RU2008100493A - SILVER N- (6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINSULPHONE) -N'-ISONICOTINOYLHYDRASIDE SALT, MANIFESTING IMMUNOTROPIC RESISTANCE MEDICINE ON ITS BASIS - Google Patents
SILVER N- (6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINSULPHONE) -N'-ISONICOTINOYLHYDRASIDE SALT, MANIFESTING IMMUNOTROPIC RESISTANCE MEDICINE ON ITS BASIS Download PDFInfo
- Publication number
- RU2008100493A RU2008100493A RU2008100493/04A RU2008100493A RU2008100493A RU 2008100493 A RU2008100493 A RU 2008100493A RU 2008100493/04 A RU2008100493/04 A RU 2008100493/04A RU 2008100493 A RU2008100493 A RU 2008100493A RU 2008100493 A RU2008100493 A RU 2008100493A
- Authority
- RU
- Russia
- Prior art keywords
- cristaphone
- silver salt
- silver
- immunotropic
- mixture
- Prior art date
Links
- 230000000686 immunotropic effect Effects 0.000 title claims abstract 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 229910052709 silver Inorganic materials 0.000 title 1
- 239000004332 silver Substances 0.000 title 1
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract 12
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims abstract 10
- 239000000203 mixture Substances 0.000 claims abstract 6
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract 6
- 230000000843 anti-fungal effect Effects 0.000 claims abstract 4
- 230000000845 anti-microbial effect Effects 0.000 claims abstract 4
- 239000007900 aqueous suspension Substances 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000002244 precipitate Substances 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000013543 active substance Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 230000001857 anti-mycotic effect Effects 0.000 claims abstract 2
- 229940121375 antifungal agent Drugs 0.000 claims abstract 2
- 239000002543 antimycotic Substances 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims abstract 2
- 238000001035 drying Methods 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 238000001914 filtration Methods 0.000 claims abstract 2
- 230000003993 interaction Effects 0.000 claims abstract 2
- 229940126601 medicinal product Drugs 0.000 claims abstract 2
- 239000002674 ointment Substances 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract 2
- 239000011541 reaction mixture Substances 0.000 claims abstract 2
- 239000000829 suppository Substances 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 2
- 238000005406 washing Methods 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Серебряная соль N-(6-метил-2,4-диоксо-1,2,3,4-тетрагидро-5Н-пиримидинсульфон)-N'-изоникотиноилгидразида (кристафона), полученная путем его взаимодействия с нитратом серебра при диспергировании их смеси в молярном соотношении от 50:50 мол.% до 20:80 мол.% в воде, с последующей промывкой, фильтрацией и высушиванием, проявляющая иммунотропную, противомикробную, противогрибковую (противомикотическую) активность. ! 2. Серебряная соль кристафона по п.1, отличающаяся тем, что она представляет собой соединение формулы I ! ! или соединение формулы II ! , ! или смесь соединений I и II. ! 3. Способ получения серебряной соли кристафона по п.1 или 2, заключающийся в том, что в водную суспензию кристафона, интенсивно перемешанную до однородного состояния, добавляют нитрат серебра при мольном соотношении кристафона к нитрату серебра от 1:1 до 1:4, затем без доступа света реакционную смесь перемешивают до получения объемного гомогенного осадка, полученный осадок фильтруют, многократно промывают бидистиллированной водой и высушивают при температуре 50-80°С. ! 4. Способ по п.3, отличающийся тем, что для приготовления водной суспензии используют кристафон в мелко дисперсном состоянии. ! 5. Лекарственное средство, обладающее иммунотропной, противомикробной, противогрибковой активностью, содержащее активное вещество, отличающееся тем, что в качестве активного вещества оно содержит серебряную соль кристафона по любому из пп.1, 2 либо смесь кристафона и его серебряной соли в соотношении от 1:1 до 4:1. ! 