RU2007101495A - Секреция инсулина с помощью антоцианинов и антоцианидинов - Google Patents
Секреция инсулина с помощью антоцианинов и антоцианидинов Download PDFInfo
- Publication number
- RU2007101495A RU2007101495A RU2007101495/14A RU2007101495A RU2007101495A RU 2007101495 A RU2007101495 A RU 2007101495A RU 2007101495/14 A RU2007101495/14 A RU 2007101495/14A RU 2007101495 A RU2007101495 A RU 2007101495A RU 2007101495 A RU2007101495 A RU 2007101495A
- Authority
- RU
- Russia
- Prior art keywords
- anthocyanin
- glycoside
- anthocyanidin
- mixture
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 6
- 102000004877 Insulin Human genes 0.000 title claims 3
- 108090001061 Insulin Proteins 0.000 title claims 3
- 229940125396 insulin Drugs 0.000 title claims 3
- 230000028327 secretion Effects 0.000 title claims 2
- 229930002877 anthocyanin Natural products 0.000 claims 10
- 235000010208 anthocyanin Nutrition 0.000 claims 10
- 239000004410 anthocyanin Substances 0.000 claims 10
- 150000004636 anthocyanins Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 7
- 229930014669 anthocyanidin Natural products 0.000 claims 5
- 150000001453 anthocyanidins Chemical class 0.000 claims 5
- 235000008758 anthocyanidins Nutrition 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 235000013399 edible fruits Nutrition 0.000 claims 3
- 235000013311 vegetables Nutrition 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 2
- 230000003914 insulin secretion Effects 0.000 claims 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
Claims (11)
1. Способ увеличения секреции инсулина клетками поджелудочной железы, выделяющими инсулин, который включает обеспечение бета-клеток поджелудочной железы антоцианином, или антоцианидином, или их смесью с целью увеличения секреции инсулина по сравнению с уровнем секреции его в отсутствие антоцианина.
2. Способ по п.1, отличающийся тем, что антоцианин выделен из фруктов, овощей и цветов.
3. Способ по п.1, отличающийся тем, что антоцианин выбран из группы, включающей цианидин-3-гликозид, дельфинидин-3-гликозид, пеларгонидин-3-гликозид и их смеси.
4. Способ по любому из пп.1, 2 или 3, отличающийся тем, что клетки поджелудочной железы находятся in vivo.
5. Способ по любому из п.1, 2 или 3, отличающийся тем, что клетки поджелудочной железы находятся in vitro.
6. Антоцианин, или антоцианидин, или их смесь в качестве дозированного лекарственного средства для увеличения производства инсулина клетками поджелудочной железы in vivo.
7. Композиция по п.6, отличающаяся тем, что антоцианин выделен из фруктов, овощей и цветов.
8. Композиция по п.6, отличающаяся тем, что антоцианин выбран из группы, включающей цианидин-3-гликозид, дельфинидин-3-гликозид, пеларгонидин-3-гликозид и их смеси.
9. Способ по п.1, отличающийся тем, что антоцианин, или антоцианидин, или их смесь выделены и очищены.
10. Композиция по п.6, отличающаяся тем, что антоцианин, или антоцианидин, или их смесь выделены и очищены.
11. Способ по п.1, отличающийся тем, что антоцианин, или антоцианидин, или их смесь находятся в соке фрукта или овоща.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59180604P | 2004-07-29 | 2004-07-29 | |
| US60/591,806 | 2004-07-29 | ||
| US11/071,929 | 2005-03-04 | ||
| US11/071,929 US7737121B2 (en) | 2004-07-29 | 2005-03-04 | Insulin secretion by anthocyanins and anthocyanidins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007101495A true RU2007101495A (ru) | 2008-09-10 |
Family
ID=35733129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007101495/14A RU2007101495A (ru) | 2004-07-29 | 2005-06-21 | Секреция инсулина с помощью антоцианинов и антоцианидинов |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7737121B2 (ru) |
| EP (1) | EP1773356A4 (ru) |
| JP (1) | JP2008508277A (ru) |
| AU (1) | AU2005301315B2 (ru) |
| BR (1) | BRPI0513723A (ru) |
| CA (1) | CA2573510C (ru) |
| MX (1) | MX2007000932A (ru) |
| NZ (1) | NZ552550A (ru) |
| RU (1) | RU2007101495A (ru) |
| WO (1) | WO2006049657A2 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7772195B2 (en) * | 2004-07-29 | 2010-08-10 | Board Of Trustees Of Michigan State University | Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia |
| EP1967078A1 (en) * | 2007-03-08 | 2008-09-10 | Probelte Pharma, S.A. | Process and apparatus for preparing pomegranate extracts |
| KR20100104482A (ko) * | 2009-03-18 | 2010-09-29 | 한림대학교 산학협력단 | 췌장베타세포를 보호하는 활성과 혈당조절 활성이 우수한 흑옥수수 안토시아닌（ｐｕｒｐｌｅ ｃｏｒｎ ａｎｔｈｏｃｙａｎｉｎｓ） |
| US8494973B1 (en) * | 2012-03-05 | 2013-07-23 | Reputation.Com, Inc. | Targeting review placement |
