RU2010145439A - MEANS FOR TREATMENT OF LIVER DISEASES CAUSED BY EXPOSURE TO CHEMICAL OR BIOLOGICAL AGENTS - Google Patents
MEANS FOR TREATMENT OF LIVER DISEASES CAUSED BY EXPOSURE TO CHEMICAL OR BIOLOGICAL AGENTS Download PDFInfo
- Publication number
- RU2010145439A RU2010145439A RU2010145439/15A RU2010145439A RU2010145439A RU 2010145439 A RU2010145439 A RU 2010145439A RU 2010145439/15 A RU2010145439/15 A RU 2010145439/15A RU 2010145439 A RU2010145439 A RU 2010145439A RU 2010145439 A RU2010145439 A RU 2010145439A
- Authority
- RU
- Russia
- Prior art keywords
- exposure
- chemical
- biological agents
- treatment
- diseases caused
- Prior art date
Links
- 239000003124 biologic agent Substances 0.000 title claims abstract 3
- 239000013043 chemical agent Substances 0.000 title claims abstract 3
- 208000019423 liver disease Diseases 0.000 title 1
- KLAOPOKEJSDMEV-UHFFFAOYSA-N 1-(4-bromophenyl)-6-hydroxy-5-nitrosopyrimidine-2,4-dione Chemical group OC1=C(N=O)C(=O)NC(=O)N1C1=CC=C(Br)C=C1 KLAOPOKEJSDMEV-UHFFFAOYSA-N 0.000 claims abstract 2
- 206010067125 Liver injury Diseases 0.000 claims abstract 2
- 150000001768 cations Chemical class 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 231100000234 hepatic damage Toxicity 0.000 claims abstract 2
- 230000008818 liver damage Effects 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Средство для лечения поражений печени, вызванных воздействием химических или биологических агентов, отличающееся тем, что оно представляет собой 1-(4-бромфенил)-6-гидрокси-5-нитрозо-1,2,3,4-тетрагидро-пиримидин-2.4-дион: !! или его соли общей формулы: ! , ! где X выбран из ряда: Na+, K+, Li+, NH4 +, NH2CONH3 + или другой фармакологически приемлемый катион. An agent for treating liver damage caused by exposure to chemical or biological agents, characterized in that it is 1- (4-bromophenyl) -6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidin-2.4- dion: !! or its salts of the general formula:! ! where X is selected from the series: Na +, K +, Li +, NH4 +, NH2CONH3 + or another pharmacologically acceptable cation.
Claims (1)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010145439/15A RU2010145439A (en) | 2010-11-08 | 2010-11-08 | MEANS FOR TREATMENT OF LIVER DISEASES CAUSED BY EXPOSURE TO CHEMICAL OR BIOLOGICAL AGENTS |
| ES11839641T ES2730943T3 (en) | 2010-11-08 | 2011-10-10 | Drug to treat liver lesions caused by the action of chemical or biological agents |
| US13/883,854 US8999959B2 (en) | 2010-11-08 | 2011-10-10 | Drug for treating liver lesions caused by the action of chemical or biological agents |
| PL11839641T PL2638900T3 (en) | 2010-11-08 | 2011-10-10 | Drug for treating liver lesions caused by the action of chemical or biological agents |
| EP11839641.5A EP2638900B1 (en) | 2010-11-08 | 2011-10-10 | Drug for treating liver lesions caused by the action of chemical or biological agents |
| PCT/RU2011/000792 WO2012064221A1 (en) | 2010-11-08 | 2011-10-10 | Drug for treating liver lesions caused by the action of chemical or biological agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010145439/15A RU2010145439A (en) | 2010-11-08 | 2010-11-08 | MEANS FOR TREATMENT OF LIVER DISEASES CAUSED BY EXPOSURE TO CHEMICAL OR BIOLOGICAL AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010145439A true RU2010145439A (en) | 2012-05-20 |
Family
ID=46051175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010145439/15A RU2010145439A (en) | 2010-11-08 | 2010-11-08 | MEANS FOR TREATMENT OF LIVER DISEASES CAUSED BY EXPOSURE TO CHEMICAL OR BIOLOGICAL AGENTS |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8999959B2 (en) |
