RU2008114496A - Противомикробные препараты, содержащие инкапсулированный в липосомах октенидина дигидрохлорид - Google Patents
Противомикробные препараты, содержащие инкапсулированный в липосомах октенидина дигидрохлорид Download PDFInfo
- Publication number
- RU2008114496A RU2008114496A RU2008114496/15A RU2008114496A RU2008114496A RU 2008114496 A RU2008114496 A RU 2008114496A RU 2008114496/15 A RU2008114496/15 A RU 2008114496/15A RU 2008114496 A RU2008114496 A RU 2008114496A RU 2008114496 A RU2008114496 A RU 2008114496A
- Authority
- RU
- Russia
- Prior art keywords
- weight
- octenidine
- drug
- dihydrochloride
- liposomes
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract 13
- 229940079593 drug Drugs 0.000 title claims abstract 13
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 title claims abstract 11
- 239000002502 liposome Substances 0.000 title claims abstract 5
- 229960001774 octenidine Drugs 0.000 title claims abstract 5
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract 3
- 239000004599 antimicrobial Substances 0.000 title claims abstract 3
- 150000003904 phospholipids Chemical class 0.000 claims abstract 8
- 239000006071 cream Substances 0.000 claims abstract 2
- 230000003013 cytotoxicity Effects 0.000 claims abstract 2
- 231100000135 cytotoxicity Toxicity 0.000 claims abstract 2
- 239000006185 dispersion Substances 0.000 claims abstract 2
- 239000000499 gel Substances 0.000 claims abstract 2
- 125000005639 glycero group Chemical group 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000002674 ointment Substances 0.000 claims abstract 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims abstract 2
- 239000000829 suppository Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Abstract
1. Противомикробный препарат, который содержит октенидина дигидрохлорид, инкапсулированный в липосомах. ! 2. Препарат по п.1, отличающийся тем, что он находится в форме раствора, дисперсии, геля, крема, мази или суппозитория. ! 3. Препарат по п.1 или 2, отличающийся тем, что он содержит от 0,001 до 5% по весу, предпочтительно от 0,003 до 1% по весу, более предпочтительно от 0,005 до 0,1% по весу, в частности от 0,01 до 0,06% по весу октенидина дигидрохлорид (в расчете на массу препарата). ! 4. Препарат по п.1, отличающийся тем, что липосомы содержат (глицеро)фосфолипиды, предпочтительно фосфатидилхолин. ! 5. Препарат по п.4, отличающийся тем, что количество фосфолипида составляет от 0,1 до 30% по весу, предпочтительно от 0,5 до 20% по весу, в частности от 1 до 10% по весу, например от 3 до 8% по весу, в расчете на массу конечного препарата. ! 6. Способ получения содержащего октенидина дигидрохлорид антимикробного препарата, в котором воду смешивают с фосфолипидом и октенидина дигидрохлоридом при повышенной температуре, и эту смесь затем гомогенизируют. ! 7. Применение фосфолипидов для получения содержащего октенидина дигидрохлорид препарата для уменьшения цитотоксичности препарата.
Claims (7)
1. Противомикробный препарат, который содержит октенидина дигидрохлорид, инкапсулированный в липосомах.
2. Препарат по п.1, отличающийся тем, что он находится в форме раствора, дисперсии, геля, крема, мази или суппозитория.
3. Препарат по п.1 или 2, отличающийся тем, что он содержит от 0,001 до 5% по весу, предпочтительно от 0,003 до 1% по весу, более предпочтительно от 0,005 до 0,1% по весу, в частности от 0,01 до 0,06% по весу октенидина дигидрохлорид (в расчете на массу препарата).
4. Препарат по п.1, отличающийся тем, что липосомы содержат (глицеро)фосфолипиды, предпочтительно фосфатидилхолин.
5. Препарат по п.4, отличающийся тем, что количество фосфолипида составляет от 0,1 до 30% по весу, предпочтительно от 0,5 до 20% по весу, в частности от 1 до 10% по весу, например от 3 до 8% по весу, в расчете на массу конечного препарата.
6. Способ получения содержащего октенидина дигидрохлорид антимикробного препарата, в котором воду смешивают с фосфолипидом и октенидина дигидрохлоридом при повышенной температуре, и эту смесь затем гомогенизируют.
