RU2003114740A - NITROGEN-CONTAINING AROMATIC DERIVATIVES - Google Patents

Claims (42)

1. The compound represented by the following General formula:

where A ^g represents an optionally substituted C _6-14 aryl group or an optionally substituted 5-14 membered heterocyclic group; X ^g represents a single bond, —O—, —S—, a C _1-6 alkylene group, —SO—, —SO ₂ - or —N (R ^g3 ) - (where R ^g3 represents a hydrogen atom, optionally substituted with C _{1- 6} alkyl group or optionally substituted C _2-7 acyl group); Y ^g represents an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered heterocyclic group, an optionally substituted C _1-8 alkyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl-C _{A 1-6} alkyl group, an optionally substituted 5-14 membered heteroaryl-C _1-6 alkyl group, - (CH ₂ ) _g SO ₂ - (where g is an integer from 1 to 8), - (CH ₂ ) _fa - CH = CH- (CH ₂ ) _fb - (where each of fa and fb represents 0, 1, 2 or 3), - (CH ₂ ) _fa -CH = CH- (CH ₂ ) _fb -SO ₂ - (where each from fa and fb represents 0, 1, 2 or 3), - (CH ₂ ) _fa -C = C- (CH ₂ ) _fb - (where each of fa and fb represents 0, 1, 2 or 3) or - (CH ₂ ) _fa -CC- (CH ₂ ) _fb -SO ₂ - (where each of fa and fb represents 0, 1, 2 or 3); and T ^g1 means (1) a group represented by the following general formula:

(where E ^g represents a single bond or —N (R ^g2 ) - (where R ^g2 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _2-7 acyl group or optionally substituted C _2-7 alkoxycarbonyl group); R ^g1 represents a hydrogen atom, optionally substituted C _1-6 alkyl group, optionally substituted C _2-6 alkenyl group optional no substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _2-7 acyl group or an optionally substituted C _2-7 alkoxycarbonyl group; and Z ^g is a hydrogen atom, an optionally substituted C _1-8 alkyl group, optionally substituted C _2-6 alkenyl group, optionally substituted C _2-6 alkynyl group, optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _6-14 aryl group, optionally substituted C _6-14 an aryl-C _1-6 alkyl group, -OR ²⁰⁰ , -SR ²⁰⁰ , -COR ²⁰⁰ , -SO ₂ R ²⁰⁰ (where R ²⁰⁰ represents a hydrogen atom, an optionally substituted C _1-8 alkyl group, an optionally substituted C _3-8 alicyclic a hydrocarbon group, an optionally substituted C _6-14 aryl group, an optionally substituted C _6-14 aryl-C _1-6 alkyl group, an optionally substituted 5-14 membered heterocyclic group, or an optionally substituted 5-14 membered heterocyclyl C _1-6 alkyl group), an optionally substituted 5-14 membered heterocyclic group, or an optionally substituted 5-14 h ennuyu heterocyclyl-C _1-6 alkyl group), or (2) a group represented by the following general formula:

where R ^g1 and Z ^g have the same meanings as R ^g1 and Z ^g described above; and Z ^g1 and Z ^g2 may be the same or different and each of them represents (1) a single bond, (2) an optionally oxo-substituted C _1-6 alkylene group, also optionally having one or more atoms selected from —O—, —S - and a nitrogen atom inside or at the end of the chain, or (3) an optionally substituted C _2-6 alkenyl group, its salt and hydrate. 2. The compound represented by the following General formula:

where A represents an optionally substituted 5-14 membered aromatic heterocyclic group; X represents an oxygen atom, a sulfur atom, —SO— or —SO ₂ ; Y represents an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered aromatic heterocyclic group, or an optionally substituted C _1-6 alkylene group; E represents a single bond or —NR ² -; each of R ¹ and R ² independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally a substituted C _2-7 acyl group or an optionally substituted C _2-7 alkoxycarbonyl group; and Z represents a group represented by the formula —Z ¹¹ —Z ¹² (wherein Z ¹¹ represents a single bond, an oxygen atom, a sulfur atom, —CO—, —SO ₂ - or an optionally substituted C _1-6 alkylene group, and Z ¹² represents an atom hydrogen, an optionally substituted C _1-6 alkyl group, an optionally substituted C _1-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl group, optionally substituted 5-14 membered heterocyclic group, optional flax substituted 5-14-membered aromatic heterocyclic group, or a group represented by the formula:

where each of Z ³¹ , Z ³³ and Z ³⁴ independently represents a methylene group, —CO—, —NH or —O—, and Z ³² represents a single bond, a methylene group, —CO—, —NH or —O— provided that that A may be optionally substituted with 1-6 groups, each of which is selected from the group consisting of (1) a cyano group, (2) a halogen atom, (3) a nitro group, and (4) a group of the formula -V ^X1 -V ^X2 -V ^X22 -V ^X3 (where each of V ^X1 , V ^X2 and V ^X22 independently represents a single bond, an oxygen atom, a sulfur atom, -CO-, -SO-, -SO ₂ -, -NR ^X1 -, -CONR ^X1 -, - NR ^X1 CO-, -SO ₂ NR ^X1 -, -NR ^X1 SO ₂ -, -O-CO-, -C (O) O-, -NR ^X1 C (O) O-, -NR ^X1 C (O) ^{NR X2 -, -OC (O)} NR X1 -, -OC (O) O-, an optionally substituted nnuyu C _1-6 alkylene group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 a membered heterocyclic group, an optionally substituted 5-14 membered aromatic heterocyclic group; and each of V ^X3 , V ^X1 and V ^X2 independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, optionally substituted C _3-8 an alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered heterocyclic group, an optionally substituted 5-14 membered aromatic heterocyclic group, or an optionally substituted C _1-6 alkoxy group), a salt or hydrate thereof. 3. The compound according to claim 2, its salt or hydrate, where X represents an oxygen atom or a sulfur atom. 4. The compound according to claim 2 or 3, its salt or hydrate, where Z represents an optionally substituted cyclopropyl group, an optionally substituted 2-thiazolyl group or a group represented by the formula

where Z ¹³ represents a nitrile group, a methylsulfonyl group or a group —NHCOCH ₃ . 5. The compound according to any one of claims 2 to 4, its salt or hydrate, where E is a group represented by the formula —NR ² - (where R ² has the same meaning as R ² as defined in claim 2), and Y represents an optionally substituted phenyl group, an optionally substituted pyridyl group or a group represented by the formula

where each of W ¹¹ and W ¹² independently represents an optionally substituted carbon atom or a nitrogen atom. 6. The compound according to any one of claims 2 to 4, its salt or hydrate, where E represents a single bond, and Y, in addition, represents an optionally substituted group represented by the formula

where W ¹³ represents an optionally substituted carbon atom or a nitrogen atom. 7. The compound according to any one of claims 2 to 6, its salt or hydrate, where a means a group represented by the formula

where W represents an optionally substituted carbon atom or a nitrogen atom; R ^a13 represents a hydrogen atom, a halogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _1-6 alkoxy group, an amino group or a nitro group; R ^a12 represents a cyano group or a group represented by the formulas:

where V ^all represents —CO— or —SO ₂ -; and each of V ^a12 , V ^a13 and V ^a14 independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic a hydrocarbon group, an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered heterocyclic group or an optionally substituted 5-14 membered aromatic heterocyclic group; and R ^a11 is a group of the formula -V ^a21 -V ^a22 -V ^a23 (wherein V ^a21 is an optionally substituted C _1-6 alkylene group, a single bond or a group represented by the formula

V ^a22 represents a single bond, an oxygen atom, a sulfur atom, -CO- -SO-, -SO ₂ -, -CONR ^a14 -, -SO ₂ NR ^al4 -, -NR ^al4 SO ₂ -, -NR ^a14 CO- or - NR ^al4 - (where R ^a14 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group or an optionally substituted C _3-8 alicyclic hydrocarbon group); and V ^a23 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 ylkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _6-14 an aryl group, an optionally substituted 5-14 membered heterocyclic group or an optionally substituted 5-14 membered aromatic heterocyclic group). 8. The compound according to any one of claims 2 to 6, its salt or hydrate, where a represents a group of the formula

where W represents an optionally substituted carbon or nitrogen atom; and R ^a11 , R ^a12 and R ^a13 have the same meanings as R ^a11 , R ^a12 and R ^a13 defined in claim 7. 9. The compound according to any one of claims 2 to 6, its salt or hydrate, where A, in addition, represents an optionally substituted group represented by the formulas

where W represents an optionally substituted carbon atom or a nitrogen atom; and A ^b11 represents (1) an optionally substituted 5-14 membered heterocyclic group or (2) a group represented by the formula

where each of V ^b11 and V ^b12 independently represents a single bond, SO ₂ -, —NHCO— or a group represented by the formula - (CH ₂ ) _b —CO— (where b is an integer from 0 to 6); R ^b13 represents a ^single bond, an optionally substituted C _1-6 alkylene group, an optionally substituted C _3-8 alicyclic hydrocarbon group, or an optionally substituted 5-14 membered heterocyclic group; and each of R ^b11 and R ^b12 independently represents a hydrogen atom, a hydroxyl group, a halogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, optionally substituted C _{3 -8 an} alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered aromatic heterocyclic group, or an optionally substituted 5-14 membered heterocyclic group. 10. The compound according to any one of claims 2 to 6, its salt or hydrate, where a represents a group of the formula