| EP (1) | EP2638900B1 (en) |
| ES (1) | ES2730943T3 (en) |
| PL (1) | PL2638900T3 (en) |
| RU (1) | RU2010145439A (en) |
| WO (1) | WO2012064221A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2595868C1 (en) * | 2015-03-27 | 2016-08-27 | Виктор Вениаминович Тец | Drug preparation with hepatoprotective activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2333537A1 (en) | 1998-05-26 | 1999-12-02 | Rimma Iliinichna Ashkinazi | N-substituted derivatives of 5-oxyiminobarbituric acid |
| RU2188196C2 (en) | 1998-05-26 | 2002-08-27 | Ашкинази Римма Ильинична | N-substituted derivatives of 5-hydroxyimino-barbituric acid |
| AU2001282162A1 (en) | 2000-07-05 | 2002-01-14 | Biotie Therapies Corp. | Inhibitors of copper-containing amine oxidases |
-
2010
- 2010-11-08 RU RU2010145439/15A patent/RU2010145439A/en unknown
-
2011
- 2011-10-10 ES ES11839641T patent/ES2730943T3/en active Active
- 2011-10-10 EP EP11839641.5A patent/EP2638900B1/en active Active
- 2011-10-10 US US13/883,854 patent/US8999959B2/en active Active
- 2011-10-10 PL PL11839641T patent/PL2638900T3/en unknown
- 2011-10-10 WO PCT/RU2011/000792 patent/WO2012064221A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2638900A4 (en) | 2014-04-02 |
| PL2638900T3 (en) | 2019-11-29 |
| ES2730943T3 (en) | 2019-11-13 |
| US20130237704A1 (en) | 2013-09-12 |
| EP2638900B1 (en) | 2019-05-15 |
| US8999959B2 (en) | 2015-04-07 |
| EP2638900A1 (en) | 2013-09-18 |
| WO2012064221A1 (en) | 2012-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1122266T1 (en) | 3-AMINOCYCLALKYL COMPOUNDS AS ROR-GAMMA-T INHIBITORS AND USES THEREOF | |
| CY1124519T1 (en) | SOLID AND PHARMACEUTICAL FORMS OF (S)-4-(8-AMINO-3-(1-(BUT-2-YNOYL)PYRROLIDIN-2-YL)IMIDAZO[1,5-α|PYZIN-1-YL)- N-(PYRIDIN-2-YL) BENZAMIDO | |
| CY1119533T1 (en) | NEW THERAPEUTIC FACTORS | |
| CY1122272T1 (en) | 3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | |
| GT201600123A (en) | SYK INHIBITORS | |
| UA111770C2 (en) | BROMDOMEN INHIBITORS | |
| UA109667C2 (en) | HINAZOLINE-4 (3H) -ONE DERIVATIVES USED AS PI3-KINASE INHIBITORS | |
| EA201170832A1 (en) | PURINE CONNECTIONS | |
| EA201100750A1 (en) | SUBSTITUTED DIOXOPIPERIDINYL-PHTHALIMIDE DERIVATIVES | |
| ECSP099786A (en) | PIRAZOL AMIDAS OF CARBOXYL ACID USEFUL AS MICROBICIDES | |
| TR201905814T4 (en) | Biprazole salt as a jack inhibitor. | |
| DOP2015000305A (en) | BROMODOMINIUM INHIBITORS | |
| EA201400735A1 (en) | DERIVATIVES ALPHA-AMINO BORONIC ACID, SELECTIVE INHIBITORS IMMUNOPROTEASOMA | |
| MX2019008122A (en) | Heterocycle amines and uses thereof. | |
| EA201300684A1 (en) | DERIVATIVES OF 6-AMINO-2-PHENYLAMINO-1H-BENZIMIDAZOLE-5-CARBOXAMIDE AND THEIR APPLICATION AS AN INHIBITORS OF MICROSOMIC PROSTAGLANDIN-E2-SYNTHASE-1 | |
| EA201590748A1 (en) | ANTI-VIRUS CONNECTIONS AGAINST RSV | |
| MX374513B (en) | HETEROARYL ACID MORPHOLINONE COMPOUNDS AS MDM2 INHIBITORS FOR CANCER TREATMENT. | |
| EA201291300A1 (en) | DERIVATIVES OF NAFT-2-LUCUS ACID FOR THE TREATMENT OF AIDS | |
| CY1116168T1 (en) | TOY CCR3 HYPERCELLULATORS AND SALT SALTS | |
| EA201301301A1 (en) | TIAZOLE DERIVATIVES | |
| EA201790779A1 (en) | SUBSTITUTED AMINOPURIN COMPOUNDS, THEIR COMPOSITIONS AND METHODS OF TREATMENT USING SUCH CONNECTIONS | |
| CR20140135A (en) | NEW DERIVATIVES OF ARIL-QUINOLINA | |
| AR077080A1 (en) | COMPOUNDS OF 2,3-DIHIDRO-1H-INDENO | |
| EA201491276A1 (en) | NEW BENZILSULPHONAMIDE DERIVATIVES SUITABLE FOR USE AS MOGAT-2 INHIBITORS | |
| EA201200087A1 (en) | 2-CARBOXAMIDES CYCLOAMINUM CEAMS WHICH ARE PI3K INHIBITORS |