RU2010114475A - METHOD FOR CORRECTION OF OSTEOPOROSIS AND PREVENTION OF OCCURRENCE OF OSTEOPOROTIC FRACTURES WITH RESEVERROL IN COMBINATION WITH ENALAPRIL - Google Patents
METHOD FOR CORRECTION OF OSTEOPOROSIS AND PREVENTION OF OCCURRENCE OF OSTEOPOROTIC FRACTURES WITH RESEVERROL IN COMBINATION WITH ENALAPRIL Download PDFInfo
- Publication number
- RU2010114475A RU2010114475A RU2010114475/14A RU2010114475A RU2010114475A RU 2010114475 A RU2010114475 A RU 2010114475A RU 2010114475/14 A RU2010114475/14 A RU 2010114475/14A RU 2010114475 A RU2010114475 A RU 2010114475A RU 2010114475 A RU2010114475 A RU 2010114475A
- Authority
- RU
- Russia
- Prior art keywords
- osteoporosis
- enalapril
- occurrence
- combination
- dose
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title claims abstract 5
- 108010061435 Enalapril Proteins 0.000 title claims abstract 3
- 208000001164 Osteoporotic Fractures Diseases 0.000 title claims abstract 3
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 title claims abstract 3
- 229960000873 enalapril Drugs 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims abstract 3
- 230000002265 prevention Effects 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 claims abstract 4
- 238000009806 oophorectomy Methods 0.000 claims abstract 4
- 241000700157 Rattus norvegicus Species 0.000 claims abstract 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract 2
- 230000002146 bilateral effect Effects 0.000 claims abstract 2
- 230000004089 microcirculation Effects 0.000 claims abstract 2
- 230000000577 osteoprotective effect Effects 0.000 claims abstract 2
- 229940016667 resveratrol Drugs 0.000 claims abstract 2
- 235000021283 resveratrol Nutrition 0.000 claims abstract 2
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Способ коррекции остеопороза и профилактики возникновения остеопоротических переломов, отличающийся тем, что на фоне моделирования остеопороза в эксперименте с помощью билатеральной овариэктомии, самкам крыс линии Wistar в течение восьми недель после овариэктомии вводят ежедневно однократно в сутки внутрибрюшинно резвератрол в дозе 2 мг/кг и внутрижелудочно эналаприл в дозе 0,5 мг/кг, оценивая остеопротективное действие резвератрола в комбинации с эналаприлом по уровню микроциркуляции в костной ткани и ширине костных трабекул. A method for correcting osteoporosis and preventing the occurrence of osteoporotic fractures, characterized in that, against the background of modeling osteoporosis in an experiment using bilateral ovariectomy, female Wistar rats are injected intraperitoneally with a dose of 2 mg / kg and intragastrically daily once a day for eight weeks after ovariectomy. at a dose of 0.5 mg / kg, evaluating the osteoprotective effect of resveratrol in combination with enalapril according to the level of microcirculation in the bone tissue and the width of the bone trabeculae.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010114475/14A RU2437160C1 (en) | 2010-04-12 | 2010-04-12 | Method for reservatrol and enalapril based osteoporosis correction and fragility fracture prevention |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010114475/14A RU2437160C1 (en) | 2010-04-12 | 2010-04-12 | Method for reservatrol and enalapril based osteoporosis correction and fragility fracture prevention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010114475A true RU2010114475A (en) | 2011-10-20 |
| RU2437160C1 RU2437160C1 (en) | 2011-12-20 |
Family
ID=44998812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010114475/14A RU2437160C1 (en) | 2010-04-12 | 2010-04-12 | Method for reservatrol and enalapril based osteoporosis correction and fragility fracture prevention |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2437160C1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2541184C1 (en) * | 2013-09-23 | 2015-02-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Method for correction of bone tissue microcirculaton in experimental osteoporosis and associated fractures with combination of recombinant erythropoietin and rosuvastatin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2301670C1 (en) * | 2005-12-28 | 2007-06-27 | Михаил Владимирович Покровский | Method for correction of endothelial dysfunction by combination of enalapril and resveratrol in l-name-induced deficiency of nitrogen oxide |
| WO2009082459A2 (en) * | 2007-12-24 | 2009-07-02 | Natrol, Inc. | Anti-aging composition containing resveratrol and method of administration |
| RU2369390C1 (en) * | 2008-06-02 | 2009-10-10 | Михаил Владимирович Покровский | Method of osteoporosis correction and prevention of osteoporotic fracture by means of enalaprils |
-
2010
- 2010-04-12 RU RU2010114475/14A patent/RU2437160C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2437160C1 (en) | 2011-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120413 |