RU2006104991A - Метод мониторинга уровня глюкозы - Google Patents
Метод мониторинга уровня глюкозы Download PDFInfo
- Publication number
- RU2006104991A RU2006104991A RU2006104991/14A RU2006104991A RU2006104991A RU 2006104991 A RU2006104991 A RU 2006104991A RU 2006104991/14 A RU2006104991/14 A RU 2006104991/14A RU 2006104991 A RU2006104991 A RU 2006104991A RU 2006104991 A RU2006104991 A RU 2006104991A
- Authority
- RU
- Russia
- Prior art keywords
- glucose
- determining
- calculated
- level
- invasive method
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract 63
- 239000008103 glucose Substances 0.000 title claims abstract 63
- 238000000034 method Methods 0.000 title claims abstract 24
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 238000005259 measurement Methods 0.000 claims abstract 20
- 239000008280 blood Substances 0.000 claims abstract 17
- 210000004369 blood Anatomy 0.000 claims abstract 17
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000005674 electromagnetic induction Effects 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 230000010287 polarization Effects 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B7/00—Instruments for auscultation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Claims (19)
1. Неинвазивный способ определения уровня глюкозы в крови внутри тела пациента, включающий шаги:
a. неинвазивное измерение скорости звука в крови пациента,
b. неинвазивное измерение электропроводимости крови пациента,
c. неинвазивное измерение теплоемкости крови пациента,
d. расчет соответствующего уровня глюкозы для каждого из измерений: скорости звука, электропроводимости крови, теплоемкости крови,
e. сравнение трех вычисленных уровней глюкозы, и
f. 1. если все три вычисленных уровня глюкозы близки в пределах допуска, то вычисление окончательного уровня глюкозы путем определения взвешенного среднего этих трех уровней глюкозы, или
2. если только два из трех вычисленных уровней близки в пределах допуска, то вычисление окончательного уровня глюкозы путем определения взвешенного среднего только двух близких вычисленных уровней глюкозы.
2. Неинвазивный способ определения уровня глюкозы по п.1, также включающий шаги:
g. повторение измерения одного из параметров: скорости, проводимости или теплоемкости по любому одному из шагов a-c,
h. вычисление соответствующего уровня глюкозы для измерения параметра согласно шагу g и
i. периодическое повторение шагов a-f для подтверждения точности вычисления уровня глюкозы.
3. Неинвазивный способ определения уровня глюкозы по п.1, в котором скорость звука определяют путем измерений ультразвукового сигнала, распространяющегося в теле.
4. Неинвазивный способ определения уровня глюкозы по п.1, в котором электропроводимость крови определяют с помощью электромагнитной индукции.
5. Неинвазивный способ определения уровня глюкозы по п.1, в котором теплопроводность крови определяют с помощью изменения температуры в измеряемом объеме.
6. Неинвазивный способ определения уровня глюкозы в крови, внутри тела пациента, включающий шаги:
a. неинвазивное измерение трех различных параметров тела, по которым может быть рассчитан уровень глюкозы,
b. расчет соответствующего уровня глюкозы для каждого из трех измерений,
c. сравнение трех рассчитанных уровней глюкозы и
d. 1. если все три вычисленных уровня глюкозы близки в пределах допуска, то вычисление окончательного уровня глюкозы путем определения взвешенного среднего этих трех уровней глюкозы, или
2. если только два из трех вычисленных уровней близки в пределах уровня допуска, то вычисление окончательного уровня глюкозы путем определения взвешенного среднего только двух близких вычисленных уровней глюкозы.
7. Неинвазивный метод определения уровня глюкозы по п.6, также включающий шаги:
e. повторение измерения одного из параметров,
f. вычисление соответствующего уровня глюкозы для измерения параметра по шагу e и
g. периодическое повторение шагов a-d для подтверждения точности вычисления уровня глюкозы.
