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RU2003113145A - SUBSTITUTED 5R1, 6R2-1, 3,4-THIADIAZIN-2, AMINES AND THEIR CONTAINING PHARMACEUTICAL COMPOSITIONS AS PHARMACOLOGICALLY ACTIVE AGENTS WITH ANTI-AAGULATE AND ANTIMATE - Google Patents

SUBSTITUTED 5R1, 6R2-1, 3,4-THIADIAZIN-2, AMINES AND THEIR CONTAINING PHARMACEUTICAL COMPOSITIONS AS PHARMACOLOGICALLY ACTIVE AGENTS WITH ANTI-AAGULATE AND ANTIMATE

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Publication number
RU2003113145A
RU2003113145A RU2003113145/04A RU2003113145A RU2003113145A RU 2003113145 A RU2003113145 A RU 2003113145A RU 2003113145/04 A RU2003113145/04 A RU 2003113145/04A RU 2003113145 A RU2003113145 A RU 2003113145A RU 2003113145 A RU2003113145 A RU 2003113145A
Authority
RU
Russia
Prior art keywords
thiadiazin
amines
substituted
pharmaceutical compositions
active agents
Prior art date
Application number
RU2003113145/04A
Other languages
Russian (ru)
Other versions
RU2259371C2 (en
Inventor
Олег Николаевич Чупахин
Лариса Петровна Сидорова
Наталья Михайловна Перова
Валерий Николаевич Чарушин
Владимир Леонидович Русинов
Александр Георгиевич Муляр
Original Assignee
Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд"
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд" filed Critical Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд"
Priority to RU2003113145/04A priority Critical patent/RU2259371C2/en
Priority claimed from RU2003113145/04A external-priority patent/RU2259371C2/en
Publication of RU2003113145A publication Critical patent/RU2003113145A/en
Application granted granted Critical
Publication of RU2259371C2 publication Critical patent/RU2259371C2/en

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Claims (3)

1. Замещенные 5R1, 6R2-1,3,4-тиадиазин-2-амины общей формулы I и содержащие их фармацевтические композиции в качестве фармакологически активных средств, обладающих сочетанным антикоагулянтным и антиагрегантным действием.1. Substituted 5R 1 , 6R 2 -1,3,4-thiadiazin-2-amines of the general formula I and pharmaceutical compositions containing them as pharmacologically active agents having a combined anticoagulant and antiplatelet effect.
Figure 00000001
Figure 00000001
 где R1 - фенил, который может быть замещен одним или более атомами хлора, брома, С1-С4-алкокси или C1-C4алкильными группами; или R1 - остаток этоксалилметоксима;where R 1 is phenyl, which may be substituted by one or more chlorine, bromine, C 1 -C 4 alkoxy or C 1 -C 4 alkyl groups; or R 1 is a residue of ethoxalylmethoxime; R2 - атом водорода или С1-С4-алкильные группы.R 2 is a hydrogen atom or C 1 -C 4 alkyl groups. R3 - N-морфолинил, N-тиоморфолинил, N-пиперидинил, N-пирролидинил, N-гексаметилениминил, N-метиламино-(1-фенил-2,3-диметил-пиразол-5-он-4-ил), N-амино-(1-фенил-2,3-диметилпиразол-5-он-4-ил);R 3 - N-morpholinyl, N-thiomorpholinyl, N-piperidinyl, N-pyrrolidinyl, N-hexamethyleneiminyl, N-methylamino (1-phenyl-2,3-dimethyl-pyrazol-5-one-4-yl), N amino (1-phenyl-2,3-dimethylpyrazol-5-one-4-yl); 2. Фармацевтически приемлемые соли замещенных 5R1, 6R2-1,3,4-тиадиазин-2-аминов общей формулы I в качестве фармакологически активных средств, обладающие антикоагулянтным и антиагрегантным действием.2. Pharmaceutically acceptable salts of substituted 5R 1 , 6R 2 -1,3,4-thiadiazin-2-amines of the general formula I as pharmacologically active agents having anticoagulant and antiplatelet action. 3. Фармацевтические композиции, обладающие антикоагулянтным и антиагрегантным действием и содержащие эффективное количество, по крайней мере, одного из 5R1, 6R2-тиадиазин-2-аминов формулы I или фармацевтически приемлемой их соли в качестве активного агента, и фармацевтически приемлемый наполнитель, разбавитель и/или другие вспомогательные вещества.3. Pharmaceutical compositions having anticoagulant and antiplatelet action and containing an effective amount of at least one of the 5R 1 , 6R 2 -thiadiazin-2-amines of formula I or a pharmaceutically acceptable salt thereof as an active agent, and a pharmaceutically acceptable excipient, diluent and / or other excipients.
RU2003113145/04A 2003-05-05 2003-05-05 Substituted 5r1,6r2 -1,3,4-thiadiazine-2-amines and pharmaceutical compositions comprising thereof as pharmacologically active agents eliciting anticoagulant and anti-aggregating effect RU2259371C2 (en)

