RU2004111596A - Офтальмические композиции в форме депо для периокулярного или субконъюнктивального введения - Google Patents
Офтальмические композиции в форме депо для периокулярного или субконъюнктивального введения Download PDFInfo
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- RU2004111596A RU2004111596A RU2004111596/15A RU2004111596A RU2004111596A RU 2004111596 A RU2004111596 A RU 2004111596A RU 2004111596/15 A RU2004111596/15 A RU 2004111596/15A RU 2004111596 A RU2004111596 A RU 2004111596A RU 2004111596 A RU2004111596 A RU 2004111596A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (16)
1. Офтальмическая композиция в форме депо, содержащая действующее вещество, которая предназначена для периокулярного или субконъюнктивального введения.
2. Композиция по п.1, содержащая микрочастицы практически чистого действующего вещества.
3. Композиция по п.1, где действующее вещество заключено в биосовместимый фармакологически приемлемый полимер или липидный капсулирующий агент.
4. Композиция по п.3, где полимер представляет собой сложный эфир полиола и сополимера полилактида и гликолида.
5. Композиция по п.4, где полимер представляет собой сложный эфир полиола и сополимера полилактида и гликолида с соотношением компонентов 40/60-60/40.
6. Композиция по п.5, содержащая микрочастицы.
7. Композиция по п.6, где внешняя поверхность микрочастиц практически не содержит действующего вещества.
8. Жидкая композиция, представляющая собой растворенный фармацевтически приемлемый полимер и растворенное или диспергированное действующее вещество, которая после инъекции образует депо в месте инъекции.
9. Композиция по п.1, где действующее вещество присутствует в количестве до 300 мкг на однократную дозу.
10. Композиция по одному из предыдущих пунктов, где действующее вещество представляет собой стауроспорин формулы (I), фталазин формулы (II) или его офтальмически приемлемую соль.
11. Способ лечения глазного заболевания, заключающийся в том, что
I) приготавливают содержащую действующее вещество композицию в форме депо, и
II) вводят указанную композицию в форме депо периокулярно или субконъюнктивально.
12. Способ по п.11, где действующее вещество заключают в фармакологически приемлемый биосовместимый полимер или липидный капсулирующий агент.
13. Способ по п.11, где действующее вещество диффундирует из композиции в форме депо в область, пораженную указанным глазным заболеванием.
14. Способ по п.11, где поддерживают эффективную дозу действующего вещества в области, пораженной указанным глазным заболеванием, в течение продолжительного периода времени.
15. Способ по одному из пп.11-14, где эффективную дозу действующего вещества поддерживают в течение периода времени до 3 месяцев.
16. Микрочастица, содержащая стауроспорин формулы (I), фталазин формулы (II) или его офтальмически приемлемую соль, заключенные в биосовместимый фармакологически приемлемый полимер или липидный капсулирующий агент.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0122318.9 | 2001-09-14 | ||
| GBGB0122318.9A GB0122318D0 (en) | 2001-09-14 | 2001-09-14 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004111596A true RU2004111596A (ru) | 2005-04-20 |
| RU2316315C2 RU2316315C2 (ru) | 2008-02-10 |
Family
ID=9922147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004111596/15A RU2316315C2 (ru) | 2001-09-14 | 2002-09-13 | Офтальмические композиции в форме депо для периокулярного или субконъюнктивального введения |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20040234611A1 (ru) |
| EP (1) | EP1429725B1 (ru) |
| JP (3) | JP2005504797A (ru) |
| KR (1) | KR20040030869A (ru) |
| CN (2) | CN102008428A (ru) |
| AT (1) | ATE389385T1 (ru) |
| AU (1) | AU2002342694B2 (ru) |
| BR (1) | BR0212475A (ru) |
| CA (1) | CA2455680C (ru) |
| CO (1) | CO5560548A2 (ru) |
| DE (1) | DE60225701T2 (ru) |
| EC (1) | ECSP044967A (ru) |
| ES (1) | ES2302849T3 (ru) |
| GB (1) | GB0122318D0 (ru) |
| HU (1) | HU229453B1 (ru) |
| IL (2) | IL160027A0 (ru) |
| MX (1) | MXPA04002421A (ru) |
| NO (1) | NO333825B1 (ru) |
| NZ (1) | NZ531481A (ru) |
| PL (1) | PL203949B1 (ru) |
| PT (1) | PT1429725E (ru) |
| RU (1) | RU2316315C2 (ru) |
| WO (1) | WO2003024420A1 (ru) |
| ZA (1) | ZA200400524B (ru) |
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