7. Применение фосфолипидов для получения содержащего октенидина дигидрохлорид препарата для уменьшения цитотоксичности препарата.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005045146A DE102005045146A1 (de) | 2005-09-15 | 2005-09-15 | Antimikrobielle Zubereitungen mit einem Gehalt an Octenidindihydrochlorid verkapselt in Liposomen |
| DE102005045146.2 | 2005-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008114496A true RU2008114496A (ru) | 2009-10-20 |
Family
ID=37831652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008114496/15A RU2008114496A (ru) | 2005-09-15 | 2006-09-12 | Противомикробные препараты, содержащие инкапсулированный в липосомах октенидина дигидрохлорид |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080254084A1 (ru) |
| EP (2) | EP1926473B1 (ru) |
| JP (1) | JP2009507891A (ru) |
| DE (1) | DE102005063375A1 (ru) |
| ES (2) | ES2637666T3 (ru) |
| PL (2) | PL2537514T3 (ru) |
| RU (1) | RU2008114496A (ru) |
| WO (1) | WO2007031519A2 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008011691A1 (de) * | 2008-02-28 | 2009-09-10 | Schülke & Mayr GmbH | Stabilisierte, antimikrobiell wirksame Zusammensetzung mit einem Gehalt an Bispyridiniumalkan |
| EP2201951A1 (de) | 2008-11-14 | 2010-06-30 | Ahmet Melih Aydinoglu | Octenidin-Zusammensetzung |
| JP2011051966A (ja) * | 2009-09-03 | 2011-03-17 | Daiya Seiyaku Kk | 爪白癬治療用貼付剤 |
| DE102009049506A1 (de) * | 2009-10-15 | 2011-04-21 | Schülke & Mayr GmbH | Octenidindihydrochlorid enthaltende Wundauflage zur Anwendung bei der Antiseptik von Kathetereintrittsstellen |
| DE102009049504A1 (de) | 2009-10-15 | 2011-04-21 | Schülke & Mayr GmbH | Wund- und Schleimhautantiseptikum auf der Basis von Bispyridiniumalkanen |
| DE102010013081A1 (de) | 2010-03-26 | 2011-09-29 | B. Braun Melsungen Ag | Antimikrobielle Öl in Wasser Emulsion |
| WO2011143788A1 (en) * | 2010-05-17 | 2011-11-24 | Zhejiang Beta Pharma Inc. | Novel glucagon like peptide analogs, composition, and method of use |
| DE102010025932A1 (de) | 2010-07-02 | 2012-01-05 | Schülke & Mayr GmbH | Antiseptikum auf der Basis von Bispyridiniumalkanen |
| DE102010044787A1 (de) | 2010-09-09 | 2012-03-15 | Beiersdorf Ag | Makroemulsionen mit verbesserter Deodorantwirksamkeit |
| DE102013109514A1 (de) * | 2013-09-02 | 2015-03-05 | Jacobs University Bremen Ggmbh | Reduktion der Zelltoxizität von Bakteriostatika mittels Farbstoffen |
| TW201605444A (zh) | 2013-12-18 | 2016-02-16 | 阿爾米雷爾有限公司 | 包含奧替尼啶二鹽酸鹽之局部醫藥組成物或化妝品組成物 |
| US10786477B2 (en) | 2014-10-16 | 2020-09-29 | Natureza, Inc. | Formulations having anti-inflammatory activity and antimicrobial activity against gram-positive bacteria |
| EP3111958A1 (en) * | 2015-06-30 | 2017-01-04 | Pharmbridge Sp. z o.o. | Supramolecular aggregate composed of phosphatidylocholinea and octenidine, compositions comprising (containing) it and metod for obtaining thereof |
| KR101718306B1 (ko) | 2015-07-27 | 2017-03-27 | 주식회사 퍼슨 | 옥테니딘염산염(Octenidine dihydrochloride)의 개선된 합성방법과 옥타니딘염산염을 포함하는 새로운 복합제의 제조방법 |
| CA3072197A1 (en) | 2017-08-11 | 2019-02-14 | Natureza, Inc. | Lauric acid derivatives displaying inhibitory activity against gram-positive and/or gram-negative organisms |
| EP3672942A4 (en) * | 2017-08-21 | 2021-02-24 | Dishman Carbogen Amcis Ltd. | Octenidine based compounds |
| WO2020136552A1 (en) | 2018-12-27 | 2020-07-02 | 3M Innovative Properties Company | Antimicrobial compositions with 1,2-alkanediols |
