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RU2003115431A - NEW APPLICATIONS OF THE UNITED 5-NT1A AGONISTS AND SEROTONIN REVERSION INHIBITORS - Google Patents

NEW APPLICATIONS OF THE UNITED 5-NT1A AGONISTS AND SEROTONIN REVERSION INHIBITORS

Info

Publication number
RU2003115431A
RU2003115431A RU2003115431/15A RU2003115431A RU2003115431A RU 2003115431 A RU2003115431 A RU 2003115431A RU 2003115431/15 A RU2003115431/15 A RU 2003115431/15A RU 2003115431 A RU2003115431 A RU 2003115431A RU 2003115431 A RU2003115431 A RU 2003115431A
Authority
RU
Russia
Prior art keywords
butyl
acceptable salt
physiologically acceptable
cyanophenyl
carbonitrile
Prior art date
Application number
RU2003115431/15A
Other languages
Russian (ru)
Other versions
RU2288719C2 (en
Inventor
Герд Бартошик
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2003115431A publication Critical patent/RU2003115431A/en
Application granted granted Critical
Publication of RU2288719C2 publication Critical patent/RU2288719C2/en

Links

Claims (6)

1. Применение соединений которые являются объединенными селективными ингибиторами обратного захвата серотонина (5-НТ) (SSRI) и агонистами 5-HT1A рецептора, для производства медикамента для использования в ветеринарной медицине для лечения расстройств, связанных с поведенческими стрессорами.1. The use of compounds that are combined selective serotonin reuptake inhibitors (5-HT) (SSRIs) and 5-HT 1A receptor agonists, for the manufacture of a medicament for use in veterinary medicine for the treatment of behavioral stressor related disorders. 2. Применение по п.1, в котором соединения, являющиеся объединенными селективными ингибиторами обратного захвата серотонина (5-НТ) (SSRI) и агонистами 5-HT1A рецептора, выбирают из группы, которая состоит из 1-[4-(5-цианоиндол-3-ил)бутил]-4-(2-карбамоил-бензофуран-5-ил)-пиперазина или его физиологически приемлемой соли, или 3-{4-[4-(4-цианофенил)-пиперазин-1-ил]-бутил}-1Н-индол-5-карбонитрила или его физиологически приемлемой соли.2. The use according to claim 1, in which the compounds, which are combined selective serotonin reuptake inhibitors (5-HT) (SSRI) and 5-HT 1A receptor agonists, are selected from the group consisting of 1- [4- (5- cyanoindol-3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) piperazine or its physiologically acceptable salt, or 3- {4- [4- (4-cyanophenyl) piperazin-1-yl ] -butyl} -1H-indole-5-carbonitrile or a physiologically acceptable salt thereof. 3. Применение по п.2, в котором физиологически приемлемой солью 1-[4-(5-цианоиндол-3-ил)бутил]-4-(2-карбамоил-бензофуран-5-ил)-пиперазина является гидрохлорид 1-[4-(5-цианоиндол-3-ил)бутил]-4-(2-карбамоил-бензофуран-5-ил)-пиперазина.3. The use according to claim 2, in which the physiologically acceptable salt of 1- [4- (5-cyanoindol-3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) piperazine is 1- [ 4- (5-cyanoindol-3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) piperazine. 4. Применение по п.2, в котором физиологически приемлемой солью 3-{4-[4-(4-цианофенил)-пиперазин-1-ил]-бутил}-1Н-индол-5-карбонитрила является гидрохлорид 3-{4-[4-(4-цианофенил)-пиперазин-1-ил]-бутил}-1Н-индол-5-карбонитрила.4. The use according to claim 2, in which the physiologically acceptable salt of 3- {4- [4- (4-cyanophenyl) piperazin-1-yl] butyl} -1H-indole-5-carbonitrile is 3- {4 hydrochloride - [4- (4-cyanophenyl) piperazin-1-yl] butyl} -1H-indole-5-carbonitrile. 5. Фармацевтическая композиция для лечения расстройств, связанных с поведенческими стрессорами, для использования в ветеринарной медицине, отличающаяся тем, что содержит, по крайней мере, одно соединение являющееся объединенным селективным ингибитором обратного захвата серотонина (5-НТ) (SSRI) и агонистом 5-HT1A рецептора.5. A pharmaceutical composition for treating behavioral stressor related disorders for use in veterinary medicine, characterized in that it contains at least one compound which is a combined selective serotonin reuptake inhibitor (5-HT) and a 5- agonist HT 1A receptor. 6. Фармацевтическая композиция по п.5, в которой объединенный селективный ингибитор обратного захвата серотонина (5-НТ) (SSRI) и агонист 5-HT1A рецептора, выбирают из группы, которая состоит из 1-[4-(5-цианоиндол-3-ил)бутил]-4-(2-карбамоил-бензофуран-5-ил)-пиперазина или его физиологически приемлемой соли, или 3-{4-[4-(4-цианофенил)-пиперазин-1-ил]-бутил}-1Н-индол-5-карбонитрила или его физиологически приемлемой соли.6. The pharmaceutical composition according to claim 5, in which the combined selective serotonin reuptake inhibitor (5-HT) (SSRI) and a 5-HT 1A receptor agonist are selected from the group consisting of 1- [4- (5-cyanoindole- 3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) piperazine or a physiologically acceptable salt thereof, or 3- {4- [4- (4-cyanophenyl) piperazin-1-yl] - butyl} -1H-indole-5-carbonitrile or a physiologically acceptable salt thereof.
RU2003115431/15A 2000-11-14 2001-10-16 Using compound combining property of serotonin reverse uptake inhibitor and agonist of 5-ht1a-receptor RU2288719C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124815.2 2000-11-14
EP00124815 2000-11-14

