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RU2005141456A - Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве - Google Patents

Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве Download PDF

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Publication number
RU2005141456A
RU2005141456A RU2005141456/13A RU2005141456A RU2005141456A RU 2005141456 A RU2005141456 A RU 2005141456A RU 2005141456/13 A RU2005141456/13 A RU 2005141456/13A RU 2005141456 A RU2005141456 A RU 2005141456A RU 2005141456 A RU2005141456 A RU 2005141456A
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Russia
Prior art keywords
circuit
container
microfluidic device
plate
thermal contact
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RU2005141456/13A
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English (en)
Inventor
Вэйн БРЭЙДФОРД (US)
Вэйн БРЭЙДФОРД
Кристи А. ЛАНКАСТЕР (US)
Кристи А. ЛАНКАСТЕР
Джон Вэлленс ХАЙЕНГА (US)
Джон Вэлленс ХАЙЕНГА
Рональд Л. БАРДЕЛЛ (US)
Рональд Л. БАРДЕЛЛ
Джефри Ф. ТОНН (US)
Джефри Ф. ТОНН
Бернхард Х. ВЭЙЛ (US)
Бернхард Х. ВЭЙЛ
Original Assignee
Майкроникс, Инк. (Us)
Майкроникс, Инк.
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Publication of RU2005141456A publication Critical patent/RU2005141456A/ru

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1877—Means for temperature control using chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Claims (10)

1. Микрожидкостное устройство с комплексной системой термоциклирования, содержащая микрожидкостное устройство, имеющее первую пластину и вторую пластину, причем первая пластина имеет первую поверхность и вторую поверхность, и в котором в первой поверхности выполнены контуры транспортирования жидкости, при этом вторая пластина имеет внутреннюю сторону и внешнюю сторону, причем внутренняя сторона второй пластины герметично примыкает к первой поверхности первой пластины; и по меньшей мере одну емкость, прикрепленную к внешней поверхности и находящуюся в тепловом контакте с частью контура, в результате чего на температуру жидкости в контуре влияет температура емкости, при этом емкость также содержит впускной порт, имеющий отверстие.
2. Микрожидкостное устройство по п.1, в котором емкость также включает в себя содержащийся в ней экзотермический материал, причем открытие впускного порта емкости приводит в действие экзотермический материал и инициирует изменение температуры в емкости и в части контура в тепловом контакте с емкостью.
3. Микрожидкостное устройство по п.1, в котором емкость также включает в себя содержащийся в ней эндотермический материал, причем открытие впускного порта емкости приводит в действие экзотермический материал и инициирует изменение температуры в емкости и в части контура в тепловом контакте с емкостью.
4. Микрожидкостное устройство по п.1, которое также содержит по меньшей мере две емкости, установленные на внешней поверхности микрожидкостного устройства, при этом первая емкость находится в тепловом контакте с первой частью контура, а вторая емкость находится в тепловом контакте со второй частью контура.
5. Микрожидкостное устройство по п.1, которое также содержит три емкости, установленные на внешней поверхности микрожидкостного устройства, причем три емкости повышают температуру находящихся в тепловом примыкании частей контура до температур, необходимых для завершения полимеразной цепной реакции (ПЦР).
6. Микрожидкостное устройство по п.1, которое также имеет воздухонепроницаемое уплотнение на отверстии впускного порта емкости.
7. Микрожидкостное устройство по п.1, которое выполнено портативным.
8. Микрожидкостное устройство с комплексной системой термоциклирования, содержащее микрожидкостное устройство, имеющее первую пластину и вторую пластину, причем первая пластина имеет первую поверхность и вторую поверхность, при этом первая поверхность имеет первый контур транспортирования жидкости и второй контур транспортирования жидкости, выполненные в ней, причем первый и второй контуры транспортирования жидкости находятся в тепловом контакте, и вторая пластина герметично примыкает к первой поверхности первой пластины.
9. Теплообменная система, содержащая устройство, включающее контуры течения жидкости; первый контур течения жидкости, находящийся в устройстве; и второй контур течения жидкости в тепловом контакте с первым контуром течения жидкости, в результате чего второй контур жидкости придает температуру первому контуру.
10. Теплообменная система по п.9, в которой второй контур течения жидкости содержит непрерывно текущую жидкость.
RU2005141456/13A 2003-06-06 2004-06-07 Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве RU2005141456A (ru)

Applications Claiming Priority (2)

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US47635203P 2003-06-06 2003-06-06
US60/476,352 2003-06-06

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RU2005141456A true RU2005141456A (ru) 2006-06-10

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US (1) US7544506B2 (ru)
EP (1) EP1633481A1 (ru)
JP (1) JP4758891B2 (ru)
KR (1) KR101203402B1 (ru)
CN (1) CN1812839A (ru)
AU (1) AU2004245094A1 (ru)
CA (1) CA2528208A1 (ru)
RU (1) RU2005141456A (ru)
WO (1) WO2004108287A1 (ru)

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