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RU2007119067A - MEANS FOR TREATMENT OF AN IRRITATED INTESTINAL SYNDROME WITH PREVENTION OF DIARRHEA - Google Patents

MEANS FOR TREATMENT OF AN IRRITATED INTESTINAL SYNDROME WITH PREVENTION OF DIARRHEA Download PDF

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Publication number
RU2007119067A
RU2007119067A RU2007119067/15A RU2007119067A RU2007119067A RU 2007119067 A RU2007119067 A RU 2007119067A RU 2007119067/15 A RU2007119067/15 A RU 2007119067/15A RU 2007119067 A RU2007119067 A RU 2007119067A RU 2007119067 A RU2007119067 A RU 2007119067A
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RU
Russia
Prior art keywords
diarrhea
ramosetron
women
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
RU2007119067/15A
Other languages
Russian (ru)
Other versions
RU2351327C2 (en
Inventor
Акито НИСИДА (JP)
Акито НИСИДА
Акира НИВА (JP)
Акира НИВА
Ютака АЦУТА (JP)
Ютака АЦУТА
Original Assignee
Астеллас Фарма Инк. (Jp)
Астеллас Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2004/000896 external-priority patent/WO2004066998A1/en
Priority claimed from PCT/JP2004/006657 external-priority patent/WO2005073220A1/en
Application filed by Астеллас Фарма Инк. (Jp), Астеллас Фарма Инк. filed Critical Астеллас Фарма Инк. (Jp)
Publication of RU2007119067A publication Critical patent/RU2007119067A/en
Application granted granted Critical
Publication of RU2351327C2 publication Critical patent/RU2351327C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (6)

1. Фармацевтическая композиция для лечения синдрома раздраженного кишечника у женщин с преобладанием диареи, содержащая от 0,002 до 0,02 мг гидрохлорида рамозетрона как суточную дозу или эквивалентное молярное количество рамозетрона или другой его фармацевтически приемлемой соли в качестве активного ингредиента.1. A pharmaceutical composition for treating irritable bowel syndrome in women with a predominance of diarrhea, containing from 0.002 to 0.02 mg of ramosetron hydrochloride as a daily dose or an equivalent molar amount of ramosetron or its other pharmaceutically acceptable salt as an active ingredient. 2. Фармацевтическая композиция для снижения выраженности симптома диареи при синдроме раздраженного кишечника у женщин, содержащая от 0,002 до 0,02 мг гидрохлорида рамозетрона как суточную дозу или эквивалентное молярное количество рамозетрона или другой его фармацевтически приемлемой соли в качестве активного ингредиента.2. A pharmaceutical composition for reducing the symptom of diarrhea in irritable bowel syndrome in women, containing from 0.002 to 0.02 mg of ramosetron hydrochloride as a daily dose or an equivalent molar amount of ramosetron or its other pharmaceutically acceptable salt as an active ingredient. 3. Применение гидрохлорида рамозетрона в суточной дозе от 0,002 до 0,02 мг, или рамозетрона, или другой его фармацевтически приемлемой соли в эквимолярном количестве для получения медикамента для лечения синдрома раздраженного кишечника с преобладанием диареи у женщин.3. The use of ramosetron hydrochloride in a daily dose of 0.002 to 0.02 mg, or ramozetron, or its other pharmaceutically acceptable salt in an equimolar amount, to obtain a medicament for the treatment of irritable bowel syndrome with a predominance of diarrhea in women. 4. Применение гидрохлорида рамозетрона в суточной дозе от 0,002 до 0,02 мг, или рамозетрона, или другой его фармацевтически приемлемой соли в эквимолярном количестве для получения медикамента для снижения выраженности диареи у женщин, страдающих синдромом раздраженного кишечника.4. The use of ramosetron hydrochloride in a daily dose of from 0.002 to 0.02 mg, or ramozetron, or its other pharmaceutically acceptable salt in an equimolar amount, to obtain a medication to reduce the severity of diarrhea in women suffering from irritable bowel syndrome. 5. Способ лечения синдрома раздраженного кишечника у женщин с преобладанием симптома диареи, включающий введение пациенту от 0,002 до 0,02 мг гидрохлорида рамозетрона как суточной дозы, или эквивалентного молярного количества рамозетрона, или другой его фармацевтически приемлемой соли.5. A method of treating irritable bowel syndrome in women with a predominant symptom of diarrhea, comprising administering to the patient from 0.002 to 0.02 mg of ramosetron hydrochloride as a daily dose, or an equivalent molar amount of ramosetron, or another pharmaceutically acceptable salt thereof. 6. Способ снижения выраженности симптома диареи при синдроме раздраженного кишечника у женщин, включающий введение пациенту от 0,002 до 0,02 мг гидрохлорида рамозетрона как суточной дозы, или эквивалентного молярного количества рамозетрона, или другой его фармацевтически приемлемой соли.6. A method of reducing the severity of the symptom of diarrhea in irritable bowel syndrome in women, comprising administering to the patient from 0.002 to 0.02 mg of ramosetron hydrochloride as a daily dose, or an equivalent molar amount of ramosetron, or another pharmaceutically acceptable salt thereof.
RU2007119067/15A 2004-01-30 2007-05-22 Medication for treatment of irritate bowels syndrome with diarrhea prevalence RU2351327C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP2004/000896 WO2004066998A1 (en) 2003-01-31 2004-01-30 Stable solid medicinal composition for oral administration
JPPCT/JP2004/000896 2004-01-30
PCT/JP2004/006657 WO2005073220A1 (en) 2004-01-30 2004-05-12 Remedy for irritable bowel syndrome with diarrhea
JPPCT/JP2004/006657 2004-05-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2005127333/15A Division RU2314808C2 (en) 2004-01-30 2005-01-27 Means for treating irritated intestine syndrome cases with diarrhea predominance

