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RU2011151392A - PRODUCT FOR STORAGE OF LYOPHYLIZED MILK-ACID BACTERIA MIXED WITH POWDER FOR SOLUTION FOR ORAL REHYDRATION - Google Patents

PRODUCT FOR STORAGE OF LYOPHYLIZED MILK-ACID BACTERIA MIXED WITH POWDER FOR SOLUTION FOR ORAL REHYDRATION Download PDF

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RU2011151392A
RU2011151392A RU2011151392/13A RU2011151392A RU2011151392A RU 2011151392 A RU2011151392 A RU 2011151392A RU 2011151392/13 A RU2011151392/13 A RU 2011151392/13A RU 2011151392 A RU2011151392 A RU 2011151392A RU 2011151392 A RU2011151392 A RU 2011151392A
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foil
product
acid bacteria
product according
probiotic
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RU2011151392/13A
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RU2527515C2 (en
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Кристоффер ЛУНДКВИСТ
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Биогайа Аб
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/173—Reuteri
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B32B2307/7246—Water vapor barrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Packages (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

1. Пробиотический продукт, включающий лиофилизированные молочно-кислые бактерии, смешанные с безводным порошком для раствора для пероральной регидратации, лиофилизированные молочно-кислые бактерии и безводный порошок для раствора для пероральной регидратации упакованы в фольгу с осушителем, интегрированным в фольгу.2. Пробиотический продукт по п.1, в котором фольга включает алюминий.3. Пробиотический продукт по п.2, в котором фольга дополнительно включает слой полиэтилена.4. Пробиотический продукт по п.1, в котором осушитель, интегрированный в материал фольги, включает оксид кальция.5. Пробиотический продукт по п.1, в котором лиофилизированные молочно-кислые бактерии представляют Lactobacillus reuteri.6. Пробиотический продукт по п.1, в котором после 12 месяцев хранения при температуре около 30°C количество Lactobacillus reuteri составляет по меньшей мере 10КОЕ/г, начиная с 5·10КОЕ/г Lactobacillus reuteri.7. Пробиотический продукт по п.6, где после 12 месяцев хранения Lactobacillus reuteri составляет по меньшей мере 10КОЕ/г.8. Пробиотический продукт по п.7, где после 12 месяцев хранения Lactobacillus reuteri составляет по меньшей мере 10КОЕ/г.9. Продукт для жизнеспособного хранения продукта, чувствительного к влаге, включающий безводный порошок для раствора для пероральной регидратации для смешивания с продуктом, чувствительным к влаге, и упаковку для продукта, чувствительного к влаге, и безводного порошка для раствора для пероральной регидратации, включающую материал химического осушителя, введенный в слой фольги.10. Продукт по п.9, где продукт представляет чувствительный к влаге продукт, включающий жизнеспособные лиофилизированные молочно-кислые бактерии.11. Продукт по п.1. A probiotic product including lyophilized lactic acid bacteria mixed with anhydrous powder for oral rehydration solution, lyophilized lactic acid bacteria and anhydrous powder for oral rehydration solution are packaged in a foil with a desiccant integrated in the foil. 2. The probiotic product according to claim 1, in which the foil includes aluminum. The probiotic product according to claim 2, in which the foil further comprises a layer of polyethylene. The probiotic product according to claim 1, wherein the desiccant integrated into the foil material includes calcium oxide. The probiotic product of claim 1, wherein the lyophilized lactic acid bacteria are Lactobacillus reuteri. The probiotic product according to claim 1, in which after 12 months of storage at a temperature of about 30 ° C, the amount of Lactobacillus reuteri is at least 10 CFU / g, starting from 5 · 10 CFU / g of Lactobacillus reuteri. The probiotic product according to claim 6, where after 12 months of storage of Lactobacillus reuteri is at least 10 CFU / g. The probiotic product according to claim 7, where after 12 months of storage of Lactobacillus reuteri is at least 10 CFU / g. A product for the viable storage of a moisture sensitive product, including an anhydrous powder for an oral rehydration solution for mixing with a moisture sensitive product, and a packaging for a moisture sensitive product and an anhydrous powder for an oral rehydration solution, including a chemical desiccant material, introduced into the foil layer. 10. The product of claim 9, wherein the product is a moisture-sensitive product comprising viable lyophilized lactic acid bacteria. The product according to

Claims (17)