where W represents an optionally substituted carbon atom or a nitrogen atom; R ^c13 represents (1) a hydrogen atom, (2) a cyano group, (3) a halogen atom, (4) a formyl group, (5) an optionally substituted C _1-6 alkyl group, (6) a group represented by the formula

where V ^c21 represents a ^—CO— or methylene group; each of V ^c22 and V ^c23 independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted 5-14-membered heterocyclic group, optionally substituted 5-14-membered aromatic heterocyclic group or an optionally substituted C _6-14 aryl group or (7) a group represented by the formula -V ^c21 -OV ^c22 (wherein V ^c21 and V ^c22 have the same meanings as V ^c21 and V ^c22, as defined above); R ^c12 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group or an optionally substituted C _3-8 alicyclic hydrocarbon group; and R ^c11 represents a group of the formula —V ^c11 —V ^c12 —V ^c13 (where V ^c11 represents a ^single bond, an oxygen atom, an optionally substituted benzene ring, an optionally substituted 5-14 membered aromatic heterocyclic group or —CO—; V ^c12 represents a simple a bond, an oxygen atom or an optionally substituted C _1-6 alkylene group; and V ^c13 represents (1) an optionally substituted C _1-6 alkyl group, (2) an optionally substituted C _2-6 alkenyl group, (3) an optionally substituted C _{2- 6} alkynyl group, (4) optionally substituted C _3-8 alicyclic hydrocarbon group, (5) hydroxyl group, (6) carboxyl group, (7) optionally substituted C _2-7 alkoxycarbonyl group, (8) optionally substituted 5-14 membered heterocyclic group, (9) optionally substituted 5-14- membered aromatic heterocyclic group, (10) optionally substituted C _6-14 aryl group, (11) a group represented by the formula -NR ^c21 R ^c22 (wherein R ^c21 and R ^c22 are independently represents a hydrogen atom or an optionally substituted C _1-6 alkyl group), or (12) a hydrogen atom). 11. The compound represented by the following General formula:

where R ¹ , R ² and Z ¹² have the same meanings as R ¹ , R ² and Z ¹² defined in claim 2, but Z ^{12 is} not a pyrazolyl group; Y ^a1 represents a group of the formula

where each of W ³¹ and W ³² independently represents an optionally substituted carbon atom or a nitrogen atom; each of R ³⁰⁰ and R ³⁰¹ independently represents a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, an optionally substituted C _1-6 alkyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _1-6 alkoxy group, optionally substituted C _2-7 alkoxycarbonyl group, formyl group, group represented by the formula

where each of V ³⁰⁰ and V ³⁰¹ independently represents a hydrogen atom or an optionally substituted C _1-6 alkyl group, or an optionally substituted C _2-7 acyl group; and R ^a11 and R ^a12 have the same meanings as R ^a11 and R ^a12 defined in claim 7, with the exception of the following compounds (1) and (2) :( 1) compounds where R ^a12 means a group represented by the formulas

where V ^a12 and V ^a13 have the same meanings as V ^a12 and V ^a13 defined in claim 7, R ¹ and R ² represent hydrogen atoms, and Z ¹² represents a C _6-14 aryl group, 6-14 membered a heterocyclic group or a 6-14 membered aromatic heterocyclic group; and (2) compounds wherein R ^a12 represents a group selected from groups represented by formulas

where V ^a11 , V ^a12 , V ^a13 and V ^a14 have the same meanings as V ^a11 , V ^a12 , V ^a13 and Va ¹⁴ defined in claim 7, R ² represents a hydrogen atom, and Z ¹² represents (a) C _6-14 aryl group, (b) 5-14 membered heterocyclic group, (c) 5-14 membered aromatic heterocyclic group, (d) C _1-6 alkyl group substituted with a 5-10 membered heterocyclic group or C _{A 5-10} alicyclic hydrocarbon group, (f) a C _2-6 alkenyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (f) a _2-6 alkynyl group substituted with a 5-10 a heterocyclic group or a C _5-10 alicyclic hydrocarbon group; or (g) a C _3-8 alicyclic hydrocarbon group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, a salt or hydrate thereof. 12. The compound according to claim 11, its salt or hydrate, where R ^a11 represents a methyl group, a 2-methoxyethyl group or a group represented by the formulas

where R ^a53 represents a methyl group, a cyclopropylmethyl group or a cyanomethyl group; R ^a51 represents a hydrogen atom, a fluorine atom or a hydroxyl group; and R ^a52 represents a 1-pyrrolidinyl group, 1-piperidinyl group, 4-morpholinyl group, dimethylamino group or diethylamino group. 13. The compound according to claim 11 or 12, its salt or hydrate, where Z ¹² represents a methyl group, an ethyl group, a cyclopropyl group, a 2-thiazolyl group or a 4-fluorophenyl group. 14. The compound according to any one of paragraphs.11-13, its salt or hydrate, where Y ^a1 represents a group of the formula