8. Неинвазивный способ определения уровня глюкозы по п.6, в котором три различных параметра тела, по которым может быть рассчитан уровень глюкозы, выбирают из группы, содержащей: скорость звука в теле, проводимость, теплоемкость крови, акустический импеданс, электрический/магнитный коэффициент, теплопроводность, упругость, плотность крови, удельную массу, коэффициент поляризации, рассеяние света, ядерный магнитный резонанс, аналит, температуру крови, температуру тела, эффекты тепловых волн, естественное инфракрасное излучение, испускаемое телом, ответы ткани на раздражения, электрические свойства, электродвижущую силу и электрический ток.
9. Неинвазивный способ определения уровня глюкозы по п.1, в котором вес каждого рассчитанного уровня глюкозы основан на надежности измерения соответствующего параметра.
10. Неинвазивный способ определения уровня глюкозы по п.6, в котором вес каждого рассчитанного уровня глюкозы основан на надежности измерения соответствующего параметра.
11. Неинвазивный способ определения уровня глюкозы по п.2, в котором шаги a-f повторяют через заранее определенные промежутки времени.
12. Неинвазивный способ определения уровня глюкозы по п.2, в котором шаги a-f повторяют через заранее определенное число измерений.
13. Неинвазивный способ определения уровня глюкозы по п.7, в котором шаги a-d повторяют через заранее определенные промежутки времени.
14. Неинвазивный способ определения уровня глюкозы по п.7, в котором шаги a-d повторяют через заранее определенное число измерений.
15. Неинвазивный способ определения уровня глюкозы по п.1, в котором если один из рассчитанных уровней глюкозы не попадает в заранее определенный допуск, то проверяют два оставшихся рассчитанных уровня для подтверждения того, что они находятся в более узком диапазоне допуска, и затем рассчитывают окончательный уровень глюкозы путем определения взвешенного среднего только этих двух близких вычисленных уровней глюкозы.
16. Неинвазивный способ определения уровня глюкозы по п.6, в котором если один из рассчитанных уровней глюкозы не попадает в заранее определенный допуск, то проверяют два оставшихся рассчитанных уровня для подтверждения того, что они находятся в более узком диапазоне допуска, и затем рассчитывают окончательный уровень глюкозы путем определения взвешенного среднего только этих двух близких вычисленных уровней глюкозы.
17. Неинвазивный способ определения уровня глюкозы по п.1, содержащий дополнительные шаги: увеличение счетчика каждый раз, как один из рассчитанных уровней глюкозы не попадает в допуск, и процедуру перекалибровки измерения, когда счетчик показывает заранее установленное число раз, что рассчитанный уровень глюкозы не попадал в допуск.
18. Неинвазивный способ определения уровня глюкозы по п.6, содержаший дополнительные шаги: увеличение счетчика каждый раз, как один из рассчитанных уровней глюкозы не попадает в допуск, и процедуру перекалибровки измерения, когда счетчик показывает заранее установленное число раз, что рассчитанный уровень глюкозы не попадал в допуск.
