RU2013109815A - Конструкция, используемая для крепления ортопедического имплантата, и способ его установки на кости - Google Patents
Конструкция, используемая для крепления ортопедического имплантата, и способ его установки на кости Download PDFInfo
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- RU2013109815A RU2013109815A RU2013109815/14A RU2013109815A RU2013109815A RU 2013109815 A RU2013109815 A RU 2013109815A RU 2013109815/14 A RU2013109815/14 A RU 2013109815/14A RU 2013109815 A RU2013109815 A RU 2013109815A RU 2013109815 A RU2013109815 A RU 2013109815A
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- anchor support
- orthopedic implant
- implant according
- longitudinal axis
- bone
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- 239000007943 implant Substances 0.000 title claims abstract 25
- 230000000399 orthopedic effect Effects 0.000 title claims abstract 23
- 210000000988 bone and bone Anatomy 0.000 title claims abstract 12
- 238000009434 installation Methods 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title 1
- 230000007423 decrease Effects 0.000 claims abstract 4
- 239000000463 material Substances 0.000 claims 2
- 239000002639 bone cement Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3601—Femoral heads ; Femoral endoprostheses for replacing only the epiphyseal or metaphyseal parts of the femur, e.g. endoprosthetic femoral heads or necks directly fixed to the natural femur by internal fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3859—Femoral components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/389—Tibial components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30205—Three-dimensional shapes conical
- A61F2002/3021—Three-dimensional shapes conical frustoconical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3082—Grooves
- A61F2002/30827—Plurality of grooves
- A61F2002/30828—Plurality of grooves parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30879—Ribs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30897—Stepped protrusions, i.e. having discrete diameter changes
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Surgical Instruments (AREA)
Abstract
1. Ортопедический имплантат (10, 50, 60, 70, 100) для установки на концевой части кости (B), содержащий:основную часть (12, 112) и первую и вторую поперечные части (14, 16, 114, 116), отходящие в поперечном направлении от основной части (12, 112), задавая внутреннюю область (18, 118) имплантата (10, 100), размер которой позволяет поместить в нее концевую часть кости (B); ипо меньшей мере одну анкерную опору (30, 130), выступающую из основной части (12, 112) и имеющую такой размер и форму, что она может быть помещена в отверстие (O, O'), выполненное в концевой части кости (В), причем анкерная опора (30, 130) проходит вдоль продольной оси (L) и содержит проксимальный конец (30a, 130a), прикрепленный к основной части (12, 112), и противоположный дистальный конец (30b, 130b), причем анкерная опора (30, 130) имеет коническую наружную поверхность (36, 136), которая вдоль продольной оси (L) сходит на конус внутрь в проксимально-дистальном направлении.2. Ортопедический имплантат по п.1, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) задает изменяющийся угол конусности относительно продольной оси (L), который уменьшается в проксимально-дистальном направлении вдоль продольной оси (L).3. Ортопедический имплантат по любому из пп.1 и 2, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) задает вогнутую кривую (С), проходящую в проксимально-дистальном направлении вдоль продольной оси (L).4. Ортопедический имплантат по п.3, в котором вогнутая кривая (С) задает изменяющуюся конусность относительно продольной оси (L), которая уменьшается в проксимально-дистальном направлении вдоль продольной оси (L).5. Ортопедический имплантат по п.3, в котором вогнутая кривая (C) проходит вдоль �
Claims (17)
1. Ортопедический имплантат (10, 50, 60, 70, 100) для установки на концевой части кости (B), содержащий:
основную часть (12, 112) и первую и вторую поперечные части (14, 16, 114, 116), отходящие в поперечном направлении от основной части (12, 112), задавая внутреннюю область (18, 118) имплантата (10, 100), размер которой позволяет поместить в нее концевую часть кости (B); и
по меньшей мере одну анкерную опору (30, 130), выступающую из основной части (12, 112) и имеющую такой размер и форму, что она может быть помещена в отверстие (O, O'), выполненное в концевой части кости (В), причем анкерная опора (30, 130) проходит вдоль продольной оси (L) и содержит проксимальный конец (30a, 130a), прикрепленный к основной части (12, 112), и противоположный дистальный конец (30b, 130b), причем анкерная опора (30, 130) имеет коническую наружную поверхность (36, 136), которая вдоль продольной оси (L) сходит на конус внутрь в проксимально-дистальном направлении.
2. Ортопедический имплантат по п.1, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) задает изменяющийся угол конусности относительно продольной оси (L), который уменьшается в проксимально-дистальном направлении вдоль продольной оси (L).
3. Ортопедический имплантат по любому из пп.1 и 2, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) задает вогнутую кривую (С), проходящую в проксимально-дистальном направлении вдоль продольной оси (L).
4. Ортопедический имплантат по п.3, в котором вогнутая кривая (С) задает изменяющуюся конусность относительно продольной оси (L), которая уменьшается в проксимально-дистальном направлении вдоль продольной оси (L).
5. Ортопедический имплантат по п.3, в котором вогнутая кривая (C) проходит вдоль радиуса r1 вогнутой поверхности, который больше максимального радиуса r2 выпуклой поверхности анкерной опоры (30, 130), измеренного от продольной оси (L).
6. Ортопедический имплантат по любому из пп.1, 2, 4 или 5, в котором анкерная опора (30, 130), в общем, имеет коническую форму.
7. Ортопедический имплантат по любому из пп.1, 2, 4 или 5, в котором анкерная опора (30, 130) имеет форму усеченного конуса.