where R ^a61 represents a hydrogen atom, a methyl group, a trifluoromethyl group, a chlorine atom or a fluorine atom. 15. The compound according to any one of claims 11-14, its salt or hydrate, where R ^a12 represents a cyano group or a group represented by the formula —CONHR ^a62 (where R ^a62 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _1-6 alkoxy group or optionally substituted C _3-8 cycloalkoxy group). 16. The compound represented by the following General formula:

where Z ²¹ represents a hydrogen atom, an optionally substituted C _1-6 alkyl) group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group or an optionally substituted C _3-8 alicyclic hydrocarbon group; R ^a120 represents a cyano group or a group represented by formulas

where V ^a15 represents an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group or an optionally substituted C _3-8 alicyclic hydrocarbon group, and V ^a11 , V ^a12 , V ^a13 and V ^a14 have the same meanings as V ^a11 , V ^a12 , V ^a13 and V ^a14 as defined in claim 7; R ³⁰⁰ and R ³⁰¹ have the same meanings as R ³⁰⁰ and R ³⁰¹ as defined in claim 11; and R ^a11 has the same meaning as R ^a11 defined in claim 7, except for the compound where R ^a120 represents a group selected from the group of formulas

where V ^a11 , V ^a12 , V ^a13 and V ^a14 have the same meanings as V ^a11 , V ^a12 , V ^a13 and V ^a14 defined in claim 7, and V ^{a15 are} defined above, and Z ²¹ represents (a) C _3-8 alicyclic hydrocarbon group, (b) C _1-6 alkyl group substituted with 5-10 membered heterocyclic group or C _5-10 alicyclic hydrocarbon group, (c) C _2-6 alkenyl group substituted with 5-10- a heterocyclic membered group or a C _5-10 alicyclic hydrocarbon group, or (d) a C _2-6 alkynyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, its salt or hydrate. 17. The compound represented by the following General formula:

where Z ²² represents an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered heterocyclic group, or an optionally substituted 5-14 membered aromatic heterocyclic group; R ³⁰⁰ and R ³⁰¹ have the same meanings as R ³⁰⁰ and R ³⁰¹ as defined in claim 11; V ^d13 represents a group selected from the group of formulas

where V ^a12 and V ^a13 have the same meanings as V ^a12 and V ^a13 defined in claim 7; V ^d11 represents an optionally substituted C _1-6 alkylene group or a group represented by the formula

and V ^d12 represents (1) a group of the formula NR ^d11 R ^d12 (where each of R ^d11 and R ^d12 represents a hydrogen atom, an optionally substituted C _1-6 alkyl group or an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted with C _{6- 14 an} aryl group, an optionally substituted 5-14 membered heterocyclic group or an optionally substituted 5-14 membered aromatic heterocyclic group); or (2) an optionally substituted 5-14 membered heterocyclic group, a salt or hydrate thereof. 18. The compound represented by the following General formula:

where R ¹ , R ² and Z ¹² have the same meanings as R ¹ , R ² and Z ¹² defined in claim 2; W ¹¹ represents an optionally substituted carbon atom or a nitrogen atom; R ³⁰⁰ has the same meaning as R ³⁰⁰ as defined in claim 11; R ^a11 has the same meaning as R ¹¹ as defined in claim 7; and R ^a120 has the same meaning as R ^a120 defined in ^clause 16, with the exception of the following compounds (1) and (2): (1) compounds where R ^a120 represents a group of formulas

where V ^a12 and V ^a13 have the same meanings as in V ^a12 and V ^a13 defined in claim 7; R ¹ and R ² represent hydrogen atoms, and Z ¹² represents a C _6-14 aryl group; A 6-14 membered heterocyclic group or a 6-14 membered aromatic heterocyclic group; (2) compounds wherein R ^a120 represents a group selected from the group of formulas

where V ^a11 , V ^a12 , V ^a13 and V ^a14 have the same meanings as V ^a11 , V ^a12 , V ^a13 and V ^a14 as defined in claim 7, and V ^a15 has the same meaning as V ^a15 , as defined in clause 16, R ² represents a hydrogen atom, and Z ¹² represents (a) a C _6-14 aryl group, (b) a 5-14 membered heterocyclic group, (c) a 5-14 membered aromatic heterocyclic group, ( d) a C _1-6 alkyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (e) a C _2-6 alkenyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon discharge group, (f) C _2-6 alkynyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, or (g) a C _3-8 alicyclic hydrocarbon group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, a salt or hydrate thereof. 19. The compound represented by the following General formula:

where each of W ⁴¹ and W independently represents an optionally substituted carbon atom or a nitrogen atom, but W ⁴¹ and W are not both nitrogen atoms; X ^y1 represents an optionally substituted group selected from the group of the following formulas:

where Z ¹² has the same meaning as Z ¹² defined in claim 2, W ¹¹ represents an optionally substituted carbon atom or nitrogen atom; and A ^b11 has the same meaning as A ^b11 defined in claim 9], its salt or hydrate. 20. The compound represented by the following General formula:

where R ^c13 has the same meaning as R ^c13 defined in clause 10; X ^y2 represents an optionally substituted group selected from the groups of the following formulas:

where Z ¹² , R ¹ and R ² have the same meanings as Z ¹² , R ¹ and R ² , as defined in claim 2, and W ¹¹ represents an optionally substituted carbon atom or nitrogen atom; and R ^c11 and R ^c12 have the same meanings as R ^c11 and R ^c12 as defined in claim 10; with the exception of the following compounds (1) and (2): (1) compounds where R ¹ and R ² represent a hydrogen atom, and Z ¹² represents (a) a C _6-14 aryl group, (b) a 5-14 membered heterocyclic a group, (c) a C _1-6 alkyl group substituted with a 5-10 membered aromatic heterocyclic group, a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (d) a C _2-6 alkenyl group substituted with a 5- 10-membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (e) C _2-6 alkynyl group, a substituted 5-10-membered heterocyclic Rupp or a C _5-10 alicyclic hydrocarbon group, or (f) a C _3-8 alicyclic hydrocarbon group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group; (2) compounds wherein X ^y2 is a group represented by the formula

where Z ¹² represents (a) a C _6-14 aryl group, (b) a 5-14 membered heterocyclic group, (c) a 5-14 membered aromatic heterocyclic group, (d) a C _1-6 alkyl group substituted with a 5- A 10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (e) a C _2-6 alkenyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, (f) C _2-6 alkynyl group substituted with a 5-10 membered heterocyclic group or a C _5-10 alicyclic hydrocarbon group, or (g) a _3-8 alicyclic hydrocarbon one group), its salt or hydrate. 21. The compound according to claims 10 or 20, its salt or hydrate, where R ^c11 represents a group of the formula

where V ^f11 represents a single bond, optionally substituted by a C _1-6 alkylene group or a group represented by the formula

and V ^f12 represents (1) a hydrogen atom, (2) a hydroxyl group, (3) an optionally substituted 5-14 membered heterocyclic group, (4) an optionally substituted 5-14 membered aromatic heterocyclic group, (5) optionally substituted C _{6 A -14} aryl group or (6) a group represented by the formula —NR ^f21 R ^f22 (wherein each of R ^f21 and R ^f22 independently represents a hydrogen atom or an optionally substituted C _1-6 alkyl group). 22. The compound represented by the following General formula:

where X has the same meaning as X defined in claim 2; R ³⁰⁰ and R ³⁰¹ have the same meanings as R ³⁰⁰ and R ³⁰¹ as defined in claim 11; and A ³¹ represents a group selected from the group of formulas

where R ^c13 has the same meaning as R ^c13 defined in clause 10; W, R ^a11 and R ^a13 have the same meanings as W, R ^a11 and R ^a13 defined in claim 7; and A ^b11 has the same meaning as A ^b11 as defined in clause 9; R ^c12 has the same meaning as R ^c12 defined in claim 10, and R ^e11 represents a group of the formula

where V ^f11 and V ^f12 have the same meanings as V ^f11 and V ^f12 defined in ^item 21, but V ^{f12 is} not a hydrogen atom, its salt or hydrate. 23. A compound represented by the following general formula:

where Z ¹² , R ¹ and R ² have the same meanings as Z ¹² in R ¹ and R ² defined in claim 2; R ³⁰⁰ and R ³⁰¹ have the same meanings as R ³⁰⁰ and R ³⁰¹ as defined in claim 11; and A ³² represents a group selected from a group of formulas