1. Пробиотический продукт, включающий лиофилизированные молочно-кислые бактерии, смешанные с безводным порошком для раствора для пероральной регидратации, лиофилизированные молочно-кислые бактерии и безводный порошок для раствора для пероральной регидратации упакованы в фольгу с осушителем, интегрированным в фольгу.1. A probiotic product comprising lyophilized lactic acid bacteria mixed with anhydrous powder for oral rehydration solution, lyophilized lactic acid bacteria and anhydrous powder for oral rehydration solution are packaged in a foil with a desiccant integrated in the foil. 2. Пробиотический продукт по п.1, в котором фольга включает алюминий.2. The probiotic product according to claim 1, in which the foil includes aluminum. 3. Пробиотический продукт по п.2, в котором фольга дополнительно включает слой полиэтилена.3. The probiotic product according to claim 2, in which the foil further includes a layer of polyethylene. 4. Пробиотический продукт по п.1, в котором осушитель, интегрированный в материал фольги, включает оксид кальция.4. The probiotic product according to claim 1, wherein the desiccant integrated into the foil material includes calcium oxide. 5. Пробиотический продукт по п.1, в котором лиофилизированные молочно-кислые бактерии представляют Lactobacillus reuteri.5. The probiotic product according to claim 1, in which the lyophilized lactic acid bacteria are Lactobacillus reuteri. 6. Пробиотический продукт по п.1, в котором после 12 месяцев хранения при температуре около 30°C количество Lactobacillus reuteri составляет по меньшей мере 107 КОЕ/г, начиная с 5·109 КОЕ/г Lactobacillus reuteri.6. The probiotic product according to claim 1, in which after 12 months of storage at a temperature of about 30 ° C, the amount of Lactobacillus reuteri is at least 10 7 CFU / g, starting with 5 · 10 9 CFU / g of Lactobacillus reuteri. 7. Пробиотический продукт по п.6, где после 12 месяцев хранения Lactobacillus reuteri составляет по меньшей мере 108 КОЕ/г.7. The probiotic product according to claim 6, where after 12 months of storage of Lactobacillus reuteri is at least 10 8 CFU / g 8. Пробиотический продукт по п.7, где после 12 месяцев хранения Lactobacillus reuteri составляет по меньшей мере 109 КОЕ/г.8. The probiotic product according to claim 7, where after 12 months of storage of Lactobacillus reuteri is at least 10 9 CFU / g 9. Продукт для жизнеспособного хранения продукта, чувствительного к влаге, включающий безводный порошок для раствора для пероральной регидратации для смешивания с продуктом, чувствительным к влаге, и упаковку для продукта, чувствительного к влаге, и безводного порошка для раствора для пероральной регидратации, включающую материал химического осушителя, введенный в слой фольги.9. A product for the viable storage of a moisture sensitive product, including an anhydrous powder for an oral rehydration solution for mixing with a moisture sensitive product, and a packaging for a moisture sensitive product and an anhydrous powder for an oral rehydration solution, including chemical material a desiccant introduced into the foil layer. 10. Продукт по п.9, где продукт представляет чувствительный к влаге продукт, включающий жизнеспособные лиофилизированные молочно-кислые бактерии.10. The product according to claim 9, where the product is a moisture-sensitive product, including viable lyophilized lactic acid bacteria. 11. Продукт по п.9, где фольга включает алюминий.11. The product according to claim 9, where the foil includes aluminum. 12. Продукт по п.11, где фольга дополнительно включает слой полиэтилена.12. The product according to claim 11, where the foil further includes a layer of polyethylene. 13. Способ длительного хранения жизнеспособных лиофилизированных пробиотических молочнокислых бактерий, включающий:13. A method for long-term storage of viable lyophilized probiotic lactic acid bacteria, including: a) обеспечение безводного порошка для раствора для пероральной регидратации;a) providing anhydrous powder for oral rehydration solution; b) смешивание лиофилизированных молочно-кислых бактерий с безводным порошком для раствора для пероральной регидратации;b) mixing lyophilized lactic acid bacteria with anhydrous powder for oral rehydration solution; c) упаковку смешанных лиофилизированных молочно-кислых бактерий и безводного порошка для раствора для пероральной регидратации в упаковку, включающую химический осушающий материал, введенный в слой фольги; иc) packaging mixed lyophilized lactic acid bacteria and anhydrous powder for oral rehydration solution in a package comprising chemical drying material introduced into the foil layer; and d) герметизацию упаковок, таким образом, что герметизация является неповрежденной.d) sealing the packages so that the sealing is intact. 14. Способ по п.13, где фольга является алюминиевой фольгой.14. The method according to item 13, where the foil is an aluminum foil. 15. Способ по п.14, где фольга дополнительно включает слой полиэтилена.15. The method according to 14, where the foil further includes a layer of polyethylene. 16. Способ по п.13, где осушитель, интегрированный в материал фольги, включает оксид кальция.16. The method according to item 13, where the desiccant integrated into the foil material includes calcium oxide. 17. Способ по п.13, где лиофилизированные молочно-кислые бактерии представляют Lactobacillus reuteri. 17. The method according to item 13, where the lyophilized lactic acid bacteria are Lactobacillus reuteri.
RU2011151392/13A 2009-07-10 2010-07-09 Product for storage of lyophilised lactic acid bacteria mixed with powder for solution for oral rehydration RU2527515C2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27056609P 2009-07-10 2009-07-10
US61/270,566 2009-07-10
US12/803,758 2010-07-06
US12/803,758 US20110014324A1 (en) 2009-07-10 2010-07-06 Product for the storage of freeze-dried lactic acid bacteria mixed with oral rehydration solution
PCT/EP2010/059856 WO2011003995A1 (en) 2009-07-10 2010-07-09 Product for the storage of freeze-dried lactic acid bacteria mixed with a powder for an oral rehydration solution

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RU2011151392A true RU2011151392A (en) 2013-08-20
RU2527515C2 RU2527515C2 (en) 2014-09-10

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US (2) US20110014324A1 (en)
EP (1) EP2451298B1 (en)
JP (1) JP5608227B2 (en)
KR (1) KR101367507B1 (en)
CN (1) CN102427738B (en)
AU (1) AU2010270221B2 (en)
BR (1) BRPI1014873B1 (en)
CA (1) CA2760008C (en)
CL (1) CL2011002644A1 (en)
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IL (1) IL216544A (en)
MA (1) MA33370B1 (en)
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JP6584777B2 (en) * 2015-01-16 2019-10-02 太陽化学株式会社 Powder composition for beverages containing water electrolyte
CN111513331A (en) * 2020-04-16 2020-08-11 仙乐健康科技股份有限公司 Product containing probiotics
CN113398874B (en) * 2021-06-17 2023-08-15 干霸干燥剂(深圳)有限公司 Composite drying agent and preparation method thereof
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