RU2013101020A - Вакцины на основе модифицированного вируса гриппа - Google Patents
Вакцины на основе модифицированного вируса гриппа Download PDFInfo
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- RU2013101020A RU2013101020A RU2013101020/10A RU2013101020A RU2013101020A RU 2013101020 A RU2013101020 A RU 2013101020A RU 2013101020/10 A RU2013101020/10 A RU 2013101020/10A RU 2013101020 A RU2013101020 A RU 2013101020A RU 2013101020 A RU2013101020 A RU 2013101020A
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- 229960005486 vaccine Drugs 0.000 title claims abstract 15
- 241000712461 unidentified influenza virus Species 0.000 title claims abstract 7
- 241000712431 Influenza A virus Species 0.000 claims abstract 8
- 235000001014 amino acid Nutrition 0.000 claims abstract 8
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims abstract 6
- 229940024606 amino acid Drugs 0.000 claims abstract 6
- 150000001413 amino acids Chemical class 0.000 claims abstract 6
- 229960001230 asparagine Drugs 0.000 claims abstract 6
- 235000009582 asparagine Nutrition 0.000 claims abstract 6
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims abstract 4
- 238000006467 substitution reaction Methods 0.000 claims abstract 4
- 101710154606 Hemagglutinin Proteins 0.000 claims abstract 2
- 229940124873 Influenza virus vaccine Drugs 0.000 claims abstract 2
- 241001465754 Metazoa Species 0.000 claims abstract 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims abstract 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims abstract 2
- 101710176177 Protein A56 Proteins 0.000 claims abstract 2
- 241000700605 Viruses Species 0.000 claims abstract 2
- 230000013595 glycosylation Effects 0.000 claims abstract 2
- 238000006206 glycosylation reaction Methods 0.000 claims abstract 2
- 239000000185 hemagglutinin Substances 0.000 claims abstract 2
- 208000037797 influenza A Diseases 0.000 claims abstract 2
- 229960003971 influenza vaccine Drugs 0.000 claims abstract 2
- 230000009257 reactivity Effects 0.000 claims abstract 2
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Abstract
1. Вакцина против вируса гриппа А субтипа Н5, где указанная вакцина включает рекомбинантную молекулу гемагглютинина гриппа А субтипа Н5 (НА Н5), обладающую реактивностью в отношении антисыворотки, полученной из организма животного, которое инфицировано вирусом гриппа или противогриппозной вакциной и включающая аминокислоту аспарагин в положении, соответствующем положению 223 в НА Н5, где молекула НА не происходит из изолята человеческого Н5 А/НК/213/03.2. Вакцина по п.1, где рекомбинантная молекула НА содержит одну или несколько замен по сравнению с соответствующей молекулой НА дикого типа, причем указанная молекула НА включает аминокислоту аспарагин в положении, соответствующем положению 223 в НА Н5, а указанная молекула дикого типа включает аминокислоту, отличную от аспарагина, в положении, соответствующем положению 223.3. Вакцина по п.1, где аминокислотная замена в рекомбинантной молекуле НА вируса гриппа приводит к изменению сайта гликозилирования.4. Вакцина по п.1, где вирус гриппа представляет собой вирус гриппа А человека.5. Вакцина по п.4, где вирус гриппа А человека является представителем Н5-субтипа.6. Вакцина по п.4, где вирус гриппа А человека представляет собой вирус A/Vietnam/1203/04 (H5N1).
Claims (6)
1. Вакцина против вируса гриппа А субтипа Н5, где указанная вакцина включает рекомбинантную молекулу гемагглютинина гриппа А субтипа Н5 (НА Н5), обладающую реактивностью в отношении антисыворотки, полученной из организма животного, которое инфицировано вирусом гриппа или противогриппозной вакциной и включающая аминокислоту аспарагин в положении, соответствующем положению 223 в НА Н5, где молекула НА не происходит из изолята человеческого Н5 А/НК/213/03.
2. Вакцина по п.1, где рекомбинантная молекула НА содержит одну или несколько замен по сравнению с соответствующей молекулой НА дикого типа, причем указанная молекула НА включает аминокислоту аспарагин в положении, соответствующем положению 223 в НА Н5, а указанная молекула дикого типа включает аминокислоту, отличную от аспарагина, в положении, соответствующем положению 223.
3. Вакцина по п.1, где аминокислотная замена в рекомбинантной молекуле НА вируса гриппа приводит к изменению сайта гликозилирования.
4. Вакцина по п.1, где вирус гриппа представляет собой вирус гриппа А человека.
5. Вакцина по п.4, где вирус гриппа А человека является представителем Н5-субтипа.