where R ^c13 has the same meanings as R ^c13 defined in clause 10; W, R ^a11 , R ^a12 and R ^a13 have the same meanings as W, R ^a11 , R ^a11 and R ^a13 defined in claim 7; And ^b11 has the same meaning as A ^b11 defined in ^clause 9, and R ^c11 and R ^c12 have the same meanings as R ^c11 and R ^c12 defined in clause 10, its salt or hydrate. 24. The compound according to claim 1 or 2, its pharmacologically acceptable salt or hydrate, where the specified compound is selected from N- (4- (6-cyano-7- (3- (4-pyridyl) propoxy) -4-quinolyl) oxyphenyl) -N ’- (4-methoxyphenyl) urea, N- (4- (6-cyano-7- (2- (1,2,3-triazol-2-yl) ethoxy-4-quinolyl) oxyphenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2- (1,2,3-triazol-1-yl) ethoxy) -4-quinolyl) oxyphenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2- (1,2,3-triazol-2-yl) ethoxy-4-quinolyl) oxyphenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (2- (1,2,3-triazol-1-yl) ethoxy-4-quinolyl) oxyphenyl-N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (2- (methoxyethoxy) -4-quinolyl) oxyphenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2- (methoxyethoxy) -4-quinolyl) oxyphenyl) -N ’- (1,3-thiazol-2-yl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxyphenyl) -N ’- (3-cyanophenyl) urea, N- (4- (6-cyano-7- (2- (methoxyethoxy) -4-quinolyl) oxyphenyl) -N ’- (2- (methylsulfonyl) phenyl) urea, N- (4- (6-cyano-7- (2- (methoxyethoxy) -4-quinolyl) oxyphenyl) -N’-cyclopropylurea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (1,3-thiazol-2-yl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) hydroxy-2-fluorophenyl) -N’-cyclopropylurea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxyphenyl) -N’-cyclopropylmethylurea, N- (4- (6-cyano-7- (3- (morpholin-4-yl) propoxy) quinolin-4-yloxy) -2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (3- (diethylamino) propoxy) -4-quinolyloxy) phenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (3- (4-morpholino) propoxy) -4-quinolyl) oxyphenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (3- (methylsulfonyl) phenyl) urea, N- (4- (6-cyano-7- (3- (diethylamino) propoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (3- (1- (4-ethylpiperazino)) propoxy) -4-quinolyl) oxyphenyl) -N ’- (4-methoxyphenyl) urea, N- (4- (6-cyano-7- (3-cyanopropoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (2- (methylsulfonyl) ethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (2- (methylsulfonyl) ethoxy) -4-quinolyl) oxyphenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxyphenyl) -N’-phenylurea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (3-methoxycarbonylpropoxy) -4-quinolyl) oxyphenyl) -N ’- (4-methoxyphenyl) urea, N- (4- (6-cyano-7- (3-carboxypropoxy) -4-quinolyl) oxyphenyl) -N ’- (4-methoxyphenyl) urea, N- (4- (6-cyano-7- (2- (2-hydroxyethoxy) ethoxy) -4-quinolyl) oxyphenyl) -N ’- (4-methoxyphenyl) urea, N- (4- (6-cyano-7- (3- (diethylamino) propoxy) -4-quinolyloxy) phenyl) -N ’- (3- (methylsulfonyl) phenyl) urea, N- (4- (6-cyano-7- (3- (4-morpholino) propoxy) -4-quinolyl) oxyphenyl) -N ’- (3- (methylsulfonyl) phenyl) urea, N- (4- (6-cyano-7- (3- (diethylamino) propoxy) -4-quinolyloxy) phenyl) -N’-phenylurea, N- (4- (6-cyano-7- (3- (4-morpholino) propoxy) -4-quinolyl) oxyphenyl) -N’-phenylurea, N- (4- (6-cyano-7- (3- (4-morpholino) propoxy) -4-quinolyl) oxyphenyl) -N '- (2-oxo-1,2,3,4-tetrahydro-6- quinolyl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxyphenyl) -N ’- (3-acetamidophenyl) urea, N- (4- (6-cyano-7-beneyloxy-4-quinolyl) oxy-2-fluorophenyl) -N ’- (2,4-difluorophenyl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (4-fluorophenyl) urea, N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) hydroxy-2-fluorophenyl) -N’-phenylurea, 4- (4 - ((4-fluoroanilino) carbonyl) aminomethoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 7- (2-methoxyethoxy) -4- (4 - ((1,3-thiazol-2-ylamino) carbonyl) aminophenoxy) -6-quinolinecarboxamide, 4- (4 - ((anilinocarbonyl) amino) -3-fluorophenoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 4- (4 - ((4-fluoroanilino) carbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (4 - ((cyclopropylamino) carbonyl) aminophenoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 7-methoxy-4- (4 - ((1,3-thiazol-2-ylamino) carbonyl) aminophenoxy) -6-quinolinecarboxamide, 4- (4 - ((2,4-difluoroanilino) carbonyl) amino-3-fluorophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (4 - ((cyclopropylamino) carbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (5 - ((anilinocarbonyl) amino) -2-pyridyloxy) -7-methoxy-6-quinolinecarboxamide, 4- (4 - ((anilinocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (4 - ((anilinocarbonyl) aminophenoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 4- (4 - ((2,4-difluoroanilino) carbonyl) amino-3-fluorophenoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 4- (4 - ((4-fluoroanilino) carbonyl) amino-3-fluorophenoxy} -7- (2-methoxyethoxy) -6-quinolinecarboxamide, 7- (2-methoxyethoxy) -4- (4 - ((1,3-thiazol-2-ylamino) carbonyl) amino-3-fluorophenoxy) -6-quinolinecarboxamide and 4- (4 - ((4-fluoroanilino) carbonyl) amino-3-fluorophenoxy) -7-methoxy-6-quinolinecarboxamide. 25. The compound according to 1 or 2, a pharmacologically acceptable salt or hydrate thereof, wherein said compound is selected from: N- (4- (6-cyano-7- (2-methoxyethoxy) -4-quinolyl) oxy-2-fluorophenyl) -N ’- (4-fluorophenyl) urea, N- (2-chloro-4 - ((6-cyano-7 - ((1-methyl-4-piperidyl) methoxy) -4-quinolyl) oxy) phenyl) -N’-cyclopropylurea, N- (4 - ((6-cyano-7 - (((2R) -3- (diethylamino) -2-hydroxypropyl) oxy) -4-quinolyl) oxy) phenyl) -N '- (4-fluorophenyl) urea , N- (4 - ((6-cyano-7 - (((2R) -2-hydroxy-3- (1-pyrrolidino) propyl) oxy) -4-quinolyl) oxy) phenyl) -N '- (4- fluorophenyl) urea, N- {4- [6-cyano-7- (2-hydroxy-3-pyrrolidin-1-ylpropoxy) quinolin-4-yloxy] -2-methylphenyl} -N’-4-cyclopropylurea, 4- (4- (4-fluoroanilino) carbonyl) -4-methylaminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (3-chloro-4- (cyclopropylaminocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (3-chloro-4- (cyclopropylaminocarbonyl) aminophenoxy) -7- (2-methoxyethoxy) -6-quinolinecarboxamide, N6-cyclopropyl-4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6- (2-methoxyethyl) -4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6- (2-pyridyl) -4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6- (2-fluoroethyl) -4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6-methoxy-4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6-methyl-4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, N6-ethyl-4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, 6-carbamoyl-4- (1-ethylcarbamoyl-1H-indol-5-yloxy) -7-methoxyquinoline, 6-carbamoyl-7-methoxy-4- (1-propylcarbamoyl) -1H-indol-5-yloxy) quinoline, 6-carbamoyl-7-methoxy-4- [1- (1-methyl) ethylcarbamoyl-1H-indol-5-yloxy] quinoline, N4- (4- {4 - [(anilinocarbonyl) amino] -3-chlorophenoxy} -2-pyridyl) -1-methyl-4-piperidinecarboxamide, N1-phenyl-3-chloro-5 - [(2 - {[(1-methyl-4-piperidyl) carbonyl] amino} -4-pyridyl) oxy] -1H-1-indolecarboxamide, N4- [4- (3-chloro-4 - {[((4-fluoroanilino) carobnyl] amino} phenoxy) -2-pyridyl)] - 1-methyl-4-piperidinecarboxamide, 1- (2-chloro-4- {6- [4- (2-diethylaminoethoxy) phenyl] -7H-pyrrolo [2,3-d] pyrimidin-4-yloxy} phenyl) -3-cyclopropylurea, 1- {2-chloro-4- [6- [4 - ((2R) -2-hydroxy-3-diethylaminopropoxy) phenyl] -7H-pyrrolo [2,3-d] pyrimidin-4-yloxy] phenyl} - 3-cyclopropylurea, 1- (2-chloro-4- {6- [4 - ((2R) -2-hydroxy-3-pyrrolidinopropoxy) phenyl] -7H-pyrrolo [2,3-d] pyrimidin-4-yloxy} phenyl) - 3-cyclopropylurea and 1- (2-chloro-4- {6- [4- (2-diethylaminopropoxy) phenyl] -7H-pyrrolo [2,3-d] pyrimidin-4-yloxy} phenyl) -3-cyclopropylurea. 26. The compound according to claims 1 or 2, its pharmacologically acceptable salt or hydrate, where the specified compound is selected from: 4- (3-chloro-4- (cyclopropylaminocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (3-chloro-4- (ethylaminocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide, N6-methoxy-4- (3-chloro-4 - (((cyclopropylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide, 4- (3-chloro-4- (methylaminocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide and N6-methoxy-4- (3-chloro-4 - (((ethylamino) carbonyl) amino) phenoxy) -7-methoxy-6-quinolinecarboxamide. 27. A medicine containing, as an active ingredient, a compound according to any one of claims 1 to 6, a pharmacologically acceptable salt or hydrate thereof. 28. A drug that inhibits angiogenesis and containing as an active ingredient the compound according to any one of claims 1 to 6, its pharmacologically acceptable salt or hydrate. 29. A pharmaceutical composition comprising a compound represented by the general formula

