RU2010141846A - Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций - Google Patents
Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций Download PDFInfo
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- RU2010141846A RU2010141846A RU2010141846/15A RU2010141846A RU2010141846A RU 2010141846 A RU2010141846 A RU 2010141846A RU 2010141846/15 A RU2010141846/15 A RU 2010141846/15A RU 2010141846 A RU2010141846 A RU 2010141846A RU 2010141846 A RU2010141846 A RU 2010141846A
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- Prior art keywords
- restenotic
- acid ester
- citric acid
- acetyl
- atrombogenic
- Prior art date
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- 229940127554 medical product Drugs 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract 16
- 230000002769 anti-restenotic effect Effects 0.000 claims abstract 11
- -1 citric acid ester Chemical class 0.000 claims abstract 8
- 230000001772 anti-angiogenic effect Effects 0.000 claims abstract 7
- 230000001532 anti-fungicidal effect Effects 0.000 claims abstract 7
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract 7
- 230000000118 anti-neoplastic effect Effects 0.000 claims abstract 7
- 230000001028 anti-proliverative effect Effects 0.000 claims abstract 7
- 229940034982 antineoplastic agent Drugs 0.000 claims abstract 7
- 239000000824 cytostatic agent Substances 0.000 claims abstract 7
- 230000001085 cytostatic effect Effects 0.000 claims abstract 7
- 231100000433 cytotoxic Toxicity 0.000 claims abstract 7
- 230000001472 cytotoxic effect Effects 0.000 claims abstract 7
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical group CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims abstract 6
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims abstract 6
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000002965 anti-thrombogenic effect Effects 0.000 claims abstract 5
- 239000013543 active substance Substances 0.000 claims abstract 4
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims abstract 3
- 230000001946 anti-microtubular Effects 0.000 claims abstract 3
- 230000002095 anti-migrative effect Effects 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 125000000524 functional group Chemical group 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 208000037803 restenosis Diseases 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 239000001069 triethyl citrate Substances 0.000 claims abstract 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims abstract 3
- 235000013769 triethyl citrate Nutrition 0.000 claims abstract 3
- 239000011248 coating agent Substances 0.000 claims abstract 2
- 238000000576 coating method Methods 0.000 claims abstract 2
- 238000013508 migration Methods 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1088—Balloon catheters with special features or adapted for special applications having special surface characteristics depending on material properties or added substances, e.g. for reducing friction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Manufacturing & Machinery (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Применение эфира лимонной кислоты и противовоспалительного, цитостатического, цитотоксического, антипролиферативного, антимикротубулярного, антиангиогенного, антирестенотического (анти-рестенозные), антифунгицидного, антинеопластического, антимиграционного, атромбогенного или антитромбогенного активного вещества для покрытия катетер-баллона. ! 2. Применение по п.1, в котором эфир лимонной кислоты представляет собой ацетилтрибутилцитрат или ацетилтриэтилцитрат или соединение следующей структуры: ! ! где R, R' и R” независимо друг от друга означают атом водорода или линейный или разветвленный, насыщенный или ненасыщенный, замещенный по меньшей мере одной функциональной группой или незамещенный алкильный остаток, арилалкильный остаток или циклоалкильный остаток. ! 3. Применение по п.1, в котором эфиром лимонной кислоты является представитель из группы, состоящей из триэтилцитрата, ацетилтриэтилцитрата, трибутилцитрата и ацетилтрибутилцитрата. ! 4. Применение по п.1, в котором по меньшей мере одно противовоспалительное, цитостатическое, цитотоксическое, антипролиферативное, антимикротубулярное, антиангиогенное, антирестенотическое (анти-рестенозное), антифунгицидное, антинеопластическое, антимиграционное, атромбогенное или антитромбогенного активное вещество представляет собой паклитаксел. ! 5. Катетер-баллон с покрытием по меньшей мере из одного противовоспалительного, цитостатического, цитотоксического, антипролиферативного, антимикротубулярного, антиангиогенного, антирестенотического (анти-рестенозные), антифунгицидного, антинеопластического, антимиграционного, атромбогенного или анти
Claims (8)
1. Применение эфира лимонной кислоты и противовоспалительного, цитостатического, цитотоксического, антипролиферативного, антимикротубулярного, антиангиогенного, антирестенотического (анти-рестенозные), антифунгицидного, антинеопластического, антимиграционного, атромбогенного или антитромбогенного активного вещества для покрытия катетер-баллона.
2. Применение по п.1, в котором эфир лимонной кислоты представляет собой ацетилтрибутилцитрат или ацетилтриэтилцитрат или соединение следующей структуры:
где R, R' и R” независимо друг от друга означают атом водорода или линейный или разветвленный, насыщенный или ненасыщенный, замещенный по меньшей мере одной функциональной группой или незамещенный алкильный остаток, арилалкильный остаток или циклоалкильный остаток.