19. Неинвазивный способ определения уровня глюкозы в крови, внутри тела пациента, включающий шаги:
a. неинвазивное измерение трех различных параметров тела, по которым может быть рассчитан уровень глюкозы,
b. расчет соответствующего уровня глюкозы для каждого из трех измерений,
c. расчет уровня глюкозы путем определения взвешенного среднего трех рассчитанных уровней глюкозы,
d. повторение измерений одного из параметров,
e. расчет соответствующих уровней глюкозы для измерения параметра по шагу d и
f. периодическое повторение шагов a-c для подтверждения точности вычислений уровня глюкозы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/643,804 US6954662B2 (en) | 2003-08-19 | 2003-08-19 | Method of monitoring glucose level |
| US10/643,804 | 2003-08-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006104991A true RU2006104991A (ru) | 2006-07-27 |
| RU2376927C2 RU2376927C2 (ru) | 2009-12-27 |
Family
ID=34193961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006104991/14A RU2376927C2 (ru) | 2003-08-19 | 2004-08-09 | Метод мониторинга уровня глюкозы |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6954662B2 (ru) |
| EP (1) | EP1656065B1 (ru) |
| JP (1) | JP4538691B2 (ru) |
| KR (1) | KR100926155B1 (ru) |
| CN (1) | CN100546535C (ru) |
| AT (1) | ATE515230T1 (ru) |
| AU (1) | AU2004264570B2 (ru) |
| BR (1) | BRPI0413762B8 (ru) |
| CA (1) | CA2536133C (ru) |
| ES (1) | ES2367023T3 (ru) |
| IL (1) | IL173695A (ru) |
| MX (1) | MXPA06001917A (ru) |
| RU (1) | RU2376927C2 (ru) |
| TR (1) | TR200600651T2 (ru) |
| WO (1) | WO2005017642A2 (ru) |
| ZA (1) | ZA200600989B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2694473C1 (ru) * | 2016-03-11 | 2019-07-15 | Ф. Хоффманн-Ля Рош Аг | Нательное измерительное устройство |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
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- 2003-08-19 US US10/643,804 patent/US6954662B2/en not_active Expired - Lifetime
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- 2004-08-09 WO PCT/IB2004/003509 patent/WO2005017642A2/en not_active Ceased
- 2004-08-09 AT AT04769731T patent/ATE515230T1/de not_active IP Right Cessation
- 2004-08-09 BR BRPI0413762A patent/BRPI0413762B8/pt not_active IP Right Cessation
- 2004-08-09 RU RU2006104991/14A patent/RU2376927C2/ru active
- 2004-08-09 CA CA2536133A patent/CA2536133C/en not_active Expired - Fee Related
- 2004-08-09 ES ES04769731T patent/ES2367023T3/es not_active Expired - Lifetime
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- 2004-08-09 JP JP2006523711A patent/JP4538691B2/ja not_active Expired - Fee Related
- 2004-08-09 CN CNB2004800238851A patent/CN100546535C/zh not_active Expired - Fee Related
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- 2004-08-09 TR TR2006/00651T patent/TR200600651T2/xx unknown
- 2004-08-09 KR KR1020067003275A patent/KR100926155B1/ko not_active Expired - Fee Related
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2694473C1 (ru) * | 2016-03-11 | 2019-07-15 | Ф. Хоффманн-Ля Рош Аг | Нательное измерительное устройство |
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|---|---|
| US20050043602A1 (en) | 2005-02-24 |
| WO2005017642A2 (en) | 2005-02-24 |
| IL173695A0 (en) | 2006-07-05 |
| EP1656065A2 (en) | 2006-05-17 |
| RU2376927C2 (ru) | 2009-12-27 |
| US6954662B2 (en) | 2005-10-11 |
| IL173695A (en) | 2010-11-30 |
| TR200600651T2 (tr) | 2007-01-22 |
| BRPI0413762B8 (pt) | 2021-06-22 |
| CN1882277A (zh) | 2006-12-20 |
| KR20060061838A (ko) | 2006-06-08 |
| ATE515230T1 (de) | 2011-07-15 |
| CA2536133A1 (en) | 2005-02-24 |
| JP4538691B2 (ja) | 2010-09-08 |
| AU2004264570B2 (en) | 2009-04-23 |
| CN100546535C (zh) | 2009-10-07 |
| KR100926155B1 (ko) | 2009-11-10 |
| EP1656065A4 (en) | 2010-03-03 |
| ES2367023T3 (es) | 2011-10-27 |
| WO2005017642A3 (en) | 2005-08-04 |
| AU2004264570A1 (en) | 2005-02-24 |
| CA2536133C (en) | 2010-12-14 |
| BRPI0413762B1 (pt) | 2020-12-01 |
| ZA200600989B (en) | 2007-05-30 |
| EP1656065B1 (en) | 2011-07-06 |
| MXPA06001917A (es) | 2006-05-17 |
| BRPI0413762A (pt) | 2006-11-14 |
| JP2007521098A (ja) | 2007-08-02 |
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