RU2009140097A - APPLICATION OF A TETRANITROSIL IRON COMPLEX WITH THIOPHENOL AS AN ANTUMOR MEDICINE - Google Patents
APPLICATION OF A TETRANITROSIL IRON COMPLEX WITH THIOPHENOL AS AN ANTUMOR MEDICINE Download PDFInfo
- Publication number
- RU2009140097A RU2009140097A RU2009140097/15A RU2009140097A RU2009140097A RU 2009140097 A RU2009140097 A RU 2009140097A RU 2009140097/15 A RU2009140097/15 A RU 2009140097/15A RU 2009140097 A RU2009140097 A RU 2009140097A RU 2009140097 A RU2009140097 A RU 2009140097A
- Authority
- RU
- Russia
- Prior art keywords
- thiophenol
- pharmaceutical composition
- tetranitrosyl
- formula
- iron
- Prior art date
Links
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 title claims abstract 33
- 150000004698 iron complex Chemical class 0.000 title claims abstract 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract 12
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 12
- 239000003937 drug carrier Substances 0.000 claims abstract 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract 4
- 201000011510 cancer Diseases 0.000 claims abstract 4
- 229910052742 iron Inorganic materials 0.000 claims abstract 4
- 239000002246 antineoplastic agent Substances 0.000 claims abstract 2
- 229940041181 antineoplastic drug Drugs 0.000 claims abstract 2
- 229920001222 biopolymer Polymers 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000002504 physiological saline solution Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Применение тетранитрозильного комплекса железа с тиофенолом формулы [Fe2(SC6H5)2(NO)4] в качестве противоопухолевого лекарственного средства. ! 2. Применение тетранитрозильного комплекса железа с тиофенолом формулы [Fe2(SC6H5)2(NO)4] для получения лекарственного средства для лечения онкологических заболеваний. ! 3. Фармацевтическая композиция, содержащая эффективное количество тетранитрозильного комплекса железа с тиофенолом формулы [Fe2(SC6H5)2(NO)4], фармацевтически приемлемый носитель. ! 4. Фармацевтическая композиция по п.3, где в качестве фармацевтически приемлемого носителя используют протонсодержащую среду. ! 5. Фармацевтическая композиция по п.3, где в качестве фармацевтически приемлемого носителя используют смесь протонсодержащей среды и диметилсульфоксида. ! 6. Фармацевтическая композиция по любому из пп.4 или 5, где в качестве протонсодержащей среды используют воду, физиологический раствор, водорастворимые биополимеры. ! 7. Фармацевтическая композиция по п.3, где тетранитрозильный комплекс железа с тиофенолом присутствует в количестве 50-100 мкМ. ! 8. Набор, применяемый для лечения онкологических заболеваний, включающий: (1) фармацевтическую композицию, содержащую тетранитрозильный биядерный комплекс железа с тиофенолом формулы [Fe2(SC6H5)2(NO)4], в герметичной упаковке; и (2) вспомогательные средства. 1. The use of a tetranitrosyl iron complex with a thiophenol of the formula [Fe2 (SC6H5) 2 (NO) 4] as an antitumor drug. ! 2. The use of a tetranitrosyl iron complex with thiophenol of the formula [Fe2 (SC6H5) 2 (NO) 4] for the manufacture of a medicament for the treatment of cancer. ! 3. A pharmaceutical composition comprising an effective amount of a tetranitrosyl iron complex with a thiophenol of the formula [Fe2 (SC6H5) 2 (NO) 4], a pharmaceutically acceptable carrier. ! 4. The pharmaceutical composition according to claim 3, where a proton-containing medium is used as a pharmaceutically acceptable carrier. ! 5. The pharmaceutical composition according to claim 3, where as a pharmaceutically acceptable carrier using a mixture of proton-containing medium and dimethyl sulfoxide. ! 6. The pharmaceutical composition according to any one of claims 4 or 5, wherein water, physiological saline, and water-soluble biopolymers are used as the proton-containing medium. ! 7. The pharmaceutical composition according to claim 3, where the tetranitrosyl complex of iron with thiophenol is present in an amount of 50-100 μm. ! 8. A kit used for the treatment of cancer, including: (1) a pharmaceutical composition containing a tetranitrosyl binuclear complex of iron with a thiophenol of the formula [Fe2 (SC6H5) 2 (NO) 4], in a sealed package; and (2) auxiliaries.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009140097/15A RU2429242C2 (en) | 2007-05-30 | 2007-05-30 | Using tetranitrosyl complex of iron with thiophenol as anti-tumour medicinal agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009140097/15A RU2429242C2 (en) | 2007-05-30 | 2007-05-30 | Using tetranitrosyl complex of iron with thiophenol as anti-tumour medicinal agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009140097A true RU2009140097A (en) | 2011-05-10 |
| RU2429242C2 RU2429242C2 (en) | 2011-09-20 |
Family
ID=44732211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009140097/15A RU2429242C2 (en) | 2007-05-30 | 2007-05-30 | Using tetranitrosyl complex of iron with thiophenol as anti-tumour medicinal agent |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2429242C2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494104C2 (en) * | 2011-10-20 | 2013-09-27 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | Mononeclear dinitrosyl ferric complexes, method for preparing mononeclear dinitrosyl ferric complexes, nitrogen monoxide donor, using mononeclear dinitrosyl ferric complexes as anti-tumour drug |
| AU2013257546B2 (en) | 2012-05-10 | 2017-12-14 | Painreform Ltd. | Depot formulations of a local anesthetic and methods for preparation thereof |
| RU2687269C2 (en) * | 2016-12-28 | 2019-05-13 | Общество с ограниченной ответственностью "Фарма-Нит" (ООО "Фарма-Нит") | Use of nitrosyl iron complex with n,n-diethylthiourea as new no-donor anticancer agent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2291880C1 (en) * | 2005-12-01 | 2007-01-20 | Институт химической физики им. Н.Н. Семенова РАН (ИХФ РАН) | Polymer composition for preparing stabilized form of iron dinitrozyl complex and a method for preparing indicated form of complex |
| US8067628B2 (en) * | 2008-06-02 | 2011-11-29 | Institute of Problems of Chemcial Physics RAS (IPCP RAS) | Water-soluble binuclear nitrosyl iron complexes with natural aliphatic thiolyls possessing cytotoxic, apoptotic and no-donor activity |
-
2007
- 2007-05-30 RU RU2009140097/15A patent/RU2429242C2/en active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2429242C2 (en) | 2011-09-20 |
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