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RU2006137275A - LIQUIDS CONTAINING SUSPENDED GLASS PARTICLES - Google Patents

LIQUIDS CONTAINING SUSPENDED GLASS PARTICLES Download PDF

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Publication number
RU2006137275A
RU2006137275A RU2006137275/15A RU2006137275A RU2006137275A RU 2006137275 A RU2006137275 A RU 2006137275A RU 2006137275/15 A RU2006137275/15 A RU 2006137275/15A RU 2006137275 A RU2006137275 A RU 2006137275A RU 2006137275 A RU2006137275 A RU 2006137275A
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RU
Russia
Prior art keywords
particles
composition according
vitreous
liquid
active ingredient
Prior art date
Application number
RU2006137275/15A
Other languages
Russian (ru)
Other versions
RU2363447C2 (en
Inventor
Брюс Джозеф РОЗЕР (GB)
Брюс Джозеф РОЗЕР
Original Assignee
Кембридж Биостабилити Лимитед (Gb)
Кембридж Биостабилити Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Кембридж Биостабилити Лимитед (Gb), Кембридж Биостабилити Лимитед filed Critical Кембридж Биостабилити Лимитед (Gb)
Publication of RU2006137275A publication Critical patent/RU2006137275A/en
Application granted granted Critical
Publication of RU2363447C2 publication Critical patent/RU2363447C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A pharmaceutical composition comprising a biologically active agent preserved in particulate form, in particular a glass or amorphous particle, such as a sugar, a metal carboxylate, an amino acid or calcium phosphate, wherein said particles are suspended in at least one of a hydrofluoroether, a perfluoroether, a hydrofluoroamine, a perfluoroamine, a hydrofluorothioether, a perfluorothioether, a hydrofluoropolyether or a perfluoropolyether. The use of such fluorinated liquid media overcomes the problem of aggregation of particles and also is environmentally friendly.

Claims (11)

1. Композиция, содержащая активный ингредиент, законсервированный в стекловидных или аморфных частицах, которые суспендированы в жидкости, в которой по меньшей мере один компонент представляет собой гидрофторэфир, перфторэфир, гидрофторамин, перфторамин, гидрофтортиоэфир, перфтортиоэфир, гидрофторполиэфир, перфторполиэфир или общую формулу1. The composition containing the active ingredient, preserved in vitreous or amorphous particles, which are suspended in a liquid in which at least one component is hydrofluoroether, perfluoroether, hydrofluoroamine, perfluoroamine, hydrofluorothioether, perfluorothioether, common hydrofluoropolyether, R1-X-R2, илиR1-X-R2, or R1-X-(CF2Y)n(CF2CF2Z)m-R2, илиR1-X- (CF2Y) n (CF2CF2Z) m-R2, or R1-[(X-CF-R2)n-(X-CF2)m]OR3,R1 - [(X-CF-R2) n- (X-CF2) m] OR3, где X, Y и Z определены как О (кислород), простой эфир, NR3 (N представляет собой азот), амин или S (сера); и каждый из R1, R2 и R3 определен как нефторированная, частично фторированная или полностью фторированная алкильная, циклоалкильная, арильная или арилалкильная группа или органическая функциональная группа, галогеновая группа или цианогруппа.where X, Y and Z are defined as O (oxygen), ether, NR3 (N is nitrogen), amine or S (sulfur); and each of R1, R2 and R3 is defined as a non-fluorinated, partially fluorinated or fully fluorinated alkyl, cycloalkyl, aryl or arylalkyl group or organic functional group, halogen group or cyano group. 2. Композиция по п.1, в которой частицы содержат стекловидный сахар или стекловидное вещество, которое представляет собой смесь сахара, карбоксилата металла, аминокислоты и/или фосфата кальция, или любой их комбинации.2. The composition according to claim 1, in which the particles contain vitreous sugar or a vitreous substance, which is a mixture of sugar, metal carboxylate, amino acids and / or calcium phosphate, or any combination thereof. 3. Композиция по п.1, в которой частицы имеют плотность, которая достаточно точно соответствует плотности жидкости, чтобы при нормальных условиях частицы оставались во взвешенном состоянии.3. The composition according to claim 1, in which the particles have a density that accurately matches the density of the liquid, so that under normal conditions the particles remain in suspension. 4. Композиция по п.1, в которой жидкость содержит различные компоненты, указанные в п.1, смешанные в соотношениях, обеспечивающих требуемую плотность.4. The composition according to claim 1, in which the liquid contains various components specified in claim 1, mixed in ratios that provide the desired density. 5. Композиция по п.1, в которой жидкость содержит перфторуглерод, смешанный с одним или более чем одним компонентом, указанным в п.1.5. The composition according to claim 1, in which the liquid contains perfluorocarbon mixed with one or more than one component specified in claim 1. 6. Композиция по п.1, в которой активный ингредиент представляет собой вакцину.6. The composition according to claim 1, in which the active ingredient is a vaccine. 7. Композиция по любому из пп.1-6, в которой частицы получены в результате сушки распылением.7. The composition according to any one of claims 1 to 6, in which the particles are obtained by spray drying. 8. Композиция по любому из пп.1-6, в которой частицы получены в результате сушки вымораживанием.8. The composition according to any one of claims 1 to 6, in which the particles are obtained as a result of freeze-drying. 9. Композиция по любому из пп.1-6, в которой частицы получены в результате размалывания.9. The composition according to any one of claims 1 to 6, in which the particles are obtained by grinding. 10. Способ получения композиции по п.4 или 5, включающий стадию выбора жидкостей для обеспечения требуемых свойств соответствия по плотности и смешивания их с частицами.10. A method of obtaining a composition according to claim 4 or 5, comprising the step of selecting liquids to provide the desired density matching properties and mixing them with particles. 11. Композиция, содержащая активный ингредиент, законсервированный в стекловидных или аморфных частицах, которые суспендированы в жидкости, представляющей собой гидрофторэфир.11. A composition containing the active ingredient, preserved in vitreous or amorphous particles, which are suspended in a liquid comprising a hydrofluoroether.
RU2006137275/15A 2004-04-13 2005-04-13 Liquid, containing suspended vitreous particles RU2363447C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0408199.8 2004-04-13
GBGB0408199.8A GB0408199D0 (en) 2004-04-13 2004-04-13 Liquids containing suspended sugar glass particles
GB0504501.8 2005-03-07
GB0504501A GB2413075B (en) 2004-04-13 2005-03-07 Liquids containing suspended glass particles

