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RU2005129664A - PHEN-TAB RECOMBINANT FAGMID DNA CONTAINING A SINGLE-STAGE HUMAN ANTIBODY GENE ABLE TO BIND A HUMAN ALPH TUMOR NECROSIS FACTOR; RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI-PRODUCER OF SINGLE-RADIATED HUMAN ANTIBODY SCTAB AGAINST HUMAN ALPH TUMOR NECROSIS FACTOR; Recombinant Soluble Single-Chain Human Antibody SCTAB AGAINST HUMAN ALPHA TUMOR NECROSIS FACTOR - Google Patents

PHEN-TAB RECOMBINANT FAGMID DNA CONTAINING A SINGLE-STAGE HUMAN ANTIBODY GENE ABLE TO BIND A HUMAN ALPH TUMOR NECROSIS FACTOR; RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI-PRODUCER OF SINGLE-RADIATED HUMAN ANTIBODY SCTAB AGAINST HUMAN ALPH TUMOR NECROSIS FACTOR; Recombinant Soluble Single-Chain Human Antibody SCTAB AGAINST HUMAN ALPHA TUMOR NECROSIS FACTOR Download PDF

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Publication number
RU2005129664A
RU2005129664A RU2005129664/13A RU2005129664A RU2005129664A RU 2005129664 A RU2005129664 A RU 2005129664A RU 2005129664/13 A RU2005129664/13 A RU 2005129664/13A RU 2005129664 A RU2005129664 A RU 2005129664A RU 2005129664 A RU2005129664 A RU 2005129664A
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RU
Russia
Prior art keywords
human
tumor necrosis
necrosis factor
recombinant
human antibody
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RU2005129664/13A
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Russian (ru)
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RU2307163C2 (en
Inventor
Тать на Александровна Батанова (RU)
Татьяна Александровна Батанова
Нина Викторовна Тикунова (RU)
Нина Викторовна Тикунова
Тать на Эверестовна Юн (RU)
Татьяна Эверестовна Юн
Original Assignee
Федеральное государственное унитарное предпри тиеГосударственный научный центр вирусологии и биотехнологии "Вектор" (ФГУП ГНЦ ВБ "Вектор") (RU)
Федеральное государственное унитарное предприятие Государственный научный центр вирусологии и биотехнологии "Вектор" (ФГУП ГНЦ ВБ "Вектор")
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Priority to RU2005129664/13A priority Critical patent/RU2307163C2/en
Publication of RU2005129664A publication Critical patent/RU2005129664A/en
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Publication of RU2307163C2 publication Critical patent/RU2307163C2/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (3)

1. Рекомбинантная фагмидная ДНК pHEN-TAB, содержащая ген одноцепочечного антитела человека, способного связывать фактор некроза опухоли альфа человека, размером 5237 п.о. и молекулярной массой 3,46 Мда, включающая:1. Recombinant phagemid DNA pHEN-TAB containing a single-chain human antibody gene capable of binding human tumor necrosis factor alpha 5237 bp and a molecular weight of 3.46 Mda, including: SfiI - NotI - векторный фрагмент фагмиды pHEN2 (MRC, Великобритания) размером 4495 п.о,, содержащий сайт инициации репликации плазмиды pUC18, сайт инициации репликации нитчатого бактериофага М13, последовательности, кодирующие гистидиновый гексомер и эпитоп С-myc, промотор Lac-оперона E.coli, ген β-лактамазы (bla), супрессируемый стоп-кодон TAG, фрагмент гена белка pIII фага М 13;SfiI - NotI is a 4495 bp phagemid pHEN2 vector fragment (MRC, UK) containing the pUC18 plasmid replication initiation site, filamentous bacteriophage M13 replication initiation site, histidine hexomer coding sequence and C-myc epitope, Lac operon E promoter .coli, β-lactamase (bla) gene, TAG suppressible stop codon, gene fragment of pIII phage M 13 protein; SfiI - NotI - фрагмент размером 742 п.о., представляющий собой искусственный ген одноцепочечного антитела человека, способного связывать ФНО-α человека, в котором вариабельный домен тяжелой цепи соединен с вариабельным доменом легкой цепи иммуноглобулина человека с помощью ДНК последовательности, кодирующей гибкий пептидный линкер Ser(Gly4Ser)2AlaArgGlySerGly4Ser, имеющий нуклеотидную последовательность, приведенную на фиг.2;SfiI - NotI - 742 bp fragment, which is an artificial gene of a single chain human antibody capable of binding human TNF-α, in which the variable domain of the heavy chain is connected to the variable domain of the human immunoglobulin light chain using a DNA sequence encoding a flexible peptide linker Ser (Gly 4 Ser) 2 AlaArgGlySerGly 4 Ser having the nucleotide sequence shown in FIG. 2; содержит:contains: промотор Lac- оперона Е. coli;E. coli Lac operon promoter; генетический маркер: ген β-лактамазы (bla), определяющий устойчивость трансформированных фагмидой pHEN-TAB клеток E.coli к ампициллину;genetic marker: β-lactamase (bla) gene, which determines the resistance of ampicillin to E. coli transformed with phagemid pHEN-TAB; уникальные сайты узнавания эндонуклеазами рестрикции, имеющие следующие координаты: HindIII - 235, SfiI - 328, NotI - 1070, EcoRI - 2361.unique recognition sites by restriction endonucleases having the following coordinates: HindIII - 235, SfiI - 328, NotI - 1070, EcoRI - 2361. 2. Рекомбинантный штамм бактерий Escherichia coli HB2151/ pHEN-TAB, содержащий рекомбинантную фагмидную ДНК pHEN-TAB, согласно п.1, депонированный в НИИ ККМ ФГУП ГНЦ ВБ "Вектор" под номером В-1077, продуцент одноцепочечного антитела человека, способного связывать фактор некроза опухоли альфа человека.2. Recombinant bacterial strain Escherichia coli HB2151 / pHEN-TAB, containing recombinant phagemid DNA pHEN-TAB, according to claim 1, deposited in the Research Institute of KKM FSUE SSC VB "Vector" under the number B-1077, producer of a single-chain human antibody capable of binding factor tumor necrosis of human alpha. 3. Рекомбинантное растворимое одноцепочечное антитело человека scTAB, способное связывать фактор некроза опухоли альфа человека, полученное согласно п.2, имеющее аминокислотную последовательность, приведенную на фиг.2.3. Recombinant soluble single-chain human scTAB antibody capable of binding tumor necrosis factor human alpha, obtained according to claim 2, having the amino acid sequence shown in figure 2.
RU2005129664/13A 2005-09-22 2005-09-22 RECOMBINANT FRAGMID DNA pHEN-TAB CONTAINING HUMAN SINGLE-STRAND ANTIBODY GENE, CAPABLE OF BINDING OF HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT Escherichia coli BACTERIA STRAIN AS PRODUCER OF HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT SOLUBLE HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA RU2307163C2 (en)

