RU2007145748A - FUNGUS STRAIN HYPSIZYGUS ULMARIUS (BULL.) REDHEAD S-ULM1, USED FOR OBTAINING MEANS, has antitumor activity and antioxidant effects AND METHOD FOR OBTAINING MEANS, has antitumor activity and antioxidant effects, based on this STRAIN - Google Patents
FUNGUS STRAIN HYPSIZYGUS ULMARIUS (BULL.) REDHEAD S-ULM1, USED FOR OBTAINING MEANS, has antitumor activity and antioxidant effects AND METHOD FOR OBTAINING MEANS, has antitumor activity and antioxidant effects, based on this STRAIN Download PDFInfo
- Publication number
- RU2007145748A RU2007145748A RU2007145748/13A RU2007145748A RU2007145748A RU 2007145748 A RU2007145748 A RU 2007145748A RU 2007145748/13 A RU2007145748/13 A RU 2007145748/13A RU 2007145748 A RU2007145748 A RU 2007145748A RU 2007145748 A RU2007145748 A RU 2007145748A
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- Russia
- Prior art keywords
- antitumor activity
- strain
- funds
- antioxidant effect
- antioxidant
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract 14
- 230000003078 antioxidant effect Effects 0.000 title claims abstract 14
- 238000000034 method Methods 0.000 title claims abstract 9
- 241001237208 Hypsizygus ulmarius Species 0.000 title claims abstract 3
- 244000309464 bull Species 0.000 title claims abstract 3
- 241000233866 Fungi Species 0.000 title 1
- 235000015934 Lyophyllum ulmarium Nutrition 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 4
- 241000221198 Basidiomycota Species 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000005273 aeration Methods 0.000 claims abstract 2
- 239000003242 anti bacterial agent Substances 0.000 claims abstract 2
- 229940088710 antibiotic agent Drugs 0.000 claims abstract 2
- 238000009835 boiling Methods 0.000 claims abstract 2
- 229910052799 carbon Inorganic materials 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- 238000000605 extraction Methods 0.000 claims abstract 2
- 238000010438 heat treatment Methods 0.000 claims abstract 2
- 229910052500 inorganic mineral Chemical class 0.000 claims abstract 2
- 239000011707 mineral Chemical class 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 235000015097 nutrients Nutrition 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1. Штамм гриба Hypsizygus ulmarius (Bull.) Redhead S-ulml-01060 (KKM ГУ НИИ по изысканию новых антибиотиков им. Г.Ф.Гаузе РАМН), используемый для получения средства, обладающего противоопухолевой активностью и антиоксидантным действием. ! 2. Способ получения средства, обладающего противоопухолевой активностью и антиоксидантным действием, включающий культивирование штамма базидиомицета в погруженной культуре при аэрации на питательной среде, содержащей источники углерода, азота и минеральные соли, и выделение средства, обладающего противоопухолевой активностью и антиоксидантным действием, отличающийся тем, что из базидиомицетов для культивирования используют штамм по п.1. ! 3. Способ по п.2, отличающийся тем, что выделение средства, обладающего противоопухолевой активностью и антиоксидантным действием, осуществляют из погруженной культуры, полученной после культивирования штамма, путем термообработки: кипячением или автоклавированием при 1,2-1,8 атм в течение 1,5-3 ч. ! 4. Способ по п.2, отличающийся тем, что после культивирования штамма из полученной погруженной культуры отделяют мицелий, сушат его, и из него выделяют средство, обладающее противоопухолевой активностью и антиоксидантным действием. ! 5. Способ по п.4, отличающийся тем, что выделение средства, обладающего противоопухолевой активностью и антиоксидантным действием, осуществляют путем экстракции сухого мицелия водой или этанолом.1. The strain of the fungus Hypsizygus ulmarius (Bull.) Redhead S-ulml-01060 (KKM Research Institute for the search for new antibiotics named after GF Gauze RAMS), used to obtain funds with antitumor activity and antioxidant effect. ! 2. A method of obtaining funds with antitumor activity and antioxidant action, comprising cultivating a basidiomycete strain in a submerged culture by aeration on a nutrient medium containing carbon, nitrogen and mineral salts, and isolating an agent having antitumor activity and antioxidant effect, characterized in that from basidiomycetes for cultivation use the strain according to claim 1. ! 3. The method according to claim 2, characterized in that the allocation of funds with antitumor activity and antioxidant effect is carried out from a submerged culture obtained after cultivation of the strain, by heat treatment: boiling or autoclaving at 1.2-1.8 atm for 1 5-3 hours! 4. The method according to claim 2, characterized in that after culturing the strain, the mycelium is separated from the obtained submerged culture, dried, and an agent having antitumor activity and antioxidant action is isolated from it. ! 5. The method according to claim 4, characterized in that the allocation of funds with antitumor activity and antioxidant effect, carried out by extraction of dry mycelium with water or ethanol.
