RU2010119929A - Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины - Google Patents
Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины Download PDFInfo
- Publication number
- RU2010119929A RU2010119929A RU2010119929/15A RU2010119929A RU2010119929A RU 2010119929 A RU2010119929 A RU 2010119929A RU 2010119929/15 A RU2010119929/15 A RU 2010119929/15A RU 2010119929 A RU2010119929 A RU 2010119929A RU 2010119929 A RU2010119929 A RU 2010119929A
- Authority
- RU
- Russia
- Prior art keywords
- group
- pharmaceutically acceptable
- alkyl
- hydrogen
- active substance
- Prior art date
Links
- 239000007787 solid Substances 0.000 title claims abstract 32
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008180 pharmaceutical surfactant Substances 0.000 claims abstract 17
- 239000013543 active substance Substances 0.000 claims abstract 16
- 239000000126 substance Substances 0.000 claims abstract 13
- 239000007788 liquid Substances 0.000 claims abstract 11
- 239000011159 matrix material Substances 0.000 claims abstract 11
- 239000000203 mixture Substances 0.000 claims abstract 11
- 239000002904 solvent Substances 0.000 claims abstract 11
- 239000000463 material Substances 0.000 claims abstract 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract 7
- 229920001577 copolymer Polymers 0.000 claims abstract 5
- 239000000945 filler Substances 0.000 claims abstract 4
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract 3
- 229920002774 Maltodextrin Polymers 0.000 claims abstract 3
- 229920002678 cellulose Polymers 0.000 claims abstract 3
- 229920003086 cellulose ether Polymers 0.000 claims abstract 3
- 229940097362 cyclodextrins Drugs 0.000 claims abstract 3
- 229920001519 homopolymer Polymers 0.000 claims abstract 3
- 150000002632 lipids Chemical class 0.000 claims abstract 3
- 229920000642 polymer Polymers 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 19
- -1 fatty acid esters Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 150000005846 sugar alcohols Polymers 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 2
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000005456 glyceride group Chemical group 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 2
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical compound CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 2
- 229920001515 polyalkylene glycol Polymers 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000002036 drum drying Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 0 NC1=N*c2ccccc12 Chemical compound NC1=N*c2ccccc12 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99961807P | 2007-10-19 | 2007-10-19 | |
| US60/999,618 | 2007-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010119929A true RU2010119929A (ru) | 2011-11-27 |
Family
ID=40089463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119929/15A RU2010119929A (ru) | 2007-10-19 | 2008-10-17 | Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2197425A2 (fr) |
| JP (1) | JP2011500649A (fr) |
| KR (1) | KR20100087170A (fr) |
| CN (1) | CN101827584A (fr) |
| AU (1) | AU2008313622A1 (fr) |
| BR (1) | BRPI0818340A2 (fr) |
| CA (1) | CA2699301A1 (fr) |
| CO (1) | CO6270206A2 (fr) |
| CR (1) | CR11442A (fr) |
| DO (1) | DOP2010000117A (fr) |
| EC (1) | ECSP10010183A (fr) |
| GT (1) | GT201000102A (fr) |
| MX (1) | MX2010004291A (fr) |
| PA (1) | PA8800101A1 (fr) |
| RU (1) | RU2010119929A (fr) |
| UA (1) | UA100865C2 (fr) |
| WO (1) | WO2009050291A2 (fr) |