3. Применение по п.1, в котором эфиром лимонной кислоты является представитель из группы, состоящей из триэтилцитрата, ацетилтриэтилцитрата, трибутилцитрата и ацетилтрибутилцитрата.
4. Применение по п.1, в котором по меньшей мере одно противовоспалительное, цитостатическое, цитотоксическое, антипролиферативное, антимикротубулярное, антиангиогенное, антирестенотическое (анти-рестенозное), антифунгицидное, антинеопластическое, антимиграционное, атромбогенное или антитромбогенного активное вещество представляет собой паклитаксел.
5. Катетер-баллон с покрытием по меньшей мере из одного противовоспалительного, цитостатического, цитотоксического, антипролиферативного, антимикротубулярного, антиангиогенного, антирестенотического (анти-рестенозные), антифунгицидного, антинеопластического, антимиграционного, атромбогенного или антитромбогенного активного вещества и эфир лимонной кислоты.
6. Катетер-баллон по п.5, в котором эфир лимонной кислоты представляет собой ацетилтрибутилцитрат или ацетилтриэтилцитрат или соединение следующей структуры:
где R, R' и R” независимо друг от друга означают атом водорода или линейный или разветвленный, насыщенный или ненасыщенный, замещенный по меньшей мере одной функциональной группой или незамещенный алкильный остаток, арилалкильный остаток или циклоалкильный остаток.
7. Катетер-баллон по п.5, в котором эфиром лимонной кислоты является представитель из группы, состоящей из триэтилцитрата, ацетилтриэтилцитрата, трибутилцитрата и ацетилтрибутилцитрата.
8. Катетер-баллон по п.5, в котором по меньшей мере одно противовоспалительное, цитостатическое, цитотоксическое, антипролиферативное, антимикротубулярное, антиангиогенное, антирестенотическое (анти-рестенозное), антифунгицидное, антинеопластическое, антимиграционное, атромбогенное или антитромбогенного активное вещество представляет собой паклитаксел.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007003914 | 2007-01-21 | ||
| DE102007003914.1 | 2007-01-21 | ||
| DE102007006557.6 | 2007-02-09 | ||
| DE102007006557 | 2007-02-09 | ||
| DE102007013586 | 2007-03-21 | ||
| DE102007013586.8 | 2007-03-21 | ||
| PCT/DE2008/000096 WO2008086794A2 (de) | 2007-01-21 | 2008-01-21 | Medizinprodukt zur behandlung von verschlüssen von körperdurchgängen und zur prävention drohender wiederverschlüsse |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009131598/15A Division RU2447901C2 (ru) | 2007-01-21 | 2008-01-21 | Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010141846A true RU2010141846A (ru) | 2012-04-20 |
| RU2458710C2 RU2458710C2 (ru) | 2012-08-20 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009131598/15A RU2447901C2 (ru) | 2007-01-21 | 2008-01-21 | Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций |
| RU2010141846/15A RU2458710C2 (ru) | 2007-01-21 | 2008-01-21 | Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009131598/15A RU2447901C2 (ru) | 2007-01-21 | 2008-01-21 | Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8597720B2 (ru) |
| EP (3) | EP2269664B1 (ru) |
| JP (2) | JP4906926B2 (ru) |
| KR (3) | KR101198980B1 (ru) |
| CN (2) | CN101972492B (ru) |
| AU (2) | AU2008207191B2 (ru) |
| BR (2) | BRPI0806727B8 (ru) |
| CA (2) | CA2673991C (ru) |
| DE (1) | DE112008000881A5 (ru) |
| ES (2) | ES2409759T3 (ru) |
| IL (2) | IL199568A (ru) |
| MX (2) | MX336844B (ru) |
| NZ (2) | NZ588816A (ru) |
| PL (2) | PL2269664T3 (ru) |
| RU (2) | RU2447901C2 (ru) |
| WO (1) | WO2008086794A2 (ru) |
| ZA (1) | ZA201007601B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2766047C2 (ru) * | 2015-12-02 | 2022-02-07 | Ньюрескью Апс | Устройство и способ для неотложного лечения остановки сердца |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
| US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| FR2892939B1 (fr) * | 2005-11-10 | 2010-01-22 | Groupement Coeur Artificiel Total Carpentier Matra Carmat | Materiau hemocompatible composite et son procede d'obtention |
| DE112007000906A5 (de) * | 2006-02-09 | 2009-01-15 | B. Braun Melsungen Ag | Faltenballonbeschichtungsverfahren |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2766047C2 (ru) * | 2015-12-02 | 2022-02-07 | Ньюрескью Апс | Устройство и способ для неотложного лечения остановки сердца |
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