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RU2013110524A - Лечение диабета при помощи панкреатических эндокринных клеток-предшественников - Google Patents

Лечение диабета при помощи панкреатических эндокринных клеток-предшественников Download PDF

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Publication number
RU2013110524A
RU2013110524A RU2013110524/15A RU2013110524A RU2013110524A RU 2013110524 A RU2013110524 A RU 2013110524A RU 2013110524/15 A RU2013110524/15 A RU 2013110524/15A RU 2013110524 A RU2013110524 A RU 2013110524A RU 2013110524 A RU2013110524 A RU 2013110524A
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Russia
Prior art keywords
pancreatic endocrine
diabetes
treatment
endocrine cells
animal
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RU2013110524/15A
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English (en)
Inventor
Джин СЮЙ
Original Assignee
Янссен Байотек, Инк.
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Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of RU2013110524A publication Critical patent/RU2013110524A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Способ снижения уровней глюкозы в крови животного путем трансплантации животному популяции инкапсулированных панкреатических эндокринных клеток-предшественников.

Claims (1)

  1. Способ снижения уровней глюкозы в крови животного путем трансплантации животному популяции инкапсулированных панкреатических эндокринных клеток-предшественников.
RU2013110524/15A 2010-08-12 2011-08-11 Лечение диабета при помощи панкреатических эндокринных клеток-предшественников RU2013110524A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37310910P 2010-08-12 2010-08-12
US61/373,109 2010-08-12
PCT/US2011/047410 WO2012021698A2 (en) 2010-08-12 2011-08-11 Treatment of diabetes with pancreatic endocrine precursor cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2016133754A Division RU2682719C2 (ru) 2010-08-12 2011-08-11 Лечение диабета при помощи панкреатических эндокринных клеток-предшественников

Publications (1)

Publication Number Publication Date
RU2013110524A true RU2013110524A (ru) 2014-09-20

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RU2016133754A RU2682719C2 (ru) 2010-08-12 2011-08-11 Лечение диабета при помощи панкреатических эндокринных клеток-предшественников
RU2013110524/15A RU2013110524A (ru) 2010-08-12 2011-08-11 Лечение диабета при помощи панкреатических эндокринных клеток-предшественников

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RU2016133754A RU2682719C2 (ru) 2010-08-12 2011-08-11 Лечение диабета при помощи панкреатических эндокринных клеток-предшественников

Country Status (16)

Country Link
US (1) US20120039955A1 (ru)
EP (2) EP3981415A1 (ru)
JP (5) JP2013533319A (ru)
KR (3) KR20190027969A (ru)
CN (1) CN103052393B (ru)
AR (1) AR082674A1 (ru)
AU (1) AU2011289379A1 (ru)
BR (1) BR112013003160A2 (ru)
CA (1) CA2807158C (ru)
DK (1) DK2603226T3 (ru)
MX (1) MX2013001673A (ru)
PH (1) PH12013500199A1 (ru)
RU (2) RU2682719C2 (ru)
SG (2) SG187603A1 (ru)
WO (1) WO2012021698A2 (ru)
ZA (1) ZA201301836B (ru)

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Publication number Publication date
KR20180032674A (ko) 2018-03-30
PH12013500199A1 (en) 2019-06-26
EP2603226A4 (en) 2014-01-15
JP2013533319A (ja) 2013-08-22
CA2807158C (en) 2025-10-07
RU2016133754A3 (ru) 2018-12-10
JP2022058629A (ja) 2022-04-12
SG187603A1 (en) 2013-03-28
KR20130100122A (ko) 2013-09-09
AU2011289379A1 (en) 2013-02-07
CN103052393A (zh) 2013-04-17
JP7012128B2 (ja) 2022-01-27
EP3981415A1 (en) 2022-04-13
EP2603226A2 (en) 2013-06-19
CN103052393B (zh) 2017-11-14
RU2016133754A (ru) 2018-12-10
CA2807158A1 (en) 2012-02-16
JP2020196728A (ja) 2020-12-10
MX2013001673A (es) 2013-03-25
EP2603226B1 (en) 2021-04-07
BR112013003160A2 (pt) 2016-06-28
SG10201506264QA (en) 2015-09-29
JP2017031163A (ja) 2017-02-09
US20120039955A1 (en) 2012-02-16
JP2019131564A (ja) 2019-08-08
DK2603226T3 (da) 2021-06-07
WO2012021698A2 (en) 2012-02-16
AR082674A1 (es) 2012-12-26
KR20190027969A (ko) 2019-03-15
ZA201301836B (en) 2018-12-19
RU2682719C2 (ru) 2019-03-21
WO2012021698A3 (en) 2012-05-10

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