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RU2005129664/13A RU2307163C2 (en) 2005-09-22 2005-09-22 RECOMBINANT FRAGMID DNA pHEN-TAB CONTAINING HUMAN SINGLE-STRAND ANTIBODY GENE, CAPABLE OF BINDING OF HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT Escherichia coli BACTERIA STRAIN AS PRODUCER OF HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT SOLUBLE HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA

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RU2005129664/13A RU2307163C2 (en) 2005-09-22 2005-09-22 RECOMBINANT FRAGMID DNA pHEN-TAB CONTAINING HUMAN SINGLE-STRAND ANTIBODY GENE, CAPABLE OF BINDING OF HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT Escherichia coli BACTERIA STRAIN AS PRODUCER OF HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT SOLUBLE HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2376375C2 (en) * 2008-02-18 2009-12-20 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора RECOMBINANT PLASMID DNA pFastBac-G2R-IgG, WHICH CONTAINS FRAGMENT OF SMALLPOX VIRUS GENOME, CODING FACTOR OF TUMOUR NECROSIS, BINDING PROTEIN, AND FRAGMENT OF HUMAN GENOME, CODING SECTION OF HEAVY CHAIN OF ANTIBODY G, AND STRAIN OF BACULOVIRUS BvG2RIgG, WHICH PRODUCES SOLUBLE CHIMERIC PROTEIN, WHICH CONSISTS OF SMALLPOX VIRUS PROTEIN, BINDING FACTOR OF TUMOUR NECROSIS, AND FRAGMENT OF HEAVY CHAIN OF HUMAN ANTIBODY G
RU2513686C2 (en) * 2012-08-24 2014-04-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) RECOMBINANT PLASMID DNA pG1-Rm7, FACILITATING SYNTHESIS OF HYBRID PROTEIN G1-Rm7, AND HYBRID PROTEIN BINDING TUMOUR NECROSIS FACTOR AND HAVING BIOLUMINESCENCE
RU2531547C1 (en) * 2013-03-04 2014-10-20 Федеральное государственное бюджетное учреждение науки Институт биорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Recombinant plasmid dna pet3.54, encoding polypeptide fn3.54, interacting with human tumour necrosis factor, and strain of bacteria escherichia coli - producer of polypeptide fn3.54, interacting with human tumour necrosis factor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2376375C2 (en) * 2008-02-18 2009-12-20 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора RECOMBINANT PLASMID DNA pFastBac-G2R-IgG, WHICH CONTAINS FRAGMENT OF SMALLPOX VIRUS GENOME, CODING FACTOR OF TUMOUR NECROSIS, BINDING PROTEIN, AND FRAGMENT OF HUMAN GENOME, CODING SECTION OF HEAVY CHAIN OF ANTIBODY G, AND STRAIN OF BACULOVIRUS BvG2RIgG, WHICH PRODUCES SOLUBLE CHIMERIC PROTEIN, WHICH CONSISTS OF SMALLPOX VIRUS PROTEIN, BINDING FACTOR OF TUMOUR NECROSIS, AND FRAGMENT OF HEAVY CHAIN OF HUMAN ANTIBODY G
RU2513686C2 (en) * 2012-08-24 2014-04-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) RECOMBINANT PLASMID DNA pG1-Rm7, FACILITATING SYNTHESIS OF HYBRID PROTEIN G1-Rm7, AND HYBRID PROTEIN BINDING TUMOUR NECROSIS FACTOR AND HAVING BIOLUMINESCENCE
RU2531547C1 (en) * 2013-03-04 2014-10-20 Федеральное государственное бюджетное учреждение науки Институт биорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Recombinant plasmid dna pet3.54, encoding polypeptide fn3.54, interacting with human tumour necrosis factor, and strain of bacteria escherichia coli - producer of polypeptide fn3.54, interacting with human tumour necrosis factor

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