| EP3771337A1 (en) * | 2019-07-29 | 2021-02-03 | The Procter & Gamble Company | Antimicrobial composition |
| MA47039B1 (fr) | 2019-10-09 | 2021-09-30 | Univ Internationale Dagadir Univ | Composition de base pour l'hygiène buccale ou corporelle ou pour la santé comprenant un broyat ou une poudre ou un extrait d'une plante du genre marrube blanc ou marrubium vulgare. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1533952A (en) * | 1976-02-25 | 1978-11-29 | Sterling Drug Inc | Anti-microbial bis-pyridinium compounds |
| CA1237671A (en) * | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| JPH0761940B2 (ja) * | 1986-11-17 | 1995-07-05 | 株式会社資生堂 | 外皮用リポソ−ム製剤 |
| DE3925540C1 (ru) | 1989-08-02 | 1990-08-30 | Schuelke & Mayr Gmbh, 2000 Norderstedt, De | |
| DE9312509U1 (de) * | 1993-08-20 | 1993-10-28 | Euro-Celtique S.A., Luxemburg/Luxembourg | Präparate zur äußeren Verabreichung von antiseptischen und/oder die Wundheilung fördernden Wirkstoffen |
| DE19647692C2 (de) * | 1996-11-05 | 2002-06-20 | Schuelke & Mayr Gmbh | Waschendes Desinfektionsmittel zur hygienischen und chirurgischen Händedesinfektion |
| NZ506051A (en) * | 1998-02-09 | 2003-08-29 | Bracco Res S | Targeted delivery of biologically active media |
| US6224579B1 (en) * | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
| PT1502586E (pt) * | 1999-05-27 | 2007-01-31 | Euro Celtique Sa | Utilização de anti-sépticos no fabrico de uma preparação farmacêutica para a prevenção ou o tratamento de processos inflamatórios no interior do corpo humano |
| WO2001015750A1 (en) * | 1999-08-27 | 2001-03-08 | Department Of National Defence | Hydrogel wound dressing containing liposome-encapsulated therapeutic agent |
| WO2003030818A2 (en) * | 2001-10-05 | 2003-04-17 | Pichit Suvanprakorn | Active agents using liposome beads |
| DE10205883A1 (de) | 2002-02-13 | 2003-08-21 | Schuelke & Mayr Gmbh | Wässriges Antiseptikum auf Basis von Bispyridiniumalkanen |
| US20040156888A1 (en) * | 2002-11-26 | 2004-08-12 | Jensen Gerard M. | Liposomal formulations |
| TW200716200A (en) * | 2005-03-10 | 2007-05-01 | 3M Innovative Properties Co | Methods of reducing microbial contamination |
-
2005
- 2005-09-15 DE DE102005063375A patent/DE102005063375A1/de not_active Ceased
-
2006
- 2006-09-12 PL PL12179218T patent/PL2537514T3/pl unknown
- 2006-09-12 EP EP06806766.9A patent/EP1926473B1/en not_active Revoked
- 2006-09-12 ES ES12179218.8T patent/ES2637666T3/es active Active
- 2006-09-12 WO PCT/EP2006/066282 patent/WO2007031519A2/en not_active Ceased
- 2006-09-12 EP EP12179218.8A patent/EP2537514B1/en not_active Not-in-force
- 2006-09-12 US US12/066,833 patent/US20080254084A1/en not_active Abandoned
- 2006-09-12 PL PL06806766T patent/PL1926473T3/pl unknown
- 2006-09-12 RU RU2008114496/15A patent/RU2008114496A/ru not_active Application Discontinuation
- 2006-09-12 ES ES06806766.9T patent/ES2451527T3/es active Active
- 2006-09-12 JP JP2008530506A patent/JP2009507891A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007031519A3 (en) | 2007-05-31 |
| EP1926473B1 (en) | 2013-12-18 |
| JP2009507891A (ja) | 2009-02-26 |
| WO2007031519A2 (en) | 2007-03-22 |
| ES2451527T3 (es) | 2014-03-27 |
| EP2537514A1 (en) | 2012-12-26 |
| EP2537514B1 (en) | 2017-07-05 |
| US20080254084A1 (en) | 2008-10-16 |
| PL2537514T3 (pl) | 2017-12-29 |
| ES2637666T3 (es) | 2017-10-16 |
| PL1926473T3 (pl) | 2014-06-30 |
| EP1926473A2 (en) | 2008-06-04 |
| DE102005063375A1 (de) | 2007-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20111010 |