Publications (2)

Publication Number Publication Date
RU2006137275A true RU2006137275A (en) 2008-05-20
RU2363447C2 RU2363447C2 (en) 2009-08-10

Family

ID=32320732

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006137275/15A RU2363447C2 (en) 2004-04-13 2005-04-13 Liquid, containing suspended vitreous particles

Country Status (10)

Country Link
CN (1) CN1942171B (en)
AT (1) ATE457717T1 (en)
DE (1) DE602005019398D1 (en)
DK (1) DK1750668T3 (en)
ES (1) ES2339783T3 (en)
GB (2) GB0408199D0 (en)
MX (1) MXPA06011895A (en)
PT (1) PT1750668E (en)
RU (1) RU2363447C2 (en)
ZA (1) ZA200609158B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
GB0523638D0 (en) 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US9243626B2 (en) 2012-11-19 2016-01-26 Nordson Corporation Adhesive dispensing system and method including a pump with integrated diagnostics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07258027A (en) * 1994-03-16 1995-10-09 Shiseido Co Ltd Makeup cosmetic
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6190701B1 (en) * 1999-03-17 2001-02-20 Peter M. Ronai Composition and method for stable injectable liquids
AU2046101A (en) * 1999-11-22 2001-06-04 Universal Preservation Technologies, Inc. Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
US6562872B1 (en) * 2000-07-20 2003-05-13 Otkrytoe Aktsionernoe Obschestvo Naucho-Proizvodstven-Naya Firma “Perftoran” Emulsion of perfluoroorganic compounds for medical purposes, a process for the preparation thereof and methods for treating and preventing diseases with the use thereof
PL360052A1 (en) * 2000-10-13 2004-09-06 Cambridge Biostability Ltd. Composition and method for stable injectable liquids

Also Published As

Publication number Publication date
GB2413075A (en) 2005-10-19
DK1750668T3 (en) 2010-05-10
GB0408199D0 (en) 2004-05-19
ES2339783T3 (en) 2010-05-25
ZA200609158B (en) 2008-06-25
MXPA06011895A (en) 2007-11-20
DE602005019398D1 (en) 2010-04-01
ATE457717T1 (en) 2010-03-15
CN1942171B (en) 2011-04-06
PT1750668E (en) 2010-04-07
GB0504501D0 (en) 2005-04-13
GB2413075B (en) 2009-01-21
CN1942171A (en) 2007-04-04
RU2363447C2 (en) 2009-08-10

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20160414