6. Средство по п.5, отличающееся тем, что оно выполнено в форме таблеток, капсул, мазей, суппозиториев.1. The silver salt of N- (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulfone) -N'-isonicotinoyl hydrazide (cristaphone), obtained by its interaction with silver nitrate when dispersing them mixtures in a molar ratio of from 50:50 mol.% to 20:80 mol.% in water, followed by washing, filtering and drying, showing immunotropic, antimicrobial, antifungal (antimycotic) activity. ! 2. The silver salt of Christophone according to claim 1, characterized in that it is a compound of formula I! ! or a compound of formula II! ! or a mixture of compounds I and II. ! 3. The method for producing the silver salt of cristaphone according to claim 1 or 2, which consists in adding silver nitrate at a molar ratio of cristaphone to silver nitrate from 1: 1 to 1: 4 to an aqueous suspension of cristaphone, intensively mixed to a homogeneous state, then without access to light, the reaction mixture is stirred until a homogeneous bulk precipitate is obtained, the resulting precipitate is filtered, washed repeatedly with bidistilled water and dried at a temperature of 50-80 ° C. ! 4. The method according to claim 3, characterized in that for the preparation of an aqueous suspension using cristaphone in a finely dispersed state. ! 5. A medicinal product having immunotropic, antimicrobial, antifungal activity, containing an active substance, characterized in that as an active substance it contains a silver salt of cristaphone according to any one of claims 1, 2, or a mixture of cristaphone and its silver salt in a ratio of 1: 1 to 4: 1. ! 6. The tool according to claim 5, characterized in that it is made in the form of tablets, capsules, ointments, suppositories.
Claims (6)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008100493/04A RU2368609C1 (en) | 2008-01-09 | 2008-01-09 | Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt |
| PCT/RU2008/000809 WO2009091291A1 (en) | 2008-01-09 | 2008-12-29 | N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-isonicotinoyl hydrazide silver salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008100493/04A RU2368609C1 (en) | 2008-01-09 | 2008-01-09 | Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008100493A true RU2008100493A (en) | 2009-07-20 |
| RU2368609C1 RU2368609C1 (en) | 2009-09-27 |
Family
ID=40885510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008100493/04A RU2368609C1 (en) | 2008-01-09 | 2008-01-09 | Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2368609C1 (en) |
| WO (1) | WO2009091291A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4075C1 (en) * | 2009-12-31 | 2011-07-31 | Анатолий ЭФКАРПИДИС | Process for obtaining highly dispersed colloidal silver |
| RU2440817C1 (en) * | 2010-09-22 | 2012-01-27 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Method of treating bacterial vaginosis |
| RU2706357C1 (en) * | 2018-05-22 | 2019-11-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ПГФА) | Silver salts of 3,4-diaryl-5-[4-(acetylaminosulphonyl)phenyl]-4,6-dihydropyrrolo[3,4-c]pyrazol-6-ones exhibiting antifungal activity |
| CN113333772B (en) * | 2021-06-18 | 2023-01-03 | 南昌大学 | Preparation method of gold nanocluster and application of gold nanocluster in 2,4, 6-trinitrophenol detection |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2141322C1 (en) * | 1997-08-12 | 1999-11-20 | Голощапов Николай Михайлович | Immunomodulating agent "izofon" showing antimycobacterial activity, method of its preparing and using |
| RU2191015C2 (en) * | 1999-11-05 | 2002-10-20 | Общество с ограниченной ответственностью "Центр бифункциональных иммуномодуляторов" | N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-n′- isonicotinoyl hydrazide disodium salt eliciting antibacterial and immunotropic activity and medicinal agent based on thereof |
-
2008
- 2008-01-09 RU RU2008100493/04A patent/RU2368609C1/en active
- 2008-12-29 WO PCT/RU2008/000809 patent/WO2009091291A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009091291A1 (en) | 2009-07-23 |
| RU2368609C1 (en) | 2009-09-27 |
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