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RU2004107548A - ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID - Google Patents

ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID Download PDF

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Publication number
RU2004107548A
RU2004107548A RU2004107548/13A RU2004107548A RU2004107548A RU 2004107548 A RU2004107548 A RU 2004107548A RU 2004107548/13 A RU2004107548/13 A RU 2004107548/13A RU 2004107548 A RU2004107548 A RU 2004107548A RU 2004107548 A RU2004107548 A RU 2004107548A
Authority
RU
Russia
Prior art keywords
bacterium
amino acid
xylose
genes
expression
Prior art date
Application number
RU2004107548/13A
Other languages
Russian (ru)
Inventor
Алексей Николаевич Марченко (RU)
Алексей Николаевич Марченко
Сергей Владимирович Беневоленский (RU)
Сергей Владимирович Беневоленский
чко Елена Витальевна Кл (RU)
Елена Витальевна Клячко
Юрий Иванович Козлов (RU)
Юрий Иванович Козлов
Original Assignee
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU), Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU)
Priority to RU2004107548/13A priority Critical patent/RU2004107548A/en
Priority to US11/059,686 priority patent/US20050214913A1/en
Priority to US11/079,392 priority patent/US8003367B2/en
Priority to JP2005074490A priority patent/JP4665567B2/en
Priority to BRPI0500892-1A priority patent/BRPI0500892A/en
Priority to DE602005014825T priority patent/DE602005014825D1/en
Priority to EP05005784A priority patent/EP1577396B1/en
Priority to AT05005784T priority patent/ATE433494T1/en
Publication of RU2004107548A publication Critical patent/RU2004107548A/en
Priority to US12/349,743 priority patent/US8003368B2/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (11)

1. Бактерия семейства Enterobacteriaceae - продуцент L-аминокислоты, обладающая повышенной активностью любого из ферментов утилизации ксилозы.1. A bacterium of the Enterobacteriaceae family is a producer of L-amino acids with increased activity of any of the xylose utilization enzymes. 2. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia.2. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. 3. Бактерия по п.1, отличающаяся тем, что активность ферментов утилизации ксилозы повышены за счет усиления экспрессии локуса xylABFGHR.3. The bacterium according to claim 1, characterized in that the activity of xylose utilization enzymes is increased by enhancing the expression of the xylABFGHR locus. 4. Бактерия по п.3, отличающаяся тем, что активность ферментов утилизации ксилозы повышена за счет увеличения количесва копий локуса xylABFGHR или модификации последовательности, контролирующей экспрессию генов, таким образом, что экспрессия указанных генов усилена.4. The bacterium according to claim 3, characterized in that the activity of xylose utilization enzymes is increased by increasing the number of copies of the xylABFGHR locus or by modifying the sequence that controls gene expression, so that the expression of these genes is enhanced. 5. Бактерия по п.4, отличающаяся тем, что количесво копий указанного локуса увеличено за счет трансформации бактерии низкокопийнымо вектором, содержащим локус xylABFGHR.5. The bacterium according to claim 4, characterized in that the number of copies of the specified locus is increased due to the transformation of the bacterium with a low copy vector containing the xylABFGHR locus. 6. Бактерия по любому из пп.1-5, отличающаяся тем, что локус xylABFGHR получен из бактерии, принадлежащей к роду Escherichia.6. The bacterium according to any one of claims 1 to 5, characterized in that the xylABFGHR locus is obtained from a bacterium belonging to the genus Escherichia. 7. Способ получения L-аминокислоты, включающий стадии выращивания бактерии по любому из пп.1-6 в питательной среде, содержащей смесь глюкозы и пентоз, и выделения накопленной L-аминокислоты из культуральной жидкости.7. A method for producing an L-amino acid, comprising the steps of growing a bacterium according to any one of claims 1 to 6 in a nutrient medium containing a mixture of glucose and pentoses, and isolating the accumulated L-amino acid from the culture fluid. 8. Способ по п.7, отличающийся тем, что пентозами являются арабиноза и ксилоза.8. The method according to claim 7, characterized in that the pentoses are arabinose and xylose. 9. Способ по п.8, отличающийся тем, что указанная смесь сахаров является продуктом переработки целлюлозной биомассы.9. The method of claim 8, wherein said sugar mixture is a cellulosic biomass processing product. 10. Способ по п.9, отличающийся тем, что получаемой L-аминокислотой является L-гистидин.10. The method according to claim 9, characterized in that the resulting L-amino acid is L-histidine. 11. Способ по п.10, отличающийся тем, что в указанной бактерии усилена экспрессия генов биосинтеза L-гистидина.11. The method according to claim 10, characterized in that in said bacterium the expression of L-histidine biosynthesis genes is enhanced.
RU2004107548/13A 2004-03-16 2004-03-16 ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID RU2004107548A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
RU2004107548/13A RU2004107548A (en) 2004-03-16 2004-03-16 ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID
US11/059,686 US20050214913A1 (en) 2004-03-16 2005-02-17 Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
US11/079,392 US8003367B2 (en) 2004-03-16 2005-03-15 Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
JP2005074490A JP4665567B2 (en) 2004-03-16 2005-03-16 Method for producing L-amino acid by fermentation using bacteria with enhanced expression of xylose utilization gene
BRPI0500892-1A BRPI0500892A (en) 2004-03-16 2005-03-16 l-amino acid producing bacterium of the enterobacteriaceae family, and method for producing an l-amino acid
DE602005014825T DE602005014825D1 (en) 2004-03-16 2005-03-16 Process for the preparation of L-amino acids by fermentation of a bacterium with increased expression of genes of xylose use
EP05005784A EP1577396B1 (en) 2004-03-16 2005-03-16 Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
AT05005784T ATE433494T1 (en) 2004-03-16 2005-03-16 METHOD FOR PRODUCING L-AMINO ACIDS BY FERMENTING A BACTERIUM WITH INCREASED EXPRESSION OF XYLOSE USING GENES
US12/349,743 US8003368B2 (en) 2004-03-16 2009-01-07 Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2004107548/13A RU2004107548A (en) 2004-03-16 2004-03-16 ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2005106720/13A Substitution RU2283346C1 (en) 2004-03-16 2005-03-14 Method for production of l-amino acids by fermentation using bacteria having increased expression of xylose utilization gene

Publications (1)

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RU2004107548A true RU2004107548A (en) 2005-10-10

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RU2004107548/13A RU2004107548A (en) 2004-03-16 2004-03-16 ENTEROBACTERIACEAE FAMILY BACTERIA - L-AMINO ACID PRODUCER POSSESSING HIGH EXPRESSION OF XYLOSE DISPOSAL GENES AND METHOD FOR PRODUCING L-AMINO ACID

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Date Code Title Description
FA95 Acknowledgement of application withdrawn due to the later filing of the same application (junior application)

Effective date: 20060330