where A represents an optionally substituted 5-14 membered aromatic heterocyclic group; X represents an oxygen atom, a sulfur atom, —SO— or —SO ₂ ; Y represents an optionally substituted C _6-14 aryl group, an optionally substituted 5-14 membered aromatic heterocyclic group, or an optionally substituted C _1-6 alkylene group; E represents a single bond or —NR ² -; each of R ¹ and R ² independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally a substituted C _2-7 acyl group or an optionally substituted C _2-7 alkoxycarbonyl group; and Z represents a group represented by the formula —Z ¹¹ —Z ¹² (wherein Z ¹¹ represents a single bond, an oxygen atom, a sulfur atom, —CO—, —SO ₂ - or an optionally substituted C _1-6 alkylene group, and Z ¹² represents an atom hydrogen, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, an optionally substituted C _6-14 aryl group, optionally substituted 5-14 membered heterocyclic group, optional flax substituted 5-14-membered aromatic heterocyclic group or a group represented by the formula

where each of Z ³¹ , Z ³³ and Z ³⁴ independently represents a methylene group, —CO—, —NH— or —O—, and Z ³² represents a single bond, a methylene group, —CO—, —NH or —O— under the condition that A may optionally be substituted with 1-6 groups, each of which is selected from the group consisting of (1) a cyano group, (2) a halogen atom, (3) a nitro group, and (4) a group of the formula -V ^X1 -V ^X2 -V ^X22 -V ^X3 (where each of V ^X1 , V ^X2 and v ^X22 independently represents a single bond, an oxygen atom, a sulfur atom, -CO-, -SO-, -SO ₂ -, -NR ^X1 -, -CONR ^X1 -, -NR ^X1 CO-, -SO ₂ NR ^X1 -, -NR ^X1 SO ₂ -, -O-СО-, -С (О) O-, -NR ^X1 C (O) O-, -NR ^X1 C (O ) NR ^X2 -, -O-C (O) NR ^X1 -, -O-C (O) O-, optionally substituted C _1-6 kylen group, optionally substituted C _2-6 alkenyl group, optionally substituted C _2-6 alkynyl group, optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _6-14 aryl group, optionally substituted 5-14 a membered heterocyclic group, an optionally substituted 5-14 membered aromatic heterocyclic group; and each of V ^X3 , R ^X1 and R ^X2 independently represents a hydrogen atom, an optionally substituted C _1-6 alkyl group, an optionally substituted C _2-6 alkenyl group, an optionally substituted C _2-6 alkynyl group, an optionally substituted C _3-8 alicyclic hydrocarbon group, optionally substituted C _6-14 aryl group, an optionally substituted 5-14-membered heterocyclic group, optionally substituted 5-14-membered aromatic heterocyclic group or an optionally substituted C _1-6 alkoxy group), pharmacologically reception emuyu salt or hydrate thereof together with a pharmacologically acceptable carrier. 30. A prophylactic or therapeutic agent for treating a disease against which angiogenesis inhibition is effective, comprising, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 31. An angiogenesis inhibitor containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 32. An antitumor agent containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 33. A therapeutic agent for the treatment of angioma, containing as an active ingredient the compound according to any one of claim 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 34. An inhibitor of cancer metastasis containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 35. A therapeutic agent for the treatment of retinal revascularization or diabetic retinopathy, containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 36. A therapeutic agent for treating an inflammatory disease, comprising, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 37. A therapeutic agent for treating an inflammatory disease selected from deforming arthritis, rheumatoid arthritis, psoriasis and delayed-type hypersensitivity, containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 38. A therapeutic agent for the treatment of atherosclerosis containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 39. A therapeutic agent for treating pancreatic cancer, stomach cancer, colon cancer, breast cancer, prostate cancer, lung cancer, kidney cancer, brain tumor, blood cancer, or ovarian cancer, containing, as an active ingredient, a compound according to any one of 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 40. An antitumor agent that inhibits angiogenesis and containing, as an active ingredient, a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 41. A prophylactic or therapeutic method for treating a disease against which the inhibition of angiogenesis is effective, comprising administering to the patient a pharmacologically effective dose of a compound according to any one of claims 1 or 2, a pharmacologically acceptable salt or hydrate thereof. 42. The use of the compound according to claim 1 or 2, its pharmacologically acceptable salt or hydrate for the manufacture of a prophylactic or therapeutic agent for the treatment of a disease against which the inhibition of angiogenesis is effective.