosoglutathione reductase inhibitors

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