| EP2943928A4 (en) * | 2013-01-14 | 2016-08-24 | Zoosk Inc | SYSTEM AND METHOD FOR IMPROVING MESSAGES |
| JP2014198684A (ja) * | 2013-03-29 | 2014-10-23 | サンスター株式会社 | 血糖代謝改善剤 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO943860D0 (no) * | 1994-10-13 | 1994-10-13 | Unifob | En kjemisk forbindelse og et preparat til bruk som terapeutikum |
| AU2578997A (en) * | 1996-04-17 | 1997-11-19 | Unifob | Use of anthocyanidin and anthocyanidin derivatives |
| US6569446B1 (en) * | 1996-09-20 | 2003-05-27 | The Howard Foundation | Solubilization of flavonols |
| EP0956867A1 (de) * | 1998-05-12 | 1999-11-17 | Franz-Peter Dr. Liebel | Verwendung von Flavonoidglykosiden, Gerbstoffen und Mikroorganismen zur Therapie und Prophylaxe des Diabetes mellitus |
| US6623743B1 (en) * | 1998-12-11 | 2003-09-23 | Board Of Trustees Of Michigan State University | Method for the use of cherry isolates providing antioxidant phytoceutical or nutraceutical benefits |
| US6423365B1 (en) * | 1998-12-11 | 2002-07-23 | Board Of Trustees Of Michigan State University | Method and compositions producing cherry derived products |
| US6194469B1 (en) * | 1998-12-11 | 2001-02-27 | Board Of Trustees Operating Michigan State Univeristy | Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids |
| AU2175400A (en) * | 1998-12-11 | 2000-06-26 | Michigan State University | Method for the use of cherry isolates providing antioxidant phytoceutical or nutraceutical benefits |
| JP2000178295A (ja) * | 1998-12-17 | 2000-06-27 | Lion Corp | 抗腫瘍組成物 |
| US6676978B1 (en) * | 1999-02-16 | 2004-01-13 | Board Of Trustees Of Michigan State University | Method and compositions for producing berry derived products |
| WO2001054516A1 (en) * | 2000-01-28 | 2001-08-02 | Michigan State University | Method for inhibiting a tumor |
| US20020054924A1 (en) * | 2000-04-13 | 2002-05-09 | Leahy Margaret M. | Novel compositions derived from cranberry and grapefruit and therapeutic uses therefor |
| EP1328282B1 (en) * | 2000-08-31 | 2006-05-31 | Phenolics, LLC | Efficient method for producing compositions enriched in anthocyanins |
| GB0127031D0 (en) * | 2001-11-09 | 2002-01-02 | Medpalett Pharmaceuticals As | Process |
| JP2003252766A (ja) * | 2002-02-28 | 2003-09-10 | Sanei Gen Ffi Inc | シアニジン３−グルコシドを有効成分とする抗肥満及び／又は抗糖尿病剤 |
| WO2003074067A1 (en) * | 2002-03-01 | 2003-09-12 | Stoner Gary D | Compositions of and derived from strawberry and raspberry and therapeutic uses therefor |
| RU2336088C2 (ru) * | 2002-03-26 | 2008-10-20 | Форбз Меди-Тек Инк. | Способ экстракции антоцианинов из черного риса и их композиция |
| US20040131749A1 (en) * | 2002-08-29 | 2004-07-08 | Archer-Daniels-Midland Company | Phytochemicals from edible bean process streams |
| JP2004143130A (ja) * | 2002-10-25 | 2004-05-20 | Oriza Yuka Kk | 人血糖値上昇抑制剤 |
| US20060234957A1 (en) * | 2003-03-03 | 2006-10-19 | Takanori Tsuda | Adiponectin expression promoter |
| JP4451627B2 (ja) * | 2003-09-05 | 2010-04-14 | 株式会社ニチレイフーズ | 血糖値上昇抑制剤およびａｇｅ生成阻害剤 |
| US20070060533A1 (en) * | 2003-10-24 | 2007-03-15 | Meiji Seika Kaisha Ltd. | Novel inhibitor of the formation of advanced glycation end product and aldose reductase inhibitor |
| CN1259068C (zh) * | 2004-04-28 | 2006-06-14 | 江苏中康新药指纹图谱开发有限公司 | 山茱萸提取物及其制备方法和用途 |
-
2005
- 2005-03-04 US US11/071,929 patent/US7737121B2/en not_active Expired - Fee Related
- 2005-06-21 NZ NZ552550A patent/NZ552550A/en not_active IP Right Cessation
- 2005-06-21 MX MX2007000932A patent/MX2007000932A/es not_active Application Discontinuation
- 2005-06-21 RU RU2007101495/14A patent/RU2007101495A/ru unknown
- 2005-06-21 CA CA2573510A patent/CA2573510C/en not_active Expired - Fee Related
- 2005-06-21 JP JP2007523566A patent/JP2008508277A/ja active Pending
- 2005-06-21 BR BRPI0513723-3A patent/BRPI0513723A/pt not_active IP Right Cessation
- 2005-06-21 EP EP05851197A patent/EP1773356A4/en not_active Withdrawn
- 2005-06-21 WO PCT/US2005/021741 patent/WO2006049657A2/en not_active Ceased
- 2005-06-21 AU AU2005301315A patent/AU2005301315B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1773356A2 (en) | 2007-04-18 |
| NZ552550A (en) | 2009-05-31 |
| AU2005301315B2 (en) | 2008-04-10 |
| US7737121B2 (en) | 2010-06-15 |
| CA2573510C (en) | 2011-09-06 |
| WO2006049657A3 (en) | 2006-06-22 |
| US20060025353A1 (en) | 2006-02-02 |
| MX2007000932A (es) | 2007-04-16 |
| AU2005301315A1 (en) | 2006-05-11 |
| WO2006049657A2 (en) | 2006-05-11 |
| JP2008508277A (ja) | 2008-03-21 |
| EP1773356A4 (en) | 2010-01-13 |
| CA2573510A1 (en) | 2006-05-11 |
| BRPI0513723A (pt) | 2008-05-13 |
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