Priority Applications (1)

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RU2003113145/04A RU2259371C2 (en) 2003-05-05 2003-05-05 Substituted 5r1,6r2 -1,3,4-thiadiazine-2-amines and pharmaceutical compositions comprising thereof as pharmacologically active agents eliciting anticoagulant and anti-aggregating effect

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RU2003113145/04A RU2259371C2 (en) 2003-05-05 2003-05-05 Substituted 5r1,6r2 -1,3,4-thiadiazine-2-amines and pharmaceutical compositions comprising thereof as pharmacologically active agents eliciting anticoagulant and anti-aggregating effect

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RU2003113145A true RU2003113145A (en) 2004-12-27
RU2259371C2 RU2259371C2 (en) 2005-08-27

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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2281946C1 (en) * 2005-09-21 2006-08-20 ГОУ ВПО Уральский государственный технический университет-УПИ 2-cycloalkylimino-5-(4-nitrophenyl)-1,3,4-thiadiazines possessing biological activity against smallpox virus
RU2395850C2 (en) * 2008-06-23 2010-07-27 Петр Алексеевич Сарапульцев Method of treating experimental myocardial infarction in rats
RU2379306C1 (en) * 2008-07-22 2010-01-20 Государственное образовательное учреждение высшего профессионального образования "Уральский государственный технический университет-УПИ" 2-cycloalkylamino-5-thienyl-1,3,4-thiadiazines, hydrobromides, with antiaggregant activity
RU2411936C2 (en) * 2009-01-11 2011-02-20 Институт физиологии Коми научного центра Уральского отделения Российской академии наук. Государственное учреждение Application of 2-morpholino-5-phenyl-6h-1,3,4-tiadizin, hydrobromide as medication possessing hypolipidemic hyperglicemic effect
RU2458060C2 (en) * 2009-05-22 2012-08-10 Государственное образовательное учреждение высшего профессионального образования "Уральский государственный технический университет - УПИ имени первого Президента России Б.Н. Ельцина" 5-(4'-hydroxyphenyl)-and 5-(2',5'-dihydroxyphenyl)-6 h-1,3,4-thiadiazine-2-amines, hydrohalogenides inhibiting thrombocyte aggregation in intravenous introduction
RU2445310C2 (en) * 2010-04-12 2012-03-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" 2-piperidino-5-(thienyl-2)- and 2-piperidino-5-(thienyl-3)- 6h-1,3,4-thiadiazines hydrobromides possessing antiaggregant action
RU2456284C1 (en) * 2011-04-12 2012-07-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" 2-aminopropylmorpholino-5-aryl-6h-1,3,4-thiadiazines, dihydrobromides and 2-aminopropylmorpholino-4-arylthiazoles, hydrobromides showing antiaggregant action
LV14606B (en) 2011-05-17 2013-01-20 Tetra, Sia New Factor XII inhibitor
RU2525015C2 (en) * 2012-07-24 2014-08-10 Максим Анатольевич Ранцев Method of treating experimental pancreatonecrosis
RU2543320C2 (en) * 2013-04-01 2015-02-27 Федеральное государственное бюджетное учреждение науки Институт физиологии Коми научного центра Уральского отделения Российской академии наук Using 2-morpholino-5-phenyl-6h-1,3,4-thiadiazine hydrobromide as agent changing total spectrum power of heart rate variability and possessing anti-bradycardia properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5127996A (en) * 1995-12-28 1997-07-28 Procter & Gamble Company, The Substituted 6-r-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
DE69525548T2 (en) * 1995-12-28 2002-10-31 Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju), Ekaterinburg SUBSTITUTED 6-H-1,3,4, -THIADIAZINE-2-AMINE, THEIR USE AS ANESTHETICATING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL PREPARATION CONTAINING THEM

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