8. Ортопедический имплантат по любому из пп.1, 2, 4 или 5, в котором первая поперечная часть (14, 114) задает первую поверхность (24, 124) прилегания кости, которая наклонена конусно относительно второй поверхности (26, 126) прилегания кости, заданной второй поперечной частью (16, 116).
9. Ортопедический имплантат по п.8, в котором первая поверхность (24, 124) прилегания кости, заданная первой поперечной частью (14, 114) наклонена внутрь относительно второй поверхности (26, 125) прилегания кости, заданной второй поперечной частью (16, 116), в направлении от основной части (12, 112).
10. Ортопедический имплантат по любому из пп.1, 2, 4, 5 или 9, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) проходит по меньшей мере вдоль половины общей длины (1) анкерной опоры (30, 130).
11. Ортопедический имплантат по любому из пп.1, 2, 4, 5 или 9, в котором коническая наружная поверхность (36, 136) анкерной опоры (30, 130) проходит по меньшей мере вдоль двух третей общей длины (1) анкерной опоры (30, 130).
12. Ортопедический имплантат по любому из пп.1, 2, 4, 5 или 9, дополнительно содержащий вторую анкерную опору (30, 130), отходящую от основной части (12, 112), первой или второй поперечной части (14, 16, 114, 116), причем вторая анкерная опора (30, 130) имеет такой размер и форму, что она может быть помещена во второе отверстие (O, O'), выполненное в концевой части кости (B).
13. Ортопедический имплантат по любому из пп.1, 2, 4, 5 или 9, в котором анкерная опора (30, 130) содержит установочную часть (32, 132), выступающую из основной части (12, 112) до конической наружной поверхности (36, 136).
14. Ортопедический имплантат по п.13, в котором установочная часть (32, 132) анкерной опоры (30, 130) содержит резьбовой стержень (138), предназначенный для резьбового зацепления с резьбовым отверстием в основной части (12, 112).
15. Ортопедический имплантат по любому из пп.1, 2, 4, 5, 9 или 14, в котором анкерная опора (130) содержит одну или несколько канавок (140), проходящих в конусной наружной поверхности (136); и дополнительно содержит текучий материал (150), расположенный по меньшей мере над частью конической наружной поверхности (136) анкерной опоры (130) и в канавках (140), предназначенный для застывания в твердое состояние.
16. Ортопедический имплантат по п.15, в котором одна или несколько канавок (140) содержат несколько кольцевых канавок (140), проходящих по конической наружной поверхности (136) анкерной опоры (130).
17. Ортопедический имплантат по п.15, в котором текучий материал (150) содержит костный цемент.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37290210P | 2010-08-12 | 2010-08-12 | |
| US61/372,902 | 2010-08-12 | ||
| PCT/US2011/047414 WO2012021702A2 (en) | 2010-08-12 | 2011-08-11 | Structures for use in orthopaedic implant fixation and methods of installation onto a bone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013109815A true RU2013109815A (ru) | 2014-09-20 |
Family
ID=45565393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013109815/14A RU2013109815A (ru) | 2010-08-12 | 2011-08-11 | Конструкция, используемая для крепления ортопедического имплантата, и способ его установки на кости |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8926709B2 (ru) |
| EP (1) | EP2603173B1 (ru) |
| JP (1) | JP5951608B2 (ru) |
| KR (1) | KR101872041B1 (ru) |
| CN (1) | CN103402462B (ru) |
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| RU (1) | RU2013109815A (ru) |
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-
2011
- 2011-08-11 WO PCT/US2011/047414 patent/WO2012021702A2/en not_active Ceased
- 2011-08-11 KR KR1020137005230A patent/KR101872041B1/ko active Active
- 2011-08-11 CN CN201180049500.9A patent/CN103402462B/zh active Active
- 2011-08-11 US US13/207,888 patent/US8926709B2/en active Active
- 2011-08-11 EP EP11817036.4A patent/EP2603173B1/en active Active
- 2011-08-11 ES ES11817036.4T patent/ES2577936T3/es active Active
- 2011-08-11 CA CA2808090A patent/CA2808090C/en not_active Expired - Fee Related
- 2011-08-11 BR BR112013003254A patent/BR112013003254A2/pt not_active Application Discontinuation
- 2011-08-11 JP JP2013524229A patent/JP5951608B2/ja active Active
- 2011-08-11 AU AU2011289383A patent/AU2011289383B2/en active Active
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|---|---|
| KR101872041B1 (ko) | 2018-06-27 |
| CA2808090C (en) | 2018-09-11 |
| ES2577936T3 (es) | 2016-07-19 |
| ZA201301584B (en) | 2013-11-27 |
| AU2011289383B2 (en) | 2016-05-26 |
| EP2603173A4 (en) | 2014-05-21 |
| US20120041566A1 (en) | 2012-02-16 |
| WO2012021702A2 (en) | 2012-02-16 |
| EP2603173B1 (en) | 2016-03-23 |
| JP2013537453A (ja) | 2013-10-03 |
| EP2603173A2 (en) | 2013-06-19 |
| JP5951608B2 (ja) | 2016-07-13 |
| CN103402462A (zh) | 2013-11-20 |
| BR112013003254A2 (pt) | 2016-05-17 |
| WO2012021702A3 (en) | 2012-05-03 |
| AU2011289383A1 (en) | 2013-03-07 |
| US8926709B2 (en) | 2015-01-06 |
| CN103402462B (zh) | 2016-09-07 |
| CA2808090A1 (en) | 2012-02-16 |
| KR20130138187A (ko) | 2013-12-18 |
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