6. Вакцина по п.4, где вирус гриппа А человека представляет собой вирус A/Vietnam/1203/04 (H5N1).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70580805P | 2005-08-04 | 2005-08-04 | |
| US60/705,808 | 2005-08-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011103648/10A Division RU2480480C2 (ru) | 2005-08-04 | 2006-07-28 | Способы применения модифицированного вируса гриппа |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013101020A true RU2013101020A (ru) | 2014-07-20 |
| RU2552213C2 RU2552213C2 (ru) | 2015-06-10 |
Family
ID=37727844
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008107875/10A RU2420535C2 (ru) | 2005-08-04 | 2006-07-28 | Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины |
| RU2011103648/10A RU2480480C2 (ru) | 2005-08-04 | 2006-07-28 | Способы применения модифицированного вируса гриппа |
| RU2013101020/10A RU2552213C2 (ru) | 2005-08-04 | 2013-01-11 | Вакцины на основе модифицированного вируса гриппа |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008107875/10A RU2420535C2 (ru) | 2005-08-04 | 2006-07-28 | Модифицированный вирус гриппа, предназначенный для мониторинга и повышения эффективности вакцины |
| RU2011103648/10A RU2480480C2 (ru) | 2005-08-04 | 2006-07-28 | Способы применения модифицированного вируса гриппа |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US7871626B2 (ru) |
| EP (1) | EP1924281B1 (ru) |
| JP (2) | JP5395430B2 (ru) |
| KR (1) | KR101334047B1 (ru) |
| CN (2) | CN101283099B (ru) |
| AU (1) | AU2006278696B2 (ru) |
| BR (1) | BRPI0614297A2 (ru) |
| CA (1) | CA2617483C (ru) |
| ES (1) | ES2728791T3 (ru) |
| HU (1) | HUE043952T2 (ru) |
| PL (1) | PL1924281T3 (ru) |
| RU (3) | RU2420535C2 (ru) |
| SG (1) | SG2014007934A (ru) |
| UA (1) | UA94717C2 (ru) |
| WO (1) | WO2007019094A2 (ru) |
| ZA (1) | ZA200800505B (ru) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| CA2626866A1 (en) | 2005-10-28 | 2007-05-10 | Boehringer Ingelheim Vetmedica, Inc. | Use of vaccines for the treatment/ prevention of the transmission of influenza pathogens between species |
| JP2010501074A (ja) * | 2006-08-14 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | グリカンのデータマイニングシステム |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| JP5597128B2 (ja) * | 2007-05-11 | 2014-10-01 | テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド | Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質 |
| MX2009013635A (es) * | 2007-06-25 | 2010-05-19 | Univ Tulane | Composiciones que inhiben la influenza y metodos. |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CN103122354B (zh) | 2007-11-27 | 2018-03-23 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| CA2719252C (en) * | 2008-04-01 | 2016-01-19 | Innate Therapeutics Limited | Anti-infective agents comprising muramyl dipeptide microparticles and uses thereof |
| AU2009270404B2 (en) | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| PL2358386T3 (pl) * | 2008-11-28 | 2017-04-28 | Statens Serum Institut | Zoptymalizowane szczepionki na grypę |
| KR101145720B1 (ko) * | 2009-06-23 | 2012-05-14 | 한밭대학교 산학협력단 | 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질을 함유하는 생분해성 ｐｌｇａ 미립자의 제조 방법 |
| CA2762042C (en) | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| WO2010151673A1 (en) * | 2009-06-25 | 2010-12-29 | Medimmune, Llc | Swine influenza hemagglutinin variants |
| HRP20171564T1 (hr) | 2009-09-22 | 2017-11-17 | Medicago Inc. | Postupak za pripremu biljnih čestica sličnih virusu (vlp) |
| CN102095852A (zh) * | 2010-11-24 | 2011-06-15 | 中国检验检疫科学研究院 | 一种用于快速检测新型h1n1流感病毒的双抗体夹心法 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| SI2760882T1 (sl) * | 2011-09-30 | 2023-10-30 | Medicago Inc. | Povečanje količine virusom podobnih delcev v rastlinah |
| CN109265541A (zh) | 2012-05-10 | 2019-01-25 | 麻省理工学院 | 流感中和药剂 |
| ES2662022T3 (es) * | 2012-07-17 | 2018-04-05 | Merial, Inc. | Vacunas atenuadas de la gripe porcina y procedimientos de fabricación y uso de las mismas |
| KR101315273B1 (ko) * | 2012-10-29 | 2013-10-08 | 대한민국 | 강독화된 인플루엔자 바이러스 변이주 |
| CN104491463A (zh) * | 2014-11-18 | 2015-04-08 | 四川金堂海纳生物医药技术研究所 | 一种治疗舌溢血(舌衄)的汤剂药物及制备方法 |
| WO2016090297A1 (en) * | 2014-12-04 | 2016-06-09 | The New York Stem Cell Foundation | Perfusion bioreactor |
| JOP20190088A1 (ar) | 2016-10-21 | 2019-04-21 | Us Agriculture | نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها |
| US20180128545A1 (en) | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
| KR20210137485A (ko) | 2019-04-05 | 2021-11-17 | 아카데미아 시니카 | 시알리다제-내성 당류 및 이의 제조 및 사용 방법 |
| IL298035A (en) | 2020-05-08 | 2023-01-01 | Academia Sinica | Chimeric influenza vaccines |
| EP4164687A4 (en) | 2021-04-12 | 2024-08-14 | Academia Sinica | IMPROVED CORONAVIRUS VACCINE |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| IL127331A0 (en) | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
| JP5215561B2 (ja) * | 2003-05-28 | 2013-06-19 | ウィスコンシン アルムニ リサーチ ファンデイション | ワクチン及び遺伝子治療のための高力価組換えインフルエンザ・ウイルス |
| CN1261564C (zh) * | 2003-12-02 | 2006-06-28 | 中国农业科学院哈尔滨兽医研究所 | 人工重组的流感病毒及其应用 |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
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