| ZA (1) | ZA201002095B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090203709A1 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical Dosage Form For Oral Administration Of Tyrosine Kinase Inhibitor |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| AU2011264993B2 (en) * | 2010-06-09 | 2014-02-06 | Abbvie Bahamas Ltd. | Solid dispersions containing kinase inhibitors |
| WO2013070996A1 (fr) | 2011-11-11 | 2013-05-16 | Novartis Ag | Procédé de traitement d'une maladie proliférative |
| EP2782557B1 (fr) | 2011-11-23 | 2018-09-12 | Array Biopharma, Inc. | Formulations pharmaceutiques |
| WO2014003678A1 (fr) * | 2012-06-28 | 2014-01-03 | Xspray Microparticles Ab | Compositions pharmaceutiques comprenant de l'ambrisentan et des particules de dispersion solide contenant du tadalafil |
| WO2014003677A1 (fr) * | 2012-06-28 | 2014-01-03 | Xspray Microparticles Ab | Compositions pharmaceutiques comprenant des particules de dispersion solide contenant du tadalafil |
| WO2016198983A1 (fr) | 2015-06-09 | 2016-12-15 | Bend Research Inc. | Formulations pour obtenir une dissolution rapide d'un médicament à partir de dispersions séchées par pulvérisation dans des capsules |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009513642A (ja) * | 2005-10-25 | 2009-04-02 | アボット・ラボラトリーズ | 低水溶解度の薬剤を含む製剤およびそれの使用方法 |
| WO2007066189A2 (fr) * | 2005-12-09 | 2007-06-14 | Pfizer Products Inc. | Sels, promedicaments et formulations de 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-uree |
| CA2667720A1 (fr) * | 2006-11-09 | 2008-05-15 | Abbott Gmbh & Co. Kg. | Forme de dosage pharmaceutique pour l'administration orale d'un inhibiteur de la tyrosine kinase |
-
2008
- 2008-10-17 AU AU2008313622A patent/AU2008313622A1/en not_active Abandoned
- 2008-10-17 KR KR1020107010979A patent/KR20100087170A/ko not_active Withdrawn
- 2008-10-17 UA UAA201006029A patent/UA100865C2/ru unknown
- 2008-10-17 BR BRPI0818340 patent/BRPI0818340A2/pt not_active IP Right Cessation
- 2008-10-17 WO PCT/EP2008/064076 patent/WO2009050291A2/fr not_active Ceased
- 2008-10-17 CN CN200880112150A patent/CN101827584A/zh active Pending
- 2008-10-17 CA CA2699301A patent/CA2699301A1/fr not_active Abandoned
- 2008-10-17 MX MX2010004291A patent/MX2010004291A/es not_active Application Discontinuation
- 2008-10-17 EP EP08839333A patent/EP2197425A2/fr not_active Withdrawn
- 2008-10-17 RU RU2010119929/15A patent/RU2010119929A/ru not_active Application Discontinuation
- 2008-10-17 PA PA20088800101A patent/PA8800101A1/es unknown
- 2008-10-17 JP JP2010529408A patent/JP2011500649A/ja active Pending
-
2010
- 2010-03-24 ZA ZA2010/02095A patent/ZA201002095B/en unknown
- 2010-04-16 DO DO2010000117A patent/DOP2010000117A/es unknown
- 2010-04-16 GT GT201000102A patent/GT201000102A/es unknown
- 2010-04-27 CO CO10049271A patent/CO6270206A2/es not_active Application Discontinuation
- 2010-05-17 EC EC2010010183A patent/ECSP10010183A/es unknown
- 2010-05-19 CR CR11442A patent/CR11442A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101827584A (zh) | 2010-09-08 |
| UA100865C2 (ru) | 2013-02-11 |
| CR11442A (es) | 2010-09-06 |
| GT201000102A (es) | 2012-03-12 |
| DOP2010000117A (es) | 2010-05-15 |
| CO6270206A2 (es) | 2011-04-20 |
| AU2008313622A1 (en) | 2009-04-23 |
| CA2699301A1 (fr) | 2009-04-23 |
| WO2009050291A3 (fr) | 2010-04-08 |
| EP2197425A2 (fr) | 2010-06-23 |
| KR20100087170A (ko) | 2010-08-03 |
| ECSP10010183A (es) | 2010-06-29 |
| ZA201002095B (en) | 2011-11-30 |
| WO2009050291A2 (fr) | 2009-04-23 |
| PA8800101A1 (es) | 2009-05-15 |
| JP2011500649A (ja) | 2011-01-06 |
| BRPI0818340A2 (pt) | 2015-04-22 |
| MX2010004291A (es) | 2010-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20140609 |