Publications (2)

Publication Number Publication Date
RU2007119067A true RU2007119067A (en) 2008-11-27
RU2351327C2 RU2351327C2 (en) 2009-04-10

Family

ID=34650735

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007119067/15A RU2351327C2 (en) 2004-01-30 2007-05-22 Medication for treatment of irritate bowels syndrome with diarrhea prevalence

Country Status (6)

Country Link
EP (1) EP1559446B1 (en)
JP (1) JP3763360B2 (en)
KR (1) KR100746444B1 (en)
CN (1) CN100372533C (en)
ES (1) ES2367896T3 (en)
RU (1) RU2351327C2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4632204B2 (en) * 2005-09-21 2011-02-16 アステラス製薬株式会社 Antidiarrheal irritable bowel syndrome treatment
JP5440502B2 (en) * 2008-08-28 2014-03-12 アステラス製薬株式会社 How to treat irritable bowel syndrome
JP5741433B2 (en) * 2009-06-30 2015-07-01 アステラス製薬株式会社 A therapeutic agent for abnormal defecation in patients with inflammatory bowel disease in remission
JP5938886B2 (en) * 2010-12-14 2016-06-22 アステラス製薬株式会社 Defecation disorder therapeutic agent in active inflammatory bowel disease patients
WO2013062073A1 (en) * 2011-10-28 2013-05-02 アステラス製薬株式会社 Orally disintegrating tablet containing low-dose ramosetron
JP6355806B1 (en) * 2017-09-04 2018-07-11 株式会社三和化学研究所 A therapeutic agent for constipation containing lactulose as an active ingredient
CA3189029A1 (en) 2020-07-21 2022-01-27 Teijin Pharma Limited Light beam irradiation apparatus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0381422B1 (en) * 1989-02-02 1996-10-23 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
GB9721139D0 (en) * 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
DE69921124T2 (en) * 1998-06-12 2005-11-10 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Imidazole derivatives and their use as a somatostatin receptor
US6566369B2 (en) * 2000-07-26 2003-05-20 Solvay Pharmaceuticals Gmbh Medicament containing cilansetron for the treatment of non-obstipative male irritable bowel syndrome patients

Also Published As

Publication number Publication date
EP1559446A1 (en) 2005-08-03
JP2005213244A (en) 2005-08-11
CN1764453A (en) 2006-04-26
EP1559446B1 (en) 2011-07-13
RU2351327C2 (en) 2009-04-10
ES2367896T3 (en) 2011-11-10
KR100746444B1 (en) 2007-08-03
JP3763360B2 (en) 2006-04-05
CN100372533C (en) 2008-03-05
KR20060052661A (en) 2006-05-19

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20130128