Claims (5)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007145748/13A RU2007145748A (en) | 2007-12-11 | 2007-12-11 | FUNGUS STRAIN HYPSIZYGUS ULMARIUS (BULL.) REDHEAD S-ULM1, USED FOR OBTAINING MEANS, has antitumor activity and antioxidant effects AND METHOD FOR OBTAINING MEANS, has antitumor activity and antioxidant effects, based on this STRAIN |
| PCT/RU2008/000563 WO2009075605A1 (en) | 2007-12-11 | 2008-08-20 | Hypsizygus ultramarius (bull.) redhead s-ulm 1 fungus strain used for producing an agent exhibiting antitumor activity and anti-oxidant action and a method for producing an agent exhibiting antitumor activity and anti-oxidant action based on said strain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007145748/13A RU2007145748A (en) | 2007-12-11 | 2007-12-11 | FUNGUS STRAIN HYPSIZYGUS ULMARIUS (BULL.) REDHEAD S-ULM1, USED FOR OBTAINING MEANS, has antitumor activity and antioxidant effects AND METHOD FOR OBTAINING MEANS, has antitumor activity and antioxidant effects, based on this STRAIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007145748A true RU2007145748A (en) | 2009-06-20 |
Family
ID=40755724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007145748/13A RU2007145748A (en) | 2007-12-11 | 2007-12-11 | FUNGUS STRAIN HYPSIZYGUS ULMARIUS (BULL.) REDHEAD S-ULM1, USED FOR OBTAINING MEANS, has antitumor activity and antioxidant effects AND METHOD FOR OBTAINING MEANS, has antitumor activity and antioxidant effects, based on this STRAIN |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2007145748A (en) |
| WO (1) | WO2009075605A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2416418C1 (en) * | 2009-12-10 | 2011-04-20 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Method for producing agent showing anticancer activity, and agent produced by this method (versions) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5932480B2 (en) * | 1981-02-10 | 1984-08-09 | 呉羽化学工業株式会社 | Novel glycoprotein complex |
| JPS57206618A (en) * | 1981-06-12 | 1982-12-18 | Noda Shiyokukin Kogyo Kk | Preparation of antitumor substance |
| KR920008374B1 (en) * | 1990-12-04 | 1992-09-26 | 일양약품 주식회사 | New m/o ganoderma iucidum iy 009 |
| RU2192873C1 (en) * | 2001-05-08 | 2002-11-20 | Герасименя Валерий Павлович | Preparation influencing on tissue metabolism and use of fungus strain pleurotus 1137 for its preparing |
| US20060045887A1 (en) * | 2004-08-25 | 2006-03-02 | Gavish-Galilee Bio Applications Ltd. | Mushroom extracts having anticancer activity |
-
2007
- 2007-12-11 RU RU2007145748/13A patent/RU2007145748A/en not_active Application Discontinuation
-
2008
- 2008-08-20 WO PCT/RU2008/000563 patent/WO2009075605A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2416418C1 (en) * | 2009-12-10 | 2011-04-20 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Method for producing agent showing anticancer activity, and agent produced by this method (versions) |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009075605A1 (en) | 2009-06-18 |
| WO2009075605A8 (en) | 2009-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20091019 |