RU2010152024A - DALARGIN-CONTAINING INTRANASAL COMPOSITION AS A SPRAY, METHOD FOR ITS MANUFACTURE AND APPLICATION FOR TREATMENT OF GASTROENTEROLOGICAL DISEASES - Google Patents
DALARGIN-CONTAINING INTRANASAL COMPOSITION AS A SPRAY, METHOD FOR ITS MANUFACTURE AND APPLICATION FOR TREATMENT OF GASTROENTEROLOGICAL DISEASES Download PDFInfo
- Publication number
- RU2010152024A RU2010152024A RU2010152024/10A RU2010152024A RU2010152024A RU 2010152024 A RU2010152024 A RU 2010152024A RU 2010152024/10 A RU2010152024/10 A RU 2010152024/10A RU 2010152024 A RU2010152024 A RU 2010152024A RU 2010152024 A RU2010152024 A RU 2010152024A
- Authority
- RU
- Russia
- Prior art keywords
- dalargin
- water
- spray
- composition
- loading
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 18
- 238000000034 method Methods 0.000 title claims abstract 7
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 201000010099 disease Diseases 0.000 title claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 6
- GDPHPXYFLPDZGH-XBTMSFKCSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 GDPHPXYFLPDZGH-XBTMSFKCSA-N 0.000 claims abstract 21
- 108700029992 Ala(2)-Arg(6)- enkephalin-Leu Proteins 0.000 claims abstract 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 14
- 239000000243 solution Substances 0.000 claims abstract 9
- 239000007921 spray Substances 0.000 claims abstract 9
- 239000011780 sodium chloride Substances 0.000 claims abstract 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract 6
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 6
- 238000003756 stirring Methods 0.000 claims abstract 6
- 238000001914 filtration Methods 0.000 claims abstract 3
- 230000001954 sterilising effect Effects 0.000 claims abstract 3
- 239000013543 active substance Substances 0.000 claims abstract 2
- 238000002156 mixing Methods 0.000 claims abstract 2
- 239000008213 purified water Substances 0.000 claims abstract 2
- 238000007789 sealing Methods 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 239000008215 water for injection Substances 0.000 claims abstract 2
- 208000009663 Acute Necrotizing Pancreatitis Diseases 0.000 claims 1
- 206010058096 Pancreatic necrosis Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 238000009434 installation Methods 0.000 claims 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Даларгинсодержащая интраназальная композиция в виде спрея, содержащая в качестве активного вещества даларгин и вспомогательные вещества. ! 2. Композиция по п.1, характеризующаяся тем, что она содержит даларгин и вспомогательные вещества при следующем соотношении компонентов, мас.%: ! даларгин 26,12-33,11 вспомогательные вещества 66,89-73,88 ! 3. Композиция по п.2, характеризующаяся тем, что она содержит в качестве вспомогательных веществ натрия хлорид, бензалкония хлорид и воду при следующем соотношении компонентов, мас.%: ! даларгин 26,12-33,11 натрия хлорид 59,6-65,83бензалкония хлорид 0,66-0,73 вода остальное ! 4. Композиция по п.3, характеризующаяся тем, что она содержит в качестве воды воду для инъекций. ! 5. Композиция по п.3, характеризующаяся тем, что она содержит в качестве воды очищенную воду. ! 6. Способ изготовления даларгинсодержащей интраназальной композиции в виде спрея, включающий подачу в снабженную мешалкой емкость воды, загрузку в емкость при перемешивании натрия хлорида, последующую загрузку при перемешивании бензалкония хлорида, осуществление перемешивания до полного растворения компонентов, загрузку даларгина с перемешиванием до полного его растворения, осуществление стерилизующей фильтрации раствора и розлив с дозированием полученного раствора во флаконы и их герметизацию микроспреерами. ! 7. Способ по п.6, характеризующийся тем, что загружают натрия хлорид в емкость до получения 0,9%-го раствора. ! 8. Способ по п.6 или 7, характеризующийся тем, что после загрузки в емкость даларгина осуществляют перемешивание раствора в течение 20-25 мин. ! 9. Способ по п.8, характеризующийся тем, что осуществляют ст� 1. Dalargin-containing intranasal composition in the form of a spray containing dalargin and excipients as an active substance. ! 2. The composition according to claim 1, characterized in that it contains dalargin and excipients in the following ratio of components, wt.%:! dalargin 26.12-33.11 excipients 66.89-73.88! 3. The composition according to claim 2, characterized in that it contains sodium chloride, benzalkonium chloride and water as auxiliary substances in the following ratio, wt.%:! dalargin 26.12-33.11 sodium chloride 59.6-65.83 benzalkonium chloride 0.66-0.73 water the rest! 4. The composition according to claim 3, characterized in that it contains water for injection as water. ! 5. The composition according to claim 3, characterized in that it contains purified water as water. ! 6. A method of manufacturing a dalargin-containing intranasal composition in the form of a spray, comprising supplying water to a tank equipped with a stirrer, loading sodium chloride into a container with stirring, subsequent loading of benzalkonium chloride with stirring, mixing until the components are completely dissolved, loading of dalargin with stirring until it is completely dissolved, sterilizing solution filtration and dispensing with dosing of the resulting solution into vials and sealing them with microspreaders. ! 7. The method according to claim 6, characterized in that sodium chloride is loaded into a container until a 0.9% solution is obtained. ! 8. The method according to claim 6 or 7, characterized in that after loading into the container of dalargin, the solution is mixed for 20-25 minutes. ! 9. The method according to claim 8, characterized in that they carry out
Claims (14)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010152024/10A RU2010152024A (en) | 2010-12-20 | 2010-12-20 | DALARGIN-CONTAINING INTRANASAL COMPOSITION AS A SPRAY, METHOD FOR ITS MANUFACTURE AND APPLICATION FOR TREATMENT OF GASTROENTEROLOGICAL DISEASES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010152024/10A RU2010152024A (en) | 2010-12-20 | 2010-12-20 | DALARGIN-CONTAINING INTRANASAL COMPOSITION AS A SPRAY, METHOD FOR ITS MANUFACTURE AND APPLICATION FOR TREATMENT OF GASTROENTEROLOGICAL DISEASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010152024A true RU2010152024A (en) | 2012-06-27 |
Family
ID=46681519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010152024/10A RU2010152024A (en) | 2010-12-20 | 2010-12-20 | DALARGIN-CONTAINING INTRANASAL COMPOSITION AS A SPRAY, METHOD FOR ITS MANUFACTURE AND APPLICATION FOR TREATMENT OF GASTROENTEROLOGICAL DISEASES |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2010152024A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3556377A1 (en) | 2018-04-18 | 2019-10-23 | PVP Labs PTE. Ltd. | Antiviral immunotropic agent for the treatment of acute respiratory viral infections |
-
2010
- 2010-12-20 RU RU2010152024/10A patent/RU2010152024A/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3556377A1 (en) | 2018-04-18 | 2019-10-23 | PVP Labs PTE. Ltd. | Antiviral immunotropic agent for the treatment of acute respiratory viral infections |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20121210 |