Publications (2)

Publication Number Publication Date
RU2003115431A true RU2003115431A (en) 2004-11-27
RU2288719C2 RU2288719C2 (en) 2006-12-10

Family

ID=8170369

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003115431/15A RU2288719C2 (en) 2000-11-14 2001-10-16 Using compound combining property of serotonin reverse uptake inhibitor and agonist of 5-ht1a-receptor

Country Status (21)

Country Link
US (1) US20040082594A1 (en)
EP (1) EP1333832B1 (en)
JP (1) JP2004513924A (en)
KR (1) KR20030059244A (en)
CN (1) CN1222291C (en)
AR (1) AR031335A1 (en)
AU (2) AU2002215027B2 (en)
BR (1) BR0115296A (en)
CA (1) CA2428511C (en)
CZ (1) CZ302484B6 (en)
DE (1) DE60131675T2 (en)
ES (1) ES2296820T3 (en)
HU (1) HUP0302751A3 (en)
MX (1) MXPA03004166A (en)
NO (1) NO20032148D0 (en)
PL (1) PL204331B1 (en)
RU (1) RU2288719C2 (en)
SK (1) SK287337B6 (en)
UA (1) UA79583C2 (en)
WO (1) WO2002040024A1 (en)
ZA (1) ZA200304606B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10305739A1 (en) 2003-02-11 2004-08-19 Merck Patent Gmbh New indolyl-substituted benzofuran derivatives, are 5-HT(1A) agonists and 5-HT reuptake inhibitors useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents
DK1701940T3 (en) 2003-12-23 2008-09-08 Lundbeck & Co As H 2- (1H-indolylsulfanyl) benzylamine derivatives as SSRIs
US7893261B2 (en) 2004-03-26 2011-02-22 Baylor University Serotonin reuptake inhibitors
AR052308A1 (en) 2004-07-16 2007-03-14 Lundbeck & Co As H DERIVATIVES OF 2- (1H-INDOLILSULFANIL) -ARILAMINE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOUND
WO2006034788A1 (en) * 2004-09-28 2006-04-06 Merck Patent Gmbh Combinations of n-(indolecarbonyl-)piperazine derivatives and serotonin reuptake inhibitors
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (en) 2005-06-17 2007-06-20 Lundbeck & Co As H DERIVATIVES OF BENZO (B) FURANO AND BENZO (B) THIOPHEN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE REINFORCEMENT OF AMINA BOSS NEUTRANTS.
JP2010500386A (en) * 2006-08-11 2010-01-07 ディーエスエム アイピー アセッツ ビー.ブイ. Ligustilide derivatives for treating disorders of the central nervous system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333254A1 (en) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidines and piperazines
DE19512639A1 (en) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitriles and fluorides
DE19637237A1 (en) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazine derivatives
DE19730989A1 (en) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazine derivatives
EP1098892A1 (en) * 1998-07-20 2001-05-16 MERCK PATENT GmbH Biphenyl derivatives

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